CLUSTAL format seed alignment for MF_01121
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Features found in the protein:- The following colors are used to highlight features:
- blue indicates SIGNAL, PROPEP, TRANSMEM, DOMAIN, ZN_FING, REPEAT,
DNA_BIND and CA_BIND.
- magenta is used to display DISULFID, THIOLEST and THIOETH.
- red is used for all other features, such as INIT_MET, ACTIVE SITE,
METAL,BINDING, NP_BIND, SITE, REGION, etc.
- The ID of the sequence used as the template for feature propagation is
underlined.
- A '<' at the beginning of a sequence or '>' at the end indicate that
the protein is fused with another domain either at the N- or C-terminus.
_____________________________________________________________________________
SIR5_HUMAN MRPLQIVPSRLISQLYCGLKP---PASTRNQICLKMARPSSSMADFRKFFAKAKHIVIIS
SIR5_PONAB MRPLQIVPSRLISQLYCGLKP---PASTRNQICLKMARPSSSMADFRKLFAKAKHIVIMS
SIR5_MACMU MRPLQIVPSRLISQLYCGLKP---PASTRNQICLKMARPSSSMADFRKCFAKAKHIVIIS
SIR5_BOVIN MPPLWIIRNRLFSQLYCGLKS---PVSTQTKICLTMARPSSNMADFRKCFAKAKHIVVIS
SIR5_CANLF MQPLQIAPCRLLYGLYRGLKS---PASTGTRICPAMARPSSNMADFRKLFAKAKHIVIIS
SIR5_MOUSE MRPLLIAPGRFISQLCCRRKP---PASPQSKICLTMARPSSNMADFRKCFANAKHIAIIS
SIR5_RAT MRPLPVAPGRLFSQLCCGPKP---SASPQSKICLTMARPSSNMADFRKCFANAKHIVIIS
SIR5A_XENLA MILLTFHTRRLVSHAYCGLK----PASQKKSIALEMTRPSSNLADFREAFAKAKHIAVIT
SIR5_XENTR MILLPFHTRRLVSHVYCGLK----PASKKKGIALEMARPSSNLADFREAFAKAKHIAVIT
SIR5B_XENLA MILLPFHTRRLVSHVYCGLK----PASQNKGIALEMTRPSSNLANFREAFAKAKHIAVIT
SIR5_CHICK MCLAQCAARRLLAQVHGALK----PAPKKPNWCWEMARPSSNMADFREVFAKAKHIAIIT
SIR5_DANRE MIVRQLWCSRGSTSHLCAAVR---LNWRSP----KMTRPSSDLTAFREHFAKAKHIAIIT
SIR5_DAPPU --------------------------------MSDCLLPSSDMDAFRKILKKANSVVILT
SIR5_MONDO MSLLHFATRRLILQVLRELGLKAPPVHKTLKICIAMSRPSSNMADFRRFFARAKHIAIIT
SIR5_COPC7 -------------------------------------MPSTSIAEFREVLRNAKNIIAVA
SIR5_PHYPA MPRAGVAASAFKLRNIWHIHN------LHRVRSQQTRLMSDSVEEFSSVFQHAKKVVVLT
NPD_AQUAE ----------------------------------------------MENLN----IVTLT
NPD1_CALS4 ----------------------------------------MDFKILKEKLPQSNLTVVLT
NPD_AERPE ---------------------------------------MEAVWESARILANSRFAVAFT
NPD_METKA ----------------------------------------MPLREAAERVVEAETVVVLT
NPD_PYRAB -----------------------------------------MIVEVARVLASSKNAIAFT
NPD_PYRHO -----------------------------------------MMAEVARVLASSKNVIAFT
NPD_PYRFU -----------------------------------------MLGEVSKILAKSSMAIAFT
NPD_THEKO -----------------------------------------MLGHAAKLLARARFAIAFT
NPD_THESM -----------------------------------------MIEEAPRIIAHSRFLIAFT
NPD2_PYRAE -------------------------------------------MNVADLLASSRHCVVFT
NPD2_ARCFU --------------------------------------MEDEIRKAAEILAKSKHAVVFT
NPD1_ARCFU -----------------------------------------MDEKLLKTIAESKYLVALT
NPD_CORGL ---------------------------------MSERQLEKSIEHAVELAREARNIEVFT
NPD2_COREF -------------------------------------MDEHSIMQAVAVARGARNIEVFT
NPD2_MYCA1 ---------------------------------------------------------MLS
NPD_MYCPA -----------------------------------------------------MRIAVLS
NPD_MYCBO -----------------------------------------------------MRVAVLS
NPD_MYCTU -----------------------------------------------------MRVAVLS
NPD_MYCLE -----------------------------------------------------MRVVVLS
NPD_METCA ---------------------------------------MEFSDELLASLRDARHIAVFT
NPD1_PSEAE ---------------------------------------MRAVVELLAG---ARRLVIFT
NPD1_PSESM ------------------------------------------------------------
NPD4_PSESM ------------------------------------------MRLPAEALKDARKIVCFS
NPD_PSEPK ---------------------------------------MSNLRRAAEALRRSKTVVFFT
NPD_RALN1 --------------------------------MPTAVSDAAAPAQARAWIEAAERVMVLT
NPD_THET2 ---------------------------------------MERLEEARKRLEEAKRVAVLT
