CLUSTAL format seed alignment for MF_00177
_____________________________________________________________________________
Features found in the protein:
- The following colors are used to highlight features:
- blue indicates SIGNAL, PROPEP, TRANSMEM, DOMAIN, ZN_FING, REPEAT,
DNA_BIND and CA_BIND.
- magenta is used to display DISULFID, THIOLEST and THIOETH.
- red is used for all other features, such as INIT_MET, ACTIVE SITE,
METAL,BINDING, NP_BIND, SITE, REGION, etc.
- The ID of the sequence used as the template for feature propagation is
underlined.
- A '<' at the beginning of a sequence or '>' at the end indicate that
the protein is fused with another domain either at the N- or C-terminus.
_____________________________________________________________________________
SYK1_METAC ----------------------MHWADVIAEDVLNK------------------------
SYK1_METMA ------------------MADTIHWADVIAEDVLNK------------------------
SYK_METBA ------------------MADTIHWADVIAEDVLKK------------------------
SYK_ARCFU ----------------------MHWADVIAADLLKR------------------------
SYK_THEAC -------------------MISLFWADALVKDLS--------------------------
SYK_THEVO ----------------------MFWADAAVKDLI--------------------------
SYK_METJA ----------------------MHWADVIAEKLIEER-K---------------------
SYK_METMP ----------------------MHWADATSEKIMKKR-N---------------------
SYK_METTH -MKFTHFFVALILSRFLQVISLKHWIERIADELKER--D---------------------
SYK_PYRAB ---------------------MVHWADYVADKIIRERGE---------------------
SYK_PYRHO ---------------------MVHWADYIADKIIRERGE---------------------
SYK_PYRFU ---------------------MVHWADYMAEKIIKERGE---------------------
SYK_BORBU -------------------MKTAHWADFYAEKIKKEKGP---------------------
SYK_BORAF -------------------MKTAHWADFYAEKIKKDKGP---------------------
SYK_BORGP -------------------MKTAHWADFYAEKIKKEKGP---------------------
SYK_TREPA ---------------MSICEKSLHWADKVAHKIIKERAD---------------------
SYK_RICPR -----------MSVVLEDAIRSNAWPFIEAKKILDSLNGKAPEKG---------------
SYK_RICCN -----------MSEIWEDAIKSNAWPFVEAKKILDSLNGQIPEKG---------------
SYK_BRUME MTSHRLPEITLTPELTAAAAEAKAWPFEEARKILKRYAKTGLPE----------------
SYK_BRUSU MTSHRLPEITLTPELTAAAAEAKAWPFEEARKILKRYAKTGLPE----------------
SYK_RHILO --MAGSNTIDLNPELLAAAAESKAWPFEEAKKIIERYKGGEFPE----------------
SYK_CAUVC ----------MFEGLSPLARDARSWPFEQARATIARVLRVRLPDRADQDAAKALIDAGKT
SYK_METKA -------------------MTKEHWSEVKAREVTEHCRKHADEL----------------
SYK_STRCO ------------MPIVAQSTETTDWVSRFADEVIAESERRAPG-----------------
SYK_HALSA -------MHPDDDPYADDGSGRLFWADAAADRVLDGDPE---------------------
SYK_CENSY ---------------MEETIGRGTWIDKLAHELIEREKALGRS-----------------
SYK_AERPE --------------------MPVHWVDKLVAELEAKLQNRG-------------------
*
SYK1_METAC ----------SGKHLVATGITPSGHIHIGNMR-EVVTADAAYRALLDMGA---DARLIYI
SYK1_METMA ----------SGKHLVATGITPSGHIHIGNMR-EVVTADAAYRALLDRGA---DARFIYI
