CLUSTAL format seed alignment for MF_00191
_____________________________________________________________________________
Features found in the protein:- The following colors are used to highlight features:
- blue indicates SIGNAL, PROPEP, TRANSMEM, DOMAIN, ZN_FING, REPEAT,
DNA_BIND and CA_BIND.
- magenta is used to display DISULFID, THIOLEST and THIOETH.
- red is used for all other features, such as INIT_MET, ACTIVE SITE,
METAL,BINDING, NP_BIND, SITE, REGION, etc.
- The ID of the sequence used as the template for feature propagation is
underlined.
- A '<' at the beginning of a sequence or '>' at the end indicate that
the protein is fused with another domain either at the N- or C-terminus.
_____________________________________________________________________________
ISPH_BUCAI ------------------------------------------------------MNIILT
ISPH_BUCAP ------------------------------------------------------MNIILA
ISPH_WIGBR ------------------------------------------------------MNIFLA
ISPH_WOLPM ------------------------------------------------------MEIILA
ISPH_RHILO ---------------------------------------------MLQTTNKPPLTIRLC
ISPH_RHIME ------------------------------MPTSGFVRSTGVFMMAPSAAAKTPITIRLC
ISPH2_RHOPA ------------------------------------------------MLAKSPLKIVLC
ISPH_CAUVC --------------------------------------------MNAQTPIRRPISLVLA
ISPH1_RHOPA --------------------------------------------------------MFLA
ISPH_NEIMA ---------------------------------------------------MNEKTIILA
ISPH_CHRVO ----------------------------------------------------MTKTIMLA
ISPH_RALN1 --------------------------------------MSTTENAAIEPVTGADAEVLLA
ISPH_BORPE ---------------------------------------------MTAEVTAADAEVLLA
ISPH_NITEU -----------------------------------------------------MIRVLLA
ISPH_ECOLI ------------------------------------------------------MQILLA
ISPH_HAEDU ------------------------------------------------------MNILLA
ISPH_PSESM ------------------------------------------------------MQIKLA
ISPH_SHEON ---------------------------------------------MKFDPTSPSLNIMLA
ISPH_VIBVY ------------------------------------------------------MKILLA
ISPH_XYLFA ------------------------------------------------------MKVLLA
ISPH_RHOBA ---------------------------------------------------MTPMKIILA
ISPH_CORDI ---------------------------------MCMTSPDQLTASESADTASAHKRVLVA
ISPH_COREF ------------------------------MFGQRLDTLGAMSSSVSSPSPETGKKILLA
ISPH_MYCPA --------------------------------MPPTVDMGIPGASSSVAVNPTRKRVLLA
ISPH_STRAW --------------------------------------MVSMTASSG-------RRVLLA
ISPH_TROWT --------------------------------------MHHTGLGSGVA-----KRVLLA
ISPH_BIFLO ------------------------------MTADSCNPCLTLENTIDVQEVPMTKSVVLA
ISPH1_MYCTU -------------------------------------MAEVFVGPVAQGYASGEVTVLLA
ISPH_CHLCV -----------------------------------------------------MRRVILN
ISPH_CHLPN -----------------------------------------------------MRKLILC
ISPH_CHLTR -----------------------------------------------------MRKIILC
ISPH_PARUW ------------------------------------------------------MKLLLS
ISPH_DEIRA ----------------------------------------------------MIERIYLA
ISPH_THET2 -----------------------------------------------MGGMSGLRRVYLA
ISPH_LEPIN ----------------------------------------------------MLEKIYLA
ISPH_BACSU ------------------------------------------------------MDVIKI
ISPH_BACC1 ------------------------------------------------------MKIVKI
ISPH_HALH5 ------------------------------------------------------MNVVKI
ISPH_LISMO ------------------------------------------------------MEIIKI
ISPH_MALP2 ------------------------------------------------------MKIIKI
ISPH_HELPY ------------------------------------------------------MEIKMA
ISPH_WOLSU ------------------------------------------------------MKVKLA
ISPH_HELHP ------------------------------------------------------MKVKFA
ISPH_CAMJE ------------------------------------------------------MIIELA
ISPH_CLOPE ----------------------------------------------------MERNVILA
ISPH_CALS4 ------------------------------------------------------MEILIA
ISPH_AQUAE -----------------------------------------------------MVDIIIA
ISPH_GEOSL ------------------------------------------------------MEIVLA
ISPH_TREPA -----------------------------------------------MRKVNCIKVITRA
ISPH_TREDE ------------------------------------------------------MVVKRA
ISPH_BACTN ----------------------------------------------------MIKVEID-
ISPH_PORGI ----------------------------------------------------MIPIEID-
ISPH_CHLTE -----------------------------------------------------MKINLDR
ISPH_NOSS1 MDTKTFKRTLQHSENYNRKGFGHQAEVATQLQSEYQSSLIQEIRDRNYTLQRGDVTIRLA
ISPH_THEVB MDTRAFKRSLHSSENYHRKGFGHGEEVNQQLQGEYQSSLIQQIRANGYRWQQGDVTIRLA
