CLUSTAL format seed alignment for MF_00419
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Features found in the protein:- The following colors are used to highlight features:
- blue indicates SIGNAL, PROPEP, TRANSMEM, DOMAIN, ZN_FING, REPEAT,
DNA_BIND and CA_BIND.
- magenta is used to display DISULFID, THIOLEST and THIOETH.
- red is used for all other features, such as INIT_MET, ACTIVE SITE,
METAL,BINDING, NP_BIND, SITE, REGION, etc.
- The ID of the sequence used as the template for feature propagation is
underlined.
- A '<' at the beginning of a sequence or '>' at the end indicate that
the protein is fused with another domain either at the N- or C-terminus.
_____________________________________________________________________________
PUR4_MOUSE -------------------------------MAPVLHFYVRPSGHEGAASGRVFRRLQ--
PUR4_CAEEL --------------------------------MTKFHVKLYAKAVESRKLDQIQKDFE--
PUR4_DROME ---------------------------------MVILRYYDVQAHSAAEEESVLRRLR--
PUR4_DICDI ---------------------------------MTIQQFYRKPAISEYEIKLLKNNLK--
PUR4_ARATH <RCSAQPNKPKAAVSTGSFVTADELPSLVEKPAAEVIHFYRVPLIQESANAELLKAVQ--
PUR4_YEAST ---------------------------------MTDYILPGPKALSQFRVDNLIKDINSY
PUR4_SCHPO -----------------------------------MLVYYGGSALSVQSKKKILE-----
PUR4_NEIG1 ------------------------------------MPLRGVTALSDFRVEKLLQKAA--
PUR4_NEIMB --------------------------------MSVVLPLRGVTALSDFRVEKLLQKAA--
PUR4_RALN1 --------------------------------MAHFSCFPGALALSAFRQQRLLSTLK--
PUR4_ECOLI ----------------------------------MMEILRGSPALSAFRINKLLARFQ--
PUR4_SHIDS ----------------------------------MMEILRGSPALSAFRINKLLARFQ--
PUR4_SALTY ----------------------------------MMEILRGSPALSAFRINKLLARFQ--
PUR4_YERPE -----------------------------------MEILRGSPALSAFRITKLLSRCQ--
PUR4_VIBCH -----------------------------------MRILRGSPALSEFRVNKLLTACR--
PUR4_ALIF1 -----------------------------------MRILRGSPALSEFRVNKLLELCR--
PUR4_PHOPR -----------------------------------MEILRGSPALSEFRVNKLLERCR--
PUR4_MANSM ----------------------------------MFQIFRGSPALSEFRLNQLSARFQ--
PUR4_HAEIN ---------------------------------MTVKTFRGSPALSEFRLTQLQQKCQ--
PUR4_SHEON -----------------------------------MEIIRGAPALSTFRVQKLMEACV--
PUR4_PSEAE -----------------------------------MLILRGAPALSAFRHGKLLEQLT--
PUR4_PSE14 -----------------------------------MLILRGAPALSAFRHSKLLEQLK--
PUR4_METFK -----------------------------------MISLRGSAALSPFRIEKILAALK--
PUR4_XANCP -----------------------------------MMVLEGASALSPFRRARLETRLQ--
PUR4_XYLFA -----------------------------------MIVLKGASALSPFRLARFESRLQ--
Q8D364_WIGBR -----------------------------------MKILTGKKTNSVLYLEKIIISFK--
Q8A6Z2_BACTN -----------------------------------MILFFRTPSKSVIAVESNHQLTP--
A6LEY1_PARD8 -----------------------------------MILFFQSSTKTVLAVEAAHAFSP--
A0A6N4SRE3_CYTH3 -----------------------------------MIVFAKKSTGTIYAIHTEHSFST--
A6GXH5_FLAPJ -----------------------------------MIHFFGNQTNTVFAVQTQNELSA--
A0M079_CHRFK -----------------------------------MILFFGNQTTKVFAVETHSELSA--
I3YZP2_AEQSU -----------------------------------MIHFFGNVENTVFAVQTQANISE--
A4CNM0_ROBBH -----------------------------------MIHFFGDPQSKIFALQSNADLHP--
PUR4_MOUSE EKLP-TLQSVETELCYNVHWAAETLPWAEEMKKLMWLFGCPLVR-DDVAQEPWLVPG---
PUR4_CAEEL KKFN-RKIDVSVEYCYHVITQ-EPELISSNWEKLVTLLSHSPFE-TSVWKESQLHP----
PUR4_DROME EEDG-AVVSVRMERCYHLEYSAQAEHSLALDELLVWLVKQPLSKGQSLSRQPALQSTG--
PUR4_DICDI KQHNIDIESIETEYCFNVQYPDNHKLNESEQSTLVWLLSETFEPKNFSIDKSFLKTTTTT
PUR4_ARATH TKISNQIVSLTTEQSFNIGL--ESKLKDEKLSVLKWILQETYEPENLGTD-SFLERKKQE
PUR4_YEAST TNSTSVINELRSCYIHYVNGIAQNLSEQDTKLLEVLLTYDSALDIANDPLARQLNDAVAN
PUR4_SCHPO -LTVSGVSDLNAVYFYLIYTKSNSS-----------LNCESLRPILSDLQESEFKP----
PUR4_NEIG1 -ALGLPEVKLSSEFWYFAGS-EKALDAATVEKLQALLAAQSVEQTPEAREGL--------
PUR4_NEIMB -ALGLPEVKLSSEFWYFVGS-EKALDAATVEKLQALLAAQSVEQTPKAREGL--------
PUR4_RALN1 -RIDPEIDAVSAQYLHFVAA-DAPLSADDAARVQALLTYGSPASAETEGDR---------
PUR4_ECOLI -AARLPVHNIYAEYVHFADL-NAPLNDDEHAQLERLLKYGPALASHAPQGK---------
PUR4_SHIDS -AARLPVHNIYAEYVHFADL-NAPLNDDEHAQLERLLKYGPALASHAPQGK---------
PUR4_SALTY -AANLQVHNIYAEYVHFADL-NAPLNDSEQAQLTRLLQYGPALSSHTPAGK---------
PUR4_YERPE -DAHLLVSDIYAEYVHFADV-SAPLSADEHARLQRLLQYGPSLPEHPPAGR---------
PUR4_VIBCH -EQQLPVTGIYAEFMHFADL-KAELNPQELEKLEKLLTYGPTIQEHEPQGL---------
PUR4_ALIF1 -ELSLPVTGIYAEFAHFADV-TAELDASEVQKLEKLLTYGPTIEEHEPEGL---------
PUR4_PHOPR -ELDLPVSGIYAEFMHFADV-SAPLNSDEQSKLASLLTYGPTIAEHEPTGT---------
PUR4_MANSM -KADLPVKSCYAEYLHFADL-SAGLSAEETDELEQLLHYGPTLAQHESKGE---------
PUR4_HAEIN -QYQLPITSVYAEYLHFVEQ-KTSLVEDEIVKLQALLHYGSMFSELKPAGY---------
PUR4_SHEON -SAALPVRQIYAEYVHLADL-SELLKPTEREQLEKILTYGPAIEAHTPQGS---------
PUR4_PSEAE -QHVPAVTGLYAEFAHFADV-TGALTADEEQVLARLLKYGPSVPVQEPSGR---------
PUR4_PSE14 -QKVSAVSGLYAEFAHFADV-NDVLTSEEQQVLDRLLKYGPSVPVQEPSGR---------
PUR4_METFK -GSAPRITHLYAEFWHFAWS-DQPLSEAQQEVLKQILTYGPRMSEEAPAGE---------
PUR4_XANCP -TLVPALRLTGAWHVYFIRA-DAGRTPD-QATLQRILQAEPAPAPRDEAAS---------
PUR4_XYLFA -TTVPELHIVGAWHCYLIQI-KSGHTLD-MSALHRILQAESVSEPPQEHVV---------
Q8D364_WIGBR -KLKIYLNFINCEYIYFISH-KKNFFKNTFVKINKLLKSRNFVLPNKEISY---------
Q8A6Z2_BACTN ---------------------------DESNKLCWLFGEAVTESEENLK-----------
A6LEY1_PARD8 ---------------------------EDTQKLVWLFSEATPVQSETLE-----------
A0A6N4SRE3_CYTH3 ---------------------------EDKQKLNWLLDGEVL-SDTTLA-----------
A6GXH5_FLAPJ ---------------------------EDINKLNWLFSSAHKIEKSVLS-----------
A0M079_CHRFK ---------------------------QEISKLNWLFGNTQQIHKSALA-----------
I3YZP2_AEQSU ---------------------------ENTKKLEWLFGNQPKIEQSVLSTNA--------
A4CNM0_ROBBH ---------------------------EAIRKLSWLFGNMPRLDAASVD-----------
:
PUR4_MOUSE --------SNDLLLEVGPRLNFSTPASTNIVSVCQAAGLRA-VDRVETTRRYRLSFTDHP
PUR4_CAEEL --------EHGKNIEIGPRTAVKTAACTNILSIFESSGIKN-VERIERGIRY---LVEDD
PUR4_DROME --------SSQLLLEIGPRFNFSTPYSTNCVNIFQNLGYSE-VRRMETSTRYLVTFGEGS
PUR4_DICDI -------TENEIIIEVGPRMNFTTTYSSNATSICKSCNLSI-IDRIERSRRYLVKSVSKL
PUR4_ARATH -------GLHAVIVEVGPRLSFTTAWSTNAVSICRACGLDE-VTRLERSRRYLLFSKEPL
PUR4_YEAST NLPSSALGEDTYLIRVVPRSGTISPWSSKATNIAHVCGLQDKVQRIERGLALLIKTVPGF
PUR4_SCHPO --------DGTTMVYVFPRPGTISPWSSKATNIANVCGYKD-VIRIERGIAYSV--VFKD
PUR4_NEIG1 -----------HLFLVTPRLGTISPWASKATNIAENCGLAG-IERIERGMAVWL------
PUR4_NEIMB -----------HLFLVTPRLGTISPWASKATNIAENCGLAG-IERIERGMAVWL------
PUR4_RALN1 -------------FVVIPRFGTISPWASKATEIARHCALPQ-IHRIERGVEFTVTCKKGL
PUR4_ECOLI ------------LLLVTPRPGTISPWSSKATDIAHNCGLQQ-VNRLERGVAYYIEAGT--
PUR4_SHIDS ------------LLLVTPRLGTISPWSSKATDIAHNCGLQQ-VNRLERGVAYYIEAGT--
PUR4_SALTY ------------LLLVTPRPGTISPWSSKATDIAHNCGLQQ-VDRLERGVAYYIEAST--
PUR4_YERPE ------------LLLVTPRPGTISPWSSKATDIAHNCGLSQ-ILRLERGLAFSIQGPD--
PUR4_VIBCH ------------LLLVTPRPGTISPWSSKATDIAHNCGLHG-IKRLERGTAYYVEAETA-
PUR4_ALIF1 ------------LLLTTPRPGTISPWSSKSTDIAHNCGLDK-IARLERGTAFYIERSEE-
PUR4_PHOPR ------------MLLVTPRPGTISPWSSKSTDIAQNCALGN-VKRLERGTAYYVEVTAD-
PUR4_MANSM ------------CFVVIPRVGTISSWSSKATDIAHNCGLDK-VVRLERGIAYYFEFERT-
PUR4_HAEIN ------------CLIVTPRVGTISSWSSKATDIAHNCGLSK-VNRIERGIAYYFNIERD-
PUR4_SHEON ------------LLFVTPRPGTISPWSSKATDIAHNCGLGK-VKRLERGIAYYVESDT--
PUR4_PSEAE ------------LFLVVPRFGTISPWSSKASDIARNCGLAK-IDRLERGIAYYVQGEL--
PUR4_PSE14 ------------LFLVLPRFGTISPWSSKASDIARNCGLTK-IQRIERGIAFYVEGQF--
PUR4_METFK ------------LFLVIPRPGTISPWSSRATDIARHCGIEA-IQRLERGIAFYAATADGS
PUR4_XANCP ------------SRYVVPRLGTLSPWSSKATELMRGAG-QP-IQRVERGTRIDLAGWPE-
PUR4_XYLFA ------------SRYVMPRLGTHSPWSSKTTELLHGAG-QP-IARIERGTRIDLLGWSA-
Q8D364_WIGBR -------------FIIIPRLGTLSSWSTKIISIIKNCGLND-INKIERGIILYYHSKNN-
Q8A6Z2_BACTN ------------GCFVGPRREMITPWSTNAVEITQNMGLED-ILRIE-------------
A6LEY1_PARD8 ------------GWYVGPRREMITPWSTNAVEITQNMGLTG-ISRIE-------------
A0A6N4SRE3_CYTH3 ------------GFYRGPRKEMLTPWATNAVEITQNMGIAG-ILRIE-------------
A6GXH5_FLAPJ ------------DFFVGPRATMVTPWSTNAVEITQNMGILG-IIRIE-------------
A0M079_CHRFK ------------DFFVGPRAAMITPWSTNAVEITQNMGIHG-LIRIE-------------
I3YZP2_AEQSU -----------ADFFIGPRAAMVTPWSTNAVEITQNMGIDG-IKRIE-------------
A4CNM0_ROBBH ------------AFFVGPRAAMITPWSTNATEITQNMGIEG-IRRIE-------------
** :. .:. .: . : ::*
PUR4_MOUSE -----------TAEMEAISLAALHDRMTEQHYPDPIQSFSPQSIPAPLK----GSIDILA
PUR4_CAEEL -----------VDVNEFFEIAA--DKMTEAIYGNDVK-FDDESHQIEKV----FLIDVLE
PUR4_DROME -----------KAPEAARFVPLLGDRMTQCLYTEENTPKASFDEQLPERQANWHFVPVLE
PUR4_DICDI -----------SEKQIDQFLELIHDRMTECLYPTPIKSFDTGIIPKAVV-----YIPVVE
PUR4_ARATH -----------LENQIKEFAAMVHDRMTECVYTQKLVSFETNVVPEEVK-----YVPVME
PUR4_YEAST P---------LLENLNDISLKCVYDRMTQQLYLTEPPNTMSIFTHEEPKP--LVHVPLTP
PUR4_SCHPO D---------ISEEMLKSALNHLYDRMTEALRFKLP-EEDEVFDKHEPAP--LVRIELNC
PUR4_NEIG1 -------EGALTDEQKQQWAALLHDRMTESVLPDFQ-TASKLFHHLKSET--FSTVDVLG
PUR4_NEIMB -------EGRLNDEQKQQWAALLHDRMTESVLPDFQ-TASKLFHHLESET--FSGVDVLG
PUR4_RALN1 LRGLTGGRKQLDEATRAAVAAHLHDRMTEIVVATRE-AGYGLFDVLPAKA--LRFVDLGS
PUR4_ECOLI ----------LTNEQWQQVTAELHDRMMETVFFALD-DAEQLFAHHQPTP--VTSVDLLG
PUR4_SHIDS ----------LTNEQWQQVTAELHDRMMETVFFALD-DAEQLFAHHQPTP--VTSVDLLG
PUR4_SALTY ----------LTAEQWRQVAAELHDRMMETVFSSLT-DAEKLFIHHQPAP--VSSVDLLG
PUR4_YERPE ----------LNESQWKQLAALLHDRMMEAVFTDLQ-QAEQLFSHHQPAP--VQRVDILG
PUR4_VIBCH ----------LTAAQIATLEALLHDRMMEVVFAELT-DAQQLFSVAEPAP--MSQVDVLA
PUR4_ALIF1 ----------LSELQLIELKAILHDRMMEVVFTDFE-SASALFAVSEPAP--YTEVDLLT
PUR4_PHOPR ----------LTNAQLTDLKALIHDRMMEVVFTDVD-SAAALFTQAEPAP--VQSVDILV
PUR4_MANSM ----------LSAEQQQRLVSHIHDRMMETVVRAPE-QAAVLFDSQDPKP--FTTVDILN
PUR4_HAEIN ----------LTEAELATLKDLLHDRMLETVLNHET-EAALLFTQQEPKA--LTTIDILN
PUR4_SHEON ----------LTAEQQRTLQGLLHDRMVEVVLNDFA-KADVLFKRTEPAP--FKSVNVLA
PUR4_PSEAE -----------SESDAQQVAARLHDRMTQLVLDRLE-GAAELFSHAQPRP--LTAVDVLG
PUR4_PSE14 -----------SEAQAQAIADSLHDRMTQLVLGDHE-QAASLFSHAQPKP--LTAVDILG
PUR4_METFK ---------PLTDAEKAALRPLIHDRMTEAVFASLT-DAQKLYHTAEPAP--LSTVDILS
PUR4_XANCP -----------GEADQAAVAKLLHDPMTQSLLGSAA-AAEALFNVPDPGQ--LERIPLDA
PUR4_XYLFA -----------NAATCPAIAKQLYDPMTQSLLESED-EVKTLFNVPEPLS--LERIALID
Q8D364_WIGBR -----------ISEELKNFLNKLNDKNSKFICKDIKEAIKIFKNEETPNK--LKKIKILE
Q8A6Z2_BACTN ------------EYFPVKDENADYDPMLQRMYKGLDQNVFTTNRQPEPIV----------
A6LEY1_PARD8 ------------EYFPVSSGDADHDPMLQRIYNGLNQEIFTISKKPDPIV----------
A0A6N4SRE3_CYTH3 ------------EFSSVANTEASHDKMLEVIYQNLTQDLYNIHIQPEPIK----------
A6GXH5_FLAPJ ------------EFEKVSNDFTHFDPMLSQKYPELNQDIYTINIQPEPIL----------
A0M079_CHRFK ------------EFLRVDKNFHDFDPMISQKYENLDQDIFDIHVNPAPII----------
I3YZP2_AEQSU ------------EFHNSTVEKGTFDPMISQKFKELNQAIFEINILPEAIL----------
A4CNM0_ROBBH ------------SYQAVPADFTEYDPMLSEKYNGLGQDLFTVEHLPEPVR----------
* .