SYK_METBA ----------NGKHLVATGITPSGNIHIGNMR-EVVTADAVYRALVDKGA---NADFIYI
SYK_ARCFU ----------SNSHRIATGISPSGHIHLGNLR-EMVTADAIRRALLDAGG---EAKIVYI
SYK_THEAC -----------GPQRVSTGISPSGPIHVGNMR-EILTGDILFKAITKRGL---ESDFIYL
SYK_THEVO -----------GEQRISTGISPSGPIHVGNMR-EILTGDILYKAVIKRGL---KSDFIYL
SYK_METJA ----------ADKYIVASGITPSGHIHVGNAR-ETLTADAIYKGLINKGV---EAELIFI
SYK_METMP ----------AEEYVVSSGITPSGHIHIGNAR-ETLTADAVYKGMLKKGA---EAKLIFI
SYK_METTH ----------VEEHVVASGTSISGSIHIGNSC-DVFIASSIAKSLKKDGF---KSRTVWI
SYK_PYRAB ----------KDRYVVESGITPSGYVHVGNFR-ELFTAYIVGHALRDKGY---EVRHIHM
SYK_PYRHO ----------KEKYVVESGITPSGYVHVGNFR-ELFTAYIVGHALRDKGY---EVRHIHM
SYK_PYRFU ----------KEEYVVESGITPSGYVHVGNFR-ELFTAYIVGHALRDRGY---NVRHIHM
SYK_BORBU ----------KNLYTVASGITPSGTVHIGNFR-EVISVDLVARALRDSGS---KVRFIYS
SYK_BORAF ----------KNLYTVASGITPSGTVHIGNFR-EVISVDLVARALKDSGS---KVRFIYS
SYK_BORGP ----------KNIYTVASGITPSGTVHIGNFR-EVISVDLVARALKDSGS---QVRFIYS
SYK_TREPA ----------CDQYTCASGITPSGTVHIGNFR-EIISVDLVVRALRDQGK---SVRFVHS
SYK_RICPR ------------YILFETGYGPSGLPHIGTFA-ENARMVMVQKAFEQLSD--IPTKLICF
SYK_RICCN ------------YVLFETGYGPSGLPHIGTFG-ENARMVMVQKAFEQLSD--IPTKLICF
SYK_BRUME ------------TVIFETGYGPSGLPHIGTFG-EVARTSMVRHAFRILTQDKVKTRLICF
SYK_BRUSU ------------TVIFETGYGPSGLPHIGTFG-EVARTSMVRHAFRILTQDKVKTRLICF
SYK_RHILO ------------TILFETGYGPSGLPHIGTFG-EVARTSMVRHAFRVLTQDKVATKLLCF
SYK_CAUVC DEAVKAYPALAKAVIFETGYGPSGLPHLGTFG-EVARTTMVRQAFRALTDEAIPTRLIAF
SYK_METKA ----------PDEIVVASGASTSGRLHVGNAR-DVLTADAVARVLRERYHE--DVRVVWI
SYK_STRCO ----------KPGVVVASGLSPSGPIHLGNLR-EVMTPHLVADEVRRRGH---EVRHLIS
SYK_HALSA -----------EPIVIKGGISPSGVPHLGNMN-EIMRGYFVAAVLRERGH---EVRQVFT
SYK_CENSY ----------TDMINVESGLGASGIPHMGSLG-DAVRAYGVGLALGDMGH---AFKLIAY
SYK_AERPE ----------KDEYIFNGGLSVSGLQHIGRLRGEVLLGEAVRRELEKRGFRVKQLLTLYT
* ** *:* : . :
SYK1_METAC ADNYDPLRKVYPFLPES--------------YAEHVGKPISEVPCPCG-DCANYAEHFLK
SYK1_METMA ADNFDPLRKVYPFLPES--------------YAEHVGKPISEVPCPCG-ECANYSEHFLK
SYK_METBA ADNYDPLRKVYPFLPES--------------YVEHVGKPISEIPCPCG-NCANYAEHFLK
SYK_ARCFU ADDFDPLRRRYPFLPEE--------------YENYVGMPLCKIPDPEG-CHDSYSEHFLQ
SYK_THEAC CDDMDPLRKVYPFLSKD--------------YERYVGQPLKNIPAPQG--AGKYSDYYLE
SYK_THEVO CDDMDPLRKVYPFLDQS--------------YSKYVGFPLKNIPSPDG--VGVYSDHFLN
SYK_METJA ADTYDPLRKLYPFLPKE--------------FEQYIGMPLSEIPCPEG-CCESYAEHFLR
SYK_METMP ADDYDPLRKLYPFLPKE--------------FEKYIGMPLSEIPCPQG-CCKSYADHFLM
SYK_METTH ADDHDPLRKVPYPLPES--------------YEKYLGVPYSMIPCPEG-CCESFVEHFQR
SYK_PYRAB WDDYDRFRKVPRNVPPE--------------WKEYLGMPVSEVPDPWG-CHDSYAEHFME
SYK_PYRHO WDDYDRFRKVPRNVPQE--------------WKDYLGMPISEVPDPWG-CHESYAEHFMR
SYK_PYRFU WDDYDRFRKVPKNVPQE--------------WEEYLGMPVSEVPDPWG-CHDSYAEHFMG
SYK_BORBU WDNYDVFRKVPKNMPEQE------------LLTTYLRQAITRVPDTRS-HKTSYARANEI
SYK_BORAF WDNYDVFRKVPKNMPEQE------------LLTTYLRQAITRVPDTRS-HKTSYARANEI
SYK_BORGP WDNYDVFRKVPKNMPEQE------------LLTTYLRQAITRVPDTRG-YKTSYARANEI