ISPH_PROMP MDTQAFRRSLHHSDRYNRRGFDSPTKRAQALEEAYQSDLITSIRNNSFTYKKGRLNIKLA
ISPH_PARMW MDTHAFKRSLHHSERYNRRGFGRAEEVAESLEQAYQSGLIGTIRDNGYKLSHGRLTVRLA
ISPH_GLOVI ----------MQSKNYFRKGFGLKAEVQDDLKAEYESSLIHEIRANGYTLRRGGVTVRLA
ISPH_THEMA ------------------------------------------------------MKIVVA
ISPH_DESVH ------------------------------------------------------MNVIRA
ISPH_BUCAI NPRGFCAGVKRAILIVE---NALKVYK--------KTIYIRHELVHNQYVINTLRQKG-V
ISPH_BUCAP KPRGFCAGVKRALLIVE---NALKIYK--------KTIYVQHELVHNQYVIETLRQKG-V
ISPH_WIGBR NPRGFCAGVDRAINIVK---NAIEIYG--------PPIYVYNEVVHNKYVVNSLKKIG-S
ISPH_WOLPM EPRGFCAGVKRAVDILA---ITLEKYKNE------RQVYVLHEIVHNKYIVEDFKKQG-V
ISPH_RHILO QPRGFCAGVDRAIQIVV---LALKKYG--------APVYVRHEIVHNRYVVEGLQSLG-A
ISPH_RHIME GPRGFCAGVDRAIQIVV---LALKEFG--------APVYVRHEIVHNRYVVEGLEAKG-A
ISPH2_RHOPA SPRGFCAGVVRAIDTVE---RALALYG--------APVYVRHEIVHNKYVVDSLRAKG-A
ISPH_CAUVC SPRGFCAGVDRAIQIVE---RAVEKFG--------APVYVRHEIVHNRHVVDRLKALG-A
ISPH1_RHOPA QPRGFCAGVVRAIEIVE---RALEKYG--------PPVYVRHEIVHNKYVVESLKAKG-A
ISPH_NEIMA NPRGFCAGVDRAISIVE---RALEEFG--------APIYVRHEVVHNKFVVDNLREKG-A
ISPH_CHRVO NPRGFCAGVDRAIAIVE---RAIELYG--------APIYVRHEVVHNRFVVDDLRGKG-A
ISPH_RALN1 QPRGFCAGVDRAIEIVE---RALQRFG--------APIYVRHEIVHNAYVVSDLRSKG-A
ISPH_BORPE QPRGFCAGVDRAIDIVE---RALELHG--------APIYVRHEIVHNRYVVEDLRGKG-A
ISPH_NITEU NPRGFCAGVDRAIEIVE---RALAMYG--------APIYVRHEVVHNRFVVEDLEKKG-A
ISPH_ECOLI NPRGFCAGVDRAISIVE---NALAIYG--------APIYVRHEVVHNRYVVDSLRERG-A
ISPH_HAEDU NPRGFCAGVDRAISIVE---LALEVHG--------APIYVRHEVVHNRFVVDDLKAKG-A
ISPH_PSESM NPRGFCAGVDRAIEIVN---RALEVFG--------PPIYVRHEVVHNKFVVEDLRSRG-A
ISPH_SHEON NPRGFCAGVDRAISIVE---RALELFS--------PPIYVRHEVVHNRYVVQNLKDRG-A
ISPH_VIBVY NPRGFCAGVDRAISIVE---RALELYQ--------PPIYVRHEVVHNRFVVEGLKQRG-A
ISPH_XYLFA NPRGFCAGVDRAIEIVK---RTIDMLG--------TPIYVRHEVVHNRFVVDDLKQRG-A
ISPH_RHOBA APRGFCAGVNMAIDSLD---LTLQKFG--------PPVYVYHEIVHNQFVVKTFREKG-A
ISPH_CORDI APRGYCAGVDRAVETVE---KALEKYG--------APVYVRKEIVHNRYVVDTLAERG-A
ISPH_COREF APRGYCAGVDRAVETVE---RALEEYG--------APIYVRKEIVHNRYVVDTLAEKG-V
ISPH_MYCPA EPRGYCAGVDRAVETVE---RALEKHG--------PPVYVRHEIVHNRHVVSTLEKAG-A
ISPH_STRAW APRGYCAGVDRAVIAVE---KALEQYG--------APIYVRHEIVHNKYVVQTLERKG-A
ISPH_TROWT SPRGYCAGVDRAVIAVE---KALERHG--------PPVYVRKQIVHNVHVVGSLEKRG-A
ISPH_BIFLO DPRGFCAGVDRAILTVQTILKAAEASGKRTREDGLPPVYVRRQIVHNKHVVEDLAGQG-A
ISPH1_MYCTU SPRSFCAGVERAIETVK---RVLDVAE--------GPVYVRKQIVHNTVVVAELRDRG-A
ISPH_CHLCV NPRGFCAGVVRAIQVVE---TALEKWG--------APIYVKHEIVHNRHVVDDLKRRG-A
ISPH_CHLPN NPRGFCSGVVRAIQVVE---VALEKWG--------APIYVKHEIVHNRHVVNALRAKG-A
ISPH_CHLTR SPRGFCAGVIRAIQTVE---VALEKWG--------RPIYVKHEIVHNRHVVDKLREKG-A
ISPH_PARUW KPRGFCAGVERAIETVE---KALLLWG--------SPIYVKHEIVHNRHVVQGLKTKG-A
ISPH_DEIRA KPRGFCAGVVMAIQAVEK--AAVREDK---------PVTVYHSIVHNHTVVERLSEGGRV
ISPH_THET2 RPRGFCAGVVMAIEAVERWAEALKEKG---------ELVVYHEIVHNRVVVERLQAKG-V
ISPH_LEPIN NPRGFCAGVKYAISYVE---QVQANSE--------EQIYVRKEIVHNRRVVEDMKKNG-I
ISPH_BACSU SPRGYCYGVVDAMVIAKNASLDKSLPR---------PIYILGMIVHNKHVTDAFEEEG-I
ISPH_BACC1 SPRGYCYGVVDAMVIARNAALDTSLPR---------PIYILGMIVHNKHVTDAFEEDG-I
ISPH_HALH5 SPRGYCYGVVDAMVLARQAAQNLDLPR---------PIYILGMIVHNKHVTDAFEEEG-I
ISPH_LISMO SPRGYCYGVIDAMVIAKNASLDPNLPR---------PIHILGMIVHNKHVTDAFESIG-I
ISPH_MALP2 TPRGFCKGVVDAYATCKKIA-KLYPNH---------EKYLIGWLVHNKEIIKELEELG-I
ISPH_HELPY KDYGFCFGVKRAIQIAE--KNQ--------------NSLIFGSLIHNAKEINRLEKNFNV
ISPH_WOLSU DKHGFCFGVKRAIKLAE--SHQ--------------GGITLGPLIHNKKEIERLKNDFGV
ISPH_HELHP KKYGFCFGVKRAIRIAE--RNQ--------------HATTFGPLIHNSREIERLQKDFDV
ISPH_CAMJE KNYGFCFGVKRAIKKAE--QIK--------------DAATIGPLIHNNEEISRLQKNFNV
ISPH_CLOPE KNAGFCFGVKRAVDEAI--KYQ-KEFG--------KKIYTLGPLIHNNDVVNYLEDNNIF
ISPH_CALS4 EHAGFCFGVKRAIEIAY--EELNKQKD--------TRLYTLGEIIHNPQVVKDLEEKGVR
ISPH_AQUAE EHAGFCFGVKRAVKLAE--ESLKES-Q--------GKVYTLGPIIHNPQEVNRLKNLGVF
ISPH_GEOSL KRAGFCFGVKRATQMAF--EAAEK--E--------GETFTLGPIIHSPQVVQRLEGMGVK
ISPH_TREPA HTLGYCGGVRMAVRMA---EHARAHHR--------GSVYTLGPLVHNPVTLARLRARGIE
ISPH_TREDE EVLGYCSGVRRAVDTVLKLAKENTENK--------SGLYTFGPLIHNPSTMLRLKQMGVR
ISPH_BACTN EGSGFCFGVVTAIHKAEEELAKG------------ETLYCLGDIVHNSREVERLKAMGLI
ISPH_PORGI SGSGFCFGVVNAIRHAEKQLEKSS-----------DKLYCLGDIVHNTLEVERLGKKGLE
ISPH_CHLTE TSSGFCIGVQGTIHVAEEKLAQS------------GELYCLGDVVHNEVEVKRLEALGME
ISPH_NOSS1 QAFGFCWGVERAVAMAYETRKHFPTER----------IWITNEIIHNPSVNQRMQEMQVG
ISPH_THEVB EAFGFCWGVERAVALAYETRTHFPTER----------IWITNEIIHNPSVNERLRQMAVE
ISPH_PROMP QAFGFCWGVERAVAMAYETRRHYPDEN----------IWITNEIIHNPSVNDHLRKMNVK
ISPH_PARMW EAFGFCWGVERAVAMAYETRKHYPAER----------LWITNEIIHNPSVNDHLREMDVQ
ISPH_GLOVI EAFGFCWGVDKAVSMAYETHRMFAGRQ----------LWITNEIIHNPLVNQHLRAMGIR
ISPH_THEMA KNIGFCFGVERAIRTVEELLDEGK------------KVVTDGEIVHNKQVMEQLTKKGLK
ISPH_DESVH RTAGFCMGVSLALRKLDREVDRAEEKAAQGSP--RCRIATFGPIIHNPQVLEAYAGMGVR
.:* ** : ::*.