NPD_THET8 ---------------------------------------MERLEEARKRLEEARRVAVLT
NPD_DEIRA ----------------------------------------MDLSQARAALKAARRVAVLT
SIR2A_PLAF7 -------------------------MGNLMISFLKKDTQSITLEELAKIIKKCKHVVALT
NPD_LEPIN -----------------------------------------MKEFITKHRDKFQKISAIS
NPD_LEPIC -----------------------------------------MKEFITKHRDKFQKISAIS
SIR5_CANAL --------------------------------------MNKQLKEFQEYLPKCRKIIALV
NPD_HELPY ---------------------------------------------------MKNL-VILS
NPD_HELPJ ---------------------------------------------------MKNL-VILS
NPD_AGGAC ---------------------------------------------------MKPICVVLS
NPD_BACTN ---------------------------------------------------MKNL-VVLT
NPD_CAMJE ---------------------------------------------------MKNI-MILS
NPD_CAMJR ---------------------------------------------------MKNI-MILS
NPD_HELHP ---------------------------------------------------MPKL-VVFS
NPD_ECOLI -------------MLSRRGHRLSRFRKNKRRLRERLRQRIFFRDKVVPEAMEKPRVLVLT
NPD_ECO57 -------------MLSRRGHRLSRFRKNKRRLRERLRQRIFFRDKVVPEAMEKPRVLVLT
NPD_ECOL6 -------------MLSRRGHRLSRFRKNKRRLRERLRQRIFFRDKVVPEAMEKPRVLVLT
NPD_SHIFL -------------MLSRRGHRLSRFRKNKRRLRERLRQRIFFRDKVVPEAMEKPRVLVLT
NPD_SALTI -------------MQSRRFHRLSRFRKNKRLLRERLRQRIFFRDRVVPEMMENPRVLVLT
NPD_SALTY -------------MQSRRFHRLSRFRKNKRLLRERLRQRIFFRDRVVPEMMENPRVLVLT
NPD_YERPE ---------------MRIRHRLCRFRKSKHVRHQRFRSRIFHRDSAVAKEMKKPFVVVLT
NPD_YERPS ---------------MRIRHRLCRFRKSKHVRHQRFRSRIFHRDSAVAKEMKKPFVVVLT
NPD_PASMU -------------------------------------------------MTKQVRIVVLT
NPD_VIBVU ------------------------------------------------MNFPYRNIVVLT
NPD_VIBVY ------------------------------------------------MNFPYRNIVVLT
NPD_VIBPA ------------------------------------------------MNFPYRNIVVLT
NPD_VIBCH ------------------------------------------------MSLPYRHVVILT
NPD_SHEON ---------------------------------------------------MYQHIVVLT
NPD_BDEBA -----------------------------------------------MDLRLFKNIVILT
NPD_RHOBA -----------------------------------------------------MNVLILT
NPD_CAUVC -------------------------------------------------MRGIMKVFVLT
SIR5_HUMAN GAGVSAESGVPTFRGAG-GYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKE--P
SIR5_PONAB GAGVSAESGVPTFRGAG-GYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKE--P
SIR5_MACMU GAGVSAESGVPTFRGAG-GYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKE--P
SIR5_BOVIN GAGISAESGVPTFRGAG-GYWRKWKAQDLATPQAFARNPSQVWEFYHYRREVVQSTE--P
SIR5_CANLF GAGVSAESGVPTFRGAG-GYWRKWQAQDLATPQAFARNPSLVWEFYHYRREVMLSKE--P
SIR5_MOUSE GAGVSAESGVPTFRGAG-GYWRKWQAQDLATPQAFARNPSQVWEFYHYRREVMRSKE--P
SIR5_RAT GAGVSAESGVPTFRGTG-GYWRKWQAQHLATPLAFAHNPSQVWEFYHYRREVMRNKE--P
SIR5A_XENLA GAGVSAESGVPTFRGAG-GYWRKWQAQHLATPEAFARNPSRVWEFYHYRREVMLTKN--P
SIR5_XENTR GAGVSAESGVPTFRGAG-GYWRKWQAQHLATPEAFARNPSRVWEFYHYRREVMLTKN--P
SIR5B_XENLA GAGVSAESGVPTIIGAG-GYWRKWQAQHLATPEAFSRNPSRVWEFYHYRREVMLTKN--P
SIR5_CHICK GAGVSAESGVPTFRGAG-GFWRKWQAQELATPGAFARNPSRVWEFYHYRREVMLSKH--P
SIR5_DANRE GAGVSAESGVPTFRGPG-GFWRKWQAQDLATPEAFSRDPSLVWEFYHYRREVMRSKM--P
SIR5_DAPPU GAGVSAESGVPTFRGAG-GLWRTYSAQNLATPSAFRSNPSLVWEFYHHRRENMASKS--P
SIR5_MONDO GAGVSAESGVPTFRGPG-GFWRKWKAEDLATPEAFAQNPSLVWEFYHYRREVILKKH--P
SIR5_COPC7 GAGLSAASGIPTFRGAG-GMWRKYDAMSLATPEGFADNPSLVWQFYHYRREAALKAD--V
SIR5_PHYPA GAGISAESGIPTFRGEG-GLWRDFDATELATPGAFAANPSLVWEFYHYRRTIVAGAS--P
NPD_AQUAE GAGISAESGIPTFRGKD-GLWNKFKPEELATPEAFFRNPKLVWEWYDWKRQLIAKAQ--P
NPD1_CALS4 GAGISKESGIPTFRGED-GLWKKYNPEELATPWAFQRNPALVWEWYDYRRRIISKAK--P
NPD_AERPE GAGISAESGIPTFRGKD-GLWSRFDPRDLATPEAFNRDPRLVWEWYSWRIERVLAAK--P
NPD_METKA GAGASADSGIPTFRGKD-GLWNKYDPRELATPEAFARDPEKVWEWYLWRRRKIAEAE--P
NPD_PYRAB GAGISAESGVPTFRGKD-GLWNKYRPEELATPEAFARNPKLVWEFYKWRINKILKAK--P
NPD_PYRHO GAGISAESGIPTFRGKD-GLWKKYRPEELATPEAFERNPKLVWDFYKWRIKKILKAK--P
