AC   MF_04201;
DC   Protein; auto
TR   HAMAP; MF_04201; -; 1; level=0
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Names: ALPHA_CORONA_M
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ID   VME1
DE   RecName: Full=Membrane protein;
DE            Short=M protein;
DE   AltName: Full=E1 glycoprotein;
DE   AltName: Full=Matrix glycoprotein;
DE   AltName: Full=Membrane glycoprotein;
GN   Name=M;
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CC   -!- FUNCTION: Component of the viral envelope that plays a central role in
CC       virus morphogenesis and assembly via its interactions with other viral
CC       proteins.
CC   -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding
CC       compartment of the host cell, which is located between endoplasmic
CC       reticulum and the Golgi complex. Forms a complex with HE and S
CC       proteins. Interacts with nucleocapsid N protein. This interaction
CC       probably participates in RNA packaging into the virus.
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Multi-pass membrane protein.
CC       Host Golgi apparatus membrane; Multi-pass membrane protein.
CC       Note=Largely embedded in the lipid bilayer.
CC   -!- SIMILARITY: Belongs to the alphacoronaviruses M protein family.
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DR   Pfam; PF01635; Corona_M; 1; trigger=no
DR   General; Transmembrane; -; 3; trigger=no
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KW   Glycoprotein
KW   Host Golgi apparatus
KW   Host membrane
KW   Membrane
KW   Transmembrane
KW   Transmembrane helix
KW   Viral envelope protein
KW   Viral matrix protein
KW   Virion
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GO   GO:0030430; C:host cell cytoplasm
GO   GO:0044178; C:host cell Golgi membrane
GO   GO:0016020; C:membrane
GO   GO:0019031; C:viral envelope
GO   GO:0055036; C:virion membrane
GO   GO:0039660; F:structural constituent of virion
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FT   From: VME1_CVPPU (P04135)
FT   TOPO_DOM        18..47
FT                   /note="Virion surface"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT   TOPO_DOM        69..77
FT                   /note="Intravirion"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT   TOPO_DOM        99..112
FT                   /note="Virion surface"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT   TOPO_DOM        134..262
FT                   /note="Intravirion"
FT   REGION          237..252
FT                   /note="Interaction with N protein"
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Size: 225-262;
Related: None;
Template: P04135;
Scope:
 Viruses; Alphacoronavirus
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.4 2022/09/29
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