ISPH_BUCAI VFVEKIEQIP-----------DY-SV-----VIFSAHGVSKKVVQEAVKKKLIILDATCP
ISPH_BUCAP VFVEDISDIP-----------NN-SI-----VVFSAHGVSKKIKKKAIKKNLTILNATCP
ISPH_WIGBR IFVKKICDVP-----------EK-SI-----LIFSAHGVSKSILKEANKRKLIIFDATCP
ISPH_WOLPM VFVSSIEEIE-----------DNEGI-----LIFSAHGVSKNIEDEAKRKGIQVIDATCP
ISPH_RHILO VFIEELSEIPA---------EHRRSP-----VVFSAHGVPKSVPADAQARNLFYLDATCP
ISPH_RHIME IFVEELDEIPP---------EHRKQP-----VVFSAHGVPKSVPADADERNLFYLDATCP
ISPH2_RHOPA IFVEELEEIP-----------DTKAP-----VVFSAHGVPKSVPEHALSRNFFSIDATCP
ISPH_CAUVC VFIEELEEAP------------DDRP-----VVFSAHGVPKSVPAEAKARQMIYLDATCP
ISPH1_RHOPA IFVEELSEVP------------PKAV-----TVFSAHGVARSIEEEAAARDLPVLNATCP
ISPH_NEIMA VFIEDLAEVP------------PGAT-----LVYSAHGVSKAVRQEAAERGFRVFDATCP
ISPH_CHRVO VFIEELKDVP------------PGST-----LIYSAHGVPLSVRAEAEALGLTVFDATCP
ISPH_RALN1 VFVQELDDVP------------VGGT-----VIFSAHGVSRAVRQAAEARGLRVFDATCP
ISPH_BORPE VFIDELDQAP------------AGAI-----VVFSAHGVSQAVRGEAEARGLRVFDATCP
ISPH_NITEU VFVENLEEVP------------EGSM-----LIFSAHGVSHEVRREAAARKLQIFDATCP
ISPH_ECOLI IFIEQISEVP------------DGAI-----LIFSAHGVSQAVRNEAKSRDLTVFDATCP
ISPH_HAEDU IFVEELDEVP------------DSAI-----VIFSAHGVSQAVRQEAKRRGLKVFDATCP
ISPH_PSESM IFVEELEQVP------------DDVI-----VIFSAHGVSQAVRTEAAGRGLKVFDATCP
ISPH_SHEON VFVEELDQVP------------DNNI-----VIFSAHGVSQAVRAEAKARGLRVFDATCP
ISPH_VIBVY IFVEELHEVP------------DDNI-----VIFSAHGVSQAVRQEAKERALTVFDATCP
ISPH_XYLFA IFVEELHQVP------------DGAT-----VIFSAHGVSQAVRRQAAQRGLKVFDATCP
ISPH_RHOBA VFVDTIDEVP------------EGGV-----LLFSAHGVSPEIRKAAQARKLHALDATCP
ISPH_CORDI IFVDETTEAP------------EGAH-----LVFSAHGVSPAVHKEAEALSLKTLDATCP
ISPH_COREF IFVEEASEAP------------EGAH-----MVFSAHGVSPAVKEEAAAKNLQAIDAACP
ISPH_MYCPA VFVEETDEVP------------EGAI-----VVFSAHGVAPTVHAAAAERNLHTIDATCP
ISPH_STRAW IFVERTAEVP------------EGAI-----VMFSAHGVAPVVHEEAARGKLATIDATCP
ISPH_TROWT IFVDQVDQIP------------PGAV-----TIFSAHGVSPAVVHSANERGLQVIDATCP
ISPH_BIFLO VFVQELAEIP------------DAAAQAGIPVVFSAHGVSPVVKAEAERRGMHVVDATCP
ISPH1_MYCTU VFVEDLDEIP------------DPPP-PGAVVVFSAHGVSPAVRAGADERGLQVVDATCP
ISPH_CHLCV IFIEDLSDVP------------SGEK-----VVYSAHGIPPEVREEARTRNLFDIDATCV
ISPH_CHLPN IFVEELVDVP------------EGER-----VIYSAHGIPPSVRAEAKARKLIDIDATCG
ISPH_CHLTR IFIEDLQEVP------------RNSR-----VIFSAHGVPPSVREEAEERGLIAIDATCG
ISPH_PARUW IFIEDVEDVP------------VGAR-----LIYSAHGVSPAVREQAKKRQLIEIDATCG
ISPH_DEIRA HFVEDLDAVDA---------LPDS----GDTVIFSAHGISPAVRERARSLGLSTIDATCP
ISPH_THET2 HFVEDLAEVER---------LRRERR-LADTVVFSAHGHPPAVRRQAAEMGLTVLDATCP
ISPH_LEPIN RFINDLDEAP------------NGAT-----VIFSAHGVSPSVVEAAKQRGMKIGDATCP
ISPH_BACSU FTLDGSNR------------LDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDATCP
ISPH_BACC1 ITLDGPSR------------LDILDKIDSGTVIFTAHGVSPEVKQRAKEKGLTTIDATCP
ISPH_HALH5 ISLDGPNR------------LDILKQVDKGTVIFTAHGVSPQVRKLAKEKGLTVVDATCP
ISPH_LISMO YTVDGANR------------EEILDKITTGTVIFTAHGVSPSVKAKAVAKGLTTIDATCP
ISPH_MALP2 QTKDDKNHSRSEIIDS----IEIKDKNNPPIVIFSAHGTDQKTIDKAREKGLVVFDTTCI
ISPH_HELPY KIE-EDPKKIP----------------KNKSVIIRTHGIPKQDLEYLKNKGVKITDATCP
ISPH_WOLSU TVE-ESVENLP----------------RGSEVIIRTHGIPKDDLAKLTQSAEKIIDATCP
ISPH_HELHP SLS-RSLEEAQ----------------KFKSVIVRTHGITKDDLQVLKEHHTHIIDATCP
ISPH_CAMJE KTL-ENIQALS----------------NEKKAIIRTHGITKQDLEELRKKDIEIFDATCP
ISPH_CLOPE AIELSDADSLK----------------KGDVVLIRSHGVKESVIKDLTDKGLIVKNATCP
ISPH_CALS4 VIEEEELEKLL----------------KGDRLIIRSHGISKKLYEFLEQKGVEIIDVTCP
ISPH_AQUAE PSQ---GEEFK----------------EGDTVIIRSHGIPPEKEEALRKKGLKVIDATCP
ISPH_GEOSL VLS---DLEGI----------------GNGTVIIRSHGVTSAELEDAVRRQLEVVDATCP
ISPH_TREPA CLDPAHLSFALHAPAAPGAAPHAVEEKTARTVVIRAHGVAPEVYEALERSGAQVVDATCP
ISPH_TREDE TIDTENFTED--------------EDYKDSVIVIRAHGIPPSKKSELEKSGAKVIDATCS
ISPH_BACTN TINRDEFRQLR-----------------NAKVLLRAHGEPPETYQIAHKNNIEIIDATCP
ISPH_PORGI TIDYDAFSRLR-----------------GAKVLLRAHGEPPEIYRMAGENGVTIIDATCP
ISPH_CHLTE TIDIPAFEELR-----------------NAEVLIRAHGEPPSTYETARKNNLAITDTTCP
ISPH_NOSS1 FIPVEAG------------NKDFSVVGNNDVVILPAFGASVQEMQLLSEKGCKIVDTTCP
ISPH_THEVB FIPVVNG------------VKDFSGVRPGDVVILPAFGASVQEMQLLNERGCTIVDTTCP
ISPH_PROMP FISAKNG------------IKDFSLVSDGDVVILPAFGATVQEMKLLHEKGCHIIDTTCP
ISPH_PARMW FIPVEQG------------VKDFSGVTSGDVVILPAFGATVQEMQLLNERGCHIVDTTCP
ISPH_GLOVI FLDEDESGRRV--------PKDFERVSEKDVVILPAFGASTQEMQILDEKNCVIVDTTCP
ISPH_THEMA VSSEMTDGEV---------------------FVVRAHGIPKDRLEELKKIFPEVVDLTCP
ISPH_DESVH CLRQVDEVEAG------------------DHVVIRAHGVPQQQEKALRSRDAVVVDATCP