NPD_PYRFU GAGISAESGIPTFRGKD-GLWRKYRAEELATPEAFKRDPKLVWEFYKWRIKKILEAK--P
NPD_THEKO GAGISAESGIPTFRGRN-GLWKTYRAEELATPEAFKRDPHLVWEFYKWRMRKILKAE--P
NPD_THESM GAGVSAESGIPTFRDRG-GLWENYRIEEVATPEAFRKDPNLVWSFYKMRMKIMKGAK--P
NPD2_PYRAE GAGISAESGVPTFRGPG-GLWERYKPEELATPEAFARDPALVWRWYKWRQEVIYNAR--P
NPD2_ARCFU GAGISAESGIPTFRGED-GLWRKYDPEEVASISGFKRNPRAFWEF-SMEMKDKLFAE--P
NPD1_ARCFU GAGVSAESGIPTFRGKD-GLWNRYRPEELANPQAFAKDPEKVWKWYAWRMEKVFNAQ--P
NPD_CORGL GAGMSADSGLETYRDDKTGLWSNVDPQAMASIDAWRKDPEPMWAWYRWRAGVAARAE--P
NPD2_COREF GAGMSADSGLETYRDPETGVWSKVDPQAMASIDAWARDPEPMWAWYRWRAGQAMKAR--P
NPD2_MYCA1 GAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWRDNPQRVWGWYLWRHYLVADVA--P
NPD_MYCPA GAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWRDNPQRVWGWYLWRHYLVADVA--P
NPD_MYCBO GAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWLRNPERVWGWYLWRHYLVANVE--P
NPD_MYCTU GAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWLRNPERVWGWYLWRHYLVANVE--P
NPD_MYCLE GAGISAESDVPTFRDDKNGLWARFDPYQLSSTQGWQRNPERVWGWYLWRHYLVANVK--P
NPD_METCA GAGVSAESGIPTFRDALTGFWENYDASTLASPEGFAADPALVWGWYEWRRTRVLRAE--P
NPD1_PSEAE GAGVSAESGIPTFRDALGGLWARYDPAALATPAAFADDPALVWGWYEWRRLKVLGVQ--P
NPD1_PSESM -----MESGIPTYREKQTGFWACHNPERLETAKAFRENPSLVWGWYLWRRQQFSKAQ--P
NPD4_PSESM GAGISAESGILTYLDQMPKLWAPYDPRALETANAFRESPALVWGWYLWRRRQVDRAQ--P
NPD_PSEPK GAGISADSGIPTFRDKLTGLWAKHDPQRLETADAFRANPTLVWSWYLWRRHQVSQAK--P
NPD_RALN1 GAGVSAESGVPTFRDALTGLWARFNPEDLATEAAYREHPRMVWDWYQERRARVSQVQ--P
NPD_THET2 GAGISKPSGIPTFRDAE-GLWKNFNPLDYATPEAYARDPEKVWAWYAWRIQKVREAK--P
NPD_THET8 GAGISKPSGIPTFRDAE-GLWKNFNPLDYATPEAYARDPEKVWAWYAWRIQKVREAK--P
NPD_DEIRA GAGISAESGIPTFRDAQTGHWARFRPEDLASPDAYRRDPDLVWEWYAGRYRDVLAAQ--P
SIR2A_PLAF7 GSGTSAESNIPSFRGSSNSIWSKYDPRIYGTIWGFWKYPEKIWEVIRDISS-DYEIE--I
NPD_LEPIN GAGISAESGIPTFRGSE-GLWKNFRAEDLATPQAFSKNPKLVWEWYLWRRNIIETKR--P
NPD_LEPIC GAGISAESGIPTFRGSE-GLWKNFRAEDLATPQAFSKNPKLVWEWYLWRRNIIETKR--P
SIR5_CANAL GAGLSASSGLPTFRGSQ-GLWKNFNMIDLATPDAFYIDPGLVWQFYSWRRYGALRAK--P
NPD_HELPY GAGISAESGIKTFRDAD-GLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRR--QLFEVYP
NPD_HELPJ GAGISAESGIKTFRDAG-GLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRR--QLFEVYP
NPD_AGGAC GAGISAESGIPTYRAED-GLWAGHKIEDVCTPEALQRNRKQVLAFYNERRR--NCAEAKP
NPD_BACTN GAGMSAESGISTFRDAG-GLWDKYPVEQVATPEGYQRDPALVINFYNARRK--QLLEVKP
NPD_CAMJE GAGLSAPSGLKTFRDND-GLWEEYDVMEVCSATGFRKNPKKVLDFYDARRA--QLQNVKP
NPD_CAMJR GAGLSAPSGLKTFRDND-GLWEEYDVMEVCSATGFRKNPKKVLDFYDARRV--QLQNVKP
NPD_HELHP GAGLSAESGLETFRDNG-GLWAQYDPMEVCNYENWLDNFELVHRFYNLRRE--ELGKVQP
NPD_ECOLI GAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEIQP
NPD_ECO57 GAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEIQP
NPD_ECOL6 GAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQTFYNARRRQLQQPEIQP
NPD_SHIFL GAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEIQP
NPD_SALTI GAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFARNPGLVQTFYNARRQQLQQPEIQP
NPD_SALTY GAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFARNPGLVQTFYNARRQQLQQPEIQP
NPD_YERPE GAGISAESGIRTFRADD-GLWEDHRVEDVATPEGYRRDPELVQRFYNERRRQLQQPDIAP
NPD_YERPS GAGISAESGIRTFRADD-GLWEDHRVEDVATPEGYRRDPELVQRFYNERRRQLQQPDIAP
NPD_PASMU GAGISAESGIRTFRATD-GLWENHPVDEVATPEGFARNPKLVQRFYNERRKQLFSDQIAP
NPD_VIBVU GAGISAESGIQTFRAQD-GLWENHRIEDVATPEGFARDPDLVQDFYNQRRKKLQDPNIEP
NPD_VIBVY GAGISAESGIQTFRAQD-GLWENHRIEDVATPEGFARDPDLVQDFYNQRRKKLQDPNIEP
NPD_VIBPA GAGISAESGIQTFRAQD-GLWENHRIEDVATPEGFARDPDLVQSFYNQRRQKLQDETIKP
NPD_VIBCH GAGISAESGIQTFRAQD-GLWENHRIEDVATPEGFQRDPDMVLEFYNQRRRKLLSDAIQP
NPD_SHEON GAGISAESGLRTFRDQD-GLWEEHHIEDVATPEGYAKDAELVERFYNSRWEQLHCGTVMP
NPD_BDEBA GAGISAESGIRTFRDQD-GLWEDHRIEDVATPEAFARNPALVQRFYNLRRAQLRDPNLAP
NPD_RHOBA GAGISAESGIPTFRDAN-GLWEGHAVEEVATPQGFARNPNLVHEFYNQRRRALLNPEIQP
NPD_CAUVC GAGVSAESGLGTFRDKD-GVWTKYDLNEVATPQGFARNPALVRDFYNARRANLAGA--RP
*.: : * . .