SYK_TREPA WDDYDVFRRIPDNVPAQD------------ELKQYIRMPITSVPDPFQ-QEDSYARHHER
SYK_RICPR SDDMDGLRKVPSNIPHPE------------MVAQYMDMPLTSIPDPFG-KCKSYGHYMNA
SYK_RICCN SDDMDGLRKVPSNIPNPE------------MVAQYMDMPLTSIPDTFG-ECESYGHYMNA
SYK_BRUME SDDLDGMRKVPDNVPDRA------------ALEPYLQMPLSSVPNPFGGDYKSFAEHNNA
SYK_BRUSU SDDLDGMRKVPDNVPDRA------------ALEPYLQMPLSSVPNPFGGDYKSFAKHNNA
SYK_RHILO SDDMDGMRKIPDNVPDRA------------ALEPHLHKPLSSVPNPFGGDYASFADHNNA
SYK_CAUVC SDDMDGLRKVPDNIENKQ------------PLIEDLGKPLTVVRDPFG-THDSFGAHNNA
SYK_METKA SDDVDPLRRIPRDLDGR-------------LSEDYLGVPYKAIPVGDE----PYSDRWAR
SYK_STRCO WDDYDRYRKVPAGVPGVDE-----------SWAEHIGKPLTSVPAPKGSPHPNWAEHFKA
SYK_HALSA SDDRDPLRGLPRKLADLDGEVVALGDVNAGALGQNLGAPYTEIPDPFG-CCDSYGAHFSN
SYK_CENSY SDDLDGLRKVPEGMPSS--------------LEEHIARPVSAIPDPYG-CHDSYGMHMSG
SYK_AERPE VDPWKGKDEQRREFPDPK------------AAERYVGWPLDRVPDPKG-CHASWVDHFWS
* . . : . : :
SYK1_METAC PFIEALRRL-GINPEVLRADEMYRAGLYTEAIKTALAKRDEIAKILEEVSGK--------
SYK1_METMA PFLEALRRL-GINPEVYRADEMYRAGMYTEAIKTALVKRNEIAKILEEVSGK--------
SYK_METBA PFLEALRRL-GINPKVYRADEMYKTGKYTEAIKTALVKRDAIAKILEEVSGK--------
SYK_ARCFU PFLESLEIL-GIPVEVRRAYQMYSEGLYENNTRIALKRRDEIARIIAEVTGR--------
SYK_THEAC PFVRVMKEA-NIPARVIKTSDLYESGMLAQACDIAINNREKIKDILETVSGR--------
SYK_THEVO PFIEVMRKT-GIPARVIKTSDLYGNGILADAIDTVMERRSEIKDILEKITGR--------
SYK_METJA PYLESLDDL-GVELTTYRADENYKKGLYDEKIKIALDNREKIMEILNKFRAN--------
SYK_METMP PFLNSLEDL-GVEITTHRANECYKAGMYNDAIITALENRLKIKELLDSYRKE--------
SYK_METTH PFLEALERF-RIGVEHYSGARMYTEGLYNDYIRTSLERAPEIREIFNRFRDR--------
SYK_PYRAB KFEREVKEL-GIEVEFLYASELYKRGEYSEEIRKAFEGKEKIMEILNKYREIAKQP----
SYK_PYRHO KFEEEVEKL-GIEVDFLYASELYKRGEYSEEIRLAFEKRDKIMEILNKYREIAKQP----
SYK_PYRFU LFEEEVAKL-EMDVEFLRASELYKKGEYAEEIRKAFEAKGKIMAILNKYREVAKQP----
SYK_BORBU EFEKYLPVV-GINPEFIDQSKQYTSNAYASQIKFALDHKKELSEALNEYRTS--------
SYK_BORAF EFEKYLPIV-GINPEFIDQSKQYTNGVYASQIKFALNHKKELSNALNEYRTS--------
SYK_BORGP EFEKYLPIV-GINPEFIDQSKKYTNSTYASQIKFALNHKKELAEALNEYRTS--------
SYK_TREPA EIESALPEV-GIYPEYVYQSKQYQAGVYAQEIKIALDNRHRIQAILNEYRDEQH------
SYK_RICPR KLCAFLDKF-GFKYEFYSSTNCYKAGMFDEMLIRVLEKYDEIMALMLPTFRD--------
SYK_RICCN KLRSFLDKF-GFEYEFYSSTNCYKAGMFDAMLIMVLEKYDEIMELMLPTFRE--------
SYK_BRUME MLCRFLDTF-GFDYEFASATEYYRSGRFDTVLLKAVERYDDIMKVMLPTLGE--------
SYK_BRUSU MLCRFLDTF-GFDYEFASATEYYRSGRFDTVLLKAVERYDDIMKVMLPTLGE--------
SYK_RHILO MLCRFLDTF-GFDYEFASATQYYKSGRFDAMLLRAAERYDKIMAVMLPTLGP--------
SYK_CAUVC RLRAFLDGF-GFEYEFVSSTDCYKGGLFDATLLTALERFDAIQKVMLPTLGE--------
SYK_METKA NFVEELREF-GAEVEWISSAELYTDNGFVKLVREVVNDYYGGGGRLASVLER--------
SYK_STRCO AMVDSLAEM-GVEFDGISQTAQYTSGVYREQILHAMKHRRDIDAILDQYRTKKAPAKKSQ
SYK_HALSA LIQSSADRL-GVDVEMVSNTETYANGGFEEVTRYLLEHVTAARDVLGEYQDK--------
SYK_CENSY LLLEGLDAL-NIEYDFRRARDTYRDGLLSEQIHGILSSSSKIGEKIAEMVGQ--------
SYK_AERPE DFGPYIGVFTDGKIEVVTTRELYKGRLKEFITTMVLPRRDEIRRVINKYRGRK-------
* :
SYK1_METAC -----------------------TVAEDWSPFNPRCNECGKITTTKVAGFDLEAETVDYV
