CLUSTAL format seed alignment for MF_01019
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Features found in the protein:- The following colors are used to highlight features:
- blue indicates SIGNAL, PROPEP, TRANSMEM, DOMAIN, ZN_FING, REPEAT,
DNA_BIND and CA_BIND.
- magenta is used to display DISULFID, THIOLEST and THIOETH.
- red is used for all other features, such as INIT_MET, ACTIVE SITE,
METAL,BINDING, NP_BIND, SITE, REGION, etc.
- The ID of the sequence used as the template for feature propagation is
underlined.
- A '<' at the beginning of a sequence or '>' at the end indicate that
the protein is fused with another domain either at the N- or C-terminus.
_____________________________________________________________________________
HIS2_ARATH MAVSYNALAQSLARSSCFIPKPYSFRDTKLRSRSNVVFACNDNKNIALQAKVDNLLDRIK
G8TXZ5_SULAD --------------------------------------------------------MAVI
HIS2_HELHP ---------------------------------------------------MQDVFRQID
HIS2_WOLSU ---------------------------------------------------MNTLLDGID
HIS2_AQUAE -------------------------------------------------------MLKLK
Q1D4M6_MYXXD ----------------------------------------------------MLDLDALD
HIS2_BACTN --------------------------------------------------------MELD
HIS2_BUCBP -------------------------------------------------MLKKINFIDIN
HIS2_BUCAI -------------------------------------------------MLKKHDLLNLD
HIS2_BUCAP ------------------------------------------------MLSKKENLLKLD
HIS2_XYLFA --------------------------------------------MCNEPATSDVALPDLD
HIS2_XYLFT --------------------------------------------MCNEPATSDVALPDLD
HIS2_XANAC --------------------------------------------MGSNEVATGDPLATLD
HIS2_XANCP --------------------------------------------MGSETTAAGDALDALD
HIS2_BLOFL -------------------------------------------------MLTTEKYQGLN
HIS2_SHEON ---------------------------------------------MSTQTNTKSDFSELD
HIS2_VIBCH ---------------------------------------------MNPASPFATLTDRID
HIS2_VIBPA --------------------------------------------MSFKAAEVSSLSERIN
HIS2_VIBVU --------------------------------------------MSFKTAEVSSLAERIN
HIS2_VIBVY --------------------------------------------MSVKAAEVSSLAERIN
HIS2_PHOLL -------------------------------------------------MLTAQQIEKLD
HIS2_YERPE -------------------------------------------------MLTEQQINQLD
HIS2_SALTI -------------------------------------------------MLTEQQRRELD
HIS2_SALTY -------------------------------------------------MLTEQQRRELD
HIS2_SHIFL -------------------------------------------------MLTEQQRRELD