PUR4_MOUSE E-------GRPALEKANQELGLALDSWDLDFYTKRFQE---LQR-NPSTVEVFDLAQSNS
PUR4_CAEEL --------SKQNLIKANEELGLALDQLDLDFYYDFFVN---KVKKNPTDVELFDLAQSDS
PUR4_DROME E-------GRAALERINQELGLAFNDYDLDYYHDLFAK---ELGRNPTTVELFDCAQSNS
PUR4_DICDI E-------GRAALERVNKEMGLAFDEQDLALYTDLFQN---QLKRNPSDVECFDIGQSNS
PUR4_ARATH K-------GRKALEEINQEMGLAFDEQDLQYYTRLFRE---DIKRDPTNVELFDIAQSNS
PUR4_YEAST KD--TKQSPKDILSKANTELGLALDSGEMEYLIHAFVE--TMK-RDPTDVELFMFAQVNS
PUR4_SCHPO GQGGDKQAATERLNHANKKFGLALAPDEIDYLVECYTSEPSLKSREPTDVELFMFGQVNS
PUR4_NEIG1 G-------GKEALVKANTETGLALSADEIDYLVENYQ----ALQRNPSDVELMMFAQANS
PUR4_NEIMB G-------GKEALVKANTEMGLALSADEIDYLVENYQ----ALQRNPSDVELMMFAQANS
PUR4_RALN1 GD---AAAGRGALEAANTEMGLALSDDEIDYLVDAYR----KLGRNPTDVELMMFAQANS
PUR4_ECOLI Q-------GRQALIDANLRLGLALAEDEIDYLQDAFT----KLGRNPNDIELYMFAQANS
PUR4_SHIDS Q-------GRQALIDANLRLGLALAEDEIDYLQDAFT----KLGRNPNDIELYMFAQANS
PUR4_SALTY E-------GRQALIDANLRLGLALAEDEIDYLQEAFT----KLGRNPNDIELYMFAQANS
PUR4_YERPE Q-------GRSALEQANIKLGLALAQDEIDYLLTAFT----GLGRNPTDIELYMFAQANS
PUR4_VIBCH G-------GRRALEEANVSLGLALAEDEIDYLVESFT----KLGRNPNDIELMMFAQANS
PUR4_ALIF1 G-------GRKALEDANVTLGLALAEDEIDYLLESFTE---KLERNPTDIELMMFAQANS
PUR4_PHOPR G-------GRKALEDANLKLGLALAEDEIDYLVENFT----MLGRNPNDIELMMFAQANS
PUR4_MANSM G-------GRKALEIANVELGLALASDEMDYLVENFT----ALGRNPNDIELYMFAQANS
PUR4_HAEIN G-------GRQALEQANIALGLALADDEMDYLVESFT----ALKRNPQDVELYMFAQANS
PUR4_SHEON E-------GRRALEVANVEMGLALAEDEIDYLVENFV----RLNRNPNDIELMMFAQANS
PUR4_PSEAE G-------GRAALEKANVELGLALAEDEIDYLLKSFG----ELGRNPHDVELMMFAQANS
PUR4_PSE14 G-------GRAALEKANVELGLALAEDEIDYLITSFN----GLGRNPHDIELMMFAQANS
PUR4_METFK G-------GKAALEAANAEMGLALSPDEVDYLIENFQ----RMGRNPTDVELMMFAQANS
PUR4_XANCP L------------EQANGDLGLALAQDEIDYLRERFA----ALGRDPADVELMMFAQANS
PUR4_XYLFA L------------EHANTRWGLALTADEIDYLRTRYT----ELNRVPSDVELMMFAQANS
Q8D364_WIGBR L-------GKYALEKANIDLNLSLNKTEIEYLFNVFK----NLKRNPSDAELYIFSQANS
Q8A6Z2_BACTN --------SIEDLEAYNEKEGLALSKEEMDYLKKVEND----LGRKLTDSEVFGFAQINS
A6LEY1_PARD8 --------YIEDLEVYNQQEGLALSQEEIAYLNEVSQK----LGRKLTDSEVFGFSQVNS
A0A6N4SRE3_CYTH3 --------YIDDIAAFNKQEGLALSQEEIDYLDSVAKK----HNRKLTDSEVFGFSQVNS
A6GXH5_FLAPJ --------NIDDIAAYNKQEGLALSQEEVDYLNNLSVK----LDRKLTDSEVFAFSQANS
A0M079_CHRFK --------EVDDIESFNKQEGLALNAEEVDYLEKLSDR----LGRKLTDSEVFGFSQVNS
I3YZP2_AEQSU --------EIENISEYNQKEGLALNAEEVEYLDNLSEK----LGRKLTDSEVFGFSQVNS
A4CNM0_ROBBH --------EIQDIAAYNASEGLALNPEEVSYLEALSER----LGRPLTDSEVFGFSQVNS
* .*:: :: * .* :*
PUR4_MOUSE EHSRHWFFKGQLHVDGKKLAHSLFESIMSTQASSNPNNVLKFCDNSSAIQG-KKVKFLRP
PUR4_CAEEL EHSRHWFFRGEIWIDDRKRDGSLMKTIRETLDSSNDNSLIAFCDNSSAIRGFESVCRLRP
PUR4_DROME EHSRHWFFRGRMVIDGVEQPKSLIRMIMDTQAHTNPNNTIKFSDNSSAMVGFDHQTIV-P
PUR4_DICDI EHSRHWFFNGKLIVDGNMSDKTLFQIVKNTLKANPQNSLIAFSDNSSSIKGFKTKVLI-P
PUR4_ARATH EHSRHWFFAGNMVIDGKPMDKSLMQIVKSTWEANRNNSVIGFKDNSSAIRGFLVNQLR-P
PUR4_YEAST EHCRHKIFNADWTIDGIKQQFTLFQMIRNTHKLNPEYTISAYSDNAAVLDSENDAFFFAP
PUR4_SCHPO EHCRHKIFNADWTIDGEKKDYSLFKMIRNTHLKNPQYTISAYSDNAAVFEGNSGTLFAPV
PUR4_NEIG1 EHCRHKIFNADFILNGEKQPKSLFGMIRDTHNAHPEGTVVAYKDNSSVIKGAKIERFYPN
PUR4_NEIMB EHCRHKIFNADFILNGEKQPKSLFGMIRDTHNAHPEGTVVAYKDNSSVIEGAKIERFYPN
PUR4_RALN1 EHCRHKIFNADWTIDGETQDKSLFAMIRNTHQLAPQGTVVAYSDNAAVMEGGMAERWFPH
PUR4_ECOLI EHCRHKIFNADWVIDGEQQPKSLFKMIKNTFETTPDHVLSAYKDNAAVMEGSEVGRYFAD
PUR4_SHIDS EHCRHKIFNADWIIDGEQQPKSLFKMIKNTFETTPDHVLSAYKDNAAVMEGSEVGRYFAD
PUR4_SALTY EHCRHKIFNADWIIDGKPQPKSLFKMIKNTFETTPDYVLSAYKDNAAVMEGSAVGRYFAD
PUR4_YERPE EHCRHKIFNADWVIDGVVQPKTLFKMIKNTFEHTPDYVLSAYKDNAAVMEGSQVGRFYAT
PUR4_VIBCH EHCRHKIFNADWTIDGVKQDKSLFKMIKNTFEQTPDYVLSAYKDNAAVMTGSTVGRFFPD
PUR4_ALIF1 EHCRHKIFNADWTIDGVKQEKSLFKMIKNTFEVTPDNVLSAYKDNAAVMTGSEVGRFFPD
PUR4_PHOPR EHCRHKIFNADWTIDGVEQEKSLFKMIKNTYEKNHEHVLSAYKDNAAVMEGSEVGRFFPN
PUR4_MANSM EHCRHKIFNADWVIDGEKQEKSLFKMIKNTFEKTPDHVLSAYKDNAAVMEGSKVGRFFAD
PUR4_HAEIN EHCRHKIFNADWIIDGKKQDKSLFKMIKNTFEQTPDFVLSAYKDNAAVMEGSKVGRWFPD
PUR4_SHEON EHCRHKIFNADWTIDGKAQPKSLFKMIKNTFEVTPDHVLSAYKDNAAVMEGSVAGRFFPD
PUR4_PSEAE EHCRHKIFNASWDIDGQAQDKSLFGMIKNTYEMNREGVLSAYKDNAAVIVGHVAGRFFPD
PUR4_PSE14 EHCRHKIFNASWDIDGQSQEKSLFGMIKNTYQMHSEGVLSAYKDNASVIVGNVAGRFFPD
PUR4_METFK EHCRHKIFNADWVIDGVAQAQSLFGMIRNTHKLNPGKTVVAYADNASIVEGGKTKRFYPL
PUR4_XANCP EHCRHKIFNASWTIDGKPQERSLFRMIKHTHQQTPQHTLSAYSDNAAVVEGVPAARFRPD
PUR4_XYLFA EHCRHKIFNATWTINDKEQQHSLFQMIKHTHQHTPQYTLSAYADNAAVIEGHPTARYRPD
Q8D364_WIGBR EHCRHKIFNAKWIIDNKIKKYSLLSMIKKTTKKTPKNVISAYFDNSAIISGNCYGKFFSN
Q8A6Z2_BACTN EHCRHKIFGGTFIIDGVEQESSLFQMIKKTTQENPNKIISAYKDNVAFAEGPVVEQFAPA
A6LEY1_PARD8 EHCRHKIFGGVFIIDGEEKESSLFNLIKKTSAENPNKLVSAYKDNVAFNEGPTVEQFAPL
A0A6N4SRE3_CYTH3 EHCRHKIFNGRFIIDGVEKESSLFKLIKKTSETNPNKIVSAYKDNVSFTKGPVMEQFAPA
A6GXH5_FLAPJ EHCRHKIFNGTFVIDGEEMPTSLFKLIKKTSSENPNGIISAYKDNVAFVKGPRVQQFAPK
A0M079_CHRFK EHCRHKIFNGTFVIDGEEKSSSLFKMIRKTSEENPNNIVSAYKDNVAFVKGPRVEQFAPK
I3YZP2_AEQSU EHCRHKIFNGVFEIDGKEMPSSLFKLIKKTSAENPNDIVSAYKDNVAFVKGPTVKQWAPK
A4CNM0_ROBBH EHCRHKIFNGTFIIDHREMPDSLFKLIRKTSEANPNDIVSAYKDNVAFIKGPELVQFAPR
**.** :* . :: :*: : * : ** : .
PUR4_MOUSE EDST----RPSCFQQQQGLRHVVFTAETHNFPTGVAPFSGATTGTGGRIRDVQCTGRGAH
PUR4_CAEEL NDPT----TVSPMIAIFPPSHLIYSAETHNFPTAVCPFQGATTGTGGRIRDIHATGRGAY
PUR4_DROME SSVV----APGAVRLQSVQSDLIFTAETHNMPTAVAPFSGATTGTGGRLRDVQGVGRGGV
PUR4_DICDI KSQI----EASEYLEGEREQPIIFTAETHNFPTGIAPFEGAETGTGGRLRDTHATGRGSL
PUR4_ARATH LLPG----SVCLLDVSARDLDILFTAETHNFPCAVAPYPGAETGAGGRIRDTHATGRGSF
PUR4_YEAST NSTT-----KEWTSTKE-RIPLLIKVETHNHPTAVSPFPGAATGSGGEIRDEGATGRGSK
PUR4_SCHPO NGI--------WSMKDE-PVEFLGKVETHNHPTAVSPFPGAATGSGGEIRDEGAVGQGSL
PUR4_NEIG1 AAEN-----QGYRFHEE-DTHIIMKVETHNHPTAIAPFAGAATGAGGEIRDEGATGKGSR
PUR4_NEIMB AAEN-----QGYRFHEE-DTHIIMKVETHNHPTAIAPFAGAATGAGGEIRDEGATGKGSR
PUR4_RALN1 AGTDGETGVPQYGRREA-LTHTLMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRGAK
PUR4_ECOLI HETG------RYDFHQE-PAHILMKVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAK
PUR4_SHIDS HETG------RYDFHQE-PAHILMKVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAK
PUR4_SALTY HNTG------RYDFHQE-PAHILMKVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAK
PUR4_YERPE AEKG------IYDYHQE-EAHILMKVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAK
PUR4_VIBCH PESR------QYTYHHE-DAHILMKVETHNHPTAISPWPGASTGSGGEIRDEGATGIGGK
PUR4_ALIF1 PETR------QYNYHQE-KTHILMKVETHNHPTAISPWPGASTGSGGEIRDEGATGIGGK
PUR4_PHOPR PESR------QYNYHQE-AAHILMKVETHNHPTAISPWPGASTGSGGEIRDEGATGLGGK
PUR4_MANSM QD-G------QYRYHNE-DAHILMKVETHNHPTAISPFPGAATGSGGEIRDEGATGRGAK
PUR4_HAEIN PD-G------QYRVHQE-DVHILMKVETHNHPTAISPFPGAATGSGGEIRDEGATGRGAK
PUR4_SHEON PN-G------VYSYHTE-PMHVLMKVETHNHPTAISPYPGAATGSGGEIRDEGATGRGSK
PUR4_PSEAE PQTR------EYAASRE-PVQILMKVETHNHPTAIAPFPGASTGSGGEIRDEGATGRGAK
PUR4_PSE14 PETR------QYGAVQE-PVHILMKVETHNHPTAIAPFPGAATGSGGEIRDEGATGRGAK
PUR4_METFK AD-G------QYGFVEE-DMHFLMKVETHNHPTAISPFAGAATGAGGEIRDEGATGSGSK
PUR4_XANCP PATG------EYRSEAVVPSAFAIKVETHNHPTAIAPFPGAATGAGGEIRDEGATGRGGK
PUR4_XYLFA PITG------EYRHEAVLPGAFQIKVETHNHPTAIAPFPGASTGAGGEIRDEGATGRGGK
Q8D364_WIGBR PYTK------KYNFYQK-KNNILIKVETHNYPTALSPFSGSSTGAGGDIRDQGSTGCGSI
Q8A6Z2_BACTN DHSK-----PDFFQVKDIKSVISLKAETHNFPTTVEPFNGASTGTGGEIRDRMGGGKGSW
A6LEY1_PARD8 SGDK-----PDFFAVKDIKTVISLKAETHNFPTTVEPFNGAATGTGGEIRDRLGGGKASL
A0A6N4SRE3_CYTH3 TQDK-----PDYFERKHVESVLSLKAETHNFPTTVEPFNGAATGSGGEIRDRIAGGIGSA
A6GXH5_FLAPJ TADK-----PDFYEIKEFDSVISVKAETHNFPTTVEPFNGAATGSGGEIRDRLAGGQGSL
A0M079_CHRFK APDV-----PEYYQIKDFDSVISIKAETHNFPTTVEPFNGAATGSGGEIRDRLAGGKGSL
I3YZP2_AEQSU SGDK-----PDWYEEKDFESVISIKAETHNFPTTVEPFNGAATGSGGEIRDRLAGGKGSL
A4CNM0_ROBBH SADK-----PDYYEEKPFRSVLSLKAETHNFPTTVEPFNGAATGSGGEIRDRLAGGKGAL
..**** * : *: *: **:** :** * ..