SYK1_METMA -----------------------TVAEEWSPFNPRCNECGKITTTKVTGFDPDAETVDYV
SYK_METBA -----------------------TVASDWSPFNPRCDQCGRITTTKVTGFDLEAETVDYV
SYK_ARCFU -----------------------ELEERWYPFMPLCENCGRINSTRVTSFD--ENWIYYE
SYK_THEAC -----------------------KIEGDFYPYEPLCEKCGRISTTHVISYS--YPYAEYA
SYK_THEVO -----------------------MIEGDFYPYEPLCEKCGRINSTSVISYK--YPYAEYT
SYK_METJA -----------------------PLPDDWWPINIVCENCGKL-KTKVIKYDSEKEEITYR
SYK_METMP -----------------------PLADDWYPLNVVCEKCGKMHETKVINYNSEDKTITYV
SYK_METTH -----------------------PLRDDWLPYNPICEKCGRVNTTEAYDFS--GDTVRYR
SYK_PYRAB -----------------------PLPENWWPAMVYCPEHRKE-AEIIEWDG--EWKVKYR
SYK_PYRHO -----------------------PLPENWWPAMVYCPEHRRE-AEIIEWDG--GWKVKYK
SYK_PYRFU -----------------------PLPENWWPAMVYCPEHRKE-SEIIDWDG--EWGVKYR
SYK_BORBU -----------------------KLEENWYPISVFCTKCNRDTTTVNNYDN--HYSVEYS
SYK_BORAF -----------------------KLEENWYPISIFCTKCNRDTTTVNNYDN--HYSVEYS
SYK_BORGP -----------------------KLEENWYPISIFCTKCNRDTTTVNNYDN--HYSVKYS
SYK_TREPA -----------------------KISGTYWPVSVFCTACHKDCTTVDAWDS--HWCLQYH
SYK_RICPR -----------------------ERKTTYAPFMPICPKTGKVLQVPIEKWDAKAGTVSYK
SYK_RICCN -----------------------ERKATYSPFMPICPKTGKVLQVPIEKWDAKAGTVTYK
SYK_BRUME -----------------------ERQATYSPFLPISPKSGRVLYVPMKKVDAKAGTITFD
SYK_BRUSU -----------------------ERQATYSPFLPISPKSGRVLYVPMKKVDAKAGTITFD
SYK_RHILO -----------------------ERQATYSPFLPISPKSGRVLYVPMKHVDAKAGTITFD
SYK_CAUVC -----------------------ERRATYSPFLPISPSTGKVLQVPTLERNVEKGTIVFE
SYK_METKA -----------------------FGLEDARVYMPVCEECGRIATTRVVDVD--GWRIEYV
SYK_STRCO KPLDEAELEAAEGSGAAAEDDGSSGSAGYFPYKPYCGNCEKDLTTVTAYDD-DSTELTYA
SYK_HALSA ------------------------VDEEYVPFNPICEACGKVTETVTDVDA-DAGTVEYV
SYK_CENSY -----------------------EKFRSSLPYFAVCGQCGKMYTAEAVEYVADSRKVRYR
SYK_AERPE -----------------------PYQEGWIPLEPRCARCGRIDSTEALEILG-GERVRYR
. : :
SYK1_METAC CA-CGHSGTVPMAGG---------------------GKLTWRVDWPARWAVLGVTVEPFG
SYK1_METMA CA-CGHSGTVPMAGG---------------------GKLTWRVDWPARWAVLGVTVEPFG
SYK_METBA CA-CEHSGTVPMAGG---------------------GKLTWRVDWPARWSVLGVTVEPFG
SYK_ARCFU CD-CGHSGRVGYVGG---------------------GKLTWRVDWAARWQILSITCEPFG
SYK_THEAC CK-CGHHGFADIRKAE--------------------GKMPWRVEWPAKWFALKVTVEPFG
SYK_THEVO CK-CGHHGFADIRRAE--------------------GKMPWRIEWPAKWYALKVSIEPFG
SYK_METJA CEICGFENTVKPYKGR--------------------AKLPWRVDWPARWSIFNVTIEPMG
SYK_METMP CK-CGFENTVKPFNGI--------------------GKLPWRVDWPARWNIFGVTAEPMG
SYK_METTH CE-CGFDGEMDIKSGL--------------------GKLTWRVEWAARWKILGVTCEPFG
SYK_PYRAB CPEGHEGWVDIR-SGN--------------------VKLRWRVDWPMRWAHFDVDFEPAG
SYK_PYRHO CPEGHEGWVDIR-SGN--------------------VKLRWRVDWPMRWSHFGVDFEPAG
SYK_PYRFU CPEGHEGWTDIR-DGN--------------------VKLRWRVDWPMRWAHFGVDFEPAG
SYK_BORBU CECGNQESLDIRTTWA--------------------IKLPWRIDWPMRWKYEKVDFEPAG
SYK_BORAF CECGNQESLDIRTTWA--------------------IKLPWRIDWPMRWKYEEVDFEPAG