: :.* : :*
ISPH_BUCAI LVEKVHIEVSKSSE----KAIETILIGH-RGHPEVEGTIGQYNNKN--------------
ISPH_BUCAP LVTKVHLEVSKSSK----NGIETILIGH-RGHPEVIGTIGQYDNKK--------------
ISPH_WIGBR LVSKVHHEIKRASK----LRSEVIIIGH-KNHPEIIGTIGQYNNPN--------------
ISPH_WOLPM LVNKVHKEAKRYEN----SGKELILIGH-ENHPEVKGIRGRVNNP---------------
ISPH_RHILO LVSKVHKQAMRHQR----LGRHVLLIGH-AGHPEVIGTMGQLPE----------------
ISPH_RHIME LVSKVHKQAMRHHR----MGRHVVLIGH-AGHPEVIGTMGQLPE----------------
ISPH2_RHOPA LVTKVHREAAIHFK----RGREILLIGH-SHHPEVVGTLGQLPA----------------
ISPH_CAUVC LVSKVHVEAQKHYD----AGREIVLIGH-AGHPEVIGTMGQLPE----------------
ISPH1_RHOPA LVTKVHNQGKRYTS----KGRTLILIGH-AGHPEVEGTMGQVP-----------------
ISPH_NEIMA LVTKVHKEVARLDA----QDCEIIMIGH-KGHVEVEGTMGQLAPGK--------------
ISPH_CHRVO LVTKVHVEVKRMNK----AGMEIIMIGH-AGHPEVEGTMGQVDAG---------------
ISPH_RALN1 LVTKVHVEVSKMRT----QGFEIIMIGH-KGHPEVEGTMGQADDG---------------
ISPH_BORPE LVTKVHIEVARMRA----AGREIVMIGH-KGHPEVEGTLGQAQGG---------------
ISPH_NITEU LVTKVHVEVAKMDK----EGKEIVMIGH-QGHPEVEGTMGQIAKSK--------------
ISPH_ECOLI LVTKVHMEVARASR----RGEESILIGH-AGHPEVEGTMGQYSNP-EG------------
ISPH_HAEDU LVTKVHMQVARASK----KGTKAILIGH-QGHPEVIGTMGQYYNE-QA------------
ISPH_PSESM LVTKVHIEVARYSR----DGRECILIGH-AGHPEVEGTMGQYDAV-NG------------
ISPH_SHEON LVTKVHLQVTRASR----KGIECILIGH-AGHPEVEGTMGQYDNP-NG------------
ISPH_VIBVY LVTKVHMEVARASR----KHMEVVLIGH-AGHPEVEGTMGQYASL-QG------------
ISPH_XYLFA LVTKVHLDVARHCR----TGRDMILIGH-AGHPEVEGTMGQWDQERGT------------
ISPH_RHOBA LVTKVHLEAIKYAK----AGYTIILIGH-EGHDEVLGTMGEAPEA---------------
ISPH_CORDI LVTKVHNEVKRFAR----DGYHILLVGH-EGHEEVEGTAGEAPDV---------------
ISPH_COREF LVTKVHNEVKRFDK----QGFHILFIGH-EGHEEVEGTMGHSLDR---------------
ISPH_MYCPA LVTKVHNEARRFAR----NDYDILLIGH-EGHEEVVGTAGEAPDH---------------
ISPH_STRAW LVTKVHKEAVRFAN----EDFDILLIGH-EGHEEVIGTSGEAPEH---------------
ISPH_TROWT LVTKVHREVIRFSK----AGYFILLIGH-SGHEEVEGTSGHAPDR---------------
ISPH_BIFLO LVGKVHREVLRFVR----EGYEIVYIGH-KGHDEAVGVVGESPEH---------------
ISPH1_MYCTU LVAKVHAEAARFAA----RGDTVVFIGH-AGHEETEGTLGVAPRS---------------
ISPH_CHLCV LVTKIHSAVKLYAS----KGYQIILIGK-KKHVEVIGIRGEAPES---------------
ISPH_CHLPN LVTKVHSAAKLYAS----KGYKIILIGH-KKHVEVIGIVGEVPEH---------------
ISPH_CHLTR LVTKVHSAVKMYAK----KGYHIILIGK-RKHVEIIGIRGEAPDQ---------------
ISPH_PARUW LVTRVHSAVKRYAL----QGYQIILIGH-HNHVEIIGTAGEAPDV---------------
ISPH_DEIRA LVTKVHTEAKKYAR----EGYTILLIGDSAGHQEVIGTRGEAPENTIL------------
ISPH_THET2 LVTKVHTEAKRYAK----EGYWILLIGDSADHQEIKGTYGEAPERTIL------------
ISPH_LEPIN LVTRVHRKARKI-K----DTHQIIYIGH-EGHDEAIGTMGEAE-----------------
ISPH_BACSU DVTKTHNLILEMKE----KGYHVIYIGK-KGHPEPEGAVGVAPEIVH-------------
ISPH_BACC1 DVTKTHDLIEAKKA----EGYHVIYIGK-KNHPEPEGAVGIAPDIVH-------------
ISPH_HALH5 DVTRTHDLIREKSQ----EGYKFIYVGK-KGHPEPEGAIGVAPEFVH-------------
ISPH_LISMO DVLHTYNLILEKQA----AGYEIIYIGK-KGHPEPEGAYGTAPDVVH-------------
ISPH_MALP2 YVTKTHDLIKEKIE----QGYQIFYIGV-NNHPETISTLSIDKSII--------------
ISPH_HELPY YVIKPQQIVESMSK----EGYQIVLFGD-INHPEVKGVISY-------------------
ISPH_WOLSU FVTKPQKICEIMSQ----EGYQIIIFGD-INHPEVQGVMSY-------------------
ISPH_HELHP FVTKPQQIVEKMSQ----EGYQIIIFGD-NSHPEVKGVASY-------------------
ISPH_CAMJE FVTKPQQICEQMSK----EGYEVVIFGD-ENHPEVKGVKSY-------------------
ISPH_CLOPE YVTNIQLKVKKCYE----QGYKIIIVGD-KNHPEVIGINGW-------------------
ISPH_CALS4 FVKKVQNIVEEYYK----KGYDIVIVGD-KNHPEVIGVNGW-------------------
ISPH_AQUAE YVKAVHEAVCQLTR----EGYFVVLVGE-KNHPEVIGTLGYLRA----------------
ISPH_GEOSL FVKKAQEHVKRLSH----DGYTVVVVGD-ADHPEVQGIVSY-------------------
ISPH_TREPA RVKESQRRAQGFAA----QGLHVILAGD-RNHGEIVGIEGYVRAGAAQACSHLPGGAPDG
ISPH_TREDE RVKASQALAKKHSE----EAF-VILAGD-KNHGELISIAGYAEG----------------
ISPH_BACTN VVLRLQKRIKQEFRKEDFEEKQIVIYGK-NGHAEVLGLVGQ-------------------
ISPH_PORGI VVLRLQNKIKSRYEATRSLGAQVVIYGK-RGHAEVNGLVGQ-------------------
ISPH_CHLTE VVAKLQRTAKMLHQ----LGYQVVIYGK-KVHPEVIGINGQ-------------------
ISPH_NOSS1 WVSKVWNTVEKHKK----GDHTSIIHGK-YKHEETIATSSFAGKYLIVLNLKEAQYVADY
ISPH_THEVB WVSKVWHSVEKHKK----VSFTSIIHGK-YNHEETIATSSFAGTYLIVLNLEEARYVCDY
ISPH_PROMP WVSKVWHTVEKHKK----HTFTSIIHGK-FKHEETLATSSFADKYLVVLNLEEANYVSEY
ISPH_PARMW WVSKVWTTVEKHKK----HTITSIIHGK-VKHEETLATSSFAGTYLVVLDMEEAQIVADY
ISPH_GLOVI WVSAVWNRVGKYDR----AEFTSIIHGK-YQHEETVATASRARRYLVVLNLEEAQQVCDY
ISPH_THEMA IVSQLFKTAQRYAK-----ERKVIVFGK-EDHPEMVALRGYAPAI---------------
ISPH_DESVH KVKKAQLGIEEQCR----AGRTLLLFGE-AEHPEVRGLLSYAGEG---------------
* . * * * . .