PUR4_MOUSE VVAGTAGYCFGNLHIPD------YNLPWEDP------------------SFQYPGNFARP
PUR4_CAEEL EIAGTVGYSFGNLNLPG------LPLPWEDE------------------TFEYPTSISEP
PUR4_DROME PIAGTAGYCVGALHIPG------YKQPYEPL------------------DFKYPATFAPP
PUR4_DICDI VVAGTVGYCVGNLNIPG------YELPWENK------------------EYNYPDNMANP
PUR4_ARATH VVASTSGYCVGNLNMEG------SYAPWEDS------------------SFQYPSNLASP
PUR4_YEAST TKCGLSGFSVSDLLIPG------NEQPWELN-------------------IGKPYHIASA
PUR4_SCHPO SKAGLAGYSVSDLNIPG------YKQPWELD-------------------VGKPYHIATS
PUR4_NEIG1 PKAGLTGFTVSNLNIPD------LKQPWEQD-------------------YGKPEHISSP
PUR4_NEIMB PKAGLTGFTVSNLNIPD------LKQPWEQD-------------------YGKPEHISSP
PUR4_RALN1 PKAGLTGFTVSNLLLPE------AVQSWENARDTAQPAAQRNPGDTAPGPVGKPDRIASP
PUR4_ECOLI PKAGLVGFSVSNLRIPG------FEQPWEED-------------------FGKPERIVTA
PUR4_SHIDS PKAGLVGFSVSNLRIPG------FEQPWEED-------------------FGKPERIVTA
PUR4_SALTY PKAGLVGFSVSNLRIPG------FEQPWEED-------------------FGKPERIVTA
PUR4_YERPE PKAGLVGFSVSNLRIPG------FEQPWEEN-------------------FGKPDRIVTA
PUR4_VIBCH PKAGLVGFTTSNLRIPG------FEQPWESD-------------------FGKPSRIVNA
PUR4_ALIF1 PKAGLVAFSVSNLKIPN------FVQPWETD-------------------FGKPSRIVTA
PUR4_PHOPR PKAGLVGFTVSNLRVPG------FEQPWETD-------------------FGKPGRIVNA
PUR4_MANSM PKAGLVGFSVSNLVIPG------FEQPWENE-------------------LSKPSRISSA
PUR4_HAEIN PKAGLTGFSVSNLVIPN------FEQPWENP-------------------LSKPNRIASA
PUR4_SHEON PKAGLTGFSVSNLKIPG------FVQPWEGN-------------------YGKPDRIVSA
PUR4_PSEAE PKAGLTGFTVSNLQIPG------FEQPWEVP-------------------YGKPERIVTA
PUR4_PSE14 PKAGLTGFTVSNLQIPG------FVQPWEVP-------------------YGKPERIVTA
PUR4_METFK PKAGLTGFSVSNLHIPG------FKQPWEHN-------------------NGKPDRIASA
PUR4_XANCP PKAGLTGFSVSHLRIPT------LPQPWEAP-------------------RALNPRMAPA
PUR4_XYLFA PKAGLSGFSVSHLRIPT------LPHPWETP-------------------RALNPRMASA
Q8D364_WIGBR PKVGLSGFSVSNLFIPK------YHQPWEES-------------------FGYPKNICTA
Q8A6Z2_BACTN PIAGTAVYMTSYPRTDE-------GREWEDI------------------LPVRKWLYQTP
A6LEY1_PARD8 PIAGTAVYMTSYPRTEG-------ARKWEKV------------------LDPRPWLYQTP
A0A6N4SRE3_CYTH3 PLAGTAVYMTAYSRLTK-------DRPWEKNG-----------------MKERDWLYQTP
A6GXH5_FLAPJ PLAGTAVYMTSYSRLEE-------TRPWENA------------------MNERPWLYQTP
A0M079_CHRFK PLAGTAVYMTSYSRLDK-------DRKWENG------------------MKERDWLYQTP
I3YZP2_AEQSU PLAGTAVYMTSYSRLNDPFDSAQVDRPWEKA------------------MKERDWLYQTP
A4CNM0_ROBBH PLAGTAVYMTAYSRLEE-------GRSWEAH------------------VPARPWLYQTP
. : . :* .
PUR4_MOUSE LEVAIEASNGASDYGNKFGEPVLAGFARSLGLQLP--D------GQ--RREWIKPIMFSG
PUR4_CAEEL AKIAIEASNGASDYGNKFGEPVISGFARSFGQRLE--N------GE--RCEYLKPIMFSG
PUR4_DROME LQVLIEASNGASDYGNKFGEPVISGFALSYGLNSA--A------DASQRDEYVKPIMFSG
PUR4_DICDI LKIEIEASNGASDYGNKFGEPVIIGFTRSYGNTLP--N------GE--RREWIKPIMFSG
PUR4_ARATH LQILIDASNGASDYGNKFGEPMIQGYTRTFGMRLP--S------GD--RREWLKPIMFSA
PUR4_YEAST LDIMIEAPLGSAAFNNEFGRPCINGYFRTLTTKVLNHQ------GKEEIRGFHKPIMIAG
PUR4_SCHPO LDIMLEAPIGSSAFNNEFGRPCINGYFRTFCMEVPRGD------GTLEIRGYHKPIMAAG
PUR4_NEIG1 LDIMIEGPIGGAAFNNEFGRPNLLGYFRTFEEKF-----------DGQVRGYHKPIMIAG
PUR4_NEIMB LDIMIEGPIGGAAFNNEFGRPNLLGYFRTFEEKF-----------DGQVRGYHKPIMIAG
PUR4_RALN1 LQIMIEGPIGGAAFNNEFGRPNLGGYFRVYEQNV-----------GGTVRGYHKPIMIAG
PUR4_ECOLI LDIMTEGPLGGAAFNNEFGRPALNGYFRTYEEKVNSH-------NGEELRGYHKPIMLAG
PUR4_SHIDS LDIMTEGPLGGAAFNNEFGRPALNGYFRTYEEKVNSH-------NGEELRGYHKPIMLAG
PUR4_SALTY LDIMTEGPLGGAAFNNEFGRPALTGYFRTYEEKVNSH-------NGEELRGYHKPIMLAG
PUR4_YERPE LDIMTEGPLGGAAFNNEFGRPALLGYFRTYEERVNSH-------NGIELRGYHKPIMLAG
PUR4_VIBCH LDIMLEGPLGGAAFNNEFGRPNLLGYFRTYEEKVTSH-------AGEEVRGYHKPIMIAG
PUR4_ALIF1 LDIMLEGPLGGAAFNNEFGRPNLLGYFRTYEEKVNSH-------AGEEVRGYHKPIMLAG
PUR4_PHOPR LEIMLEGPLGGAAFNNEFGRPNLLGYFRTYEEKVTSH-------NGEEIRGYHKPIMIAG
PUR4_MANSM LDIMIEGPLGGAAFNNEFGRPALLGYFRTYEEKVNSF-------AGEEVRGYHKPIMLAG
PUR4_HAEIN LDIMIDAPLGSAAFNNEFGRPALLGYFRTYEEKVNSF-------AGKEVRGYHKPIMLAG
PUR4_SHEON LDIMTEGPLGGAAFNNEFGRPALLGYFRTYEQEVSSH-------NGVEMRGYHKPIMLAG
PUR4_PSEAE LDIMVEGPLGGAAFNNEFGRPALTGYFRTFEQKIATP-------HGEEVRGYHKPIMLAG
PUR4_PSE14 LDIMIEGPLGGAAFNNEFGRPALTGYFRTFEQSITTP-------HGDEVRGYHKPIMLAG
PUR4_METFK LQIMVDGPLGGAAYNNEFGRPNIAGYFRTLEIE-----------SAGEIRGYHKPIMLAG
PUR4_XANCP LDIMLDGPLGGAAFNNEFGRPNLLGYFRSFELAE----------GQGLTRAYDKPIMLAG
PUR4_XYLFA LDIMLEGPLGSAAFNNEFGRPNLLGYFRSFELSA----------SKTLTRAYDKPIMLAG
Q8D364_WIGBR LKIILEAPLGASSFNNEFGRPSLLGYFRTYEKKINTK-------NSFEIRGYHKPIMLSG
Q8A6Z2_BACTN EQILIKASNGASDFGNKFGQPLICGSVLTFEHTEN-----------NEVYGYDKVIMLAG
A6LEY1_PARD8 EQILIKASNGASDFGNKFGQPLICGSLLTFEHTEN-----------DKKYAYDKVIMLAG
A0A6N4SRE3_CYTH3 MDILIKASNGASDFGNKFGQPVINGSVFTFEHEEN-----------GKRYGFDKVIMQAG
A6GXH5_FLAPJ MDILIKASNGASDFGNKFGQPLITGSILTFEHEED-----------ARKLGFDKVIMQAG
A0M079_CHRFK MDILIKASNGASDFGNKFGQPLISGSVLTFEHSEH-----------DRALGYDKVIMLAG
I3YZP2_AEQSU LDILIKASNGASDFGNKFGQPLIAGSVLTFEHDEKQDVTLSAVEGSSRKLGYDKVIMMAG
A4CNM0_ROBBH MDILIKASNGASDFGNKFGQPLICGSVLTFEHEEE-----------QRVLGYDKVIMLAG
.: ... *.: :.*:**.* : * : * ** :.
PUR4_MOUSE GIGSMEAKHVGKKP-PEPGMEVVKVGGPVYRIGVGGGAASSVQVQGDNTSDLDFGAVQRG
PUR4_CAEEL GIGAIDKDEVRKEP-CAPHQKVVKIGGPVYRIGVGGGAASSVSVQGNRENQLDFAAVQRG
PUR4_DROME GLGTMPATMREKLP-PARGQLLAKIGGPVYRIGVGGGAASSVEIQGSGDAELDFNAVQRG
PUR4_DICDI GIGFMDERHLKKEQ-PEIGMVVVKAGGPAYRIGMGGGSASSMVG-GDNKHELDFSAVQRG
PUR4_ARATH GIGQIDHTHITKGE-PEVGMLVVKIGGPAYRIGMGGGAASSMVS-GQNDAELDFNAVQRG
PUR4_YEAST GFGTVRPQFALKNTPITPGSCLIVLGGQSMLIGLGGGAASSVAS-GEGSADLDFASVQRG
PUR4_SCHPO GIGRIRKQHAFKKS-IAPGSPIIVLGGPALLVGLGGGAASSMNA-GEGSEELDFASVQRG
PUR4_NEIG1 GLGSIQAQQTHKDE-IPEGALLIQLGGPGMLIGLGGGAASSMDT-GTNDASLDFNSVQRG
PUR4_NEIMB GLGSIQAQQTHKDE-IPEGALLIQLGGPGMLIGLGGGAASSMDT-GTNDASLDFNSVQRG
PUR4_RALN1 GIGNIDAGHTHKHG-LPAGTLLVQLGGPGMRIGMGGGAASSMAT-GTNTADLDFDSVQRG
PUR4_ECOLI GIGNIRADHVQKGE-INVGAKLVVLGGPAMNIGLGGGAASSMAS-GQSDADLDFASVQRD
PUR4_SHIDS GIGNIRADHVQKGE-INVGAKLVVLGGPAMNIGLGGGAASSMAS-GQSDADLDFASVQRD
PUR4_SALTY GIGNIRADHVQKGE-IVVGAKLIVLGGPAMNIGLGGGAASSMAS-GQSDADLDFASVQRD
PUR4_YERPE GLGNIRADHVQKGE-ITVGAKLVVLGGPSMNIGLGGGAASSMAS-GQSDADLDFASVQRD
PUR4_VIBCH GMGNIRAEHIQKKE-IPVGAKLIVLGGPAMNIGLGGGAASSMAS-GQSAEDLDFASVQRE
PUR4_ALIF1 GLGNIRDEHVQKKE-IPVGASLIVLGGPAMNIGLGGGAASSMDS-GSSSEDLDFASVQRE
PUR4_PHOPR GMGNIRADHVQKKE-IPVGAKLIVLGGPAMNIGLGGGAASSMAS-GQSAEDLDFASVQRE
PUR4_MANSM GIGNIRAEHVQKGE-IPVGAKLIVLGGPAMNIGLGGGAASSMTS-GKSKEDLDFASVQRD
PUR4_HAEIN GIGNIRGEQVQKGE-IPIGAKLIVLGGAAMNIGLGGGAASSMDS-GKSKEDLDFASVQRE
PUR4_SHEON GLGNIREEHVQKGE-ITVGAKLIVLGGPAMNIGLGGGAASSMAS-GQSSEDLDFASVQRE
PUR4_PSEAE GMGNIRDEHVQKGE-ISVGAKLIVLGGPAMLIGLGGGAASSMAT-GASSADLDFASVQRD
PUR4_PSE14 GMGNIREDHVQKGE-ITVGSKLIVLGGPAMLIGLGGGAASSMAT-GTSSADLDFASVQRE
PUR4_METFK GVGNISARHAKKNP-IPPGAALIQLGGPAMLIGLGGGAASSMDT-GANTENLDFDSVQRG
PUR4_XANCP GLGAIDRNQVEKLR-LQPGDAVIVLGGPAMLIGLGGGAASSVAA-GDSAEALDFASVQRE
PUR4_XYLFA GLGAIDRIHIKKLR-LQPGDVIIVLGGPAMLIGLGGGAASSVTS-GTSTEALDFASVQRD
Q8D364_WIGBR GFGSISEIHVNKKN-INPEDKIIVLGNLGMNVGIGGASSSSV----KNYLNVESPFIQSG
Q8A6Z2_BACTN GVGYGTQRDCLKGT-PEAGNKVVVIGGDNYRIGLGGGSVSSVDT-GRYSSGIELNAVQRA
A6LEY1_PARD8 GVGFANMRDALKGD-PEPGEKVVVIGGDNYRIGMGGGAVSSVNT-GQYTSGIELNAVQRA
A0A6N4SRE3_CYTH3 GIGYGVLKDAKKGL-PKTGDKIVVMGGDNYRIGMGGSAVSSLDT-GALNSAIELNAIQRS
A6GXH5_FLAPJ GIGYGKLDQAIKKK-PQEGDKIVILGGENYRIGMGGAAVSSADT-GAFSTGIELNAIQRS
A0M079_CHRFK GIGYGKQDQAIKDI-PNKGDKIVVLGGENYRIGMGGAAVSSADT-GEFSSGIELNAIQRS
I3YZP2_AEQSU GIGYGKASQAIKGK-PQEGDKIVILGGDNYRIGMGGAAVSSADT-GEFSSGIELNAIQRS
A4CNM0_ROBBH GIGYGKSDQALKDK-PVQGDRILVMGGDNYRIGMGGAAVSSADT-GAFSSAIELNAVQRS
*.* * : *. :*:**.: ** :: :*
PUR4_MOUSE DPEMEQKMNRVIRACVEAPGG---NPICSLHDQGAGGNGNVLKELSDP--EGAIIYTSRF
PUR4_CAEEL DAEMGGKLHRVVRACAERIGG---NPLMAIHDQGAGGNGNVIKELVEG--CGVTVKSDTF
PUR4_DROME DAEMENKLNRVVRACLDLGEQ---NPILAIHDQGAGGNGNVLKELVEPGFAGAVIFSKEF
PUR4_DICDI DAEMGQKLNRIVRSCVESEIHGGCNPIVSVHDQGAGGAGNVLKEIVDP--LGAKIYLDRI
PUR4_ARATH DAEMSQKLYRVVRACIEMGEK---NPIISIHDQGAGGNCNVVKEIIYP--QGAEIDIRAV
PUR4_YEAST NPEMERRCQQVIDACVALGNN---NPIQSIHDVGAGGLSNALPELVHDNDLGAKFDIRKV
PUR4_SCHPO NPEMQRRAQMVIDACTTM-DE---NIIQSIHDVGAGGVSNALPELVHDAGLGARFELRDI
PUR4_NEIG1 NPEIERRAQEVIDRCWQLGDQ---NPIISIHDVGAGGLSNAFPELVNDAGRGAVFELREV
PUR4_NEIMB NPEIERRAQEVIDRCWQLGGK---NPIISIHDVGAGGLSNAFPELVNDARRGAVFKLREV
PUR4_RALN1 NPEMQRRAQEVINACWALGED---NPILSIHDVGAGGISNAFPELVDGADRGARFDLRQV
PUR4_ECOLI NPEMERRCQEVIDRCWQLGDA---NPILFIHDVGAGGLSNAMPELVSDGGRGGKFELREI
PUR4_SHIDS NPEMERRCQEVIDRCWQLGDA---NPILFIHDVGAGGLSNAMPELVSDGGRGGKFELRDI
PUR4_SALTY NPEMERRCQEVIDRCWQLGDA---NPILFIHDVGAGGLSNAMPELVSDGGRGGKFELRDI
PUR4_YERPE NPEMERRCQEVIDRCWQLGEY---NPILFIHDVGAGGLSNAMPELVNDGGRGGRFELRDI
PUR4_VIBCH NPEMERRCQEVIDRCWQLGDK---NPIAFIHDVGAGGISNALPELVNDGDRGGKFQLRNV
PUR4_ALIF1 NPEMERRCQEVIDRCWQLGDA---NPIAFIHDVGAGGISNALPELVDDGERGGIFNLRDV
PUR4_PHOPR NPEMERRCQEVIDRCWQMGDA---NPIAFIHDVGAGGISNALPELVDDGERGGKFQLRNV
PUR4_MANSM NPEMERRCQEVIDRCWQMGEG---NPIAFIHDVGAGGLSNAMPELVHDGGRGGKFELRNI
PUR4_HAEIN NPEMERRCQEVIDRCWQLGEE---NPILFIHDVGAGGLSNAMPELVHDGKRGGKFDLRSI
PUR4_SHEON NPEMERRCQEVIDRCWQLGDK---NPIQFIHDVGAGGLSNAFPELVNDGDRGGIFNLRNV
PUR4_PSEAE NPEMERRCQEVIDRCWQLGER---NPISFIHDVGAGGLSNALPELINDGGRGGRFELRAV
PUR4_PSE14 NPEMERRCQEVIDRCWQLGDR---NPISFIHDVGAGGLSNAFPELVNDGDRGGRFELRNV
PUR4_METFK NPELERRAQEVIDRCWQLGDK---NPILSIHDVGAGGISNAFPELVNDAGVGARFQLRDV
PUR4_XANCP NPEMERRCQEVIDHCVALGTD---NPIRWFHDVGAGGLSNAIPELLHDSGVGGVIDLARV
PUR4_XYLFA NPEMQRRCQEVIDHCVALGTN---NPIRSFHDVGAGGLSNAIPELLHDSEVGGVIDLAKI
Q8D364_WIGBR NPEIQRRCQEVINRCCELEEE---NPILFIHDVGAGGLSNSILEILHHGKCGGVVFLREI
Q8A6Z2_BACTN NAEMQKRANNVVRALCEEDVN----PVVSIHDHGSAGHVNCLSELVEE--CGGLIDMSKL
A6LEY1_PARD8 NPEMQKRAANVIRAIAESDEN----PIVSIHDHGAGGHLNCLSELVEA--TGGHIDMNKL
A0A6N4SRE3_CYTH3 NPEMQKRVYNAIRAMMESGNN----PIVSIHDHGAGGHLNCLSELVES--TGGKIDLAKL
A6GXH5_FLAPJ NPEMQKRAANAIRGLVESDNN----PIVSIHDHGAGGHLNCLSELVEE--TGGLIDLDKL
A0M079_CHRFK NPEMQKRAANAVRGMVESDKN----PIVSIHDHGAGGHLNCLSELVEE--KGGKIDLDAL
I3YZP2_AEQSU NPEMQKRAANAIRAMVESDHN----PIVSIHDHGAGGHLNCLSELVEE--TGGKIELNKL
A4CNM0_ROBBH NPEMQKRAANAIRGLVEGDKN----PVVSIHDHGAGGHLNCLSELVEE--TGGKIRLDKL
:.*: : : : .** *:.* * . *: * . .
