CLUSTAL format seed alignment for MF_01020
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Features found in the protein:- The following colors are used to highlight features:
- blue indicates SIGNAL, PROPEP, TRANSMEM, DOMAIN, ZN_FING, REPEAT,
DNA_BIND and CA_BIND.
- magenta is used to display DISULFID, THIOLEST and THIOETH.
- red is used for all other features, such as INIT_MET, ACTIVE SITE,
METAL,BINDING, NP_BIND, SITE, REGION, etc.
- The ID of the sequence used as the template for feature propagation is
underlined.
- A '<' at the beginning of a sequence or '>' at the end indicate that
the protein is fused with another domain either at the N- or C-terminus.
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HIS2_AGRFC -----MSAFSLSDLERIVAKRAAAS---PDESWTAKLVAAG-----QERAAKKLGEEAVE
HIS2_RHIME -----MTDFTLSDLEKIVATRARAA---PEESWTAKLVAAG-----QTKAAKKLGEEAVE
HIS2_BRUME -----MSQFTLADLERIVAERASVT---DGTSYTASLVAKG-----QPKAAQKLGEEAVE
HIS2_RHILO -----MAEFSFSDLEAIIRDRAHSG---DPDSWTAKLFARG-----IDKAAQKLGEEAVE
HIS21_BRADU -----MPRFTIHDLAETIDARAAAG---GEGSYTRKLLDKG-----AEHCAKKFGEEAVE
HIS21_RHOPA -----MARFTLHDLAATVDARAASG---GESSYTKKLLDKG-----PEHCAKKFGEEAVE
HIS22_BRADU ------MSDSLERLYLAVLAARDLD---PATSRTARLFQRG-----PSKMAKKLAEEAIE
HIS22_RHOPA ------MADSLDRLYQAVLAARDLD---PATSRTARLFQRG-----SGKMAKKLAEEAIE
HIS2_CAUVC --MSQRLTDVLQRLAATIEARKGGD---PSVSYTAKLLN-D-----PALAAKKLGEEAVE
HIS2_LISIN ---------MLSDLYEEIKLRKTQP---KEGSYTNYLFEKG-----LDKILKKVGEETTE
HIS2_LISMO ---------MLNDLYEEIKLRKTQP---REGSYTNYLFDKG-----LDKILKKVGEEATE
HIS2_LACPL -------MQNMEELYELIKQRKATP---KKGSYTDYLFTKG-----LDKILKKVGEESTE
HIS2_BACCR ------MENAFKLLYKTIEERKGSP---LPESYTNYLFSKG-----EDKILKKIGEECAE
HIS2_CLOAB ----MDKNEILSKLYNVIEDRKNNP---IEGSYTNYLFEKG-----IDKILKKVGEETTE
HIS2_LEPIN -------MEFLLQLENILKKRKQDL---PDKSYTADLFRGG-----VDRILKKVGEEAGE
HIS2_METAC --MPEADLSILNRVYDIILDRKENY---DENSYVCKLLNHR---KGMNKILEKVGEESIE
HIS2_METMA --MPEADLSILNRVYDIILDRKENY---DENSYVCKLLNHR---KGMNKILEKVGEESIE
HIS2_METJA --------MILEEVYEIIKQRIKEK---PEGSYVAKLTTDD-KKTAINKICEKIGEESTE
HIS2_METKA ----MGDPEVLLEVYEVIRNRIEER---PEGSYVAELTEDDDTKPAINKICEKIIEESGE
HIS2_METTH ----MVDEGILREVYRVLEDRR-DR---PIDSYTSRLMRDD-DKMAEDKILEKIGEEAAE
HIS2_HALSA ------MSDPLRELFDVIEDRKETM---PENSYTASLLADD--EKGENAALEKVGEEATE
HIS2_NEIMA -----MGDSVLSAIQQTITQRKSAN---PSESYVAQLLHKG-----EDKILKKVIEEAGE
HIS2_NEIMB -----MGDSVLSAIQQTITQRKSAN---PSESYVAQLLHKG-----EDKILKKVIEEAGE
HIS2_CHRVO -----MTPDVLKNIADTLEARREAA---PQSSYVASLFHKG-----EDAILKKVAEEAAE