ISPH_BUCAI ----GKIYLVES-----IEDVHNLS----VQNSKKLNFFTQTTLSITNTKKIIAALKNKF
ISPH_BUCAP ----GKIHLIED-----IEDVNQLT----IKIDKKLNFFTQTTLSIKNTQSIILALKKKF
ISPH_WIGBR ----KKVFVIQS-----IEEICKLK----IKDPNNLFYFTQTTLSVDDTNKIIFAIKKKY
ISPH_WOLPM ------ITLVQT-----LQDVYDLK----VKDPDNLSYVTQTTLSIDDTRDIIAALKLRF
ISPH_RHILO ----GAVTLVET-----EADAARLV----PADPKALGFVTQTTLSVEDTAGIIRALRERF
ISPH_RHIME ----GAVSLVET-----VEDADVYM----PPDADNLGFVTQTTLSVDDTAGVIKRLHERF
ISPH2_RHOPA ----GAVTLIET-----AADAEAYQ----PKDPNNLAFVTQTTLSIDDTAGIVTVLRERF
ISPH_CAUVC ----GAVTLIED-----LKDAAAWE----PKDAANVAFLTQTTLSVDDTADMVALLRERF
ISPH1_RHOPA ----GPVLLVQN-----LDDVAALT----LPPETPVAYITQTTLSVDDTKDIIVALSKKF
ISPH_NEIMA ------MLLVET-----VGDVAKLE----VRNPDKLAYVSQTTLSVDETKDIIAALNARF
ISPH_CHRVO ------IYLVQT-----VDDVATLR----VVNEDQLSYVSQTTLSVDETRDIIAALKARF
ISPH_RALN1 ------MLLVES-----VDDVARLA----VKDPARLAYVTQTTLSVDETQEIVAAIKARF
ISPH_BORPE ------MYLVET-----VEDVAALQ----VSDPGNLAYVTQTTLSVDDAAAVAGALKARF
ISPH_NITEU ----GTMYLVET-----AEDVARLQ----VKNESNLAYVTQTTLSVDDAARVIEALKQRF
ISPH_ECOLI ----G-MYLVES-----PDDVWKLT----VKNEEKLSFMTQTTLSVDDTSDVIDALRKRF
ISPH_HAEDU ----G-IFLVET-----VEDIANLP----IHHHEDLTFMTQTTLSVDDTSGMIEALKNKY
ISPH_PSESM ----GAIYLVED-----EADVASLE----VRNPESLAFVTQTTLSMDDTSRVIDALRKRF
ISPH_SHEON ----G-VYLIES-----PADVETLE----VRDPNNLCFVTQTTLSVDDTLDIISALLKRF
ISPH_VIBVY ----G-MYLVEK-----PEDVLGLKA--IVKDPSNLHYVSQTTLSVDETADVIDELRRVF
ISPH_XYLFA ----GRIYLVEN-----IDDVATLH----VAQPHHLAYTTQTTLSVDDTRNIIDALRQRF
ISPH_RHOBA ------IVLVED-----EADVDRLE----FEPGTQLAYLTQTTLSVDDAGRVIRRLRERF
ISPH_CORDI ------THLVDG-----VESVDKLPE--FLHDE-KLIWLSQTTLSVDETMTIVKKLHERF
ISPH_COREF ------THLVDG-----IESIPGLPA--FLADEPNLIWLSQTTLSVDETMEIVRELKKVY
ISPH_MYCPA ------VQLVDG-----VAAVDNVR----VRDEDKVVWLSQTTLSVDETMEIVERLRQRF
ISPH_STRAW ------ITLVDG-----PGDVAKVE----VRDPSKVVWLSQTTLSVDETMETVDALKEKF
ISPH_TROWT ------VLIVNS-----PDEADTID----VPHTDKLVWLSQTTLSVDETLETVKRLRLRF
ISPH_BIFLO ------VHLIEH-----ESDVDSLD----FAPDTKLVLLSQTTLSVDETADTIAALKAKF
ISPH1_MYCTU ------TLLVQT-----PADVAALN----LPEGTQLSYLTQTTLALDETADVIDALRARF
ISPH_CHLCV ------VTVVEK-----VEDVANLP----FEESVPLFFVTQTTLSLDDVAEITQALKVRY
ISPH_CHLPN ------ITVVEK-----VADVEALP----FSSDTPLFYITQTTLSLDDVQEISSALLKRY
ISPH_CHLTR ------ITVVEN-----IAEVEALP----FSAQDPLFYVTQTTLSMDDAADIVAALKARY
ISPH_PARUW ------TTIVES-----VEDVKNLN----FSSQDKLFYITQTTLSLDDVKEITQALIVKY
ISPH_DEIRA ----VGVLGKTG---PGLNDPHAVQ----VPDPERLVVLTQTTLSVDDTRKTVDILKARF
ISPH_THET2 ----VAVHTHVGKD-PRLADPRTVE----VPDPERVVVLTQTTLSVDDTLATIAILKKRF
ISPH_LEPIN ------MFLVES-----LEDIISLKD--KIDPNKPLTYLMQTTLSVADTKNIIDQISKTF
ISPH_BACSU --------LVETE-----EDVKNLD----IQSEK-LIVTNQTTMSQWDVHDIMELVKEKY
ISPH_BACC1 --------LIERA-----DDLKTLE----IPTDK-ILVTNQTTMSQWDVQHLMEDIQKKF
ISPH_HALH5 --------LVENV-----EDVESLD----ISADK-IIITNQTTMSQWDVSEIMKKAMEKY
ISPH_LISMO --------LVETK-----ADIDALS----LLSDK-IFVTNQTTMSKWDVADLMHYIKGKF
ISPH_MALP2 --------LIETV-----NDIENIR----TESEKPIFVTNQTTISIYEFEEITETLKSKY
ISPH_HELPY --ATNQALVVNS-----LEELQ------EKKLQRKVALVSQTTKQTPKLLQIASYLVER-
ISPH_WOLSU --SSSEPIVVMS-----PKELF------GAKLKEKVALVSQTTKKIEDFLGVASFLVQR-
ISPH_HELHP --GDDVAIIAN------IDELK------HLTLKKKVALVSQTTKQPEHFGKIAALLVSL-
ISPH_CAMJE --VSTKAYVVLD-----KKELQ------NIKLPNKIAVVSQTTKKPEHFMEIVNFLILK-
ISPH_CLOPE --CNDSAIITNG-----KTELE------NIP--AKVCVVSQTTEKKETWNKVLNEIVRA-
ISPH_CALS4 --CEDKAYIVNS-----VEEAE------NLPFFEKACAVSQTTLIEKHWEDILEVLKSK-
ISPH_AQUAE --CNGKGIVVET-----LEDIG------EALKHERVGIVAQTTQNEEFFKEVVGEIALW-
ISPH_GEOSL --AEGPVHVVGS-----GEEAA------RLPNMKKVGVVAQTTQSFETLKNVVKECLLK-
ISPH_TREPA MLPQVQCFVVQN-----AREAA------ALPCLARAALLAQTTITQGEYDAIAAAARTR-
ISPH_TREDE -----KCLIVQN-----AEEAALIDLPSSLSANGSAVLIAQTTIKESEYEAIASALKKR-
ISPH_BACTN --TGGQAIVIE-----SAEEAK------KLDFTKSIRLFSQTTKSLDEFQEIVEYIKL--
ISPH_PORGI --TEGTAIVIE-----SEEELD------KIDYTRPVILFSQTTKSLEGFGQIIDSIST--
ISPH_CHLTE --CDDEGVVIKHPDLSDPEEIA------PLDLSRKTALISQTTMDVPGFYELKRNLEKLF
ISPH_NOSS1 ILHGGNREEFLQKFAKACSAGFDPD-----RDLERVGIANQTTMLKGETEQIGKLFEHTM
ISPH_THEVB ILHGGDRAAFMAKFAKACSPGFDPD-----RDLVRVGIANQTTMLKGETEQIGKLFERTM
ISPH_PROMP ILGRGNKNHFLNKFAQAFSNGFDPD-----KDLDRVGVANQTTMLKSETEEIGKVFEKTM
ISPH_PARMW ILGKGDRDAFMQRFSAACSPGFDPD-----RDLSRLGVANQTTMLKSETEEIGRLFERTM
ISPH_GLOVI ILHGGDRRAFLAHFGMAACEGFDPD-----RDLVRVGIANQTTMLKGETERIGKLFERTM
ISPH_THEMA -----------------VTKVPFKLE------EKKVVFLSQTTSSLEEYKEFVAAMIRMN
ISPH_DESVH ------ALVFGS-----VDELEGLP----LQPETEYFLAAQTTQDRVAFEVARAWLHERL
***
ISPH_BUCAI P-------------------------------EISGPNKEDICYATTNRQIAVRQLSKI-
ISPH_BUCAP L-------------------------------NISGPKKEDICYATTNRQNAIIKLSKI-
ISPH_WIGBR P-------------------------------YIIEPRKKDICYATENRQKSIKKIIKL-
ISPH_WOLPM P-------------------------------GITGPDLKDICYATQNRQNAVKKLAEI-
ISPH_RHILO P-------------------------------DLQAPAAESICYATTNRQEAVKDTAPG-
ISPH_RHIME P-------------------------------NLTAPAADSICYATTNRQEAVKQAAPG-
ISPH2_RHOPA P-------------------------------NISGPHKEDICYATTNRQAAVKKVAPV-
ISPH_CAUVC P-------------------------------GIAAPHKEDICYATTNRQDAVKHLAEQ-
ISPH1_RHOPA H-------------------------------DIEGPDTRDICYATQNRQSAVRQMSKL-