PUR4_MOUSE QLGDPTLNALEIWGAEYQESNALLLRPSDRDFLSRASARERCPACFVGTITGDKRIVLVD
PUR4_CAEEL QLGDESISLRELWTAEYQENDAALVDASLLDALQTISKREKCHVSVVGEVEKEQRVKLL-
PUR4_DROME QLGDPTITALELWGAEYQENNAILCNADQRELLEKICRRERCPISFVGVVTGDGRVTLLE
PUR4_DICDI ISGDPTLSAMEIWGAEYQENDALLIKAEHKDYLKKVSERERLPIAFVGDVTGDGIAQLIT
PUR4_ARATH VVGDHTMSVLEIWGAEYQEQDAILVKAESREILQSICKRERLSMAVIGTINGGGRCTLID
PUR4_YEAST LSLEPGMSPMEIWCNESQERYVLGVSPQDLSIFEEICKRERAPFAVVGHATAEQKLIVED
PUR4_SCHPO PCIEPSMSPMQIWCCESQERYVLSVKSEDLDTFKSICERERCPYGVVGYSTVEQRLILTD
PUR4_NEIG1 PLEEHGLTPLQIWCNESQERYVLSILEKDLDTFRAICERERCPFAVVGTATDDGHLKVRD
PUR4_NEIMB PLEEHGLNPLQIWCNESQERYVLSILEKDLDAFRAICERERCPFAVVGTATDDGHLKVRD
PUR4_RALN1 HLEESGLSPAEIWCNESQERYTLAIAPGDFPRFQAMCERERAPFSVVGFATEEQQLQVVD
PUR4_ECOLI LSDEPGMSPLEIWCNESQERYVLAVAADQLPLFDELCKRERAPYAVIGEATEELHLSLHD
PUR4_SHIDS LSDEPGMSPLEIWCNESQERYVLAVAADQLPLFDELCKRERAPYAVIGEATEELHLSLHD
PUR4_SALTY LSDEPGMSPLEIWCNESQERYVLAVAADQLPLFDELCKRERAPYAVIGDATEEQHLSLHD
PUR4_YERPE LNDEPGMSPLEVWCNESQERYVLAVAPAQMALFDEICRRERAPYAVIGEATEEKHLLLND
PUR4_VIBCH PNDEPGMSPLEIWCNESQERYVLAVAAEDMPLFDAICQRERAPYAVVGEATEERHLTLED
PUR4_ALIF1 PNDEPGMSPLEIWCNESQERYVMAVADKDMATFDAICKRERAPYAVVGKATEERELKLED
PUR4_PHOPR PNDEPGMSPLEIWCNESQERYVMAVAPENLAVFEAICKRERAPFAVVGEATEERHLTLED
PUR4_MANSM LCDERGMSPLEIWCNESQERYVLAVAPENLAVFEELCQRERAPYAIIGEATEEEHLTLHD
PUR4_HAEIN LCDEKGMSPLEIWCNESQERYVLAVAPENLELFTALCERERAPFAVIGEATQAEHLILHD
PUR4_SHEON PSDEPGMSPLEIWCNESQERYVLSVAAEDLPLFTAICERERAPFAVVGEAIQEQHLTLAD
PUR4_PSEAE PNDEPGMSPLEIWCNESQERYVLSVDAADFETFKAICERERCPFAVVGEAIEQRQLTVAD
PUR4_PSE14 PNDEPGMAPLEIWSNESQERYVLAVGVEDFDRFKAICERERCPFAVVGEATAEPQLTVTD
PUR4_METFK HNEEPGMSPREIWSNEAQERYVMAVRKEDLPLFAEICERERCPFAVVGEATEEKRLVVSD
PUR4_XANCP PSDDPSLSPLELWCNESQERYVLGVPQARLDEFAAICARERCPFAAVGVATAEERLVVGY
PUR4_XYLFA PSDDPSLSPLELWCNESQERYVLGISAAHLQAFAAICTRERCPFAAVGVATATEQLIVGY
Q8D364_WIGBR LIGNNKMSPLEILCNESQERYVLILSKSKIKIFNSICKRENAQYYIVGKITNSLNLKIYD
Q8A6Z2_BACTN PIGDKTLSAKEIIANESQERMGLLIKEEAIEHVRKIAERERAPMYVVGETTGDHRFSFQQ
A6LEY1_PARD8 PIGDPTLSAKEIVGNESQERMGLLMKEEDVARVKRIADRERAPMYVVGETTNDMKFVFEQ
A0A6N4SRE3_CYTH3 PVGDPTLSAKEIVGNESQERMGLVINQNDIATLERVAARERAPLYVVGDITGDHHFTFES
A6GXH5_FLAPJ PIGDPTLSAKEIIGNESQERMGLVIGTKDIDILQRIANRERSPMYQVGDVTADHRFTFKS
A0M079_CHRFK PVGDPTLSAKEIIGNESQERMGLVIGEAEIAQLRRVADRERSPMYEVGNVTGDHRFTFKG
I3YZP2_AEQSU PIGDPTLSDKEIMGNESQERMGLVIGEADIQKLKRVADRERSPMYEVGQVTGDQRFCFEN
A4CNM0_ROBBH PVGDPTLSAKELIGNESQERMGLVIAPRDLELLQRIADRERAPLYDVGEVTGDHRFTFAS
: : :: * ** . . **. :* .
PUR4_MOUSE DR-------------------ECLVGKTGQGDAPLTPPTPVDLDLDWVLGKM--PQKEFF
PUR4_CAEEL -------------------------GKSGE--------IAVDLD-TRQLGER--EKKVFK
PUR4_DROME KP-------------------APKDLEQALNASNRSEVSPFDLELKYVLGDM--PKRTYD
PUR4_DICDI K----------------------DGE------------TPVNLPLDKVLQKM--PPKTFV
PUR4_ARATH S----------------------TAAAKCSKEGLPPPPPAVDLELEKVLGDM--PKKTFK
PUR4_YEAST ---------------------------------PLLKTTPIDLEMPILFGKP--PKMSRE
PUR4_SCHPO ---------------------------------RLYNTTPIDLPMEVLFGKP--PKMSRV
PUR4_NEIG1 ---------------------------------DLFSNNPVDLPLNVLLGKP--PKTTRT
PUR4_NEIMB ---------------------------------DLFANNPVDLPLNVLLGKL--PKTTRT
PUR4_RALN1 GD----------------------------APADAVEHFPVNMPMDVLLGKP--PRMHRD
PUR4_ECOLI ---------------------------------RHFDNQPIDLPLDVLLGKT--PKMTRD
PUR4_SHIDS ---------------------------------RHFDNQPIDLPLDVLLGKT--PKMTRD
PUR4_SALTY ---------------------------------NHFDNQPIDLPLDVLLGKT--PKMTRD
PUR4_YERPE ---------------------------------RHFGNQPIDMPLDVLLGKT--PKMLRD
PUR4_VIBCH ---------------------------------SHFANTPIDMPMDILLGKP--PKMHRE
PUR4_ALIF1 ---------------------------------SHFDNTPIDMPMDILLGKT--PKMHRD
PUR4_PHOPR ---------------------------------EHFDNTPIDMPMDILLGKA--PKMHRD
PUR4_MANSM ---------------------------------NHFDNNPIDLPMSLLLGKT--PKMTRD
PUR4_HAEIN ---------------------------------SHFDNNPIDLPMNVLLGKT--PKMTRE
PUR4_SHEON ---------------------------------SHFDNNPIDLPLEVLLGKA--PKMSRN
PUR4_PSEAE ---------------------------------SHFDNKPVDMPLEVLLGKA--PRMHRA
PUR4_PSE14 ---------------------------------SHFGNSPVDMPLEVLLGKV--PRMHRS
PUR4_METFK ---------------------------------RHFGNTPVDMDLSVLLGKP--PKMTRD
PUR4_XANCP GV-FDAANRESGIGNRNSALPAAEAASAHSLFPTPDSPLPINLPMDVLFGKA--PKMHRD
PUR4_XYLFA GVTLPAALHVTEQQTPQRANHTETSPTPNTLPPSVREAFAIDLPMDVLFGKA--PKMHRN
Q8D364_WIGBR ---------------------------------SYFKNKVVDLPVNIFFNKSQIKKIRKK
Q8A6Z2_BACTN A----------------------------------DGVRPFDLAVEQMFGSS--PKTYMI
A6LEY1_PARD8 A----------------------------------DGVKPIDIKLEYMFGKP--PRTVMT
A0A6N4SRE3_CYTH3 SV---------------------------------DGAKPIDWPLEDMFGNP--PKTILR
A6GXH5_FLAPJ KS---------------------------------TGAKPMDYALEDFFGSS--PKVVMT
A0M079_CHRFK EK---------------------------------SGQKPMDLELSDMFGSS--PKTIMN
I3YZP2_AEQSU KK----------------------------------GEKPMDFALEDMFGSS--PKTIMK
A4CNM0_ROBBH DS-----------------------------------ERPMDLALADMFGSS--PKTVMQ
.: : .