SYK_BORGP CECGNQESLDIRTTWA--------------------IKLPWRIDWPMRWKYEKVDFEPAG
SYK_TREPA CECGHGEQVDLRQTSA--------------------VKLSWRVDWAMRWSKEHVVFEPAG
SYK_RICPR DEDGNDVEVPVT-GGH--------------------CKLQWKPDFGMRWAALKVDYEMYG
SYK_RICCN DKAGNYIEVPVT-GGH--------------------CKLQWKPDFGMRWAALKVDYEMYG
SYK_BRUME DEDGEETTLSVT-GGK--------------------VKLQWKPDFGMRWAALGVDFEMFG
SYK_BRUSU DEDGEETTLSVT-GGK--------------------VKLQWKPDFGMRWAALGVDFEMFG
SYK_RHILO DE-GTETTLSIT-GGR--------------------VKLQWKPDFGMRWAALGVDFEMFG
SYK_CAUVC DEDGSKVEVPVT-GGH--------------------VKMQWKPDWAMRWTALGVDYEMSG
SYK_METKA CEGRHEIGDAVLEGCGHRGELDLRKPIEVNGFEIPPGKLGWKIEWPTRWVYLGVACEPFG
SYK_STRCO CTACGFSETVRLSEFNR-------------------GKLVWKVDWPMRWAYEGVVFEPSG
SYK_HALSA CTDMDAGDQTIEGCGHEGTATLRE------------GKLPWRFEWPAQWRTLGVDYEPFG
SYK_CENSY CADAKVGGKQVAGCGHEGEADIGGAG----------GKLAWKVEFAARWQAFDVRFEAYG
SYK_AERPE CSYCGYQGESSIEDSK----------------------LNWRIEWAGVWWSLGVDFEPYG
: *: :: * : * *
SYK1_METAC KDHASKGGSYDTGKRIVREIYGHEPPFPIVYEWIMLG---KRGAMSSSTGVVVSISDMLE
SYK1_METMA KDHASRGGSYDTGKRIVREIYGHEPPFPIVYEWIMLG---KQGAMSSSTGVVVSISDMLE
SYK_METBA KDHASRGGSYDTGKRIVKEIFGHEPPYPIVYEWIMLG---KQGAMSSSTGVVVSISDMLK
SYK_ARCFU KDHAAAGGSYDTGVRIAREIFDYEPPYPVPYEWIHLK---GKGAMKSSKGIVLPVREMVE
SYK_THEAC KDHGAPGGSYDTGRRIAREVFGIEPPVPLMYERIILK---GKGAMHSSTGLAIAASEIME
SYK_THEVO KDHGAPGGSYDTGKRIAREIFGIEPPLPLVYERIMLK---GKGAMHSSTGLAIPASEIID
SYK_METJA KDHAAAGGSYDTGVLIAKEIYNYIPPKKVVYEWIQLKVGDKAIPMSSSKGVVFAVKDWTN
SYK_METMP KDHAASGGSYDTGIKIARQIFNYQAPEKMVYEWIQLKVGDKAMPMSSSSGVVFAVKDWTE
SYK_METTH KDHAASGGSYDVSSIISEEIFDYPAPYPVPYEWITLR----GEAMSKSRGVFFTPGQWLE
SYK_PYRAB KDHLAAGSSYDTGKEIIKAIYGKEAPMSLMYEFVGIK--GEKGKMSGSKGNVILLSDLYE
SYK_PYRHO KDHLVAGSSYDTGKEIIKEVYGKEAPLSLMYEFVGIK--GQKGKMSGSKGNVILLSDLYE
SYK_PYRFU KDHLAAGSSYDTGKEIIREVYGKEAPLTLMYEFVGIK--GQKGKMSGSKGNVILLSDLYE
SYK_BORBU KDHHSSGGSFDTSKNIV-KIFQGSPPVTFQYDFISIK--GRGGKISSSSGDVISLKDVLE
SYK_BORAF KDHHSSGGSFDTSKNIV-KIFQGSPPVTFQYDFISIK--GRGGKISSSSGDVISLKDVLE
SYK_BORGP KDHHSSGGSFDTSKNIV-KIFQGSPPVTFQYDFISIK--GRGGKISSSLGDVISLKDVLE
SYK_TREPA KDHHSQGGSFDTARLISDHIYHWPAPVSFRYDFIGLK--GLPGKMSSSAGKVVGLRDVLE
SYK_RICPR KDHLANSRLYSE----ICRILGGKPPVQFCYELFLDA---NGEKISKSRGNSISVDDWLK
SYK_RICCN KDHLANARLYSE----ICRILGGKPPVQLCYELFLDE---NGKKISKSKGNSISIDDWLK
SYK_BRUME KDHQTNAGIYDR----ICEILGGRAPEHFVYELFLDQ---LGQKISKSKGNGISIDEWLA
SYK_BRUSU KDHQTNAGIYDR----ICEILGGRAPEHFVYELFLDQ---LGQKISKSKGNGISIDEWLA
SYK_RHILO KDHQTNAVVYDR----ICNILGGRAPEHFVYELFLDE---NGQKISKSKGNGLTIDEWLT
SYK_CAUVC KDLIDSVKASGA----ICKALGGVPPEGFNYELFLDE---NNQKISKSKGNGLSMEDWLR
SYK_METKA KDHYVAGGSYEVGSAIAEEFFGFPAPVPVPYEWITLD----GKAMSSSKGHYVTLSDWGE
SYK_STRCO VDHSSPGSSFQVGGQIV-GIFGGEQPIGPMYAFVGIS---GMAKMSSSKGGVPTPADALK
SYK_HALSA KDHAE--GSWPSGTDISRNVLGDEPPTPMVYEWFTLD----GEPFSSSAGHVILVQDVLA
SYK_CENSY KDIMDSVRINDW---VSDEILSNPHPHHARYEMFLDK---GGKKISKSSGNVVTPQKWLR
SYK_AERPE KDHATPGGSRDS-AAELARLLGFEPPEGVWYEWVSLRAGGREADMSSSGFTGITPREWLD
* * * . : * .