SIR5_HUMAN NAGHRAIAECETRLGKQ------------GRRVVVITQNIDELHRKAGT-----------
SIR5_PONAB NAGHRAIAECETRLGKQ------------GRRVVVITQNIDELHRKAGT-----------
SIR5_MACMU NAGHRAIAECETRLGKQ------------GRRVVVITQNIDELHRKAGT-----------
SIR5_BOVIN NAGHLAIAECQARLHRQ------------GRQVVVITQNIDELHRKAGT-----------
SIR5_CANLF NPGHLAIAECEARLREQ------------GRRVMVITQNIDELHRRAGT-----------
SIR5_MOUSE NPGHLAIAQCEARLRDQ------------GRRVVVITQNIDELHRKAGT-----------
SIR5_RAT NPGHLAIAQCEARLRDQ------------GRRVVVITQNIDELHRKAGT-----------
SIR5A_XENLA NPAHLAIAECETRLRKQ------------GRKLVVITQNIDELHRKAGS-----------
SIR5_XENTR NPAHLAIAECETRLRKQ------------GRKLVVITQNIDELHRKAGS-----------
SIR5B_XENLA NPAHLAIAECETRLRKQ------------GRKVVVITQNIDELHHKAGS-----------
SIR5_CHICK NAAHIAIAECEKRLRKQ------------GRSVVVITQNIDELHRKAGT-----------
SIR5_DANRE NPAHLAIAECEARLGQQ------------GRSVVIITQNIDELHHRAGS-----------
SIR5_DAPPU NNAHNAIAEFEHRMTKE------------GRHVSVITQNIDELHQRAGS-----------
SIR5_MONDO NAAHVAIAACEERLSLQ------------GRRVVVITQNIDEFHTKAGT-----------
SIR5_COPC7 NAAHLALASFSIPRIRHTVAP--------GSSFTLITQNVDGLSPRAMKCVLQGWDGVTL
SIR5_PHYPA NAGHYAVAALQRRCRRL------------GKDFILLTQNIDGLHAKAGS-----------
NPD_AQUAE NEGHKILTKMEEEF----------------PNFYLITQNVDGLHQRAGSK----------
NPD1_CALS4 NKCHLLIAEFEERF----------------KNVRVITQNVDGLHEAAGST----------
NPD_AERPE NKAHRLLARLEDSG----------------VLKAVITQNVDGLHRRAGSR----------
NPD_METKA NPAHTVLARMERDG----------------LLEAVITQNVDGLHQRAGSR----------
NPD_PYRAB NPAHYALVELEDMG----------------ILRAVITQNVDDLHREAGTR----------
NPD_PYRHO NPAHYALVELEKMG----------------ILKAVITQNVDDLHREAGTK----------
NPD_PYRFU NPAHIALAELEKMG----------------IIKAVITQNVDDLHREAGSK----------
NPD_THEKO NPAHKALAELENMG----------------VLKAVITQNVDDLHREAGSR----------
NPD_THESM NNAHLALAELEKMG----------------ILKAVITQNIDNLHREAGNQ----------
NPD2_PYRAE SPGHYAIAELEAMG----------------VVRGVITQNVDGLHQRAGSR----------
NPD2_ARCFU NPAHYAIAELERMG----------------IVKAVITQNIDMLHQRAGSR----------
NPD1_ARCFU NKAHQAFAELERLG----------------VLKCLITQNVDDLHERAGSR----------
NPD_CORGL NAGHQAISYWEGSDT--------------VEHVHITTQNIDNLHERAGSS----------
NPD2_COREF NAGHETIAYWEGSHL--------------VDAVHVTTQNIDNLHERAGST----------
NPD2_MYCA1 NAGHRAIAAWQDH-----------------AEVSVITQNVDDLHERAGSR----------
NPD_MYCPA NAGHRAIAAWQDH-----------------AEVSVITQNVDDLHERAGSR----------
NPD_MYCBO NDGHRAIAAWQDH-----------------AEVSVITQNVDDLHERAGSG----------
NPD_MYCTU NDGHRAIAAWQDH-----------------AEVSVITQNVDDLHERAGSG----------
NPD_MYCLE NDGHRAIAAWQEQ-----------------IEVSVITQNVDDLHERAGST----------
NPD_METCA NPAHYAIAALAADC----------------PRLTLITQNVDDLHERAGSA----------
NPD1_PSEAE NPAHRAIAALSGRI----------------ANTRLVTQNVDDLHERAGSR----------
NPD1_PSESM NAAHLALREMAGSM----------------GTVSIITQNIDDLHERAGSV----------
NPD4_PSESM NAAHLVWPQMVNLG----------------YEVSVVTQNVDDLHERAGST----------
NPD_PSEPK NSAHLSIPQLADAG----------------WDVSVVTQNIDDLHERAGSS----------
NPD_RALN1 NPAHLAIAALATR-----------------KTVALVTQNVDGLHQRAGSV----------
NPD_THET2 NPAHYALVELERRILSR------------GGSFLLVTQNVDGLHARAGSQ----------
NPD_THET8 NPAHYALVELERRILSR------------GGSFLLVTQNVDGLHALAGSQ----------
NPD_DEIRA NRGHELLAELERR---K------------GPGFFLATQNVDGLHARAGSGSAG-------
SIR2A_PLAF7 NNGHVALSTLESLG----------------YLKSVVTQNVDGLHEASGNT----------
NPD_LEPIN NPGHFALVELERIH----------------PDFFLITQNVDGLHSQAGSK----------
NPD_LEPIC NPGHFALVELERIH----------------PDFFLITQNVDGLHSQAGSK----------
SIR5_CANAL NKGHYALSKLSHKFN--------------SDEYITITQNVDGLSSRSGHNLD--------