PUR4_MOUSE LQRKPPVLQPLALPPE---LSVRQ-------ALNRVLRLPAVASKRYLTNKVDRSVGGLV
PUR4_CAEEL LKSAPRVLKKLELPEN---LTVRK-------ALKRVLMLPSVASKRYLTCKVDRSVTGLV
PUR4_DROME LKREQTPLKELSLPKG---LLLDE-------ALERVLSLVAVGSKRFLTNKVDRCVGGLI
PUR4_DICDI LDHVEKQLKPFTLPKE---LLVGDHQTCFNECLNRVLRLLSVGSKRFLINKVDRAVTGLV
PUR4_ARATH FNRIAYAREPLDIAPG---ITLMD-------ALKRVLRLPSVSSKRFLTTKVDRCVTGLV
PUR4_YEAST TITEALNLPEANLSEI---PSLQ-------DAIQRVLNLPSVGSKSFLITIGDRSVTGLI
PUR4_SCHPO AETQTIPLSKFDSSLK---SYLAPSSDPILDAVERVLRMPAVASKSFLITIGDRSVTGLI
PUR4_NEIG1 DKTVTP-SKKPFHAGD---IDIT-------EAAYRVLRLPAVAAKNFLITIGDRSVGGMT
PUR4_NEIMB DKTVAP-SKKPFHAGD---IDIT-------EAAYRVLRLPAVAAKNFLITIGDRSVGGLT
PUR4_RALN1 VRRVAQ-ALPEVDVTG---LDLE-------TVARDVLRHPTVASKSFLITIGDRTVGGLN
PUR4_ECOLI VQTLKA-KGDALAREG---ITIA-------DAVKRVLHLPTVAEKTFLVTIGDRSVTGMV
PUR4_SHIDS VQTLKA-KGDALVREG---ITIA-------DAVKRVLHLPTVAEKTFLVTIGDRSVTGMV
PUR4_SALTY VQTLKA-KGDALNRAD---ITIA-------DAVKRVLHLPTVAEKTFLVTIGDRTVTGMV
PUR4_YERPE VTRLQA-KGDALQRAD---ISLA-------EAVKRIMHLPAVAEKTFLITIGDRTVTGMV
PUR4_VIBCH ASTLKV-SSPALERSG---IELN-------EAVDRVLRLPAVAEKTFLITIGDRSVTGLV
PUR4_ALIF1 AKTLKA-NNPAIDRSG---IEMN-------EAVDRVLRLPTVAEKTFLITIGDRSVTGLV
PUR4_PHOPR AKTLKV-EGQAIDRSG---IELE-------AATQRVLRLPAVAEKTFLITIGDRSVTGLV
PUR4_MANSM VKSTQV-NNSPVDQTN---IELK-------EAFHRVLRLPVVAEKTFLITIGDRTVTGMV
PUR4_HAEIN VLSKTV-ENQSLKIES---IQLK-------EAFHRVLRLPVVAEKTFLITIGDRSVTGMV
PUR4_SHEON VVSAKA-VSPALEQSQ---IDVK-------DAVKRVLSLPTVADKTFLITIGDRTVTGLV
PUR4_PSEAE VTREAE-LGDDFDAAG---LELQ-------ESVERVLRHPAVASKSFLITIGDRTITGLV
PUR4_PSE14 VEREAE-IGDDFDPST---LDIE-------ESVQRVLRHPAVASKSFLITIGDRSITGLV
PUR4_METFK VQHVAR-ELPAFDHSR---IDLK-------EAAQRVLRLPGVADKTFLITIGDRSVTGMI
PUR4_XANCP AVHPAAPQWPVLQTGA---LDLQ-------EAGLRVLAHPTVASKSFLVTIGDRSVGGLT
PUR4_XYLFA TAHPPPPHWPTLDSTQ---LDLH-------HAGLRVLAHPTVAAKNFLVTIGDRSIGGLT
Q8D364_WIGBR SKNVCHIKKIPINKKN---INLT-------DAINRVLHLPSVSDKNFLITIGDRSITGSV
Q8A6Z2_BACTN DKTVERHYEMPEYELPKLHE-----------YLTNVLQLEAVACKDWLTNKVDRSVTGKV
A6LEY1_PARD8 DHTVTESYQPVVYKESELHH-----------YLENVLQLEAVACKDWLTNKVDRSVTGKI
A0A6N4SRE3_CYTH3 DETPTATFEEITYEQSKLNE-----------YLEAVLQLEAVACKDWLTNKVDRSVTGKV
A6GXH5_FLAPJ DKTIDRKYSELEYTEDKIAT-----------YLEQVLQLEAVACKDWLTNKVDRCVGGKV
A0M079_CHRFK DKTIKRNYEDVSYETSKIHQ-----------YLDQVLQLEAVACKDWLTNKVDRCVTGRV
I3YZP2_AEQSU DKTINRTYKNSDYDVSKIKE-----------YVAQVLQLEAVACKDWLTNKVDRCVTGRV
A4CNM0_ROBBH DEKQDRTYAGVDYEFQRFHA-----------YLEEVLQLEAVACKDWLTNKVDRCVGGLV
:: *. * :* ** : *
PUR4_MOUSE AQQQCVGPLQTPLADVAVVALSHQECI---GAATALGEQPVKSLLDPKAAARLAVSEALT
PUR4_CAEEL AQQQCVGPLHTPLADVAVVALSHFDTV---GGAVSLGEQPIKMLIDAEKGARMCIAETIM
PUR4_DROME AQQQCVGPLQAPLADYALTTVSHFSHS---GIATSIGTQPLKGLLDPAAMARMCVAEALS
PUR4_DICDI ARQQCVGPLHTPVSNVAVISSGYFGKS---GAATSIGEQPIKGFISAKSMAYLTVGEALT
PUR4_ARATH AQQQTVGPLQITLADVAVIAQTFTDLT---GGACAIGEQPIKGLLDPKAMARLAVGEALT
PUR4_YEAST DRDQFVGPWQVPVADVGVTGTSLGETIISTGEAMAMGEKPVNALISASASAKLSVAESLL
PUR4_SCHPO ARDQMVGPWQVPVADVGVTVTSYGKGI-NTGEALAMGEKPISALVSAAASARMAVAECIM
PUR4_NEIG1 HRDQMVGKYQTPVADCAVTMMGFNTYR---GEAMSMGEKPAVALFDAPASGRMCVGEAIT
PUR4_NEIMB HRDQMVGKYQTPVADCAVTMMGFNTYR---GEAMSMGEKPTVALFDAPASGRMCVGEAIT
PUR4_RALN1 TRDQMVGPWQVPVADVAVTTLDYKGYA---GEAMTMGERTPLAVIDAPASGRMAIGEAIT
PUR4_ECOLI ARDQMVGPWQVPVANCAVTTASLDSYY---GEAMAIGERAPVALLDFAASARLAVGEALT
PUR4_SHIDS ARDQMVGPWQVPVANCAVTTASLDSYY---GEAMAIGERAPVALLDFAASARLAVGEALT
PUR4_SALTY ARDQMVGPWQVPVADCAVTTASLDSYY---GEAMSIGERAPVALLDFAASARLAVGEALT
PUR4_YERPE TRDQMVGPWQIPVADCAVTSASLDSYY---GEAMSLGERAPVALLDFAASARLAVGEALT
PUR4_VIBCH ARDQMVGPWQVPVANCAVTAASFDSYH---GEAMSMGERTPVALLDFGASARLAVGEAIT
PUR4_ALIF1 ARDQMVGPWQVPVANCAVTAASYDSYH---GEAMSLGERTPVALLDFGASARLAVGEAIT
PUR4_PHOPR ARDQMVGPWQVPVANCAVTAASYDTYH---GEAMSMGERTPVALLDFGASARLAVGEAIT
PUR4_MANSM ARDQMVGPWQIPVSDVAVTTAALDTYH---GEAMSIGERAPVALLDFAASARLAVAESIT
PUR4_HAEIN ARDQMVGPWQIPVSDVAVTTASLDSYH---GEAMAIGERSPVALLDFSASARLAVAEAIT
PUR4_SHEON NRDQMVGPWQVPVADCAVTAASFDTYA---GEAMSLGERTPLALLDFGASARMAVAESIM
PUR4_PSEAE ARDQMVGPWQVPVADCAVTATSFDVYT---GEAMAMGERTPLALLDAPASGRMAIGETVT
PUR4_PSE14 ARDQMVGPWQVPVADCAVTATSFDVNT---GEAMAMGERTPLALLDAPASGRMAIGETLT
PUR4_METFK ARDQMVGPWQVPVADVAVTLDGFETYR---GEAFAIGEKAPLALIDAPASGRMAIGEAIT
PUR4_XANCP AREQMIGPWQLPLADCAITLAGFETFD---GEAMSIGERTPLALLNAAASARMAVGEAIT
PUR4_XYLFA AREQMIGPWQLPLADCAITLAGFGTYA---GEAFAIGERAPLALLNSAAAARMAVGEAIT
Q8D364_WIGBR VKDQMVGPWQIPVSDCAVTTSSFDSYF---GEAISIGERSPASLIDFNASSRLSLGEAIT
Q8A6Z2_BACTN ARQQCQGELQLPLSDCGVVALDYRGEK---GIATSIGHAPQAALADPAAGSILSVSEALT
A6LEY1_PARD8 ARQQCQGELQLPLSDLGAVALDYRGKA---GIATSIGHAPQVAMVDPAAGSVMAIAESLT
A0A6N4SRE3_CYTH3 AQQQNVGSLQLPLSNFGAMALDYKGVV---GVATAVGHAPAVALINPEAGSRIAIAEALA
A6GXH5_FLAPJ AKQQCAGPLQLPLNNCGVMALDYQGKE---GIATSIGHSPIASLIDPVAGTRTAIAESLS
A0M079_CHRFK AKQQTAGPLQLPLNNCGVMALDYKGKE---GVATSIGHSPVSALVDPVAGSKNSIAESLS
I3YZP2_AEQSU AKQQTAGPLQLPLNNCGVMALDYHGKE---GVATSIGHSPLTALIDAAAGSRNAITESLT
A4CNM0_ROBBH AKQQCAGPLQLPLNNCGVMALDFKGKD---GLATSVGHSPVSGLIHAGAGSRNSIAEALT
::* * : .: : . * * ::* . . : * :
PUR4_MOUSE NLVFALVTD-LRDVKCSGNWMWAAKL-PGEGAALADACEAMV-AVMAALGVAVDGGKDSL
PUR4_CAEEL NLIWAPITD-LKDVKMSGNWMWAAKC-DGEGARLVDAVGALC-RGLREIGCAIDGGKDSL
PUR4_DROME NLVFVKISE-LADVKCSGNWMWAAKL-PGEGARMFDACKELC-QILEELHIAIDGGKDSL
PUR4_DICDI NLMWASITD-LGDVKCSGNWMWAAKL-KGEGVELYDAAIEMH-DVMVELGIAIDGGKDSL
PUR4_ARATH NLVWAKVTA-LSDVKASGNWMYAAKL-EGEGSAMYDAAIALS-EAMIELGIAIDGGKDSL
PUR4_YEAST NIFAADVKS-LNHIKLSANWMSPASH-QGEGSKLYEAVQALGLDLCPALGVAIPVGKDSM
PUR4_SCHPO NLVAASIPA-LDRIRLSANWMAAPSH-PGEGAKLYEAVQAIGLELCPSLGISIPVGKDSM
PUR4_NEIG1 NIAAVNIGD-IGNIKLSANWMAACGN-EGEDEKLYRTVEAVS-KACQALDLSIPVGKDSL
PUR4_NEIMB NIAAVNIGD-IGNIKLSANWMAACGN-EGEDEKLYRTVEAVS-KACQALDLSIPVGKDSL
PUR4_RALN1 NIAAAPIAS-LAQLKLSANWMAACGV-DGEDARLYDTVKAVGMELCPALGISIPVGKDSL
PUR4_ECOLI NIAATQIGD-IKRIKLSANWMAAAGH-PGEDAGLYEAVKAVGEELCPALGLTIPVGKDSM
PUR4_SHIDS NIAATQIGD-IKRIKLSANWMAAAGH-PGEDAGLYEAVKAVGEELCPALGLTIPVGKDSM
PUR4_SALTY NIAATQIGD-IKRIKLSANWMAAAGH-PGEDAGLYDAVKAVGEELCPQLGLTIPVGKDSM
PUR4_YERPE NIAATQIGE-LKRIKLSANWMSAAGH-PGEDAGLYDAVRAVGEELCPALEITIPVGKDSM
PUR4_VIBCH NIAATDIGE-LKRIKLSANWMSPAGH-PGEDAGLYEAVKAVGEELCPALGITIPVGKDSM
PUR4_ALIF1 NIAATNIGD-IKHIKLSANWMSPAGH-PGEDAGLYEAVKAVGEELCPALGLTIPVGKDSM
PUR4_PHOPR NIASADIGD-MKRINLSANWMSPAGH-PGEDAGLYEAVKAVGEELCPALGLTIPVGKDSM
PUR4_MANSM NIAATNIGD-IKRIKLSANWMSAAGH-EGEDAGLYEAVKAVGEELCPALGLTVPVGKDSM
PUR4_HAEIN NIAGTLIGE-MKRIKLSANWMSAAGH-TGEDAGLYEAVKAVGEELCPALGLTIPVGKDSM
PUR4_SHEON NIAGADIGS-FKRIKLSANWMSAAGH-PGEDAGLYEAVKAVGEELCPELSLTIPVGKDSM
PUR4_PSEAE NLAAARVGK-LSDIKLSANWMAAAGH-PGEDARLYDTVKAVGMELCPELGITIPVGKDSM
PUR4_PSE14 NIAASCIEK-LSDIKLSANWMSAAGH-PGEDARLYDTVKAVGMELCPELGITIPVGKDSM
PUR4_METFK NIAASLIED-IADLKLSANWMAPAGH-PGEDAALFDTVKAVGMELCPQLGISIPVGKDSM
PUR4_XANCP NLCAAPVQT-LDSIKLSANWMAAAGH-AGEDALLYDAVRAVGMELCPALELSIPVGKDSL
PUR4_XYLFA NLCAAPVES-LSMVKLSANWMAAAEH-PGEDALLYDAVKAIGIELCPALDISIPVGKDSL
Q8D364_WIGBR NISSMYVNS-LKNIKLSANWMIDSSN-NHDTFKLYKAVENLGKKTCPELDLSIVVGKDSM
Q8A6Z2_BACTN NLVWAPMAEGMDSISLSANWMWPCRSQEGEDARLYTAVKALS-DFCCALQINVPTGKDSL
A6LEY1_PARD8 NIVFAPLTDKLESVSLSANWMWPCRN-EGEDARLYTAVQAAS-DFACSLGINIPTGKDSL
A0A6N4SRE3_CYTH3 NIVFAPIDGGLSGVSLSANWMWPCKN-KGEDARLYAAVEAVS-DFACDLGINIPTGKDSL
A6GXH5_FLAPJ NIIWAPIKDGLNGISLSANWMWACKN-EGEDARLYAAVKSCS-DFAIELGINIPTGKDSL
A0M079_CHRFK NIVWAPLEKGLRSISLSANWMWPCNN-EGEDARLYEAVEAVS-KFAISLGINVPTGKDSL
I3YZP2_AEQSU NIVWAPLKDGLKSISLSANWMWPCNN-EGEDARLYAAVKAVS-EFSIDLGINVPTGKDSL
A4CNM0_ROBBH NLVWAPLEKGLKSVSLSANWMWPCNN-PGEDARLYEAVQAAS-QFAIALGINIPTGKDSL
*: : : : *.*** : : : : : ****:
PUR4_MOUSE SMAARV-------------------------------GTETVQAPGSLVISAYAVCPDIT
PUR4_CAEEL SMAVTA-------------------------------HGEVVKSPGTLVLSAYAPCTNVT
PUR4_DROME SMAAKV-------------------------------GGETIKSPGTLVISTYAPCPDVR
PUR4_DICDI SMAAKAPKSD--------------------------GSQELVKAPGALVVSTYVPCDDIT
PUR4_ARATH SMAAHA-------------------------------DGEVVKAPGNLVISAYVTCPDIT
PUR4_YEAST SMKMKWDD-------------------------------KEVTAPLSLNITAFAPVFNTS
PUR4_SCHPO SMSMKWNED---------------------------GREKSVTAPLSLIITGFSPVDDLY
PUR4_NEIG1 SMKTVWQDG---------------------------EEKKSVVSPLSLIISAFAPVKDVR
PUR4_NEIMB SMKTVWQDG---------------------------EEKKSVVSPLSLIISAFAPVKDVR
PUR4_RALN1 SMRTKWDDA---------------------------GEAKEVVAPVSLIVSAFAPVTDVR
PUR4_ECOLI SMKTRWQEG---------------------------NEEREMTSPLSLVISAFARVEDVR
PUR4_SHIDS SMKTRWQEG---------------------------NEEREMTSPLSLVISAFARLEDVR
PUR4_SALTY SMKTRWQEG---------------------------NEQREMTSPLSLVISAFARVEDVR
PUR4_YERPE SMKTRWQEG---------------------------HEQREMTSPLSLVITAFARIEDVR
PUR4_VIBCH SMKTKWQEN---------------------------GEQKEVTSPLSLIITAFARVEDIR
PUR4_ALIF1 SMKTKWEEN---------------------------GEQKEVTSPLSLVITAFARVEDVR
PUR4_PHOPR SMKTKWEQD---------------------------GEQKEVTSPLSLVITAFGRVEDVR
PUR4_MANSM SMKTTWSEN---------------------------GEQKTVTAPLSLVISAFARVEDVR
PUR4_HAEIN SMKTTWIDN---------------------------GEQKSVTAPLSLVISAFARVEDVR
PUR4_SHEON SMKTAWQQD---------------------------GVNKTVTSPMSLVITAFGVVQDIR
PUR4_PSEAE SMKTRWQDN---------------------------GEDKSVTSPVSLIVTGFAPVADVR
PUR4_PSE14 SMKTRWSDE---------------------------GTEKSVTSPLSLIVTGFAPVVDIR
PUR4_METFK SMKTVWEER---------------------------NEKKAVTAPISLVVTAFAPTADAR
PUR4_XANCP SMQAQWQVGNGESGIGNGETPAPSASAIPDSRLPIPGETLKSVSPVSLIISAFAPVSDVR
PUR4_XYLFA SMQSRWQAD---------------------------GATHTCISPVSLVISAFTPVADAR
Q8D364_WIGBR FMKTEWLEK---------------------------KNKISIISPPSLIITACSPIEDVR
Q8A6Z2_BACTN SMTQKYPNG------------------------------EKVISPGTVIVSAGGEVSDVK
A6LEY1_PARD8 SMTQKYGD-------------------------------DKVIAPGTVIISAGAEVSDIK
A0A6N4SRE3_CYTH3 SMTQKYKD-------------------------------GVVYAPGTVIISASGEVSDIR
A6GXH5_FLAPJ SMKQKYPN-------------------------------DEVIAPGTVIISAAGNCTNIT
A0M079_CHRFK SMKQKYKD-------------------------------SQVISPGTVIISAAGHCNDIT
I3YZP2_AEQSU SMKQKYKD-------------------------------GEVISPGTVIISAAGNCNDIQ
A4CNM0_ROBBH SMKQKYRD-------------------------------QEVLAPGTVIISAAAHCSDRR
* :* : :: :
PUR4_MOUSE ATVTPDLKHP-----GGKGHLLYVPLSPGQHRLGGTALAQCFSQ------LGEHPPDLDL
PUR4_CAEEL KVVNPSLKAVP----GSKILWIKIGSSEEKMRLGGSALAQVYSQ------IGDDCPDIEN
PUR4_DROME LKVTPDLKGPG----AGSKTSLLWINLENSARLGGSALAQAYAQ------QGKDTPNLTR
PUR4_DICDI LTVTPDLKLSS----KDDSVILYLDLGCANNFIGGSALTQVFNQ------VGNDEP-HHN
PUR4_ARATH KTVTPDLKLGG-----DDGILLHVDLAKGKRRLGGSALAQVFGQ------IGNDCPDLDD
PUR4_YEAST KTWTPLLNRNT---DDSVLVLVDLSAKQETKSLGASALLQVYNQ------VGNKSPTVYD
PUR4_SCHPO SIWTPQLRKVE---DIGSTSLIFIDLANGKQRLGGSILAQSYKQ------LGDEVPDLDN
PUR4_NEIG1 KTVTPELKNVE------GSVLLFIDLGFGKARMGGSAFGQVYNN------MSGDAPDLDD
PUR4_NEIMB KTVTPELKNVE------DSVLLFVDLGFGKARMGGSAFGQVYNN------MSGDAPDLDD
PUR4_RALN1 KTLTPQLKPVASAGEAADTTLIVIDLGHGKHRLGGSILAQVTQQ------IGNSVPDVGD
PUR4_ECOLI HTITPQLSTE-------DNALLLIDLGKGNNALGATALAQVYRQ------LGDKPADVRD
PUR4_SHIDS HTITPQLSTE-------DNALLLIDLGKGNNALGATALAQVYRQ------LGDKPADVRD
PUR4_SALTY HTLTPQLSTE-------DNALLLIDLGKGHNALGATALAQVYRQ------LGDKPADVRD
PUR4_YERPE RTVTPQLRTDK-----GDNALLLIDLGAGHNALGATALTQVYRQ------LGDKPADVRN
PUR4_VIBCH KTVTPQLRT-----DLGETSLILIDLGNGQNRLGATALAQVYKQ------LGDKPADVDN
PUR4_ALIF1 KTITPQLRTPDNLEGLGDTSLVLIDLGNGKNRLGATALAQVYKQ------LGDKPADVDN
PUR4_PHOPR KTVTPQLRT-----DKGESSLILIDLGCGQNRLGATALAQVYKQ------LGDKPADVDN
PUR4_MANSM KTVTPQLRTDK-----GETALLLIDLGEGKNRLGATALAQVYKQ------LGDKPADVVN
PUR4_HAEIN KTLTPQLRTDK-----GFSSLLLIDLGEGHNRLGATALAQVYKQ------LGDKPADVVK
PUR4_SHEON NTVTPELRSDK-----GETSLLLVDLGAGQNRLGGSCLAQVYGE------LGDVAPDLDD
PUR4_PSEAE QSLTPQLRLDK-----GETDLILIDLGRGKNRLGGSILAQVHGK------LGRAVPDVDD
PUR4_PSE14 QTLTPELRMDK-----GITDLILIDLGRGQNRMGASILAQTHGK------LGRVAPDVDD
PUR4_METFK KTLTPQLRTDL-----GDTRLLLIDLGAGRNRLGGSALAQVYGS------VGNVAPDVED
PUR4_XANCP TQLTPLLQRED------ESELWLIGLGGGKQRLGGSVLAQVYADDSALPAFGGETPDLDD
PUR4_XYLFA RQLTPLLHHQT------NSELWLIALDGGKQRLGGSVLAQVHADSAALPTFGGECPDLDT
Q8D364_WIGBR LNVTPQLKSDI------DNIILFIDLGDFNQSLGGTALSQVYQQ------IGDNVADLRD
Q8A6Z2_BACTN KVVSPVLVNNE------KTTLYHIDFSFDELKLGGSAFAQSLGK------VGDDVPCVQD
A6LEY1_PARD8 KIVSPVLAQDK------NTYIYYIDFSFDTLKLGGSAFAQALNK------LGNEVPTVKD
A0A6N4SRE3_CYTH3 KGVTPNVVKEA------GTGLIYIDLTCMPLTLGGSSFAQILNK------LGNSSPDILD
A6GXH5_FLAPJ KVVEPVLQHN-------AGAIYYINLSQDGFKLGGSSFAQTLNK------IGTEAPTIKD
A0M079_CHRFK KVVEPVLKKN-------GGDIYYINLSQDDFKLGGSSFAQILNK------VGSEVPTIKN
I3YZP2_AEQSU KVVEPVLQKN-------GGSIYYINISQDDFKLGGSSFGQIMNS------IGNEAPDVKS
A4CNM0_ROBBH KVVEPVFRPG-------GGPVYYLSFSGSEFALGGSSFAQVLGK------VGNQVPDIPD
* . :*.: : * . . .