HIS2_ECOL6 -------------------------------------------------MLTEQQRRELD
HIS2_ECOLI -------------------------------------------------MLTEQQRRELD
HIS2_ECO57 -------------------------------------------------MLTEQQRRELD
HIS2_HAEIN -----------------------------------------------------MNITKID
HIS2_CAMJE ------------------------------------------------MQNFKELNEKIA
HIS2_PASMU --------------------------------------------------------MKIN
HIS2_DEIRA ----------------------------------------------------MTDLSELN
HIS2_STAES ------------------------------------------------------MNKLID
HIS2_STAAM -----------------------------------------------------MTKYKID
HIS2_STAAW -----------------------------------------------------MTNYKID
HIS2_PROMP -----------------------------------------------MAYSKNFSIEELR
HIS2_PROMA -----------------------------------------------MMPMNQEFIQKLR
HIS2_PROMM -----------------------------------------------MQPLSPAFIDQLC
HIS2_PARMW -----------------------------------------------MQPLSPAFIDQLR
HIS2_GLOVI --------------------------------------MAPHQFKSKGAPTLVHVREAAR
HIS2_SYNY3 ------------------------------------------MSHSDLPLANAVPLDKIR
HIS2_NOSS1 -----------------------------------------MSFIDSLSPQNVIPVEEIR
HIS2_THEVB ----------------------------------------------MPATALSLPLDEIR
HIS2_THEMA ------------------------------------------------------------
HIS2_PYRFU -------------------------------------------------MEIEKLLEQVN
HIS2_LACLA --------------------------------------------------------MRPD
HIS2_OCEIH -------------------------------------------------MTKSISIEHLQ
HIS2_HALH5 -----------------------------------------------------MNVDDLT
HIS2_BACSU ----------------------------------------------------MKQADELR
F7Z4H7_BACC6 ------------------------------------------------------------
HIS2_CALS4 ----------------------------------------------------MIDIKELK
HIS2_ARATH WDD-KGLAVAIAQNVDTGAVLMQGFVNREALSTTISSRKATFFSRSRSTLWTKGETSNNF
G8TXZ5_SULAD HEHNKTLYPVIVQHVRTLQVLMFAFADDEALRLTRETGYAHFYSRSRQALWKKGETSGHV
HIS2_HELHP WER-YELIPTIVQEKQSQQILMLAYSSKQSLELSLQTHLAHYFSRSKQRIWQKGEQSGHI
HIS2_WOLSU WEK-HPLLPAIVQERGSGEVLMLAYMNQEALNLTLSTQVAHYFSRSKGRIWKKGESSGHI
HIS2_AQUAE FNE-EGLIPVIAQDYRTGEVRMLAYANEEAIKKTLETGYAHYYSRSRKKIWKKGETSGEL
Q1D4M6_MYXXD FAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGP-WHKGATSGNV
HIS2_BACTN FDKMNGLVPAIIQDNETRKVLMLGFMNKEAYDKTVETGKVTFFSRTKNRLWTKGEESGNF
HIS2_BUCBP WNKVDNMLPVVIQHNLSGKVLMHGYMNQEALKRTQNEGIVTFYSRTKQRLWTKGETSKNF
HIS2_BUCAI WTKTNGMIPVIIQDYSSSEVLMHGYMNQDALTKTQEDGLVTFYSRTKNCLWTKGEISGNY