SYK1_METAC VVPPEVLRYLIIR-TKPEKHIQFDPGQPLLNLVDEYERLRDKFRENDPSLGDFEKRIYEL
SYK1_METMA VVPPEVLRYLIIR-TKPEKHIQFDPAQPLLTIVDEYERLREKFRDNDPSMGEFEKRIYEL
SYK_METBA IVPPEVLRYLIIR-TKPEKHIQFDPGQPLLSLVDEYERLRTQFRENDPSLGTFQGRVYEL
SYK_ARCFU VIPPEIVRYITIR-VKPERHIEFDPGLGLLDLVEEFE---EKFKEKD--------RSVEL
SYK_THEAC VIPPDLLRYMIAR-VNPGRHIDFDPGMGILALSDELEKLQDAYFENRASLDEDQAAMVEY
SYK_THEVO VMPPELLRFLIAR-VNPSRHIDFDPGLGLLNLFDEFERYLNKYRE--GDIDGDSKAIIEY
SYK_METJA IAHPEILRFLLLR-SKPTKHIDFDL-KKIPDLVDEYDRLEDFYFNNKDK---DELSEEEQ
SYK_METMP ICHPEVLRFLILK-GKPTKHIDFDL-KAISNLVDDYDELERKYFELIEKQKTEELNDNEN
SYK_METTH IGPPESLNYFIFR-SKPMKHKDFNPDMPFLDLMDQFDRTERIYYGMEDAASEKEEQKLRN
SYK_PYRAB VLEPGLVRFIYAR-HRPNKEIRIDLGMGLLNLYDEFDKVERIYFGVEDAKGDVE--ELKR
SYK_PYRHO VLEPGLVRFIYAR-HRPNKEIKIDLGLGILNLYDEFDKVERIYFGVEGGKGDDE--ELRR
SYK_PYRFU VLEPGLVRFIYAK-HRPNKEIRIDLGLGLLNLYDEFDRVERIYFGIEKGKGDEE--ELKR
SYK_BORBU VYTPEVTRFLFAA-TKPNTEFSISFDLDVIKIYEDYDKFERIYYGVEDVKEEKK-RAFKR
SYK_BORAF VYTPEVTRFLFAS-TRPNTEFSISFDLDVIKIYEDYDRFERIYYGVEDIKEEKK-RAFKR
SYK_BORGP IYTPEVTRFLFAA-TKPNTEFSISFDLDVIKIYEDYDRFERIYYGVEDIKEEKK-RSFKR
SYK_TREPA VYQPEVLRYLFVS-TRPNTEFSISFDLDVLKIYEDYDKSERVAWGIHAAKSEHEFMRHKR
SYK_RICPR YASVESIALFMYKNPARAKRLFFDL---IPKNVDEYITLNQKYHLEEDMVTRFANPVYHI
SYK_RICCN YAPVESMALFMYQNPTRAKRLFFDV---IPKNVDEYITFNQKYHLEEDRAKRFANPVYHI
SYK_BRUME YAPTESLTLYNFQKPKTAKKLYFDV---IPKTVDEYFTYLSAYARQE-WKDRLNNPVWHI
SYK_BRUSU YAPTESLALYNFQKPKTAKKLYFDV---IPKTVDEYFTYLSAYARQE-WKDRLNNPVWHI
SYK_RHILO YAPTESLGLYMYQRPRQAKKLYFDV---IPRAVDEYYTFLGAYPRQD-WKERLGNPVWHM
SYK_CAUVC YGAPESLSYYMFQSPKSAKKLYFDV---IPKASDEYLQQLDGFGRQE-PAKQLDNPVWHI
SYK_METKA VCHREVLRYLVLR-GKPLKHLDLDLRFGLLQAVDDYDELEKRYFAGEADERERRIYELSR
SYK_STRCO IMEPQLLRWLYAR-RRPNQSFKIAFDQEIQRLYDEWDRLDAKVADGSALPADAAAHARAV
SYK_HALSA LLELPVVRYFFSKDPRRARDFSIEH---LDQLVDEFDRMERVYFGEAADASEDERERAAR
SYK_CENSY YGTPQSILLLMYKRITGARELGLED---VPALMDEYGDLQREYFAGGGRGGKAREAKNRG
SYK_AERPE IAHPQILRFIYFL-HPPTRRVVVDL-SEIPSYYSQYYRAERIYFGIEEASTVEETRYLAR
. . .:
SYK1_METAC SRA----------TGICHPEIPFKQMVTIYQVARGDF-------EQVLKIVKRSG-----
SYK1_METMA SRA----------TGICHPEIPFKQMVTIFQVARGNF-------EQILQIVKRSG-----
SYK_METBA SRA----------TGVCQSEIPFKQMVTIYQVARGDF-------DQVLKIVKRSG-----
SYK_ARCFU SLV----------GEVVYSDVPFRHLIVVGQIANWDL-------EKALEIIERTG-----
SYK_THEAC SLVN---------KDRKPYPVDFRHLVTLVQIYRTE--------DEILRAVKKG------
SYK_THEVO SLIE---------KEKLSYPIDFRHLITLIQIYQKK--------EDILRAAMAS------
SYK_METJA EKIRIYELSTPKIPETKPFVIPYRFCSIIAQLTYDEEKE-DINMERVFEILRRNN-----
SYK_METMP EKISLYELVTPKIPERLPLQVAYRFCSIIAQIALDKETQ-KIDMERVFDILGRNG-----
SYK_METTH IYRV-----SMIEEFDLPLRPSYRFMTVACQIAGDDP-------ERLYDILRRNSQLPEE
SYK_PYRAB TYELS---NPRI-PNRLIAQAPFRFLAVLVQMPHLDE-------DGIISVLTNQG-----
SYK_PYRHO TYELS---MPKK-PERLVAQAPFRFLAVLVQLPHLTE-------EDIINVLIKQG-----
SYK_PYRFU TYELS---VPKK-PKRLVAQAPFRFLAVLVQLPHLSI-------EDIIFTLVKQG-----
SYK_BORBU IYELS---QPYMPSKRIPYQVGFRHLSVISQIFENNI-------NKILNYL---------
SYK_BORAF IYELS---QPYMPSKRIPYQIGFRHLSVICQIFENNI-------NKILNYL---------
SYK_BORGP IYELS---QPYMPSKRIPYQIGFRHLSVICQIFENNI-------NKILNYL---------