PUR4_MOUSE PENLVRAFHITQGLL---------KECRLCSGHDVSDGGLVTCLLEMAFAG-NCGIEVDV
PUR4_CAEEL FSEISKVFSIVQQLLNREELAGPLRKPIILAGHDISDGGLLTAILEMAFAG-NVSIDIDI
PUR4_DROME SDVLGKAFAVTQSLL---------GDGLIQAGHDVSDGGLLVCVLEMAIGG-LSGLRVDL
PUR4_DICDI TPLLKNTFMAIQKLV---------KQQLISAGHDRSDGGLITTLIEMSLSG-NRGLEINL
PUR4_ARATH VPYLKNVFDGVQALI---------AENLVSAGHDISDGGLVVTALEMAFAG-NKGINLDL
PUR4_YEAST NAILKGFLESLIQLHQQ-------KEDIVLAYHDRSDGGLLITLLEMAFAS-RCGLEINI
PUR4_SCHPO LDTFKNFINVITQLH---------KTNYIQAYHDKSDGGLFVTLSEMAFAG-HVGIECEL
PUR4_NEIG1 AGRLKAFYSVIQQLV---------AEDKLLAYHDRSDGGLFATLAEMAFAA-RCGISADI
PUR4_NEIMB TGRLKAFYSVIQQLV---------AENKLLAYHDRSDGGLFAVLVEMAFAG-RCGLDIDL
PUR4_RALN1 AEDLKRFFAAIQQLN---------AAGMLLAYHDRSDGGLWATVCEMAFAG-HCGVSINV
PUR4_ECOLI VAQLKGFYDAIQALV---------AQRKLLAYHDRSDGGLLVTLAEMAFAG-HCGIDADI
PUR4_SHIDS VAQLKGFYDAIQALV---------AQRKLLAYHDRSDGGLLVTLAEMAFAG-HCGIDADI
PUR4_SALTY VAQLKGFYDAMQALV---------AARKLLAWHDRSDGGLLVTLAEMAFAG-HCGVQVDI
PUR4_YERPE VQQLAGFFNAMQRLV---------ADQHLLAYHDRSDGGLLVTLAEMAFAG-HCGVTVDI
PUR4_VIBCH AAQLKGFFDAVQTLV---------RNDKLVAYHDKGDGGLLVTLAEMAFAG-HCGIKANI
PUR4_ALIF1 AAQLKGFYEGVQALV---------ANDQVVAYHDKGDGGLFVTLAEMAFAG-HCGVNANI
PUR4_PHOPR PELLKGFFYAVQALV---------RDEKVLAYHDRGDGGLYVTLAEMAFAG-HTGVEVDI
PUR4_MANSM VELLKGFYNAMQTLV---------QQGKLLAYHDRSDGGLIVTLAEMAFAG-NCGIRAEI
PUR4_HAEIN VQRLKDFYNAMQTLV---------AEDKLLAYHDRSDGGLITTLAEMAFAG-HCGVEVDI
PUR4_SHEON AALLRGFFETMQKLV---------ANKLVIAYHDRSDGGLFTTLVEMAFAG-NIGLDIDV
PUR4_PSEAE AEDLKAFFAVIQGLN---------ADGHILAYHDRSDGGLITSVLEMAFAG-HCGVELNL
PUR4_PSE14 AEDLKAFFAVIQGLN---------SDGHILSYHDRSDGGLLVSTLEMAFAG-HCGLNLHL
PUR4_METFK ADSLKHFFNAVQKLN---------REGRLLAYHDRSDGGLFATVVEMAFAG-RTGLELDI
PUR4_XANCP PQRLRQFFELIRDAR---------EGGLLLAYHDRSDGGAFAALCEMAFAS-RQGLDITL
PUR4_XYLFA PETLRAFFALMNDAR---------NAGLLLAYHDRSDGGAFAALCEMAFAS-HLGLDITC
Q8D364_WIGBR TKKFKMFFYIFQKLI---------KSNKIIAYHDRSDGGLLVTILEMAFAG-HCSININL
Q8A6Z2_BACTN AEYFRDAFLAVQELVN---------KGLILAGHDISAGGLITTLLEMCFANVEGGMEISL
A6LEY1_PARD8 PEYFRDAFNAVQDAIE---------KKLILAGHDISAGGMITALLEMCFANVEGGLDVNL
A0A6N4SRE3_CYTH3 TEHFERTFDAIQDLLQ---------DELILAGHDVSSGGLITTLLEMCFPENGIGMNVSL
A6GXH5_FLAPJ ASFFKNAFNTIQDLIK---------DRQIVAGHDIGSGGLITTLLEMCFADVNLGAKISF
A0M079_CHRFK DKKFAETFNAIQELIK---------TDLILAGHDVASGGLITSLLEMCFADVNLGADLNL
I3YZP2_AEQSU AAYVKTVFNTLQELIK---------DDKILAGHDVASGGLITTLLEMCFADVNLGANLDL
A4CNM0_ROBBH ADRFARAFDALQDLIK---------KGKVLAGHDVASGGLVTTLLEMCFADGQLGADLDL
. : : ** . ** **.: .
PUR4_MOUSE PAPG---------------IHALP------------VLFAEEPGLVLEVQEADVAGVRQR
PUR4_CAEEL KPPNQN-------------IKPID------------ILFAEECGILLEVSNPE--NVLHI
PUR4_DROME SEPLAK-------------LKNFDKSVEKLNRPELAVLFAEECGWVVEVLDTDLERVRST
PUR4_DICDI PDTHNSD---------QSPLSIIK------------LLFSEELGAVLEIKKSNQQIVLDI
PUR4_ARATH ASNG---------------ISLFE------------TLFSEELGLVLEISKTNLDAVMEK
PUR4_YEAST DGG--------------------------DLESQLTNLFNEELGAVFQISAKNLSKFEKI
PUR4_SCHPO DSL--------------------------SSDN-IAALFNEELGAVIQVCDRDIAKVLEL
PUR4_NEIG1 DCLMDKFLPIHLPDFQGDPAEDLSDEL--YNHAAIKILFNEELGAVIQIRQKDRDYVDAA
PUR4_NEIMB NLLLAQTFITNHTALSQSLRTEEVKALAEWQETIARTLFNEELGAVIQVRKQDVADIINL
PUR4_RALN1 DMLTLDGAHASDYGDAKNWAQQVSGRR---ADMTLRALFAEELGAVIQVPAAQRDAVFAV
PUR4_ECOLI AT---------------------------LGDDRLAALFNEELGAVIQVRAADREAVESV
PUR4_SHIDS AT---------------------------LGDDRLAALFNEELGAVIQVRAADREAVESV
PUR4_SALTY AA---------------------------LGDDHLAALFNEELGGVIQVRAEDRDAVEAL
PUR4_YERPE QS---------------------------LGNDALAALFNEELGAVIQVRAEQRADVEKL
PUR4_VIBCH ET---------------------------LGDDALAALFNEELGAVVQVKNDELNAVLAT
PUR4_ALIF1 EA---------------------------LGEDTLAALFNEELGAVIQVRNDDLDAVLST
PUR4_PHOPR NTSESD-----------------------ACDDVLAMLFNEELGAVLQVRTEDLDTVKSV
PUR4_MANSM SA---------------------------LGDNDLGILFSEELGAVIQVRESDLAAVREV
PUR4_HAEIN SA---------------------------LGDNDLAVLFNEELGAVIQVADSQLESVREV
PUR4_SHEON ED---------------------------LQGTDLERLFNEELGAVLQVSRDNAAKIAAQ
PUR4_PSEAE DALAD------------------------SREELAAVLFSEELGAVIQVREGATPEVLAQ
PUR4_PSE14 DGVAD------------------------NVSELSAILFNEELGAVIQVRQDATPLVLAQ
PUR4_METFK AS---------------------------LGEDAVAVLYNEELGAVLQVRAADLDAITAE
PUR4_XANCP DA---------------------------WGDDAFRSLFNEELGAVVQIANEDRAAFADL
PUR4_XYLFA DN---------------------------RTEHLFPHLFNEELGAIVQVADEHRTAFTDL
Q8D364_WIGBR SK---------------------------LGNDIIKILFNEELGVVIQIKKNDYNNVFSI
Q8A6Z2_BACTN DKMK--------------------------EQDIIKILFAENPGIVIQISDKHKEEVKKI
A6LEY1_PARD8 DKIS--------------------------ESDIVKILFAENPGILVQVKD--KKAFEKL
A0A6N4SRE3_CYTH3 DFLG--------------------------ETDLVKCLFAENPALVLQVKD--AVKVQDM
A6GXH5_FLAPJ DSFE--------------------------EKDLIKILFSENIGIVFQAKN--DQTVEAK
A0M079_CHRFK SALK--------------------------ENDIIKLLFNENCGIVFQAK---DNSIEEI
I3YZP2_AEQSU SGLG--------------------------ESDIVKLLFAENCGVVIQASE--DVSVEKM
A4CNM0_ROBBH TAIG--------------------------EPDSMKLLFAENAGVVFQAV---DSKVEKE
*: *: . :.: .
