AC   MF_04167;
DC   Protein; auto
TR   HAMAP; MF_04167; -; 1; level=0
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Names: APNUC_T5
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ID   APNUC
DE   RecName: Full=DNA-(apurinic or apyrimidinic site) endonuclease;
DE            EC=3.1.-.-;
DE   AltName: Full=AP endonuclease;
DE   AltName: Full=Apurinic-apyrimidinic endonuclease;
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CC   -!- FUNCTION: Performs endonucleolytic cleavage at abasic sites, which are
CC       generated by the base-excision activity of host Ung. The cleavage
CC       generates a 5'-deoxyribose phosphate and 3'-hydroxyl end. The sites are
CC       specifically recognized through the formation of a complex with host
CC       Ung. The viral endonucleolytic activity damages the host DNA, blocks
CC       host DNA replication and induces cell division arrest. This may provide
CC       an advantage for the phage and save nucleotides for the viral
CC       replication since specifically targets the host DNA, which possesses
CC       more misincorporated uracils than the viral genome.
CC   -!- SUBUNIT: Interacts with host Ung; this interaction allows the viral AP
CC       endonuclease to localize to newly formed AP sites and cleave them,
CC       leading to inhibition of bacterial growth.
CC   -!- SIMILARITY: Belongs to the apurinic/apyrimidinic endonuclease family.
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KW   Bacterial host gene expression shutoff by virus
KW   Degradation of host chromosome by virus
KW   Endonuclease
KW   Nuclease
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GO   GO:0003906; F:DNA-(apurinic or apyrimidinic site) endonuclease activity
GO   GO:0099015; P:degradation of host chromosome by virus
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FT   None
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Size: 110-130;
Related: None;
Template: Q6QGS2;
Scope:
 Viruses
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.2 2021/08/03
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