HIS2_BUCAP WIKTNGLIPAIIQDFASNLVLMHGYMNKEAFLKTQKEGFVTFYSRTKKRLWTKGEESGNL
HIS2_XYLFA WAKGDGLLPVIVQDADTLRVLMLGYMNSQALEVTQRSRLVTFYSRSKQRLWTKGERSGHV
HIS2_XYLFT WAKGDGLLPVIVQDADTLRVLMLGYMNSQALEVTQRSRLVTFYSRSKQRLWTKGERSGHV
HIS2_XANAC WNKGEGLLPVIVQDADNLRVLMLGYMNAQALAVTQQRGEVTFFSRSKQRLWTKGESSGNV
HIS2_XANCP WNKGDGLLPVIVQDADNLRVLMLGYMNAEALAVTRARGEVTFFSRSKQRLWTKGESSGNV
HIS2_BLOFL WSKNHGLIPAIIQHSISGEVLMLGYMNQESMAITEKTGYVTFFSRSKNRLWIKGESSGNV
HIS2_SHEON WDKQDGLIPAVIQNHLSGKVLMLGYMDKAALEQTLATGDVTFFSRSKQRLWTKGETSGHT
HIS2_VIBCH WQKVDGLVPAIVQDFQSSQVLMMGYMNPEALQKTLDTQQVTFFSRSKQRLWTKGETSGHV
HIS2_VIBPA WEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERLWTKGETSGNV
HIS2_VIBVU WEKVDGLVPAIVQDFQSSQVLMMGYMNQEALVKTGETGQVTFFSRTKERLWTKGETSGNV
HIS2_VIBVY WEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERLWTKGETSGNV
HIS2_PHOLL WEKVAYMMPVIVQHAISGDVLMMGYMNKEALNITISSGKITFFSRSKQRLWTKGESSGHF
HIS2_YERPE WEKVDHLMPAIVQHAVSGEVLMMGYMNQEALAVTEKTGKVTFFSRTKQRLWTKGESSGHF
HIS2_SALTI WEKTDGLMPAIVQHAVSGEVLTLGYMNPQALDKTIESGHVTFFSRTKQRLWTKGETSGHV
HIS2_SALTY WEKTDGLMPAIVQHAVSGEVLMLGYMNPQALDKTIESGHVTFFSRTKQRLWTKGETSGHV
HIS2_SHIFL WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTIESGKVTFFSRTKQRLWIKGETSGNF
HIS2_ECOL6 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDRTIESGKVTFFSRTKQRLWTKGETSGNF
HIS2_ECOLI WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF
HIS2_ECO57 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTIESGKVTFFSRTKQRLWTKGETSGNF
HIS2_HAEIN WQKVNGLLPVIIQNISTREVLMLGYMNEEALTKTIKERKVTFFSRTKQRLWTKGEISGNF
HIS2_CAMJE WQKVDNLLPVIIQDAKTCEVLMLGFMNNEALEKSLESGKVVFFSRTKQRLWMKGEESGNF
HIS2_PASMU WQKVDNLLPVIIQNVATCEVLMLGYMNQEALEKTLAEKRVTFFSRTKNRLWTKGETSGHF
HIS2_DEIRA FDP-SGLIPVVTQDARSGAVLMQAYADRAAVERTLDTREATYYSRSRGEQWVKGQTSGHT
HIS2_STAES FSK--GLVPVILQHAQTDSVLMLGYMNEEAYQKTLKEKKVTFFSRSKQRLWTKGETSGHF
HIS2_STAAM FSK--GLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHT
HIS2_STAAW FSK--GLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHT
HIS2_PROMP FDN-KGLIPAIAQDWLDGSILMLAWMNKESLNKTLETRNVHYWSRSRSEIWRKGATSGST
HIS2_PROMA FNE-KGLIPAIAQDWLDGAILMMAWMNKESLEKTLITGEVHYWSRSREKLWHKGETSGHF
HIS2_PROMM FDD-IGLIPAISQDWLDGAVLMMAWMNRTALEQTLKSGQVHYWSRSRQELWHKGATSGHT
HIS2_PARMW FNE-AGLIPAIAQDWLDGAVLMVAWMNRESIQQTLNSGEAHYWSRSRQELWHKGATSGHT
HIS2_GLOVI FDR-DGLIPAVVQDVLDGTVLMVAWMNREALERTLETGESWFWSRSRQELWHKGATSGHR
HIS2_SYNY3 YND-QGLVPAIAQDYLDGTVLMLAWMNEAALAKTLATGQVWYWSRSRQELWHKGATSGHF
HIS2_NOSS1 YDE-RGLVPAIVQDYLDGTVLMMAWMNRESLQKTLDTGETWFWSRSRQEFWHKGGTSGHT
HIS2_THEVB YDE-RGLVPAIVQDYLDGTVLMLAWMNRESLQKTLETGRTWFWSRSRQELWPKGETSGHV
HIS2_THEMA ---MMTLYPVVVQERTTGEVLMLAYANEEALELTKKTGYAHFFSRERQKIWKKGETSGNT