NPD_HELPY NKAHKALAELEKHYQV-----------------NIITQNVDDLHERAGSS----------
NPD_HELPJ NKAHKALAELEKHYQV-----------------NIITQNVDDLHERAGSS----------
NPD_AGGAC NAAHKVLVELERSYNV-----------------QIITQNVEDLHERAGST----------
NPD_BACTN NRGHELLAELEKNFNV-----------------TVITQNVDNLHERAGSS----------
NPD_CAMJE NHAHEKIAQLKEKWGK---------------NLFVITQNVDDLLERAGCK----------
NPD_CAMJR NHAHEKIAQLKEKWGK---------------NLFVITQNVDDLLERAGCK----------
NPD_HELHP NAMHKFLASLPMILNKPRIALSAKKKHKDPIEVIHITQNVDDLLERAGVS----------
NPD_ECOLI NAAHLALAKLQDALG---------------DRFLLVTQNIDNLHERAGNT----------
NPD_ECO57 NAAHLALAKLQDALG---------------DRFLLVTQNIDNLHERAGNT----------
NPD_ECOL6 NAAHLALAKLQDALG---------------DRFLLVTQNIDNLHERAGNT----------
NPD_SHIFL NAAHLALAKLQDALG---------------DRFLLVTQNIDNLHERAGNT----------
NPD_SALTI NAAHLALAKLEEALG---------------DRFLLVTQNIDNLHERAGNR----------
NPD_SALTY NAAHLALAKLEEALG---------------DRFLLVTQNIDNLHERAGNR----------
NPD_YERPE NAAHFALADLEAVLG---------------DNLVLITQNIDNLHERAGSK----------
NPD_YERPS NAAHFALADLEAVLG---------------DNLVLITQNIDNLHERAGSK----------
NPD_PASMU NAAHFALAELEKKLG---------------DNLLIVTQNVDNLHERAGSK----------
NPD_VIBVU NAAHLALGRLEAELD---------------GQVTIVTQNIDNLHERGGNK----------
NPD_VIBVY NAAHLALGRLEAELD---------------GQVTIVTQNIDNLHERGGNK----------
NPD_VIBPA NAAHLALGRLEAELE---------------GKVTVITQNIDNLHERGGSQ----------
NPD_VIBCH NPAHLALGKLEKELQ---------------GSVTVITQNIDNLHERGGSQ----------
NPD_SHEON NAAHLALAKLEAEFS---------------GQLLVVTQNIDDLHERAGSR----------
NPD_BDEBA NPAHQALVDLENLWE---------------GNFLLVTQNVDNLHRRAGSK----------
NPD_RHOBA NAAHVALADFEREHLENGR-----------GDFLLVTQNIDNLHQRAGSQ----------
NPD_CAUVC NAAHDALAQLEAGLARRG------------GELFLCTQNVDDLHEKAGCR----------
. * ***:: : .
SIR5_HUMAN ----KNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSG---------------------
SIR5_PONAB ----KNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSG---------------------
SIR5_MACMU ----KNLLEIHGSLFKTRCTSCGIVAENYKSPICPALSG---------------------
SIR5_BOVIN ----KNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSG---------------------
SIR5_CANLF ----KNLLEIHGSLFKTRCTSCGIVAENYKSPICPALSG---------------------
SIR5_MOUSE ----KNLLEIHGTLFKTRCTSCGTVAENYRSPICPALAG---------------------
SIR5_RAT ----KNLLEIHGTLFKTRCTSCGNVAENYKSPICPALLG---------------------
SIR5A_XENLA ----RNLFDIHGSLFKTRCTSCGRVKENYKSPICPALDG---------------------
SIR5_XENTR ----RNLFEIHGSLFKTRCTSCGSVKENYKSPICPALAG---------------------
SIR5B_XENLA ----RNLFEIHGSLFKTRCTSCGSVKENYKSPICSALAG---------------------
SIR5_CHICK ----KHLLEIHGSLFKTRCTNCGNVTANYKSPICPALAG---------------------
SIR5_DANRE ----KHVYEIHGSLFKTRCMSCGEVKANHKSPICPALDG---------------------
SIR5_DAPPU ----VNVLELHGSLFKTRCLKCKKIEPNHDSPICEALRG---------------------
SIR5_MONDO ----KNILELHGSLFKTRCCSCGNVRVNYNNPICPALEG---------------------
SIR5_COPC7 PEDPPYLIEMHGRLFDVKCTQCDHVELDTSSPICEGLAGT--------------------
SIR5_PHYPA ----TDVVELHGSLWETRCCHCKAVEANRNMPICPALDG---------------------
NPD_AQUAE -----KVIELHGNIWKVRCVECGNERYEYTTP----------------------------
NPD1_CALS4 -----NVIELHGNIWKVKCTKCDFRGINREVP----------------------------
NPD_AERPE -----RVLELHGNVLRARCTRCGSKLEWREKP----------------------------
NPD_METKA -----RVIELHGNIWRDECVSCEYQRVNDPER----------------------------
NPD_PYRAB -----NLIELHGNIFRVKCTKCNFKEYLKESQ----------------------------
NPD_PYRHO -----NLIELHGNIFRVRCTSCEFREHLKESG----------------------------