ISPH_NEIMA P-------------------------------NIRNPHKEDICYATTNRQTAVKELAEQ-
ISPH_CHRVO P-------------------------------NIHSPKKDDICYATQNRQDAVKLLADQ-
ISPH_RALN1 P-------------------------------AVHEPKKQDICYATQNRQDAVKFMAPQ-
ISPH_BORPE P-------------------------------GIVEPKKSDICYATQNRQDAVKLLAPE-
ISPH_NITEU P-------------------------------KIIGPKKDDICYATQNRQDAVKKLVKL-
ISPH_ECOLI P-------------------------------KIVGPRKDDICYATTNRQEAVRALAEQ-
ISPH_HAEDU P-------------------------------AIQGPRKNDICYATTNRQQAVRELAKQ-
ISPH_PSESM P-------------------------------AIGGPRKDDICYATQNRQDAVKQLADE-
ISPH_SHEON P-------------------------------SIEGPRKDDICYATQNRQDAVRNLSAD-
ISPH_VIBVY P-------------------------------EIQGPRKDDICYATQNRQDAVRELAKD-
ISPH_XYLFA P-------------------------------TIQGPKNNDICYATQNRQDAVRELARE-
ISPH_RHOBA P-------------------------------EIHSPPKDDICYATQNRQEAVKLLRED-
ISPH_CORDI A-------------------------------HLQDPPSDDICYATQNRQVAVKAIAAE-
ISPH_COREF P-------------------------------QLQDPPSDDICYATQNRQVAVKAIAER-
ISPH_MYCPA P-------------------------------KLQDPPSDDICYATQNRQVAVKAMAPE-
ISPH_STRAW P-------------------------------QLISPPSDDICYATQNRQLAVKQMGEE-
ISPH_TROWT P-------------------------------HIQDPPSDDICYATQNRQAAVKKIAPL-
ISPH_BIFLO P-------------------------------WIQEPPSSDICYATSNRQAAVKLVAQQ-
ISPH1_MYCTU P-------------------------------TLGQPPSEDICYATTNRQRALQSMVGE-
ISPH_CHLCV P-------------------------------HIITLPSSSVCYATQNRQEALRSVLPK-
ISPH_CHLPN P-------------------------------SIITLPSSSICYATTNRQKALRSVLSR-
ISPH_CHLTR P-------------------------------RIFTLPSSSICYATQNRQGALRNILPQ-
ISPH_PARUW P-------------------------------HVETLPSSSICYATTNRQMALREITDL-
ISPH_DEIRA P-------------------------------ALVVPPSEDLCYATKNRQDAVKNIAPN-
ISPH_THET2 P-------------------------------KLVVPSRKDLCYATQNRQEAVKRIAPK-
ISPH_LEPIN P-------------------------------FVEHPSKDDICYATTERQEAVSLMMDK-
ISPH_BACSU P-------------------------------HVE--YHQEICLATQVRQEAVSEQAKK-
ISPH_BACC1 P-------------------------------TAE--FHKEICLATQVRQEAVAKQADV-
ISPH_HALH5 P-------------------------------QAE--VHNEICLATQVRQEAVAEQARE-
ISPH_LISMO P-------------------------------KAI--QHQEICMATQVRQEAVALQAKD-
ISPH_MALP2 K-------------------------------NIE--FKNDICNAAKDRQDAVINMPSE-
ISPH_HELPY --------------------------------CTEVRIFNTICNATSYNQKAALDLSKE-
ISPH_WOLSU --------------------------------CAEVRIFNTICNATFDNQEAARHLSQE-
ISPH_HELHP --------------------------------VNECRIFNTICSATFENQFAVDELSRE-
ISPH_CAMJE --------------------------------TKEVRVFNTICDATFKNQDAIKELSLK-
ISPH_CLOPE --------------------------------SKEIVAFNTICSATDVRQKSVQELSKE-
ISPH_CALS4 --------------------------------AKELVYFNTICNATQKRQEAADALSKK-
ISPH_AQUAE --------------------------------VKEVKVINTICNATSLRQESVKKLAPE-
ISPH_GEOSL --------------------------------GGEIRVFNTICDATAVRQDEAKALARE-
ISPH_TREPA --------------------------------VRELTVARTICAATARRQAALRALAPT-
ISPH_TREDE --------------------------------ISDLKVFNTICPATSDRQAALKKLAYE-
ISPH_BACTN ----HISPDA------------------------TFEYYDTICRQVANRMPNLREFAAT-
ISPH_PORGI ----RMQPGV------------------------TFEHHDTICRQVANRIPHIGAFATA-
ISPH_CHLTE AEHGHRNPGTQSGEWMAVRDIDITAEKTGALAMPKLVFKDTICRQVSSRNGKLRDFALA-
ISPH_NOSS1 LQKYGPVE-----------------------LNQHFQSFNTICDATQERQDAMLELVQEN
ISPH_THEVB IQKYGPDR-----------------------LNEHFMSFNTICDATQERQDAMLSLVKEP
ISPH_PROMP LHKFGPEK-----------------------LNSHFLAFNTICDATEERQDAMFSLVDED
ISPH_PARMW LSKYGPAE-----------------------LNDHFVAFNTICDATQERQDAMFSLVDEP
ISPH_GLOVI MRRYGPAN-----------------------LADHFMSHDTICDATQERQDAMFKLVEEP
ISPH_THEMA E-------------------------------FEEAVFLNTICPVTVNREREVEELSKI-
ISPH_DESVH G--------------------------------HEVPVLETICDATRLRQQEAIDIARK-
:* . .
ISPH_BUCAI ADIIFVIGSNNSSNSNRLAELGKETGTF----TKLISSFLDIKKKW--------------
ISPH_BUCAP TDIILVIGSKNSSNSSRLSELGKETGVF----TKQIESFSDIKEEW--------------
ISPH_WIGBR VDIIFIIGSKNSSNSNRLFEIANKSGKK----SYLIDTYKEIKKSW--------------
ISPH_WOLPM VDMVLVVGSKNSSNSNRLLDLCTARGKR----AYLIDNYSCVNKSW--------------
ISPH_RHILO ADLYLIVGAPNSSNSRRLVEVAERAGAT---MSLLVQRAAEIPWND--------------
ISPH_RHIME CDLFLVVGAPNSSNSKRLVEVALRAGAK---KAVLVQRASEIDWST--------------
ISPH2_RHOPA VDAMIVVGAPNSSNSQRLREVAEREGCK---VAVLVQRASDLDWSQ--------------
ISPH_CAUVC SELILVVGSKNSSNSVRLKEVGLKAGAR---DAHLIDDASGIDWTW--------------
ISPH1_RHOPA VDLILVVGANNSSNSNRLREIGTEAGIP----SYLIADGSELDPAW--------------
ISPH_NEIMA CDIVIVVGSPNSSNSNRLREVAASRGID----AYMVDNAGYLQRAW--------------
ISPH_CHRVO CDIVVVVGSPNSSNSNRLREVAALKGVD----AYMVDNASLLEPEW--------------
ISPH_RALN1 VEVVIVVGSPNSSNSNRLRELAEKLGVP----AYMVDTPEQVRPEW--------------
ISPH_BORPE CDLVLVVGSTNSSNSNRLREVAERKGVA----AYLIDGAHAIDPAW--------------
ISPH_NITEU CDLVVVVGSPNSSNSNRLCEVARNENVE----AYMVDQAEQLQESW--------------
ISPH_ECOLI AEVVLVVGSKNSSNSNRLAELAQRMGKR----AFLIDDAKDIQEEW--------------
ISPH_HAEDU AQLVLVVGSKNSSNSNRLAELASRMGVL----AKLIDGPQDILPEW--------------
ISPH_PSESM CDVVLVVGSPNSSNSNRLRELAERMATP----AYLIDGAEDMQKGW--------------