PUR4_MOUSE YESAGLRCLELGHTGEA---------GPQAMARISVNKA----VVVEEPVGELRALWEET
PUR4_CAEEL FSEAGIKCQEIGKASAVF--------GPDAHVKIHVNGH----LEINEKLVDLREEWELV
PUR4_DROME YEKAGVPNYYLGVTEGF---------GLDSRVVLKNGKS----ELLDQPLRVLYKKWERT
PUR4_DICDI LKQFNVPTQVIGNTSCNNNNNNNNNGSDEDLFIVKVGDK----LIYNIKLSQLSKQWEET
PUR4_ARATH LRAFDVTAEIIGNVT------------DSPLIEVKVDGI----THLSEKTSFLRDMWEDT
PUR4_YEAST LNENGVAKEYISIVGKPS----------FQSQEIKIINSTTNDVIYANSRSELEQTWSKT
PUR4_SCHPO FAANGLSTCVHRIGKVLS----------GQAQTISFSRS--GKIIFKSTRSKLHGIWHET
PUR4_NEIG1 FETAGLTDAVSRIGSPDF----------DNEFISFFGYG----YFLEQNRADLQRAWQET
PUR4_NEIMB FYQQQLHHNVFEIGTLTD----------ENTLIIRDGQT----HLISDNLIKLQQTWQET
PUR4_RALN1 LREHGLAACSHVIGAPNA----------SGQIEIWRDAK----KVFSAPRIELQRAWTDV
PUR4_ECOLI LAQHGLADCVHYVGQAVS----------GDRFVITANGQ----TVFSESRTTLRVWWAET
PUR4_SHIDS LAQHGLADCVHYVGQAVS----------GDRFVITANGQ----TVFSESRTTLRVWWAET
PUR4_SALTY LAQYGLADCVHYLGQALA----------GDRFVITANDQ----TVFSESRTTLRVWWAET
PUR4_YERPE LADHGLANCVHYLGRAVA----------GDTFDIRSGTD----VVYSEKRSTLRLWWAET
PUR4_VIBCH LAAHGLEACAHVIGEVEA----------SDRLLITCGEE----VLIERSRTELRTIWAEM
PUR4_ALIF1 LAANGLEACSHVIGSVEA----------SDELVIKSGES----VVIERNRTELRTIWAET
PUR4_PHOPR LAEHGLTACSHVIGTVVD----------EDVVRIWNGND----RVLEQSRTDLRTVWAET
PUR4_MANSM LTQHGLIHLTKDLGLVTE----------YDEFEIKRGTK----VVLSEKRSELRGIWAEL
PUR4_HAEIN LKAHNLLGIIHQLGTVTA----------DDRFEISRGSH----KLFSEKRSELRSIWAEL
PUR4_SHEON FAIAGVP--CHVIGTLAD----------DQCITIKDGAR----EIFSDTRVALRTVWSET
PUR4_PSEAE FSAAGLDDCVAVIGQPVN----------GYEINLNYNGE----TVYSAQRRILQRIWSET
PUR4_PSE14 FSAAGLEDCVAVIGQPIN----------NDEVSISFHGE----PVFSGQRRLLQRQWAET
PUR4_METFK L-ETTLRGKVHVIGAPAS----------HGDIVIRQGTK----LVFAESRVALHRAWSET
PUR4_XANCP VERHALTECAQRIARPTG----------TPRVRVSGQGR----VLAEWRWEALFDAWWSV
PUR4_XYLFA VEQHGLTAYTQRIAHPTT----------APSIRIMHNDQ----CLAQWTWETLFDAWWSV
Q8D364_WIGBR FKSFGLNDYIYNIGYSYI----------GDQFSLTYKNK----ILYENSITTLRLWWSET
Q8A6Z2_BACTN LEDAGVGFVKLGK-PTDER-------------HILVSKG---DATYQFGVDYMRDVWYSS
A6LEY1_PARD8 MEEAGVGFAIIAK-PTDER-------------HVLVSKE---GIQYHFGIDYMRDVWYES
A0A6N4SRE3_CYTH3 LVTKGVGAAIIGTVEPGAS-------------AVSIQLN---GTTTDFDIAALRTVWYKT
A6GXH5_FLAPJ LKESNVNFYKIGS-VTSTE-------------TLDL-------THATFDVSKYRDIWFKT
A0M079_CHRFK LKEKNIEFFNIGK-VTEGN-------------DLKIKNI---GTDLSFNISELRDTWYKT
I3YZP2_AEQSU LSSKNIDFKKIGT-ISDNE-------------TLHIKNN---SEELSFSIPEMRDAWYKT
A4CNM0_ROBBH LKSAGLEVYRIGT-VLREP-------------RLHIKNH---RQSMDLDVAALRDVWYKT
: *
PUR4_MOUSE SFQLDLLQAEPRCVIEEKQGLKERTGPSYY---LPPTFPVASVPCKPG------------
PUR4_CAEEL GDRLGEFQTNPKSLKEAREVRRTCQKINYK---CDFDWYYNPAFIHNEQYF---------
PUR4_DROME SYELEKLQANPECAEAEYNSLEYRQAPQYR---GPQNVQAELTLKRSS------------
PUR4_DICDI SYQLELLQANPTFVESEMKNLLKRATGKGKGPNYNMTYKISPISKELALLA---------
PUR4_ARATH SFQLEKLQRLASCVEMEKEGLKFRHE-----PNWKLSF-IPSSTNNNYMSQ---------
PUR4_YEAST SYEMQKLRDNPKTAEEEFASITDDRDPGLQYALTYNPADDMKIG-------LELSSQ---
PUR4_SCHPO SYKMQEIRDNPECARQEMENIADNNDPGLGYHLTFDPNVSVTAD-------LALTS----
PUR4_NEIG1 SHAIQRLRDNPACADSEFALIGDNERSALFADVKFDVNEDIAAP-------FINS-----
PUR4_NEIMB SHQIQRLRDNPACADSEFALIGDNERSALFADVKFDVNEDIAAP-------FINS-----
PUR4_RALN1 SWRIASLRDNPECTQSEYDRLLDAEDPGISPNLTFDLAEDVAAP-------FIAT-----
PUR4_ECOLI TWQMQRLRDNPECADQEHQAKSNDADPGLNVKLSFDINEDVAAP-------YIAT-----
PUR4_SHIDS TWQMQRLRDNPECADQEHQAKSNDADPGLNVKLSFDINEDVAAP-------YIAT-----
PUR4_SALTY TWQMQRLRDNPQCADQEHEAKANDTDPGLNVKLSFDINEDIAAP-------YIAT-----
PUR4_YERPE SWQMQRLRDNPDCADQEHQAKQDESDPGLNVKLTFDPAEDIAAP-------FILK-----
PUR4_VIBCH THKMQALRDNSACADQEFAAKQDNRDPGLNAKLTYDVQADVAAP-------YIAK-----
PUR4_ALIF1 THKMQGLRDNPACADQEHEAKKDNSDPGLNVKLSFDVNEDIAAP-------FINT-----
PUR4_PHOPR TYQMQAMRDNPAGALQEFEAKKDNSDPGLSAQLTFDINEDVAAP-------FIAAPFITK
PUR4_MANSM THQMQRLRDNPECADQEFAAKKDPANQGFSAHLTYDINEDVAAP-------YIAT-----
PUR4_HAEIN TYQMQRLRDNPECAEQEFEAKKNPDDKGLSAFLTYDVNEDITAP-------FINK-----
PUR4_SHEON TYRMQAMRDNPACALEEFKLKQDETDLGLTVNLSFDPSEDVAAP-------YILK-----
PUR4_PSEAE SYQIQRLRDNADCAEQEFDALLDEDNPGLSIKLSYDVNDDIAAP-------YIKK-----
PUR4_PSE14 SYQIQRLRDNAECADQEFDALLEEDNPGLTVKLGFDVNEDIAAP-------YIKT-----
PUR4_METFK TYQMQKLRDNPVCAQQEYDRLLDERDAGLHAKLTFDINENIAAP-------YIAS-----
PUR4_XANCP THAMQKLRDNPDSADEERAVARNFQAPGLRPKLVFDPSEDVAAP-------FVAT-----
PUR4_XYLFA THAMQRLRDNPECADEEREIARTFTAPGLKPTLSFDPAVDVAMP-------FIAT-----
Q8D364_WIGBR TWNIQRLRDDPKSANQEHEVRGDFNNPGLDTCLSFDYENDTSFP-------FFIT-----
Q8A6Z2_BACTN SYLLDRKQSMNGCAKKRFENYKMQPVEFAFMPGFKGKLSQYGITPDRRT-----------
A6LEY1_PARD8 SYKLDVKQSGSVCAGNRFENYKMQPIQYKFHKDFTGKLSSYGISADRRT-----------
A0A6N4SRE3_CYTH3 SYLLDEKQSTPAYAKERFENYTKHEIQFSFPANFTGKLNSYGLDAARTT-----------
A6GXH5_FLAPJ SFLLDTKQSKNGMAQERYDNYKKQPLTYTFPSHFDGKA-PILDHS---------------
A0M079_CHRFK SFLLDEKQSGIDKATERYHNYKEQPLEFKFPEHFTGKL-PVNSNANEKS-----------
I3YZP2_AEQSU SYLLDRNQIGATLAKVRFDNYKNQPLKFEFPKNFTGKASPNSSKGEELP-----------
A4CNM0_ROBBH SYLLDARQTAGDLAATRYREYKAQPLRYTFPKKFKGSLPEMKQPP---------------
: :
PUR4_MOUSE ----------------GPVPRVAILREEGSNGDREMADAFHLAGFEVWDVTMQDLCSGAI
PUR4_CAEEL ----------------STAPRVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILAGH-
PUR4_DROME -----------------APVRVAVLREEGVNSEREMMACLLRANFEVHDVTMSDLLQGTA
PUR4_DICDI ----------------NKAPKVAVIREEGSNGDREMAAAFHFAGFQAFDVTMSDLLNGNI
PUR4_ARATH ----------------DVKPKVAVIREEGSNGDREMSAAFYAAGFEPWDVTVSDLLAGDI
PUR4_YEAST ------------------RPKVAILREQGVNGQMEMAWCFQQAGFNSVDVTMTDLLEGRF
PUR4_SCHPO ------------------RPKVAILREQGVNGYLEMAYAFYASGFTAVDVHMTDILSGRV
PUR4_NEIG1 ----------------GAKPKIAILREQGVNGQIEMAAAFTRAGFDAYDVHMSDLMAGRF
PUR4_NEIMB ----------------GAKPKIAILREQGVNGQIEMAAAFTRAGFDAYDVHMSDLMAGRI
PUR4_RALN1 ----------------GARPRMAILREQGVNSQVEMAYAMDKAGFDAYDVHMSDLLAGRT
PUR4_ECOLI ----------------GARPKVAVLREQGVNSHVEMAAAFHRAGFDAIDVHMSDLLTGRT
PUR4_SHIDS ----------------GARPKVAVLREQGVNSHVEMAAAFHRAGFDAIDVHMSDLLAGRT
PUR4_SALTY ----------------GARPKVAVLREQGVNSHVEMAAAFHRAGFDAIDVHMSDLLGGRI
PUR4_YERPE ----------------QARPKVAVLREQGVNSHVEMAAAFHRAGFDAVDVHMSDLLAGRT
PUR4_VIBCH ----------------GVRPKMAILREQGVNSHVEMAAAFDRAGFDAVDVHMSDILTGQT
PUR4_ALIF1 ----------------GAKPKMAILREQGVNSHVEMAAAFDRAGFEATDIHMSDILTGQA
PUR4_PHOPR APKTGASVVNAPAINLGAKPQMAILREQGVNSHVEMAAAFDRAGFEATDVHMSDILSGNV
PUR4_MANSM ----------------GKKPRIAVLREQGVNSHVEMGAAFDRAGFEAIDVHMSDLHTARQ
PUR4_HAEIN ----------------GVKPTIAILREQGVNSHYEMAAAFDRAGFNAIDVHMSDLMIGRR
PUR4_SHEON ----------------GAAPKMAILREQGVNSHVEMAAAFDRAGFESRDVHMSDILSGRI
PUR4_PSEAE ----------------GVRPKVAILREQGVNGQVEMAAAFDRAGFAAIDVHMSDILAGRV
PUR4_PSE14 ----------------GVRPQVAVLREQGVNGQVEMAAAFDRAGFNAIDVHMSDILAGRV
PUR4_METFK ----------------GARPKMAILREQGVNGQVEMAAAFDRAGFNAFDVHMSDIISGRV
PUR4_XANCP ----------------GARPKVAILREQGVNGQIEMAYNFERAGFRAFDVHMSDLIEGRV
PUR4_XYLFA ----------------GIRPTVAILREQGINGHIEMALCFERAGFHCVDIHMNDLITGRV
Q8D364_WIGBR ----------------GKYPKVAILREQGTNAYLEMAHAFYKAGFQPIDIHMNDLRYSKN
Q8A6Z2_BACTN ----------------PSGVRAAIIREKGTNGEREMAYSLYLAGFDVKDVTMTDLISGRE
A6LEY1_PARD8 ----------------PNGIKAAVIREKGTQCERETAYALYLAGFDVKDVHMTDLASGRE
A0A6N4SRE3_CYTH3 ----------------KSGIKAAIIREKGVNGDREMAYSMWLAGFDVKDVHMTDLIAGRE
A6GXH5_FLAPJ ----------------KPRPKAAIIREKGSNSEREMANAMYLAGFDVKDVHMTDLISGRE
A0M079_CHRFK ----------------QPKIKAAIIREKGSNSEREMARAMYLAGFDVKDVHMTDLISGRE
I3YZP2_AEQSU ----------------TECPKAAVIREKGSNSEREMAYMMHLAGFDVKDVHMTDLIEGRE
A4CNM0_ROBBH ----------------GTRPKAAILREKGSNSEREMAHAMFLAGFDVKDVHMTDLISGRE
*::**:* : * : :.* *: : *: .
PUR4_MOUSE RLDT-FRGVAFVGGFSYADVLGSAKGWAAAVTFNPQAREELGRFRR-RPDTFSLGVCNGC
PUR4_CAEEL TLEA-YRGVAFVGGFSYADVLGSAKGWAAGVQFNESVSKQFEAFRS-RPDTFSYGVCNGC
PUR4_DROME SVSQ-YRGLIFPGGFSYADTLGSAKGWAANILHNPRLLPQFEAFKR-RQDVFSLGICNGC
PUR4_DICDI QLDERFKGVAFVGGFSYGDVMDSAKGWAGSIRFNQQVSKQFDHFYG-RNDTFSLGLCNGC
PUR4_ARATH TLDQ-FRGIVFVGGFSYADVLDSAKGWAASIRFNEPVLSQFQEFYK-RPDTFSLGICNGC
PUR4_YEAST -HLDDFIGLAACGGFSYGDVLGAGAGWAKSVLYHEGVRSQFSKFFNERQDTFAFGACNGC
PUR4_SCHPO -HLDDFVGIAACGGFSYGDVLGSGNGWATSILLHEDARNEFYRFFNERKDTFGLGICNGC
PUR4_NEIG1 -RLADFKMLAACGGFSYGDVLGAGEGWAKSILFHPALRDQFAAFFA-DPNTLTLGVCNGC
PUR4_NEIMB -HLADFKMLAACGGFSYGDVLGAGEGWAKSILFHPALRDQFAAFFA-DPDTLTLGVCNGC
PUR4_RALN1 -RLADFKGFVACGGFSYGDVLGAGEGWAKTILFNGMLAEQFAAFFN-RADSIALGVCNGC
PUR4_ECOLI -GLEDFHALVACGGFSYGDVLGAGEGWAKSILFNDRVRDEFATFFH-RPQTLALGVCNGC
PUR4_SHIDS -GLEDFHALVACGGFSYGDVLGAGEGWAKSILFNDRVRDEFATFFH-RPQTLALGVCNGC
PUR4_SALTY -GLGNFHALVACGGFSYGDVLGAGEGWAKSILFNHRVRDEFETFFH-RPQTLALGVCNGC
PUR4_YERPE -DLQSFQTLVACGGFSYGDVLGAGEGWAKSILFNDRVRDEFEAFFH-RPTTLALGVCNGC
PUR4_VIBCH -VLDAYQGLVACGGFSYGDVLGAGEGWAKSILFNAQAREQFEQFFQ-RKDTFSLGVCNGC
PUR4_ALIF1 -VLEEYNGLVACGGFSYGDVLGAGEGWAKSVLFNDSTRDQFENFFK-REDTFSLGVCNGC
PUR4_PHOPR -QLEGFNGLVACGGFSYGDVLGAGEGWAKSVLFNNIARDQFEAFFK-RNDTFSLGVCNGC
PUR4_MANSM -NLKDFNALVACGGFSYGDVLGAGGGWAKSVLFNTALRDQFQAFFE-REDTLALGVCNGC
PUR4_HAEIN -NLAEFNAMVACGGFSYGDVLGAGGGWAKSILFNPKLHEQFSQFFI-NPNTLTLGVCNGC
PUR4_SHEON -SLEEFQGLVACGGFSYGDVLGAGEGWAKSILFNERARNEFSRFFE-RDSSFALGVCNGC
PUR4_PSEAE -DLDAFKGLVACGGFSYGDVLGAGEGWAKSILFNARARDGFQAFFA-RKDSFALGVCNGC
PUR4_PSE14 -DLNDFKGMVACGGFSYGDVLGAGEGWAKSALFNSRARDAFQGFFE-RADSFTLGVCNGC
PUR4_METFK -SLKDFAGFVACGGFSYGDVLGAGEGWAKSILFNPRARDEFTAFFN-RTDSFALGVCNGC
PUR4_XANCP -DLAQFAGFAACGGFSYGDVLGAGRGWATSILERAALRDAFAAFFA-RSDTFALGVCNGC
PUR4_XYLFA -HLDEFVGLAACGGFSYGDVLGAGRGWATSILERTALRDQFAAFFT-RTDRFALGVCNGC