HIS2_BORPA MTTPTAGDDILSRIADTLATRRPEAGGDPQSSYVAKLLSKA-----PDAFLKKIGEEATE
HIS2_BORPE MTTPTAGDDILSRIADTLATRRPEAGGDPQSSYVAKLLSKA-----PDAFLKKIGEEATE
HIS2_BORBR MTPPTAGDDILSRIADTLATRRPEAGGDPQSSYVAKLLSKA-----PDAFLKKIGEEATE
HIS2_RALN1 ------MSDTLRRLGEVLESRKLANGGDPEKSYIARLFHKG-----DDAILKKIGEEATE
HIS2_PSEAE ------MSDTLTRLAAVLEERKNAA---PDSSYVASLYHKG-----LNKILEKVGEESVE
HIS2_PSEPK ------MSDTLNRLAEVLEERKQAA---PDSSYVASLYHKG-----LNKILEKLGEESVE
HIS2_PSESM ------MTDTLSRLAEVLESRKDAA---ADSSYVASLYHKG-----LNKILEKLGEESIE
HIS2_GEOSL ---MNERDDILQAVYEVILDRKGAL---PESSYTASLFHKG-----IDKILKKVGEEATE
HIS2_NITEU ----MTASTILQRLARTIEARKNAD---PSISYTAKLLNSS-----QDKVLKKIAEEAAE
HIS2_CORGL -------MKTFDSLYEELLNRAQTR---PEGSGTVAALDKG-----IHHLGKKVIEEAGE
HIS2_COREF ---MMYCVKTFDSLYEELLDRAQNR---PEGSGTVAALDKG-----VHHIGKKVIEEAGE
HIS2_CORDI -------MKNFDSLYHELAERAEKR---PEGSGTVAALNSS-----LHTLGKKVIEEAGE
HIS2_MYCTU -MQQSLAVKTFEDLFAELGDRARTR---PADSTTVAALDGG-----VHALGKKLLEEAGE
HIS2_MYCPA -MKQSLAVKTFEDLFAELGERARTR---PAGSATVAALDGG-----VHGLGKKILEEAGE
HIS2_MYCLE -MKQSLAVKTFEDLFAELSERARTR---PTDSATVASLDGG-----IHALGKKILEEAGE
HIS2_BIFLO -------MKTFESLFAELSEKAQTR---PEGSLTVDELDKG-----THFIGKKIIEEAGE
HIS2_STRCO -----MSKKTFEELFTELQHKAANGD--PATSRTAELVDKG-----VHAIGKKVVEEAAE
HIS2_STRAW -----MSKKTFEELFTELQHKAANGD--PSTSRTAELVGKG-----VHAIGKKVVEEAAE
HIS2_RHOBA ---MPESLLPLDRLMTTLRTRAAER---PEGSYTTKLMNGG-----AEAIGRKIREEAEE
HIS2_SACS2 -----MSNEIVDELYKIILDRIEKR---PTGSYTAEIVNKG-----KPYVARKVGEESVE
HIS2_SULTO -----MSSNVLDTLYSIILDRISNK---KEGSYTVKLLEKG-----KPYIARKVGEEATE
HIS2_PYRAE -----MSCQIFEKLEAVIRQRIAEG---NPQSYTYRLYSSG-----VSTIARKVGEEAVE
. : : * .*. ** *
HIS2_AGRFC AVIAAIAQ---DRD--------GLKNEAADLLYHLLVVLKIADIPLSDVFAELERRTGQT
HIS2_RHIME TVIAAIGE---DRK--------NLVDESADLLYHLMVVLNIAAVPLQDVMSELARRTSQS
HIS2_BRUME TVIAAVSG---DRA--------GVVSESADLLYHLAVVWNIAGVALEDVLQELQRRTAQT
HIS2_RHILO TAIAAVKG---DRQ--------GLVSESADLIYHWLVVLGLSGVPLSDVLKELESRTGRS
HIS21_BRADU TVIAAVEN---DRA--------HLIAEGADLLYHFLVLLKARGIKLEEVEAALGKRTSMS
HIS21_RHOPA MVIAAVEN---DRG--------HLISETADVLFHMLVLLKSRGVKLEEVEAALAQRTSMS
HIS22_BRADU VVIDAVNG---DTD--------AVVRESADLLYNLTVLWASAGVRPEDVWREMTRREDML
HIS22_RHOPA VVIDAVNG---NRE--------AVIRESADLLYNLTVLWASAGVRPEDVWAEMRRRENLL
HIS2_CAUVC TVIAAVAQ---GSD--------ALAAESADLLYHWLALMAASGVSLDAVAEKLEAREGTS
HIS2_LISIN VVIAAKN----NNE--------ELISEITDLTYHLLVLLAEKDIPLEDIKQELQSREGKL
HIS2_LISMO VVIAAKN----DNQ--------ELIAEVSDLAYHLLVLLAEKNIPLVAIQTELQKREGKL