ISPH_SHEON VDLLIVVGSKNSSNSNRLRELALKTGTQ----SYLVDTADDIDSSW--------------
ISPH_VIBVY VDVVVVVGSKNSSNSTRLKELAEKLGTP----AYLTDCPQDIEPQW--------------
ISPH_XYLFA CDLVLVVGSPNSSNSNRLSELAQREGVA----SYLIDSAAEIDPAW--------------
ISPH_RHOBA ADVIVVLGSQNSSNSQRLKELAAEQGKR----AMLVDGPQDLAVDQ--------------
ISPH_CORDI SDVVIVVGSQNSSNSKRLVEVALQAGA--GA-SYLVDYAHQIDESW--------------
ISPH_COREF CDLMIVVGSTNSSNSVRLVEVALQAGA--KN-AYLVDYAHQIDEAW--------------
ISPH_MYCPA CDLVIVVGSRNSSNSVRLVEVALGGGA--GA-AHLVDWADDIDPAW--------------
ISPH_STRAW ADLVIVVGSRNSSNSVRLVEVAKLAGA--RD-AYLVDFADEIDEAW--------------
ISPH_TROWT SDLVIVVGSANSSNSVRLVEVALENGA--KA-AVRLDYADELDPAL--------------
ISPH_BIFLO SDCVVIVGSANSSNSVRLMEVAQEGLGERGK-AYRVDDASELDPAW--------------
ISPH1_MYCTU CDVVLVIGSCNSSNSRRLVELAQRSGT---P-AYLIDGPDDIEPEW--------------
ISPH_CHLCV VNFVYVIGDVQSSNSNRLREVAEKRNIP----ARLVNSPDHISDEI--------------
ISPH_CHLPN VNYVYVVGDVNSSNSNRLREVALRRGVP----ADLINNPEDIDTNI--------------
ISPH_CHLTR VDFVYVIGDTQSSNSNRLREVAERRGVT----ARLVNHPDEVTEEI--------------
ISPH_PARUW TDLVLVVGDPQSSNSNRLREAASTRGIE----SYLINDEKEIHPEW--------------
ISPH_DEIRA VDAFLVLTSTHSSNGMRLLELAEAECGR----AYRLETAADLTRLEQNGD----------
ISPH_THET2 VEAFLVLTSPHSSNGMRLLELAQSLVGR----AYRLERPEELRPEW--------------
ISPH_LEPIN IDAMLVIGADNSSNSLRLLQLAQKSKPH----SFKVSTADDLSKEYIQ------------
ISPH_BACSU ADLTIVVGDPKSNNSNRLAQVSEEIAG---TKAYRIGDLSELKLEW--------------
ISPH_BACC1 ADLTIVVGDPKSNNSNRLAQVSQEIAG---TKAYRVADVSEIKLEW--------------
ISPH_HALH5 CDLVIVVGDPKSNNSNRLAQVSEQIAG---TKAYRIGDVTELQQEW--------------
ISPH_LISMO ADLTIVVGDPRSNNTARLAQVSIEKAG---TKAYRIADITELDIEW--------------
ISPH_MALP2 VDLLLVVGDIKSNNSKKLVEIGIKKQ----IESHLIWNTKNIKDEW--------------
ISPH_HELPY VDIMIVVGGKTSSNTKQLLSIAKQHCKD----SYLVEDENELELAWFKDK----------
ISPH_WOLSU VDIMIIAGGKNSSNTKQLLSICLEHCQD----SYLIEDESELDPQWFTNK----------
ISPH_HELHP ADIMVIVGGKNSSNTKQLFKIAKEYCTD----SYLIEDENEIDNTWFVGK----------
ISPH_CAMJE SDVMVVVGGKNSANTKQLFLIAKTNCED----SYLIETEEELKKEWFLDK----------
ISPH_CLOPE ADLVFVIGGKNSSNTTKLYEICKKECPK----SYHIENVKELDESLLEDES---------
ISPH_CALS4 VDVMFVIGGKHSSNTQKLRKICEKNCKN----TYHIERADEITFEMLKGH----------
ISPH_AQUAE VDVMIIIGGKNSGNTRRLYYISKELNPN----TYHIETAEELQPEWFRGV----------
ISPH_GEOSL VDCMIVIGGFNSANTKRLAEVCSELQPR----TYHIETAQELDASWFQGV----------
ISPH_TREPA VEALLVIGGAHSANTQRLLHTARETSLP----TWLVERVEDIPPDIYAFS----------
ISPH_TREDE VDALLVIGGKNSANTKRLFQTAVDTKKP----AWLIEDASEIPKEIFSYS----------
ISPH_BACTN HDLIFFVSGKKSSNGKMLFEECLKVNAN----SHLIDNEKEIDPTLLRNV----------
ISPH_PORGI HELVFFVAGEKSSNGKVLFGHCLAANPR----SIFISSPEVIVPDMLVPLP---------
ISPH_CHLTE NDCIVFAAGRKSSNGQVLYSICKDANPH----SYFIEDVDEIRPEWFVGEN---------
ISPH_NOSS1 LDLMIVIGGFNSSNTTQLQQISQERGLP----SYHIDVVERIKS-INSIEHRQLNGE-LV
ISPH_THEVB LDLMVVIGGYNSSNTTHLQEIAIEHGIP----SYHIDSADRIGP-GNRIEHKPLHQN-PT
ISPH_PROMP LDILVVIGGYNSSNTTHLQEIAINKNIS----SFHIDTPERISVKENSILHKPLKSE-MV
ISPH_PARMW LDLMVVIGGFNSSNTTHLQEIALSRGIR----SFHIDTPDRLDAQANAIEHKPLNEN-LR
ISPH_GLOVI LDLLVVIGGYNSSNTTHLQEIAVERGLP----SFHIDGADRLVS-AQFIEHRDLHSKSLV
ISPH_THEMA CDLSIVVGGKHSSNTGKLFRIASKHSKT-----IWIESPDELPADV--------------
ISPH_DESVH VDAMVVVGGFDSGNTRRLADVAAAQGVF----TVHVENESQLPVEQ--------------
: . * * * :
ISPH_BUCAI ------LKNVNYIGITAGASAPEILVTEVIQYLRKIGAHKP------IEMIGVREKKIFK
ISPH_BUCAP ------LKNKKNIGITAGASAPDILVEEVIKHLKKLGFKNPP-----KEMLGDEEKTIFK
ISPH_WIGBR ------LNGVNNIGITAGASAPEILVQQVVNYLKIFYKNSVNI----YQVDGDIEKTKFM
ISPH_WOLPM ------FQGVEKIGITAGASAPDILVDELIDYLKVNLSVKIS-----VMPGGITENVQFK
ISPH_RHILO ------IGTISTLGLSAGASAPEIIVDEIIDAFRQRFDVTID------LAITATETEDFP
ISPH_RHIME ------VGDISMVGLSAGASAPEVIVNEIIEAFRDRYDATVE------LADTVEENEHFL
ISPH2_RHOPA ------FEGIKVLGLTAGASAPEVIVEEIMGAFAERFDLSVE------TVSAAEENEFFP
ISPH_CAUVC ------FDGISRVGLTAGASAPEDLVQGVIDAISARFDTTVE------ELVEARETITFK
ISPH1_RHOPA ------LDGKKAVGITAGASAPEVLVDDVIEALRRIVPVTVS------VLPGREENIEFV
ISPH_NEIMA ------FEGKNKVGVTAGASAPEVLVREVLATIRGWGHETVR------EGEGAEESIVFV
ISPH_CHRVO ------FAGKRRVGVTAGASAPEVLVQAVIDRIKAFDVTQVT------ELPGVEESTVFA
ISPH_RALN1 ------LAGKRRVGLTAGASAPEELAQSIVDRLRALGARSVR------PLDGIQENMSFP
ISPH_BORPE ------LQGRRSIGITAGASAPEVLVQQVVERVRELGAVSVR------TMPGLEESVAFP
ISPH_NITEU ------LTNKRCIGITAGASAPEILVQQVLERLEQIAAKQSNQGVIIEELSGVLESVTFP
ISPH_ECOLI ------VKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI------PLEGREENIVFE
ISPH_HAEDU ------LDNVETIGITAGASAPEILVQSVVAHLQTLGATSVA------NLVGCEENMVFE
ISPH_PSESM ------FDGVERIGITAGASAPEVLVRGVIQQLQAWGATGAD------ELAGREENITFS
ISPH_SHEON ------FENITKVAVTAGASAPEVLVQQVVQAIAKLAPSVVT------EVEGRKEDTVFA
ISPH_VIBVY ------FDGKVKVGVTAGASAPEELVNQILTRIKELGAQSVE------EVLGREENMFFE
ISPH_XYLFA ------VIDKHHIGVTAGASAPQVLVDGVLARLYELGATSVS------EHSGKPESMVFA
ISPH_RHOBA ------FSDDDRVLITAGASAPESVVQSTIDWLKENFDASVD------TQVVREEDVQFP
ISPH_CORDI ------LDGATTVGVSSGASVPEILVRGVLEFLDARGFHDVK------EITTAAEKITFA
ISPH_COREF ------LDGVQTIGISSGASVPEILVTGVLERLAGYGFDDVE------EVTTAAEKIVFA
ISPH_MYCPA ------LEGVTTVGVTSGASVPEVLVQGVLERLAECGFDVVQ------PVTTAQETLVFA
ISPH_STRAW ------LEGVSTVGVTSGASVPEILVEQVLEWLSQRGFEDVE------IVKAAEESITFS
ISPH_TROWT ------LDKVDVVGVTSGASVPEILVRDLLEVLARAGYTKVE------SVQTAVEDLVFS