NPD_PYRFU -----NVIELHGNIFRVKCTSCSYREYLKESD----------------------------
NPD_THEKO -----KVVELHGNIFRVRCVSCSYRENLKESG----------------------------
NPD_THESM -----HIVELHGNIYRVKCTRCDYMENLLESG----------------------------
NPD2_PYRAE -----LVVELHGSIWRARCVKCGSVYILDKP-----------------------------
NPD2_ARCFU -----RVLELHGSMDKLDCLDCHETYDWSEF-----------------------------
NPD1_ARCFU -----NVIHLHGSLRVVRCTSCNNSFEVESA-----------------------------
NPD_CORGL -----DVTHLHGSLFEYRCSDCATPWEDDKN-----------------------------
NPD2_COREF -----EVTHLHGSLFEFRCSICSKPWRDDGD-----------------------------
NPD2_MYCA1 -----PVHHLHGSLFEFRCARCAKPYTGELP-----------------------------
NPD_MYCPA -----PVHHLHGSLFEFRCARCAKPYTGELP-----------------------------
NPD_MYCBO -----AVHHLHGSLFEFRCARCGVPYTDALP-----------------------------
NPD_MYCTU -----AVHHLHGSLFEFRCARCGVPYTDALP-----------------------------
NPD_MYCLE -----PVHHLHGSLFKFHCARCNVAYTGALP-----------------------------
NPD_METCA -----DPIRLHGSLHHPRCSACEAPYRLPPGIP---------------------------
NPD1_PSEAE -----DVLHLHGSLHAPRCATCAAAYRDALPDS---------------------------
NPD1_PSESM -----DVLHLHGSLSKPKCFACHRPGMVRNES----------------------------
NPD4_PSESM -----DVIHLHGSLTMPKCFACHRPAELTSDQM---------------------------
NPD_PSEPK -----PVVHLHGSLMDVKCFGCHRPAELSPDQL---------------------------
NPD_RALN1 -----GVIELHGNLFANKWLDGCGKCDV--------------------------------
NPD_THET2 -----NLVELHGNLLRARCEACGKRFPL--------------------------------
NPD_THET8 -----NLVELHGNLLRARCEACGKRFPL--------------------------------
NPD_DEIRA ----GELVELHGNLLQARDELTGEVFPLA-------------------------------
SIR2A_PLAF7 -----KVISLHGNVFEAVCCTCNKIVKLNKIML---------------------------
NPD_LEPIN -----KLTEIHGNIFINRCISCGQESKE--------------------------------
NPD_LEPIC -----KLTEIHGNIFINRCISCGQESKE--------------------------------
SIR5_CANAL -----SLYEIHGSLFDLKCTSFMCNYVDHNNFKQPLTKALEDTEFEYSNLSTRKRTFGDS
NPD_HELPY -----RILHLHGELLSVRSEKD---PNLVYR-----------------------------
NPD_HELPJ -----RILHLHGELLSVRSEKD---PNLVYR-----------------------------
NPD_AGGAC -----NVLHLHGELTKARSSFD---PDYIVP-----------------------------
NPD_BACTN -----HIVHLHGELTKVCSSRDPYNPHYIKE-----------------------------
NPD_CAMJE -----DVVHLHGFLPELRCLKC----EGIFN-----------------------------
NPD_CAMJR -----DVVHLHGFLPELRCLKC----EGIFN-----------------------------
NPD_HELHP -----NVIHLHGELCKIICPQC----EHIFD-----------------------------
NPD_ECOLI -----NVIHMHGELLKVRCSQSGQVLDWTGD-----------------------------
NPD_ECO57 -----NVIHMHGELLKVRCSQSGQVLDWTGD-----------------------------
NPD_ECOL6 -----NVIHMHGELLKVRCSQSGQVLDWTGD-----------------------------
NPD_SHIFL -----NVIHMHGELLKVRCSQSGQVLDWTGD-----------------------------
NPD_SALTI -----NIIHMHGELLKVRCSQSGQILEWNGD-----------------------------
NPD_SALTY -----NIIHMHGELLKVRCSQSGQILEWNGD-----------------------------
NPD_YERPE -----RVIHMHGELLKVRCTQSGQVLDWQGD-----------------------------
NPD_YERPS -----RVIHMHGELLKVRCTQSGQVLDWQGD-----------------------------
NPD_PASMU -----NLIHMHGELLKVRCVKSGKIYDWQGD-----------------------------
NPD_VIBVU -----NIIHMHGELLKSRCSVSNQVIEETGD-----------------------------
NPD_VIBVY -----NIIHMHGELLKSRCSVSNQVIEETGD-----------------------------
NPD_VIBPA -----NVIHMHGELLKARCSESNQVIEHTED-----------------------------
NPD_VIBCH -----NIIHMHGELLKARCPESNQTVEQKED-----------------------------
NPD_SHEON -----RLLHMHGELSKGRCPRSRQTFLLREP-----------------------------
NPD_BDEBA -----NLLHMHGRLDRVFCLHCDEHFEWLLD-----------------------------