HIS2_PYRFU WEKNNGIVPVIVQD-EKGEVLTLAYMNKEALRKTLETGIAHYYSRSKGRIRMKGEVSGNI
HIS2_LACLA FHK-QELIPVIVQDYQTNQVLMLAYTNEVAFEKMLETGETWFWSRSRQKLWHKGEESGHF
HIS2_OCEIH FDE-KGLIPAIVQDHQSGQVLTLAYMNSDSITKTIETNETWFYSRKRQELWNKGATSGNK
HIS2_HALH5 FDD-KGLIPAVVQDAQSKEVVTVAYMNRESFEKTVETGETWFYSRSRQELWHKGATSGHT
HIS2_BACSU FNE-DGLIPAIVQDAASKEVLTLAYMNKESYEKTLETKETWFYSRSRQALWHKGETSGNT
F7Z4H7_BACC6 ---------------------MLAYMNEEAYEKTLETKETWFYSRSRGSLWHKGETSGNT
HIS2_CALS4 FDE-KGLIPAIVQDYYTKQVLMLAYMNEESLKLTLEKGETYFFSRSRGKIWHKGETSGNT
. . : : ** . . ** *
HIS2_ARATH INILDVYVDCDRDSIIYLGT-PDGP-TCHTGEETCYYTSVFD---QLNNDEASGNKLALT
G8TXZ5_SULAD QPVIDIRTDCDQDTYLYLVD-SPYP-ACHLNRDSCFGDAP---------------KAPAD
HIS2_HELHP QHIKEVKLDCDNDSLIFIVE-QVGV-ACHTGEKSCFFRIFSLDKNCQNPPVSMPQKYPIG
HIS2_WOLSU QKIHEIFLDCDSDTILLQVE-QVGV-ACHTGRKSCFFQKVELDSSLSLTSEAPDTSALYG
HIS2_AQUAE QKVIEVRVDCDEDALIYVIE-QEKDRACHTGERNCFFRDIEG--------NKVEKPLPFE
Q1D4M6_MYXXD QRVVALRADCDGDAVLARVA-KAGP-ACHLGTKTCFGP------------------GRWD
HIS2_BACTN LHVVSIKADCDNDTLLIQAD-PAGP-VCHTGTDTCWGEKNEE---------------PVM
HIS2_BUCBP LYVTDIRLDCDQDALLIFVR-PVGK-TCHLNHVSCFQVPS----------------ENLF
HIS2_BUCAI LKVIEISTDCDNDTLLILVA-AQGK-TCHLGNSSCFISNK----------------YNIN
HIS2_BUCAP LKVIDIVTDCDYDTILIIVE-PLGK-TCHLNRKSCFFLKE----------------NTLN
HIS2_XYLFA LHLVAIDADCDADTLLVQAR-PRGP-TCHLGRTSCFPA------------------APGQ
HIS2_XYLFT LHLVAIDADCDADTLLVQAR-PRGP-TCHLGRTSCFPA------------------APGQ
HIS2_XANAC LRVVSIQTDCDADTLLVQAR-PHGP-TCHLGRTSCFPS------------------APGQ
HIS2_XANCP LRVVAIETDCDADTLLVQAR-PHGP-TCHLGRTSCFPT------------------APSQ
HIS2_BLOFL LKLINWYPDCDFDSLLILVL-PQGF-TCHKNTNSCFHPAL----------------TDFS
HIS2_SHEON LKLVAIDKDCDNDSLLVQVL-PNGP-TCHKGTESCWLDG-----------------NAHP
HIS2_VIBCH LQLKNIALDCDQDTLLVKVN-PIGP-TCHTGTVTCWDGDAQE-------------ESQMV
HIS2_VIBPA LQLVNISLDCDNDTLLVRVN-PIGP-TCHTGTTTCWDGDAQE-------------ESQMV
HIS2_VIBVU LQLVNMSLDCDNDTLLVKVN-PIGP-TCHTGTTTCWDGDPQE-------------ESQMV
HIS2_VIBVY LQLVNMSLDCDNDTLLVKVN-PIGP-TCHTGTTTCWDGDPQE-------------ESQMV
HIS2_PHOLL LNLVNIYPDCDNDTLLALAD-PIGP-TCHFGTHSCFAPAQ----------------TEWG
HIS2_YERPE LNVVNIYPDCDNDTLLILVK-PIGP-TCHLGNSSCFAPAA----------------SDWS
HIS2_SALTI LNVVSIAPDCDNDTLLVLAN-PVGP-TCHKGTSSCFGDAS----------------HQWL
HIS2_SALTY LNVVSIAPDCDNDTLLVLAN-PVGP-TCHKGTSSCFGDAS----------------HQWL
HIS2_SHIFL LNVVSIAPDCDNDTLLVLAN-PIGP-TCHKGTSSCFGNTA----------------HQWL
HIS2_ECOL6 LNVVSIAPDCDNDTLLVLAN-PIGP-TCHKGTSSCFGDTA----------------HQWL
HIS2_ECOLI LNVVSIAPDCDNDTLLVLAN-PIGP-TCHKGTSSCFGDTA----------------HQWL
HIS2_ECO57 LNVVNIAPDCDNDTLLVLAN-PIGP-TCHKGTSSCFGDTA----------------HQWL
