AC   MF_04168;
DC   Protein; auto
TR   HAMAP; MF_04168; -; 1; level=0
XX
Names: HOLIN_D29
XX
ID   HOLIN
DE   RecName: Full=Holin;
XX
CC   -!- FUNCTION: Accumulates harmlessly in the cytoplasmic membrane until it
CC       reaches a critical concentration that triggers the formation of micron-
CC       scale pores (holes) causing host cell membrane disruption and endolysin
CC       escape into the periplasmic space. Determines the precise timing of
CC       host cell lysis. Participates with the endolysin protein in the
CC       sequential events which lead to the programmed host cell lysis
CC       releasing the mature viral particles from the host cell.
CC   -!- SUBUNIT: Homomultimer. Self-associates to form a pore.
case <AnyFeature:Transmembrane>=2> and <Feature:Coiled_coil>
CC   -!- SUBCELLULAR LOCATION: Host cell inner membrane; Multi-pass membrane
CC       protein.
CC   -!- DOMAIN: The first transmembrane region undergoes a helix to beta-
CC       hairpin conformational change, which is responsible for its self-
CC       association and pore formation in the host membrane. The coiled coil
CC       region is required for host cell lysis and for cytotoxic activity. The
CC       C-terminus determines the size of the hole.
end case
case <AnyFeature:Transmembrane>=2> and not <Feature:Coiled_coil>
CC   -!- SUBCELLULAR LOCATION: Host cell inner membrane; Multi-pass membrane
CC       protein.
CC   -!- DOMAIN: The first transmembrane region undergoes a helix to beta-
CC       hairpin conformational change, which is responsible for its self-
CC       association and pore formation in the host membrane. The C-terminus
CC       determines the size of the hole.
end case
case <AnyFeature:Transmembrane<2> and <Feature:Coiled_coil>
CC   -!- SUBCELLULAR LOCATION: Host cell inner membrane.
CC   -!- DOMAIN: The coiled coil region is required for host cell lysis and for
CC       cytotoxic activity. The C-terminus determines the size of the hole.
end case
case <AnyFeature:Transmembrane<2> and not <Feature:Coiled_coil>
CC   -!- SUBCELLULAR LOCATION: Host cell inner membrane.
CC   -!- DOMAIN: The C-terminus determines the size of the hole.
end case
CC   -!- SIMILARITY: Belongs to the D29 holin family.
XX
DR   Pfam; PF16081; Phage_holin_7_1; 1; trigger=no
DR   General; Transmembrane; -; 2; trigger=strict
DR   General; Coiled_coil; -; 0-unlimited; trigger=strict
XX
case <Feature:coiled>
KW   Coiled coil
end case
KW   Cytolysis
KW   Host cell inner membrane
KW   Host cell lysis by virus
KW   Host cell membrane
KW   Membrane
KW   Transmembrane
KW   Transmembrane helix
KW   Viral release from host cell
XX
GO   GO:0140911; F:pore-forming activity
GO   GO:0016020; C:membrane
GO   GO:0020002; C:host cell plasma membrane
XX
FT   None
XX
Size: 120-170;
Related: None;
Template: O64204;
Scope:
 Viruses; Caudoviricetes
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.5 2022/12/01
//