HIS2_LACPL VIVAAKNP---GDD--------ELTYETADLLYHVLVLLVERGVSFDQIKQELAKREGKM
HIS2_BACCR VIIACKNN---DKE--------EVVKEMVDVFYHCFVLLAEKNIALEDVMREVKERNGKL
HIS2_CLOAB VIIASKDD---NKE--------DLINEICDVIYHTLVLLNYKNIKLEDIEKELQKRNEKI
HIS2_LEPIN VIIAAKNS---DKK--------ELTHEVADLLFHLQVLLVEQGLSLQEIVEELHKRHS--
HIS2_METAC TILAVRNE---DHK--------EIVSESSDLIFHLLVLLAANNVTLDEIAGELSARHEKM
HIS2_METMA TILAVRNE---DHR--------EIVSESSDLIFHLLVLLAANNITLEEIADELSTRHEKM
HIS2_METJA LILAAKDD---KKD--------EIIYEAADLIFHTMVLLAYKNIEFEELLKEFERRKK--
HIS2_METKA LILAAKDG---DRE--------GVVYESTDLIFHVLVLLAYLGIEIGEVFDEFERRRK--
HIS2_METTH VIIASKND-----E--------NLVEEAADLIFHTLLLLVYKGVPLDSLLEEFAARRK--
HIS2_HALSA FLLAAKDG---DTD--------ELAHEGADVVYHMLVVLAQQDMDVEALLAELDDRR---
HIS2_NEIMA VLMASKDK---NPS--------HLVYEVADLWFHTMILLTHHDLKAEDVLDELARRQGLS
HIS2_NEIMB VLMASKDK---NPS--------HLVYEVADLWFHTMILLTHHDLKAEDVLDELARRQGLS
HIS2_CHRVO TLMASKDK---DKL--------HLVREVADLWFHTMVLLTYHGLRPEDVVMELHRREGIS
HIS2_BORPA LVMAAKDG---QPD--------RIISETADLWFHCLVALTHYNLRPEDVLAELARREGLS
HIS2_BORPE LVMAAKDG---QPD--------RIISETADLWFHCLVALTHYNLRPEDVLAELARREGLS
HIS2_BORBR LVMAAKDG---QPD--------RIISETADLWFHCLVALTHYNLRPEDVLAELARREGLS
HIS2_RALN1 TVMAAKDA---RAAGMTDEARGKVVYEVADLWFHTMVLLSHFDLTPDDVVNELARREGLS
HIS2_PSEAE TIIAAKDA---AASG----DCQDLIYETADLWFHSLVMLSALGQHPQAVLDELERRFGLS
HIS2_PSEPK TIIAAKDA---QISK----DYSDVIYETADLWFHSLVMLSALGQHPQAVLDELERRFGLS
HIS2_PSESM TIIAAKDA---AVSG----DCSDVIYETADLWFHSMVMLAALGQHPQAVLDELDRRFGLS
HIS2_GEOSL VIIAGKGG---KRE--------EIVYETADLLFHTLVLLGHYDIAPADVYNELRRRFGTS
HIS2_NITEU TIMACKDN---DRE--------QIIYETADLWFHCLIMLTRHDISPEDILRELERREGIS
HIS2_CORGL VWIAAEYE---TDE--------ELAGEISQLIYWTQVIMVARGLKPEDIYKNL-------
HIS2_COREF VWIAAEYQ---SDE--------ELAEEISQLMYWTQVMMVARGIKPEDVYKNL-------
HIS2_CORDI VWLAAEYQ---SDA--------ELAEEISQLMYWAQVIMIKRGLTPEDIYKYL-------
HIS2_MYCTU VWLAAEHE---SND--------ALAEEISQLLYWTQVLMISRGLSLDDVYRKL-------
HIS2_MYCPA VWLAAEHE---SDD--------ALAGEISQLLYWTQVLMTARGLSLDDVYRKL-------
HIS2_MYCLE VWLAAEHE---PKE--------VLAEEISQLLYWTQVLMISRGLSLDDVYRKL-------
HIS2_BIFLO TWMAAEYE---GAD--------RTAEEMSQLLYHVQVMMIKHGLTLEDVYKHL-------
HIS2_STRCO VWMAAEYE---GKD--------AAAEEISQLLYHVQVMMVARGISLDDVYAHL-------
HIS2_STRAW VWMAAEYE---GKD--------AAAEEISQLLYHVQVMMVARGISLDDVYAHL-------
HIS2_RHOBA LIEAADEPDEAGRQ--------HAIYEAGDLIYHAMVLMAWRGIELDEVAAELARREGTS
HIS2_SACS2 TIVASLAE---NKE--------RFISEVADLIYHLLVLMALEGVTPEDIYRELERRRK--
HIS2_SULTO VIVASLSE---GRE--------RFISEVADLIYHLFVLMAVEGVKPEDVYEELKRRMK--