NPD_RHOBA -----NVLAMHGQLLQVRCVYSEEIFDWTGD-----------------------------
NPD_CAUVC -----RVIHMHGELAVTRCHHCEATWPDTGP-----------------------------
:** :
SIR5_HUMAN ----------KGAPEPGTQDASIPVEKLPRCEEAG--CGGLLRPHVVWFGENLD---PAI
SIR5_PONAB ----------KGAPEPGTQDASIPIEKLPRCEEAG--CGGLLRPHVVWFGENLD---PAI
SIR5_MACMU ----------KGAPEPGTQDASIPVEKLPRCEEAG--CGGLLRPHVVWFGENLD---PAI
SIR5_BOVIN ----------KGAPDPQTQDAGIPVEKLPRCEEAG--CGGLLRPHVVWFGENLD---PAI
SIR5_CANLF ----------KGAPDPEAQDARIPVEKLPRCEEAG--CGGLLRPHVVWFGENLD---PAI
SIR5_MOUSE ----------KGAPEPETQDARIPVDKLPRCEEAG--CGGLLRPHVVWFGENLD---PAI
SIR5_RAT ----------KGAPEPDTQESRIPVHKLPRCEEAG--CGGLLRPHVVWFGENLD---PAI
SIR5A_XENLA ----------KGAPESDVQDAKIPVEQLPRCEENG--CSGLLRPNVVWFGETLD---SNL
SIR5_XENTR ----------KGAPEPDVQDAKIPVEQLPRCDENG--CNGLLRPNVVWFGETLD---SNL
SIR5B_XENLA ----------KGAPESDVQDAKIPVEKLPRCEENG--CNGLLRPNVVWFGETLD---SNL
SIR5_CHICK ----------KGAPDPEIEDAAIPVEELPQCEEDG--CHGLLRPHVVWFGETLD---PDV
SIR5_DANRE ----------KGAPDPNTKEARIPVELLPRCERKS--CNGLLRPHVVWFGETLD---SDI
SIR5_DAPPU ----------KGSPSPNEVGELVPESLLPRCKVSS--CGGLLRPHVVWFHENLD---SAV
SIR5_MONDO ----------KGLPDPNAPDAQIPLENLPRWKTTGDFSVLFLLDASPLYPSNLS---CSH
SIR5_COPC7 ----------EKLVEQAVLDPEIPEENLPRCKKCG----SLARPGVVWFGEM-----PHD
SIR5_PHYPA ----------KGAPDT-VHEANIPSMQLPRCNKCN----GLLRPRVIWFGECLE---RDV
NPD_AQUAE --------------------LPEIPPKCEKCGGL-------LRPGVVWFGESLP---VDA
NPD1_CALS4 --------------------LSKIPPECPKCGSI-------VRPDVVWFGEPLP---SDK
NPD_AERPE ---------------------SNLPPSCPRCGGV-------LRPDVVWFGEPLD---TSL
NPD_METKA --------------G-EGLEYDELPPRCPECGDP-------LRPGVVWFGEPLP---SDA
NPD_PYRAB --------------RLEEVLKE-DLPKCPRCGSL-------LRPDVVWFGEPLP---REE
NPD_PYRHO --------------RIDEILSE-DLPKCPKCGSL-------LRPDVVWFGEPLP---SKE
NPD_PYRFU --------------RIGWLLSQ-ELPRCPKCGSL-------LRPDVVWFGEALP---EKE
NPD_THEKO --------------RVFEFVREKELPKCPKCGSL-------LRPDVVWFGEPLP---REA
NPD_THESM --------------KLEDFLKEKNLPKCPECASL-------LRPDVVWFGEPLP---QEA
NPD2_PYRAE --------------------VEEVPPLCRKCGGL-------LRPDVVWFGEPLP---QEA
NPD2_ARCFU ----------------VEDFNKGEIPRCRKCGSYY------VKPRVVLFGEPLP---QRT
NPD1_ARCFU -------------------PKIPPLPKCDKCGSL-------LRPGVVWFGEMLP---PDV
NPD_CORGL --------------YPQEPIARLAPPQCEKCGGL-------IRPGVVWFGENLP---VEE
NPD2_COREF --------------YPREPVERLAPPTCSLCGNP-------VRPGVVWFGEALP---QEE
NPD2_MYCA1 --------------AMAEPALEVQPPVCG-CGGL-------IRPDIVWFGEQLP---DEP
NPD_MYCPA --------------AMAEPALEVQPPVCG-CGGL-------IRPDIVWFGEQLP---DEP
NPD_MYCBO --------------EMPEPAIEVEPPVCD-CGGL-------IRPDIVWFGEPLP---EEP
NPD_MYCTU --------------EMPEPAIEVEPPVCD-CGGL-------IRPDIVWFGEPLP---EEP
NPD_MYCLE --------------DMPEPVLEVDPPVCY-CGGL-------IRPAIVWFGEPLP---DEP
NPD_METCA --------------DEPEGGRRVDPPRCARCGAP-------VRPGVVWLGENLP---QAA
NPD1_PSEAE --------------VEPEEGRRIEPPRCPACGGQ-------VRPGVVWFGEALP---EAA
NPD1_PSESM --------------AIMEEGALIEPPRCTRCNGK-------LRPGVVWYGEDLL---PDV
NPD4_PSESM --------------EIPDEGALVEPPRCKRCRGK-------LRPGVVWYGEDLP---PGT
NPD_PSEPK --------------AVPLEGQLIEPPRCTRCNGR-------LRPGVVWFRENLP---DNA
NPD_RALN1 --------------ATAEPGR---PPRCAACGAM-------LRPGVVWFGERLP---VVA
NPD_THET2 ------------------PEAFAPPPFCPACGHR-------ARPDVVWFGELLP---EGA
NPD_THET8 ------------------PEAFAPPPFCPACGHR-------ARPDVVWFGEFLP---EGA
NPD_DEIRA -----------------APDELTLPPLSPN-GQR-------MRPHIVWFGEYLP---VDA
SIR2A_PLAF7 --------------QKTSHFMHQLPPECPCGGIF--------KPNIILFGEVVS---SDL
NPD_LEPIN ---------------TISENTTPLPPQCQNCNSF-------LRPGVVWFGESYD---DFK