Q8D364_WIGBR NILKEFSVLVACGGFSYGDVLNGGYGWAKTILLNNKLRDMFESFFN-DKNTLSFGVCNGC
Q8A6Z2_BACTN -TLEDVNMIVYCGGFSNSDVLGSAKGWAGGFLFNPKAKEALDKFYA-REDTLSLGICNGC
A6LEY1_PARD8 -TLEDVNFIVFCGGFSNSDVLGSAKGWAGGFLYNEKAKKAIDNYYA-RKDTLSMGICNGC
A0A6N4SRE3_CYTH3 -DLGDVNFIVFVGGFSNSDVLGSAKGWAGAFLYNEKAKKALDNFYA-RPDTLSLGVCNGC
A6GXH5_FLAPJ -TLEDIQFIGAVGGFSNSDVLGSAKGWAGAFLYNEKANTALKNFFK-REDTLSVGICNGC
A0M079_CHRFK -TLEDIQFIAAVGGFSNSDVLGSAKGWAGAFLYNEKAKNALDSFFA-RKDTLSLGVCNGC
I3YZP2_AEQSU -DLEEIKLLVAVGGFSNSDVLGSAKGWAGSFLYNEKANTALKNFFA-KDDTLSLGVCNGC
A4CNM0_ROBBH -TLEDIRFIGAVGGFSNSDVLGSAKGWAGAFKYNDKANRALNNFFA-RPDTLSVGICNGC
. **** .*.:... *** . : : : * ****
PUR4_MOUSE QLLALLGWVGSDPSEEQAEPGQDSQPTQPGLLLRHNLSGRFESRWATVRVE------PGP
PUR4_CAEEL QLMAQLGWIG------------DEEQKGPTVFLDENECGRFDSSFGPVKIE------KNV
PUR4_DROME QLMTLIGFVGS---------AKSEVGADPDVALLHNKSQRFECRWATVKIP------SNR
PUR4_DICDI QLMALLGWVP-----------YRGIEQTHQPRFIHNASGRFESRWVNVKIM------PSP
PUR4_ARATH QLMALLGWVPG--------PQVGGSLDTSQPRFVHNESGRFECRFTSVTIK------DSP
PUR4_YEAST QFLSRLKDIIP--------------GCENWPSFERNVSEQYEARVCMVQISQEKDNSSEE
PUR4_SCHPO QLFSRLKSLIP--------------GAKSWPMFTFNESAQYEGRAVMLKID---ETSGSK
PUR4_NEIG1 QMVSNLAEIIP--------------GAETWPKFKRNLSEQFEARLNMVHVP------KSA
PUR4_NEIMB QMVSNLAEIIP--------------GTAGWPKFKRNLSEQFEARLSMVHVP------KSA
PUR4_RALN1 QMMANLAPIIP--------------GAGAWPKFTRNQSEQYEGRLVTVQVE------ASP
PUR4_ECOLI QMMSNLRELIP--------------GSELWPRFVRNTSDRFEARFSLVEVT------QSP
PUR4_SHIDS QMMSNLRELIP--------------GSELWPRFVRNTSDRFEARFSLVEVT------QSP
PUR4_SALTY QMMSNLRELIP--------------GSELWPRFVRNHSDRFEARFSLVEVT------QSP
PUR4_YERPE QMMSNLRELIP--------------GAEHWPRFVRNLSDSFEARFSLVEVA------SSP
PUR4_VIBCH QMLSNLRDLIP--------------GAELWPRFVRNESDRFEARFSLVEVQ------KSP
PUR4_ALIF1 QMLSNLRDLIP--------------GAEYWPRFVRNESERFEARFSLVEVQ------KSD
PUR4_PHOPR QMMSNLSELIP--------------GSDLWPRFVRNESERFEARFSLVEVQ------KSD
PUR4_MANSM QMISTLADIIP--------------GTENWPRFVRNTSERFEARAALVRIN------ESN
PUR4_HAEIN QMISNLAEIIP--------------GTENWPHFVRNKSERFEARVSLVKIN------EVD
PUR4_SHEON QMLSNLKEIIP--------------GSEHWPRFVRNRSERFEARFSLVEVQ------QSP
PUR4_PSEAE QMMSNLHELIP--------------GTEFWPHFVRNRSEQFEARVAMVQVQ------ESS
PUR4_PSE14 QMLSNLHELIP--------------GSEFWPHFVRNRSEQFEARVAMVQVQ------ESA
PUR4_METFK QMMSNLHSIIP--------------GAGHWPHFVRNRSEQFEARVAMVEVL------DSP
PUR4_XANCP QMLSQLKDIIP--------------GAEHWPRFLRNRSEQFEARTALLEVV------ESP
PUR4_XYLFA QMLSQLKSMIP--------------GAEHWPRFVRNRSEQFEARTALLEVI------QSP
Q8D364_WIGBR QMMSYLREIIP--------------GSKFWPKFVKNKSNRFESRIVLVEVM------NSP
Q8A6Z2_BACTN QLMMELGLINP--------------EHEKKGKMLHNDSHKFESTYVGLTIPT------NR
A6LEY1_PARD8 QLMAELGLVYP--------------EHEKKHKMVHNDSHKFESNFVSLEIPK------NN
A0A6N4SRE3_CYTH3 QLMVELGLINQ--------------NHESKPKMHHNSSGKFESIYLNVDVAKE-----NK
A6GXH5_FLAPJ QLFMELELVNP--------------EHKVHGKMLHNNSQKHESIFTSVTVQK------NN
A0M079_CHRFK QLFIELGLINS--------------EHEQKPKMLHNESHKFECNFTSVEIQE------NN
I3YZP2_AEQSU QLFVELGLLNP--------------EDDEKPKMLHNDTGKFECVFTSVKIQE------NN
A4CNM0_ROBBH QLFMELGLIHP--------------DHDDHGKLTYNDSGKHESAFTSVEVAP------NH
*:. : : : * .: : :
PUR4_MOUSE ALMLRGMEGSVLPVWSAHGEGYMAFSSPEL-QAKIEAKGLVPLHWADD-------DGNPT
PUR4_CAEEL SIMLSGMENSVLGLWSSHGEGRFTYRNLQN-FQNLKTNGQVCIRFCDDRGMTGADHGSVK
PUR4_DROME SIMLGSMKDLVLGCWVAHGEGRFAFRDEKL-ISHLQSEQLVTLQYVDD-------VGKPT
PUR4_DICDI ALLLKGMEGSVLGVWSQHGEGRFWSEDQSI-VNDIKANNLSPIRYVDD-------DGEIT
PUR4_ARATH SIMLKGMEGSTLGVWAAHGEGRAYFPDEGV-LDHMLHSDLAPLRYCDD-------DGNVT
PUR4_YEAST SVFLNGMAGSKLPIAVAHGEGKATFSKSAEQLEKFEKDGLCCIRYVDN-------YGNVT
PUR4_SCHPO SIFTESMAGSSLPVVVAHGEGRAVFD-SESDYEQFKKEGLDLIYYVNN-------YNERT
PUR4_NEIG1 SLILNEMQDSSLPVVVSHGEGRADFA--LH-GGNISADLGIALQYVDG-------QNQVT
PUR4_NEIMB SLILNEMQGSSLPVVVSHGEGRADFA--LH-GGNISADLGIALQYIDG-------QNQVT
PUR4_RALN1 SIFYAGMEGSRIPIVVAHGEGYADFS--QQ-GD--IGKVAVGLRYVDN-------RGEVT
PUR4_ECOLI SLLLQGMVGSQMPIAVSHGEGRVEVRDAAH-LAALESKGLVALRYVDN-------FGKVT
PUR4_SHIDS SLLLQGMVGSQMPIAVSHGEGRVEVRDAAH-LAALESKGLVALRYVDN-------FGKVT
PUR4_SALTY SLLLQGMVGSQMPIAVSHGEGRVEVRDDAH-LAALESKGLVALRYVDN-------FGKVT
PUR4_YERPE SLFMQDMVGSRMPIAVSHGEGQVEVRDAAH-LAALEQSHLVALRFVNN-------HGVVT
PUR4_VIBCH SLFFSEMAGSRMPIAVSHGEGRVEVRDAQH-LAAIEQSGTVAIRFVDN-------FGQPT
PUR4_ALIF1 SVFFNGMEGSRMPIAVSHGEGRVEVRDNDH-LNAIENSGTVALRYVDN-------HGNPT
PUR4_PHOPR SLFFNEMAGSRMPIAVSHGEGRVEVRNGEH-LNAIEQSGTVALRYLDN-------FGNVT
PUR4_MANSM SVWFQGMAGSHMPIAVSHGEGRVEFKNDSQ-LQGLRDQGLIIAQYVDN-------NIRPT
PUR4_HAEIN SVWFAGMAGSHMPIAVSHGEGQVKFKSVEQ-FAGLKAQGIIAAQYIDN-------NGSPT
PUR4_SHEON SLFFQGMAGSRMPIAVSHGEGHAEFASAQA-LALAEASGTIALRFVNG-------KGEIA
PUR4_PSEAE SIFLQGMAGSRLPIAIAHGEGHAEFESEEA-LLEADLSGCVSLRFVDN-------HGKVT
PUR4_PSE14 SIFLQGMAGSRMPIAIAHGEGHAEFRNDDA-LLEADVSGTVALRFVDN-------HGKVT
PUR4_METFK SLFFNGMAGSRMPIAVAHGEGYAEFADAAA-QQRAQDARLVTLRYVDN-------SGLPT
PUR4_XANCP SILLRGMAGSRIPVAVAHGEGRAEFD-----TAVDQAAARVALRFIDG-------DGAVA
PUR4_XYLFA SIFLSGMAGSRLPVAVAHGEGYAMFD-----TPADQAAAHVALRYING-------HGQAA
Q8D364_WIGBR SLLFQGMKGSYIPISVAHSLGRVEFKKHFH-LNKLENSKLVVLKYVDN-------YRMTT
Q8A6Z2_BACTN SVMFGSLSGSKLGIWVAHGEGKFSLPYDED-------QYNVVAKYSYD------------
A6LEY1_PARD8 SVMFGSLSGTKLGVWVAHGEGKFEFPYEEK-------EYNIIAKYNYD------------
A0A6N4SRE3_CYTH3 SILLKSIEGSKLGIWVAHGEGKFYFPYDVT-------KYNIVLNYSHA------------
A6GXH5_FLAPJ SVMLSTLEGATLGVWVSHGEGKFNLPEAEE-------NYNIVGKYGYK------------
A0M079_CHRFK SVMLSSLAGSKLGIWAAHGEGKFSFPYEEE-------KYNIVGKYGYE------------
I3YZP2_AEQSU SVMLSSLAGSTLGIWSAHGEGKFSFPNKES-------HYNIVAKYGYD------------
A4CNM0_ROBBH SVMLGSLAGSRLGVWISHGEGKFALPYDRS-------RYNIVATYGYD------------
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PUR4_MOUSE EQYPLNPNGSPGGIAGICSQDGRHLALMPHPERAVRLWQWAWRP-------SPFDVLPTS
PUR4_CAEEL LPYPWNPNGSIDDVAAICSRDGRHLAMMPHADRSFLTWQWAESSEVPWNARFDQKTVALS
PUR4_DROME ELYPLNPNGSPQGIAGLCSSDGRHLALMPHPERCSSMYQWPYVP----SSFEVSPTQSES
PUR4_DICDI ESYPFNPSGTQEGFASLCSKDGRHLAIMPHPERSFLSWQWPFMPEN--IKQNVGGLDQPS
PUR4_ARATH EAYPFNLNGSPLGIAAICSPDGRHLAMMPHPERCFLMWQFPWYPTS--WDVEKAG---PS
PUR4_YEAST ERFPFNPNGSTNGIAGIKSPNGRVLAMMPHPERVCRLEANSWYPEG-----KYEEWGGYG
PUR4_SCHPO SRYPFNPNGSRDAIAGVRSPCGRFLAMMPHPERVVLKVANSYYPHS-----KASEWGVHG
PUR4_NEIG1 QTYPLNPNGSPQGIAGITNADGRVTIMMPHPERVYRAAQMSRKPEG-----WTEL----S
PUR4_NEIMB QTYPLNPNGSPQGIAGVTNADGRITIMMPHPERVYRAAQMSWKPEG-----WTEL----S
PUR4_RALN1 QTYPLNPNGSPQGIASVTTHDGRFTVLMPHPERVFRAVQMSWHPKD-----WAAAGDGSS
PUR4_ECOLI ETYPANPNGSPNGITAVTTESGRVTIMMPHPERVFRTVSNSWHPEN-----WGED----G
PUR4_SHIDS ETYPANPNGSPNGITAVTTESGRVTIMMPHPERVFRTVSNSWHPEN-----WGED----G
PUR4_SALTY ETYPANPNGSPNGITAVTTENGRVTIMMPHPERVFRTVANSWHPEN-----WGED----S
PUR4_YERPE EQYPANPNGSANGITAVTSVSGRATVMMPHPERVFRTVSNSWHPEE-----WGED----S
PUR4_VIBCH QAYPSNPNGSPNAITGLTTQDGRVTIMMPHPERVFRTVANSWHPDN-----WGEN----G
PUR4_ALIF1 QQYPNNPNGSPNAITGLTTTDGRVTIMMPHPERVFRTVANSWSPEG-----WGEN----G
PUR4_PHOPR QNYPANPNGSPNGITGLTTMDGRVTIMMPHPERVFRTVANSWHPDD-----WNEN----S
PUR4_MANSM EVYPANPNGSVDGITALSNTNGRVAIMMPHPERVFRTVSNSWHPED-----WSED----G
PUR4_HAEIN ELYPANPNGSSEGITAITNLDGRVAIMMPHPERVFRAVSNSWHPEN-----WTED----G
PUR4_SHEON TQYPQNPNGSPNGLTGICTTDGRVTLMMPHPERVFRTVANSWHPDN-----WGED----S
PUR4_PSEAE EAYPANPNGSPRGITGLSSRDGRVTIMMPHPERVFRAVQNSWRPDD-----WQED----G
PUR4_PSE14 ETYPANPNGSPRGIGGMTTLDGRVTIMMPHPERVFRAVQNSWRPED-----WNED----A
PUR4_METFK EVYPFNPNGSPQGITGLTTADGRFSIMMPHPERVFRTVQHSWHPDG-----WGED----G
PUR4_XANCP SQYPLNPNGSPDGITGLTSTDGRATILMPHPERTPRSVNLSWHPAG-----WGED----S
PUR4_XYLFA THYPLNPNGSPNGITGLTTTDGRITILMPHPERTPRTINLSWSPNE-----WGED----T
Q8D364_WIGBR EVYPYNPNGSKNGITAITNSDGRITISMPHPERHVRMVNCSWISNY-----SSEY----S
Q8A6Z2_BACTN -EYPGNPNGSDYSIAGLASADGRHLAMMPHLERAIFPWQNGCYPADR------KNSDQIT
A6LEY1_PARD8 -GYPANPNGSPWSVAGVCSKDGRHLAMMPHPERAIFPWQCGYYPADR------KENDEVT
A0A6N4SRE3_CYTH3 -SYPANPNGSPVNAAGIVSDDGRHLAMMPHLERSVFPWQCGYYPAD-------KAKDECT
A6GXH5_FLAPJ -SYPANPNGSDYNTAMMCDITGRHLVMMPHIERSTFPWNWANYPTDK------KD--EVS
A0M079_CHRFK -GYPANPNGSHFNTAILTDDTGRHLVMMPHLERSTFQWNWANYPNGR------KD--EVS
I3YZP2_AEQSU -ALPANPNGSDFNTAMMTDKTGRHLVMMPHLERSTFPWNWGYYPEDR------KDD-EVS
A4CNM0_ROBBH -AYPSNPNGSAFNTAMLCDDSGRHLVTMPHIERSIYPWNWAWYEPGR------ED--AIS
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PUR4_MOUSE PWLQLFINARNWTQEDSC
PUR4_CAEEL PWIKMFRNAYNWCL----
PUR4_DROME PWQIMFNNAYNWCVKSNQ
PUR4_DICDI PWIKIFQNAKSFCDSLN-
PUR4_ARATH PWLKMFQNARDWLESC--
PUR4_YEAST PWIRLFRSARRWVG----
PUR4_SCHPO PWIRLFQSARKWVG----
PUR4_NEIG1 GWYRLFAGARKALG----
PUR4_NEIMB GWYRLFAGARKALG----
PUR4_RALN1 PWMRMFRNARKQMG----
PUR4_ECOLI PWMRIFRNARKQLG----
PUR4_SHIDS PWMRIFRNARKQLG----
PUR4_SALTY PWMRIFRNARKQLG----
PUR4_YERPE PWMRMFRNARKQLG----
PUR4_VIBCH AWMRMFQNARKYFG----
PUR4_ALIF1 AWMRMFQNARKNIG----
PUR4_PHOPR PWMRMFRNARVNLG----
PUR4_MANSM AWMRLFRNARVFFK----
PUR4_HAEIN AWMRLFRNARMVF-----
PUR4_SHEON PWMRMFRNARVNLG----
PUR4_PSEAE GWLRMFRNARVWVD----
PUR4_PSE14 AWMRMFRNARAWVN----
PUR4_METFK PWIRMFRNARKFIG----
PUR4_XANCP PWLRMFRNARVWCG----
PUR4_XYLFA PWLRLFRNARAWVG----
Q8D364_WIGBR PWIKVFKNARKQIG----
Q8A6Z2_BACTN PWIEAFVNARKWVEEKTK
A6LEY1_PARD8 PWIEAFVNARKWIENNK-
A0A6N4SRE3_CYTH3 PWLEAFVNARKWVEGKK-
A6GXH5_FLAPJ PWHEAFVNAKKWIEKK--
A0M079_CHRFK PWLEGFVNARKWLEKKQ-
I3YZP2_AEQSU PWIQALVNAREWIDKK--
A4CNM0_ROBBH PWIEAFVNARKWIESNNG
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