HIS2_HAEIN LNVEEMSLDCDNDTLLILVD-PIGA-TCHTGEYSCFHQFTSP-----QSENKKQQFANWA
HIS2_CAMJE LNIIDLSLDCDNDTLLILAN-PVGP-TCHTGDISCFEKISKN--------------ADFV
HIS2_PASMU LNVVDMSLDCDNDTLLILVN-PIGE-TCHTGAESCFYQFEKT------------TQPDWI
HIS2_DEIRA QRVVSVHVDCDGDSLLYRVE-QTGP-ACHTGEYSCFYRPLLE-----------DDAPDTG
HIS2_STAES QHVESIHLDCDQDAILIKVM-PQGP-TCHTGSLSCFNSEI----------------ESRF
HIS2_STAAM QLVKDIHVDCDNDTILIDVI-PNGP-TCHTGSQSCFNT------------------EVPF
HIS2_STAAW QRVKDIHVDCDNDTILIDVI-PNGP-TCHTGSQSCFNT------------------EVPF
HIS2_PROMP QFLKEIRFDCDNDALVLSIE-QNGSGACHTGEKSCFFNEIDS---ISMNKTAKKTSPFSN
HIS2_PROMA QILKGIRFDCDSDVMLLSIE-QVGSIACHTGARSCFFQEVEENI-PDLEQNSTFNRPLSN
HIS2_PROMM QILKGIRYDCDADVLLLSIE-QTGLVSCHTGARSCFFAEVNQ----HSQGDSLTLPPPMD
HIS2_PARMW QTLRSIRYDCDADVLLLTIE-QRGDIACHTGARSCFYEGGDQ----RSDGGSNALSPPAD
HIS2_GLOVI QKIKALRYDCDSDVLLLTVE-QQGDIACHLGERSCFHRDEAG----------DYDLPPAD
HIS2_SYNY3 QKLLGIRYDCDSDALLLTIE-QKGDIACHTGERSCFHQLDGH-----------KSPPPAD
HIS2_NOSS1 QKVQSIRYDCDSDALLVGVE-QIGDIACHTGERSCFHQVEGK-----------IVAPPGD
HIS2_THEVB QWVKSIRYDCDSDALLLTVE-QVGHIACHTGERSCFHRHGAK--------GESIEPPPAD
HIS2_THEMA MRVVEIRRDCDDDAYLYIVDFPEDKVACHTGNRSCFFKVEHR----------FEETGSPT
HIS2_PYRFU QTVKEIKIDCDNDALLLIVS-PKGP-ACHTGNYSCFYRKLGE------PERVLPIDYSLS
HIS2_LACLA QKIKGMRLDCDQDTLLVFVE-QIGN-ACHTGTYSCFYDELIP-------------FDDSD
HIS2_OCEIH QTVKQISFDCDADAVLVLVD-AQGP-ACHTGEESCFYEDLYK-----------NDVALLQ
HIS2_HALH5 QKVVDIRYDCDGDALVVLVE-LKGP-ACHTGKYSCFFESVFG-------KKIYGASDRFG
HIS2_BACSU QAVKGIRYDCDQDALLVLVE-PSGP-ACHTGSYSCFTKEQTE----------EQAADRFG
F7Z4H7_BACC6 QKVKSLQADCDADTLLIRVD-PEGP-ACHTGERTCFYTRLDE----NGEAAESEIPSNRR
HIS2_CALS4 QKVKKIFYDCDEDALLIQVE-AKGP-ACHTGNISCFYRSFDE-----------ETEDGIE
: *** * : ** . .*:
HIS2_ARATH ---TLYSLESIISKRKEESTVPQEGKPSWTRRLLTD-DALLCSKIREEADELCRTLEDNE
G8TXZ5_SULAD ---PLTRLMAIIRDRLA----AGDLEHSYSAKMVTGPLERLLKKIGEEAIEVIIAAAQSQ
HIS2_HELHP VYHILDDLYHIIEQRRC-----ENIEHSYTASLLAKGVNGIGKKIIEEAGELCFALKDKD
HIS2_WOLSU ---VVDRLYHELLARQG-----ADPQSSYTAKLFSKGENTIGKKIVEEAAELSFAIKDSS
HIS2_AQUAE ---VLPRLQDVIREKIE-----RKEENSYTAKLVSQGKERVFQKFGEEAVETLIALMKGE
Q1D4M6_MYXXD ---ALSALDDTLARRAAPAERPDDAPPSYTRRLLEDRNLRL-KKLGEEAAELVTACADVD
HIS2_BACTN ---FLKALQDFIDKRHE-----EMPQGSYTTSLFESGINKIAQKVGEEAVETVIEATNGT
HIS2_BUCBP ---FLHDLDCMLKFKKH-----YGLENSYTFNLHKNGVNRIAQKVAEEAIETAISAVSKN
HIS2_BUCAI ---FLFKLEEIIEERKN-----KFSDNSYTSSLYKSGTSRIAQKVGEEAIETILAAMNKD
HIS2_BUCAP ---FLSKLEDLIEDRKN-----FNTDNSYTARLYKSGTKRIAQKVGEEAIETILAAMKND
HIS2_XYLFA ---FLGALDALVAERER-----ERPQDSYTTALFEQGVRRIAQKVGEEGVETALAGVVQV
HIS2_XYLFT ---FLGALDALVAERER-----ERPQDSYTTALFEQGVRRIAQKVGEEGVETALAGVVQA
