AC   MF_04206;
DC   Protein; auto
TR   HAMAP; MF_04206; -; 1; level=0
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Names: GAMMA_CORONA_E
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ID   VEMP
DE   RecName: Full=Envelope small membrane protein;
DE            Short=E protein;
DE            Short=sM protein;
GN   Name=E;
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CC   -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC       Acts as a viroporin and self-assembles in host membranes forming
CC       pentameric protein-lipid pores that allow ion transport. Also plays a
CC       role in the induction of apoptosis.
CC   -!- SUBUNIT: Homooligomer. Interacts with the M membrane protein in the
CC       budding compartment of the host cell, which is located between
CC       endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of
CC       both proteins are important for this function. Interacts with
CC       Nucleoprotein.
CC   -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane; Single-pass type
CC       III membrane protein. Note=The cytoplasmic tail functions as a Golgi
CC       complex-targeting signal.
CC   -!- SIMILARITY: Belongs to the gammacoronaviruses E protein family.
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DR   Pfam; PF03620; IBV_3C; 1; trigger=no
DR   General; Transmembrane; -; 1; trigger=no
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KW   Apoptosis
KW   Host Golgi apparatus
KW   Host membrane
KW   Membrane
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0044177; C:host cell Golgi apparatus
GO   GO:0044178; C:host cell Golgi membrane
GO   GO:0016020; C:membrane
GO   GO:0140975; P:disruption of cellular anatomical structure in another organism
GO   GO:0046760; P:viral budding from Golgi membrane
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FT   From: VEMP_IBVB (Q89894)
FT   TOPO_DOM        Nter..10
FT                   /note="Virion surface"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT   TOPO_DOM        32..Cter
FT                   /note="Intravirion"
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Size: 93-109;
Related: None;
Template: Q89894;
Scope:
 Viruses; Gammacoronavirus
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.7 2023/07/28
//