HIS2_PYRAE VAVAALAE---GRE--------RVVEESADLLYHLLVLLNSLGLSLGDVCKELERRMK--
* :: : : .
HIS2_AGRFC GLAEKAARPTP----------------------------
HIS2_RHIME GLQEKANRQNP----------------------------
HIS2_BRUME GLAEKASRPKG----------------------------
HIS2_RHILO GIAEKASRPKG----------------------------
HIS21_BRADU GLEEKASRKE-----------------------------
HIS21_RHOPA GLEEKASRKRD----------------------------
HIS22_BRADU GIAEKLPKSAMKLPKVASPRVAARRPIVALEGRTARKRH
HIS22_RHOPA GIAEKLPKSRIGKPAAPH---ATRRPVIPQEARAVRKHR
HIS2_CAUVC GIAEKASRA------------------------------
HIS2_LISIN SKTS-DRKEINDL--------------------------
HIS2_LISMO STTR-DRKEINDL--------------------------
HIS2_LACPL SDYK-DRPEIKNL--------------------------
HIS2_BACCR SRVG-DRREIDTL--------------------------
HIS2_CLOAB LNKKQERRPIENI--------------------------
HIS2_LEPIN ---------------------------------------
HIS2_METAC KRD------------------------------------
HIS2_METMA RRD------------------------------------
HIS2_METJA ---------------------------------------
HIS2_METKA ---------------------------------------
HIS2_METTH ---------------------------------------
HIS2_HALSA ---------------------------------------
HIS2_NEIMA GLAEKAARTES----------------------------
HIS2_NEIMB GLVEKAARTES----------------------------
HIS2_CHRVO GLDEKASRKPTA---------------------------
HIS2_BORPA GLEEKARRPRD----------------------------
HIS2_BORPE GLEEKARRPRD----------------------------
HIS2_BORBR GLEEKARRPRD----------------------------
HIS2_RALN1 GLEEKALRKSQARDAAGD---------------------
HIS2_PSEAE GHAEKAARQPSA---------------------------
HIS2_PSEPK GHDEKAARQPSA---------------------------
HIS2_PSESM GHTEKAARTAE----------------------------
HIS2_GEOSL GHAEKASRNE-----------------------------
HIS2_NITEU GIEEKLSRSQPNKTE------------------------
HIS2_CORGL ---------------------------------------
HIS2_COREF ---------------------------------------
HIS2_CORDI ---------------------------------------
HIS2_MYCTU ---------------------------------------
HIS2_MYCPA ---------------------------------------
HIS2_MYCLE ---------------------------------------
HIS2_BIFLO ---------------------------------------
HIS2_STRCO ---------------------------------------
HIS2_STRAW ---------------------------------------
HIS2_RHOBA GLVEKASRPAKKDSGTADS--------------------
HIS2_SACS2 ---------------------------------------
HIS2_SULTO ---------------------------------------
HIS2_PYRAE ---------------------------------------