HIS2_XANAC ---FLGSLDALVAERER-----ERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQD
HIS2_XANCP ---FLGSLDALIAEREH-----ERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQG
HIS2_BLOFL ---FLFQLENIISIKKNHTSSHGNQQSSYTSDLYTSGIERIAQKVGEEGLETALAAVSRN
HIS2_SHEON ---FLNNLAELIASRKG-----QSPESSYTASLFARGTKRIAQKVGEEGLETALAAATHD
HIS2_VIBCH ---WLHQLEQLLAERKN-----ADPSSSYTASLYARGTKRIAQKVGEEGVEVALAATAGD
HIS2_VIBPA ---WLHQLEQLLAARKS-----ADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGD
HIS2_VIBVU ---WLHQLEQLLAARKS-----AGPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGD
HIS2_VIBVY ---WLHQLEQLLAARKS-----ADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGD
HIS2_PHOLL ---FLYQLEKLLASRKT-----ADPDHSYTAKLYASGTKRIAQKVGEEGLETALAAAVNN
HIS2_YERPE ---FLYQLEQLLASRKS-----ADPASSYTAKLYASGTKRIAQKVGEEGVETALAATVND
HIS2_SALTI ---FLYQLEQLLAERKT-----ADPASSYTAKLYASGTKRIAQKVGEEGVETALAATVND
HIS2_SALTY ---FLYQLEQLLAERKT-----ADPTSSYTAKLYASGTKRIAQKVGEEGVETALAATVND
HIS2_SHIFL ---FLYQLEQLLAERKY-----ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD
HIS2_ECOL6 ---FLYQLEQLLAERKS-----ADPETSYTAKLYASGSKRIAQKVGEEGVETALAATVHD
HIS2_ECOLI ---FLYQLEQLLAERKS-----ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD
HIS2_ECO57 ---FLYQLEQLLAERKS-----ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD
HIS2_HAEIN ---WFIKLEQHLKEKKN-----ADPSNSYTATLHAKGTKKIAQKVGEEGVETALAAVAQD
HIS2_CAMJE ---FLARLEKLINARKN-----ADENTSYTAKLFKSGTKRIAQKVGEEGVETALAATVKD
HIS2_PASMU ---FLSKLERLIASRKG-----ADPESSYTAQLYAKGTKRIAQKVGEEGVETALAATVKD
HIS2_DEIRA LDGTLERVYATITERLA-----TLPEGSYVARLHAGGLDRVLKKISEEAGEVLLAAKNAD
HIS2_STAES ---KIQALAQTIHQSAK-----SNQSNSYTQYLLKEGIEKISKKFGEEAFEVVIGAIKHN
HIS2_STAAM ---SVQTLAQTVQDSAQ-----SNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGD
HIS2_STAAW ---SVQTLAQTVQDSAQ-----SNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGD
HIS2_PROMP ---ICSELFDTLHERSI-----NPLEKSYTNHLLTKGSNTILKKIGEETAEFIMACKDND
HIS2_PROMA ---TCSELFEVIKDRSS-----NPQKNSYTNSLLKDGDNKILKKIGEEGSEFVMACKDND
HIS2_PROMM ---ACSELFRVIDQRHT-----TPEANSYTNKLLEGGDNRILKKIGEESAEFVMACKDDD
HIS2_PARMW ---ACTELFRVIESRRD-----NPEEGSYTNKLLEGGDNKILKKIGEESAEFVMACKDDN
HIS2_GLOVI ---TLSQVFRVVEERKA-----HPHPDSYTSRLLEAGSNKILKKIGEEATEVVMAAKDGE
HIS2_SYNY3 ---MLTELARVIGDRRD-----HPTPESYTCKLLAGGDNKILKKIGEESAEVVMACKDDD
HIS2_NOSS1 ---TLSQVFQVICDRRN-----HPTESSYTSKLFAGGDNKILKKIGEESAEVVMACKDDD
HIS2_THEVB ---TLSQVYNIVCQRRD-----FPQLQSYTSSLFTAGDNKILKKLGEETAEVVMACKDDD
HIS2_THEMA ---FWLELYRLVRKRKE-----EMPEGSYTVKLFKEGKGKIAKKFGEEAVEVITGYLQND
HIS2_PYRFU ---ILKELEEIIKRRKE-----TPVEGSYTSKLFKEGREKIYKKFGEEAIEVLVAEK---