ISPH_BIFLO ------FEGLESVGISSGASVPDELVSGVIDALQNLGFTGMK------SVETIKENMHFV
ISPH1_MYCTU ------LSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVV------ERSIATETVRFG
ISPH_CHLCV ------LNYSGDIAITAGASTPEHIVQSCISRLKELIPDLQVEED-----IFAIEDVVFQ
ISPH_CHLPN ------VNHSGDIAMTAGASTPEDVVQACIRKLSSLIPGLQVEND-----IFAVEDVVFQ
ISPH_CHLTR ------LQYSGNIGITAGASTPEDVVQACLMKLQELIPDLSIEMD-----LFVEEDTVFQ
ISPH_PARUW ------LLGKQVIGLTAGASTPEEIVQKCIQCLIELGVN-EVEDI-----VYTHEDVVFQ
ISPH_DEIRA ------LGGVRSVGITSAASTPDDLVQDVVAHFRALNPALEV------IEEGEWENIEFR
ISPH_THET2 ------LEGVESLGITSAASTPEDLVQGVVARLKAQNPGLEV------VEEGAWETIAFR
ISPH_LEPIN ------NNEIKILGLTAGASTPQVLVDEIISKLKIFYPNANVE----LFPGSRDDSMNFK
ISPH_BACSU ------LKGVNTVAVTAGASTPTPITKEVIRFLEQFDHEDPS-----TWTTEHNIPLKKI
ISPH_BACC1 ------LQGVENVAVTAGASTPTPITKEVIAFLEQYDPMNPA-----TWERVRKVPLQKI
ISPH_HALH5 ------FDGVETVGVTAGASTPTPITKEVIAFIEKYDPSKPE-----TWTPERKVTLQKI
ISPH_LISMO ------IKDAKKVAVTAGASTPTQLVREVLLFLEQFDAADKT-----TWKREHNQDFERI
ISPH_MALP2 ------FINKKCLAITSGCSTPTWLANYVIIFLEKKLGTAND------------------
ISPH_HELPY ----------KLCGITAGASTPDWIIENVKQKISTI------------------------
ISPH_WOLSU ----------KTCGVTAGASTPEWIIERVVRTIEGYKG----------------------
ISPH_HELHP ----------ELCGITAGASTPDWIISRVQEKIEQI------------------------
ISPH_CAMJE ----------KHCGISAGASTPDWIIQKVIAKIENFRIN---------------------
ISPH_CLOPE ---------VKTIGITAGASTPDWIINEVISKIKEL------------------------
ISPH_CALS4 ----------DIIGITAGASTPDYVIEEVIEKIKSLKGEDENE-----------------
ISPH_AQUAE ----------KRVGISAGASTPDWIIEQVKSRIQEICEGQLVSS----------------
ISPH_GEOSL ----------ERVGVTAGASTPKWLIDEVIERIQEFDNKKKG------------------
ISPH_TREPA -----------AVGISAGASTPDCVIAAVEQALRTGGAPVASRVSSSALPKVSTCRAVCA
ISPH_TREDE -----------VIGLTAGASTPDFIIDEVEKKLLEG------------------------
ISPH_BACTN ----------KSIGVCGATSTPKWLMEKIHDHIQLLIKD---------------------
ISPH_PORGI ----------ASIGICGATSTPRWQMEEVASHIKALL-----------------------
ISPH_CHLTE ------GKPVESVGICGATSTPMWLLEKVANYIDKTFGDGSSNPNA--------------
ISPH_NOSS1 TTENWLPAGKIVVGVTSGASTPDKVVEDVIEKIFALKATAAVF-----------------
ISPH_THEVB VAENWLPDRPITIGITSGASTPDKVVEEVLNKIFALRSVATVS-----------------
ISPH_PROMP LKKNFIPDGEIKVGITSGASTPDKIVADVIEKLIAITK----------------------
ISPH_PARMW LESNFLPAGPVTVGITSGASTPDRAVEEVIEKLMLLSES---------------------
ISPH_GLOVI RTKNWLPAGEVTVGVTAGASTPDRVVAEVIARIFELKGVGESGATGAISSPVLSSAEGGP
ISPH_THEMA -------VKYGTVCVFSGTSTPNSLIENVVRKLKEMEGKRDGTI----------------
ISPH_DESVH ------LRGCGIIGLTAGASTPKSIIDATQRFLESL------------------------
: .. *.* .
ISPH_BUCAI IPKKLLNIKTILDENG-------------
ISPH_BUCAP IPKNL-NVQN-------------------
ISPH_WIGBR IPKKLILKIK-------------------
ISPH_WOLPM IPNLV------------------------
ISPH_RHILO VMRVLRDVELTPADMAFVNGAA-------
ISPH_RHIME VNRELRHVELTGADMAFVNGE--------
ISPH2_RHOPA VPRVLRPDAAE------------------
ISPH_CAUVC LPRLLTA----------------------
ISPH1_RHOPA LPAELATA---------------------
ISPH_NEIMA LPKELRREGETKPDLCKR-----------
ISPH_CHRVO LPPALRPLF--------------------
ISPH_RALN1 LPRGLQIN---------------------
ISPH_BORPE LPKGLSRKIAQTESLE-------------
ISPH_NITEU LPKAEPVSFNKYI----------------
ISPH_ECOLI VPKELRVDIREVD----------------
ISPH_HAEDU VPKELRV--REVK----------------
ISPH_PSESM MPKELRV--KSLL----------------
ISPH_SHEON VPAELR-----------------------
ISPH_VIBVY VPKELQIKQID------------------
ISPH_XYLFA LPKALRLQLVD------------------
ISPH_RHOBA LPKPLRAFAAEQAAAK-------------
ISPH_CORDI LPRDLRPART-------------------
ISPH_COREF LPRVLRPAR--------------------
ISPH_MYCPA LPREIRSAR--------------------
ISPH_STRAW LPKELRRDLRAEAAALVEQRTGNGPSAE-
ISPH_TROWT LPKGLRESRK-------------------
ISPH_BIFLO LPAELRRKK--------------------
ISPH1_MYCTU LPKQVRAQ---------------------
ISPH_CHLCV PPKELRN----------------------
ISPH_CHLPN LPKELRCS---------------------
ISPH_CHLTR LPKEL------------------------
ISPH_PARUW LPKPIVNARFSVD----------------
ISPH_DEIRA EPKKIAPTQELPRTMQ-------------
ISPH_THET2 EPKPLSPEEVLKGA---------------
ISPH_LEPIN LPGVLLS----------------------
ISPH_BACSU LPKVKAKN---------------------
ISPH_BACC1 LPRVKVKKEQ-------------------
ISPH_HALH5 LPKVKIKK---------------------
ISPH_LISMO LPKTKNKYMAEKRSQRLAHLKNGGS----
ISPH_MALP2 -----------------------------
ISPH_HELPY -----------------------------
ISPH_WOLSU -----------------------------
ISPH_HELHP -----------------------------
ISPH_CAMJE -----------------------------
ISPH_CLOPE -----------------------------
ISPH_CALS4 -----------------------------
ISPH_AQUAE -----------------------------
ISPH_GEOSL -----------------------------
ISPH_TREPA AATSSVGSAGASGAVSPGAVRPFAVGSVR
ISPH_TREDE -----------------------------
ISPH_BACTN -----------------------------
ISPH_PORGI -----------------------------
ISPH_CHLTE -----------------------------
ISPH_NOSS1 -----------------------------
ISPH_THEVB -----------------------------
ISPH_PROMP -----------------------------
ISPH_PARMW -----------------------------
ISPH_GLOVI SLS--------------------------
ISPH_THEMA -----------------------------
ISPH_DESVH -----------------------------