AC   MF_04204;
DC   Protein; auto
TR   HAMAP; MF_04204; -; 1; level=0
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Names: BETA_CORONA_E
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ID   VEMP
DE   RecName: Full=Envelope small membrane protein;
DE            Short=E protein;
DE            Short=sM protein;
GN   Name=E;
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CC   -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC       Acts as a viroporin and self-assembles in host membranes forming
CC       pentameric protein-lipid pores that allow ion transport. Also plays a
CC       role in the induction of apoptosis.
CC   -!- SUBUNIT: Homopentamer. Interacts with membrane protein M in the budding
CC       compartment of the host cell, which is located between endoplasmic
CC       reticulum and the Golgi complex. Interacts with Nucleoprotein.
CC   -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane; Single-pass type
CC       III membrane protein. Note=The cytoplasmic tail functions as a Golgi
CC       complex-targeting signal.
CC   -!- SIMILARITY: Belongs to the betacoronaviruses E protein family.
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DR   Pfam; PF02723; NS3_envE; 1; trigger=no
DR   General; Transmembrane; -; 1; trigger=no
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KW   Apoptosis
KW   Host Golgi apparatus
KW   Host membrane
KW   Membrane
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0044177; C:host cell Golgi apparatus
GO   GO:0044178; C:host cell Golgi membrane
GO   GO:0016020; C:membrane
GO   GO:0140975; P:disruption of cellular anatomical structure in another organism
GO   GO:0046760; P:viral budding from Golgi membrane
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FT   From: VEMP_SARS (P59637)
FT   TOPO_DOM        Nter..16
FT                   /note="Virion surface"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT   TOPO_DOM        38..Cter
FT                   /note="Intravirion"
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Size: 76-88;
Related: None;
Template: P59637;
Scope:
 Viruses; Betacoronavirus
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.8 2023/07/28
//