HIS2_LACLA ---IFSELEKQIIDRKL-----HPVEKSYTNYLLGEGIDKVLKKVGEEASEVIIASKNSD
HIS2_OCEIH ---IIPQVSAKIKERHE-----HPVEGAYTSYLFEKGVDKILKKIGEEATEVVIAAKNED
HIS2_HALH5 ---IIATLEALIAEREA-----EMPEGAYTTYLFEKGVDKILKKVGEEATEVVIAAKNRD
HIS2_BACSU ---IMNELERVIAERQA-----EMPEGAYTTYLFREGVDKILKKVGEEASEVIIAAKNRD
F7Z4H7_BACC6 ---IFDVLEDEVESRKI-----KPVENSYTNYLFEKGIDKIAKKFIEEAGEVVIAAKNNS
HIS2_CALS4 ---ILNKLYERIKGRKI-----NPVEGSYTNYLFEKGIDKILKKVGEEATEVVIASKNDS
: : :: : : .* ** *
HIS2_ARATH -----------EVSRTPSEMADVLYHAMVLLSKRGVKMEDVLEVLRKRFSQSGIEEKQNR
G8TXZ5_SULAD SAPDTVPARATK-DDLTWETVDLLYHLAALLTRFDLPLEALQAEVEHRHRPTESDA----
HIS2_HELHP -----------E-KAIIYECADLFYHILVGLALEHITPERVLQELRRRMGQSGIEEKASR
HIS2_WOLSU -----------E-SEIVYEAADLLYHALVGLAFRGIHPDKIKQELQRRQGVSGIAEKNSR
HIS2_AQUAE -----------K-EEVIYESADMLYTFLVSLSVSGIDIKEVMEELIRRFK----------
Q1D4M6_MYXXD -----------P-SRAAEEAADVLYHVLVAVRPLGLSLDDVKAVLARRASR---------
HIS2_BACTN -----------N-ERLIYEGADLIYHMIVLLTSKGYRIEDLARELQERHSSTWKKH----
HIS2_BUCBP -----------K-VELINESSDLVYHLLVLLHSYDLDLYDVIKNLKMRSNKQV-------
HIS2_BUCAI -----------Q-IELINEASDLIYHLVVLLHDQDLNFNLVIDNLKKRREKNLNTNSEKL
HIS2_BUCAP -----------G-DELINESSDLIYHLIVLLHDQNLNFNLIIENLKKRKTEKL-------
HIS2_XYLFA -----------D-DALLDESADLLYHLIVLLRARGLSLADAVTVLEARHR----------
HIS2_XYLFT -----------D-DALLDESADLLYHLIVLLRARGLSLADAVTVLEARHR----------
HIS2_XANAC -----------D-DALLGESADLLYHLIVLLRARGLGLGDAAALLESRHQ----------
HIS2_XANCP -----------D-AELLGESADLLYHLIVLLRARGLGLGDAVALLESRHK----------
HIS2_BLOFL -----------S-KSLIDEASDLIYHLLVLLQHESLNFHDVIQELRVRSKLKKKH-----
HIS2_SHEON -----------K-EELVNEASDLMYHLLVLLEDQALSLSDITANLLARHQKAQRK-----
HIS2_VIBCH -----------K-EELICESADLMYHLLVLLQEQGLAMNDVINKLKERHK----------
HIS2_VIBPA -----------K-AELVCESADLIYHLLVLLQDQGLSMNDVVNKLKERHK----------
HIS2_VIBVU -----------K-AELVCESADLIYHLLVLLQDQGLSMNDVINKLKERHK----------
HIS2_VIBVY -----------K-AELVCESADLIYHLLVLLQDQGLSMNDVINKLKERHK----------
HIS2_PHOLL -----------R-EELTNEAADLMYHLMVLLQDQELDLSCVIRRLRER------------
HIS2_YERPE -----------R-EELTNEASDLMYHLLVLLQDQDLDFSTVIGRLRERHEK---------
HIS2_SALTI -----------R-FELTNEASDLMYHLLVLLQDQDLNLTTVIDDLRKRHQ----------
HIS2_SALTY -----------R-FELTNEASDLMYHLLVLLQDQDLNLTTVIDNLRKRHQ----------
HIS2_SHIFL -----------R-FELTNEASDLMYHLLVLLQDQDLDLTTVIENLHKRHQ----------
HIS2_ECOL6 -----------R-FELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ----------
HIS2_ECOLI -----------R-FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ----------
HIS2_ECO57 -----------R-FELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ----------