SYK_TREPA IYELS---QVRGMPPCISYQVPFRHVCNILQINSGDI-------SAVLAFF---------
SYK_RICPR HHGNV--------PKIETFGLTYSLLLNLTAVCNTSDK------SVLWGFITKYE-----
SYK_RICCN HHGNV--------PKIETFGITYSLLLNLTSVCNPSDK------SVLWGFISKYE-----
SYK_BRUME HYGNP--------PKADL-PVTFALMLNLVSASNAESP------AVLWGFISRHV-----
SYK_BRUSU HYGNP--------PKADL-PVTFALMLNLVSASNAESP------AVLWGFISRHV-----
SYK_RHILO HDGNP--------PAIDM-PVPFSLLLNLVSASNAQNK------DVLWGFISRHT-----
SYK_CAUVC HGGKP--------PQQGS-PVSFSLMLNLVSAADASTK------EILWGFLSRYI-----
SYK_METKA VDEIP---------EECPPHVPFRFCAVVAQVVGIEDDVSEEEFERALEIFRRTG-----
SYK_STRCO GTAAG-------ELPRTPRPLPYRTLASVADITAGHE-------DQALRILGELD-----
SYK_HALSA VYPLL-----VDDIDADRVRIPFTFAAVLGMTEDSALR---------EEIARREG-----
SYK_CENSY LFEYA---NLLVKQAGPRPHAAYRLLVELSRLFKEDR------AERVTKKLVEYG-----
SYK_AERPE TYELSHP---SNPPAKPPSQIPYSHAAIVAQVVGPER-----LWTDGLERLKRAG-----
:
SYK1_METAC ---FSTEN-----EKCIRELADNVSRWLELY-APPFAKFSVKEKVPVQTATLSELQKAFL
SYK1_METMA ---FSTED-----EKCIRELVDNVSKWLELY-APPFAKFSVKENVPVQVATLSELQKAFL
SYK_METBA ---FSTED-----KKCIKELADNVSKWLKLY-APPFAKFKVKEKVPVQAATLSELQRAFL
SYK_ARCFU ---YTVDDVT---RRDVERRLKYARKWLEKY-APDNIKFEIPEKV---TAEFSEEEKKFL
SYK_THEAC ----QPSDFI---EADFRKEIEYARRWLERY-APESVKFRILPVD--QKIELSDSDLAIL
SYK_THEVO ----TKDQLD---ESALYDEIKYAKNWLERY-APDNVKFKLLAID--EKAELSDQDRAIL
SYK_METJA ---YSIDDIDEFSMKKLKDRLLMARNWALKY-GEKLVIISEDEAKE-IYEKLKDKQKEWI
SYK_METMP ---YNPAEFSEYDKSRLEKRLYMSKKWASDY-GENLEINDLDQAKE-QYETLSEEQKAWL
SYK_METTH LMDLELDQLTDKQLEQLNERIENVKNWLRLY-APEFVKFQVQEELP--DVELSEPQLKFL
SYK_PYRAB ---HVPKELEREDIERIRLRIRLAKNWVEKY-APDSVKFSILPE-PPKIEIDESVREAME
SYK_PYRHO ---HIPRDLSKEDVERVKLRINLARNWVKKY-APEDVKFSILEK-PPEVEVSEDVREAMN
SYK_PYRFU ---HVPENLTQEDIDRIKLRIKLAKNWVEKY-APEEVKFKILSV-PGVSEVDPTIREAML
SYK_BORBU ------KNVQEDQKDKLINKINCAINWIRDF-APEDFKFSLRSKFDNMEILEENSKKAIN
SYK_BORAF ------KNVQEDQKDKLINKIKCAINWIRDF-APEDFKFSLRSKFDSIEILKENSKKAIN
SYK_BORGP ------KNVQDDQKDKLINKIKCVINWIKDF-APEDFKFLLRSKFDNIEILKEDNKKAIS
SYK_TREPA ------SDIHKDQIERFVRRCQCAWNWIRDAGAPDDFKFTLKEDGVRVPLSAEITE-ALR
SYK_RICPR ------PKATPNTSTYLDHLTEFAIRYYNDFIQTHKSYLVVSEKHKIILHDILDMLSNIS
SYK_RICCN ------PKATPNTNPYLDHLAEFAIRYYNDFIKAHKLYLSPSEKHKVILQDILDMLSDIA
SYK_BRUME ------PGVTPENNPELDALVGYAIRYFNDFVKPTKKFRAPDDVERAALEALDAKLGELP
SYK_BRUSU ------PGVTPENNPELDALVGYAIRYFNDFVKPTKKFRAPDDVERAALEALDAKLGELP
SYK_RHILO ------QGVTPKTHPELDQLVGHAIRYFDDFVRPTKTFRAADEVEREALEALDAALGALP
SYK_CAUVC ------PGASPETQPLLDRLAGYAINYYEDFVKPSKVFRAPSDQERAAMLDLLAKLKAMP
SYK_METKA ---HLEAEPEGFGREWLRERLEKASRWVDRY-APEEARFRVREEPE--PVELSDKEREFL
SYK_STRCO ------PANPIASLDEARPRYDKAEAWINTHVPADQRTIVRQEPDAELLKSLDEPSRQSL
SYK_HALSA ---HIPADADADTVADALTRVERAREWARRTNNEFNYRLARAEIPA---HDFDDATAAAL
SYK_CENSY --------VVDGPSPEIERLIGLAGNYADDMYAAERSDIELDEATKGALSELVELLGSAP
SYK_AERPE -----LLGHDEYSIRWAKELLEKAYKWARRY-APKHLKFEIPDSPPEDALRRIEKPDLLE
:
SYK1_METAC GAFADLIETKGKISG-EEYHMLVYSAKDEGSELNRLIAQKVNVPVPQVDPKDLFKAIYTS
SYK1_METMA GAFADLIESKGKISG-EEYHMLVYSAKEKGSELNRLIAEKLNVPAPQVDPKDLFKAIYTS
SYK_METBA SAFAALIESRDEISG-EEYHMLVYSAKDEGSELNRRIAEKLNAHAPQVDPRELFKAIYIS
SYK_ARCFU RAYAERLRSDMKP---EEIHTLVYDVSKE----------------VGIKSSKAFQAIYKA