HIS2_HAEIN -----------K-AEVISEATDLVYHLTVLLHNQDLQWYEIIAKLQERHQGIGLHPEGGN
HIS2_CAMJE -----------K-EELICEAADLMYHLSVLLADANLSFSDVISKLKERHKA---------
HIS2_PASMU -----------K-AETICEAADLVYHLTVLLQDADLSWSDVIHKLKERHTK---------
HIS2_DEIRA -----------R-AELATETADLLFHTLFALAEVGVSPADVAAVLQGREGKSGLKGPKEV
HIS2_STAES -----------R-EEVINETADVMYHLFVLLHSLDIPFSEVEQVLAHRHQKRNNFKGERK
HIS2_STAAM -----------K-KAFVSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQ
HIS2_STAAW -----------K-KAFVSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQ
HIS2_PROMP -----------K-DEIANEASDIIYHLQVALIYKGVKWRDVLNVLESRRGKNN-------
HIS2_PROMA -----------H-ESISNEAADLIFHIQVALKYHKVEWRDVLEVLAKRRQSKSNPK----
HIS2_PROMM -----------E-KAIANEAADLLFHLQVALAHHGVNWRDVLEVLANRRGAPRRN-----
HIS2_PARMW -----------P-EEIAGEAADILFHMQVALAHHGVSWRQVQEVLAARRGAPRRH-----
HIS2_GLOVI -----------R---VAEEVADLWYHTLVLLAHADVDILDVYRALQQRRR----------
HIS2_SYNY3 -----------P-EAIAGEVADLFYHTLVALAHHNVDLRAVYRKLGDRRR----------
HIS2_NOSS1 -----------Q-EAIAGEVADLLYHTLVALAHHQVDIKAVYRKLQERRR----------
HIS2_THEVB -----------P-EAIASEVADLFYHTLVALAYHRVSLRQVYEQLQLRRR----------
HIS2_THEMA -----------R-ENLVWEIADMMYHLTVLMADAGVTVQDVMRELEKRRK----------
HIS2_PYRFU -----------R-ERIIYEVADLLYHLLVLLTYNDISLGEVMNELRRRRK----------
HIS2_LACLA -----------K-GELLGEIDDLLYHLFVLMNQQGISLEEVRQKAKERHQLEGNKKEFHT
HIS2_OCEIH -----------K-QELTSELSDLLYHSLVLMEQQGVTLEDIKKELYKRHVEKEGQQRE--
HIS2_HALH5 -----------A-EELKWEVADLLYHLLVLLREQKLPVDEVLAVLEERHRPKEE------
HIS2_BACSU -----------H-EELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE------
F7Z4H7_BACC6 -----------K-SELIYETADLLFHTFVLLSNQNVKLSEVEAELRARSAKKGNSKGDRK
HIS2_CALS4 -----------K-DEIVYEVSDLIYHLMVLLVEKNITLNDIYNELERRYKK---------
* * : : *
HIS2_ARATH TK---
G8TXZ5_SULAD -----
HIS2_HELHP KH---
HIS2_WOLSU KDS--
HIS2_AQUAE -----
Q1D4M6_MYXXD -----
HIS2_BACTN -----
HIS2_BUCBP -----
HIS2_BUCAI LK---
HIS2_BUCAP -----
HIS2_XYLFA -----
HIS2_XYLFT -----
HIS2_XANAC -----
HIS2_XANCP -----
HIS2_BLOFL -----
HIS2_SHEON -----
HIS2_VIBCH -----
HIS2_VIBPA -----
HIS2_VIBVU -----
HIS2_VIBVY -----
HIS2_PHOLL -----
HIS2_YERPE -----
HIS2_SALTI -----
HIS2_SALTY -----
HIS2_SHIFL -----
HIS2_ECOL6 -----
HIS2_ECOLI -----
HIS2_ECO57 -----
HIS2_HAEIN K----
HIS2_CAMJE -----
HIS2_PASMU -----
HIS2_DEIRA G----
HIS2_STAES KVQEW
HIS2_STAAM NIEQW
HIS2_STAAW NIEQW
HIS2_PROMP -----
HIS2_PROMA -----
HIS2_PROMM -----
HIS2_PARMW -----
HIS2_GLOVI -----
HIS2_SYNY3 -----
HIS2_NOSS1 -----
HIS2_THEVB -----
HIS2_THEMA -----
HIS2_PYRFU -----
HIS2_LACLA RTAD-
HIS2_OCEIH -----
HIS2_HALH5 -----
HIS2_BACSU -----
F7Z4H7_BACC6 KIEKW
HIS2_CALS4 -----