SYK_THEAC SDFLNGIEDMPWNS--ESIHDRIYEISQK----------------FKTNPESVFTLFYRV
SYK_THEVO SKFLEVSNSMAWDS--NEIHSTVHNVAKD----------------LGIGPDAAFSTFYKV
SYK_METJA KYFAEKLKTAEFDA--LNLHELIYQTAKE----------------LGLNPRDAFQASYMI
SYK_METMP KAFSKEVENIEIDA--NTIHELMYETATK----------------LNLAPKEAFVASYKI
SYK_METTH QDVADLMESREMSA--EELHDEMYSILRR----------------HGLKPQKAFQAIYRV
SYK_PYRAB EVAKWIESKSTFSVD--ELNNVLFEVAKK----------------RGISSKEWFSTLYKL
SYK_PYRHO EVAEWLENHEEFSVE--EFNNILFEVAKR----------------RGISSREWFSTLYRL
SYK_PYRFU EVAEWLESHEDFAVD--ELNNILFEVAKK----------------RNIPSKVWFSTLYKL
SYK_BORBU ELLDFLKKNFEVATE-QDIQNEIYKISRE----------------NNIEPALFFKQIYKI
SYK_BORAF ELLNFLKKNFEVATE-QDIQNEIYKISRE----------------NNIEPALFFKQIYKI
SYK_BORGP ELLDSLKKNFEVATE-QDIQNEIYKISRE----------------NNIEPALFFKQIYKI
SYK_TREPA LIRDTLVPRTDVLSE-KELSAELYAVARQ----------------IPVGSKELFTALYQV
SYK_RICPR DQT-EEESIQKAIYD-IGMK------------------------SGYENLRYYFKDLYQI
SYK_RICCN DQT-EAEAIQKAIYD-IGMK------------------------AGYENLRDYFKDLYQI
SYK_BRUME AGT-DGNVIQNAILD-VARAIERYQDHTKKSP-----------EGGPGVSVSFFQMLYEV
SYK_BRUSU AGT-DGNVIQNAILD-VARAIERYQDHTKKSP-----------EGGPGVSVSFFQMLYEV
SYK_RHILO ADA-GGEAIQNASLN-VARKIERYQDHSKQSP-----------EGGPGVSGAFFQMIYQV
SYK_CAUVC AGTQDAELIQNEVFE-VGKT------------------------HGFDPLRAWFQALYEV
SYK_METKA EDLVRRLESETTKEDPETLQRTVFEAART----------------AGLRPADAFRVFYNV
SYK_STRCO RLLLDGLADHWSLDG---LTHHVYGVPKVQAGFPADATPKELPPEIKTAQRTFFALLYHL
SYK_HALSA DELAAFLDDEDPDGE--ALQGEIYEAAKR----------------HDIDIGAFFAAGYRL
SYK_CENSY GDGLQDAIYGIAKSH-------------------------------GVPPRDFFRALYRI
SYK_AERPE KLAEVLESVEEWSEERIKQALVEFGEGMS-----------------SSERRRFYRDFYLA
: *
SYK1_METAC ILGQSSGPKAGWFLSSFEKGFLITRFREASTYNPEKSS-
SYK1_METMA ILGQSSGPKAGWFLSSFEEDFLINRFREASTYSPEKRE-
SYK_METBA LLGQSSGPKAGWFLSSFEKEFLVERFEEASNYSPEINV-
SYK_ARCFU ILGKTYGPRVGYFIKSLGVEWVRERIKAAL---------
SYK_THEAC FIGKDRGPRLGYFLFNLGKDFVRERIRNVIRDH------
SYK_THEVO FIGKERGPRLGYFLFNLGKDFTIARIKSVLGGNS-----
SYK_METJA LLGKKYGPKLGAFLATLGKDFVIRRYSLFE---------
SYK_METMP LLGKNYGPKLGSFLASLKKEFVIGRFNLTE---------
SYK_METTH LIGKKMGPRAASFLLSLERDFVIRRLRLEA---------
SYK_PYRAB FIGKERGPRLASFLASLDKDFVVRRLRLEG---------
SYK_PYRHO FIGKERGPRLASFLASLDRSFVIKRLRLEG---------
SYK_PYRFU FIGKDRGPKLANFLAALDREFVVRRLRLEG---------
SYK_BORBU LIDKEKGPKLAGFIKIIGIDRFEKITSKYV---------
SYK_BORAF LIDKEKGPKLAGFIKIIGIERFEKIVSRYI---------
SYK_BORGP LIDKEKGPKLAGFIKIIGIDRFEKIVSKYI---------
SYK_TREPA LIGKNQGPRLAGFMKVIGTQRLHRMLSVY----------
SYK_RICPR LLGQNEGPRLGTFIKLYGVEETKKLVEEKLLCHTVA---
SYK_RICCN LLGQNEGPRFGTFIKLYGVQEMKKLVEGQL---------
SYK_BRUME LIGQERGPRFGSFVALYGIDETRALIKKALAGELA----
SYK_BRUSU LIGQERGPRFGSFVALYGIDETRALIKKALAGELA----
SYK_RHILO LIGQERGPRFGSFAALYGVAETRALIQQALAGQLA----
SYK_CAUVC LLGQSQGPRFGSFAAIFGIDRTVALIEEKLG--------
SYK_METKA VVGKDRGPRAGTLIAAVGVDRISRLIRGCLEASED----
SYK_STRCO LVGRDTGPRLPTLLLAVGQDRVRTLLGE-----------
SYK_HALSA FFDEDQGPKLGPFLAKLDREFVVTRLRREG---------
SYK_CENSY ILDTPSGPRIGPFIEDIGREKVAGMIRGRL---------
SYK_AERPE IVGRPEGPRAAPLLSLMDRGFVVDRLRKAANLSRELKGR
... **: :