NPD_LEPIC ---------------TISENTTPLPPQCQNCNSF-------LRPGVVWFGESYD---DFK
SIR5_CANAL DGNDGVDISLSPQFNPVKTISEKDLPSCPVCHDL-------LRPGVVWFGESLPLNLITE
NPD_HELPY ---------------------WEKD---LNLGDLAK-DKSQLRPDIVWFGEAVP-----L
NPD_HELPJ ---------------------WEKD---LNLGDLAQ-DKAQLRPDIVWFGEEVP-----L
NPD_AGGAC ---------------------CMGD---QSVNDKDP-NGHPMRPHIVFFGESVP-----V
NPD_BACTN ---------------------LKPEEYEVKMGDKAG-DGTQLRPFIVWFGEAVP-----E
NPD_CAMJE ---------------------IGYEKFTDKQCPKCK-SK-DLRHNIVMFEEQAP-----A
NPD_CAMJR ---------------------IGYEKIIDKQCPKCK-SK-DLRHNIVMFEEQAP-----A
NPD_HELHP ---------------------IGYTHFEPHNCPNCD-YG-KLKPFIVFFYERAP-----K
NPD_ECOLI ---------------------VTPEDKCHCCQ-----FPAPLRPHVVWFGEMPL-----G
NPD_ECO57 ---------------------VTPEDKCHCCQ-----FPAPLRPHVVWFGEMPL-----G
NPD_ECOL6 ---------------------VTPEDKCHCCQ-----FPAPLRPHVVWFGEMPL-----G
NPD_SHIFL ---------------------VTPEDKCHCCQ-----FPAPLRPHVVWFGEMPL-----G
NPD_SALTI ---------------------VMPEDKCHCCQ-----FPAPLRPHVVWFGEMPL-----G
NPD_SALTY ---------------------VMPEDKCHCCQ-----FPAPLRPHVVWFGEMPL-----G
NPD_YERPE ---------------------LSADERCHCCQ-----FPSPLRPHIVWFGEMPM-----G
NPD_YERPS ---------------------LSADERCHCCQ-----FPSPLRPHIVWFGEMPM-----G
NPD_PASMU ---------------------IGEHDKCLCCT-----PTQILRPHIVWFGEMPL-----E
NPD_VIBVU ---------------------ILTGDLCHCCQ-----MPSQMRPHVVWFGEMPL-----R
NPD_VIBVY ---------------------ILTGDLCHCCQ-----MPSQMRPHVVWFGEMPL-----R
NPD_VIBPA ---------------------IKTGELCHCCQ-----IPSQMRPHIVWFGEMRL-----R
NPD_VIBCH ---------------------IRHGDLCHCCQ-----MPAQMRPHIVWFGEMPL-----R
NPD_SHEON ---------------------FGVNNGCTCCI-----PAQRLRPHVVWFGEMPL-----G
NPD_BDEBA ---------------------LAVDQPCPHCG-----RKGGVRPDIVWFGEMPH-----H
NPD_RHOBA ---------------------LSVDTPHPEAPDDDS-MRGCLRPNVVWFGEMPI-----G
NPD_CAUVC ---------------------LKPDTVCAACA-----RDGGARPHVVWFGEIPL-----F
.
SIR5_HUMAN LEEVDRELAHCD---LCLVVGTSSVVYPAAMFAPQVAARG----VPVAEFNTETTPATNR
SIR5_PONAB LEEVDRELAHCD---LCLVVGTSSVVYPAAMFAPQVAARG----VPVAEFNTETTPATNR
SIR5_MACMU LEEVDKELGRCD---LCLVVGTSSVVYPAAMFAPQVAARG----VPVAEFNTETTPATNR
SIR5_BOVIN LEEVDKELALCD---LCLVVGTSSVVYPAAMFAPQVSARG----VPVAEFNMETTPATER
SIR5_CANLF LEEVDKELTLCD---LCLVVGTSSVVYPAAMFAPQVSARG----VPVAEFNMETTPATNR
SIR5_MOUSE LEEVDRELALCD---LCLVVGTSSVVYPAAMFAPQVASRG----VPVAEFNMETTPATDR
SIR5_RAT LKEVDRELARCD---LCLVVGTSSVVYPAAMFAPQVASRG----VPVAEFNMETTPATNR
SIR5A_XENLA LGEVEKELETCD---LCVVVGTSSVVYPAAMFAPQVAARG----VPVAEFNMENTPATTS
SIR5_XENTR LGEVEKELEICD---LCVVVGTSSVVYPAAMFAPQVAARG----VPVAEFNMENTPATTS
SIR5B_XENLA LGEVEKELEMCD---LCVVVGTSSVVYPAAMFAPQVAARG----VPVAEFNMENTSATTT
SIR5_CHICK LTEVEKELDLCD---LCLVVGTSSVVYPAAMFAPQVSARG----VPVAEFNMEATPATDR
SIR5_DANRE LTAVERELEKCD---LCLVVGTSSIVYPAAMFAPQVASRG----VPVAEFNMECTPATQR
SIR5_DAPPU LKKADEELNSCD---LCLVVGTSSVVYPAAMFAPQVAERG----VPVAEFNMETTAATHH
SIR5_MONDO PVGAPALSEVAD---LGRWVGTSSLVYPAGMFGPHVALRG----IPVAEFNTVTTPVTQN
SIR5_COPC7 LPLIDTLVEKAD---LCLVVGTSSTVYPAAGYASEVSANG----GKVAVFNYERTMGDDD
SIR5_PHYPA LRRTDDALQGCD---LLLVVGTSAVVYLFWRNMMEVELHT----DFVESLLQDDRLRSRI
NPD_AQUAE LSRAYELSREAH---VFIVVGTSGVVYPAAELPFVAKENG----AQVIEVNPEETPITKI
NPD1_CALS4 LTEAMELSQRAD---LFIVIGTSLMVQPAASLPFLALERG----AFVVEVSPEETPLSRK
NPD_AERPE LEEAFGLARRSD---VMIIIGTSGAVDPAGLLPLAAKESG----ATLINVNPEPNRYSGV
NPD_METKA LVEAENLARSCD---VMLVIGTSGEVRPAADLPLVAKSCG----ATLIEINPSETALSPH
NPD_PYRAB LDRAFKLAEKAD---AVLVVGTSGLVYPAAYIPYIVKESG----GTVIEVNVEESAITPI
NPD_PYRHO LNEAFKLAKEAD---VVIVVGTSGLVYPAAYIPYIVKDSG----GVVIEINVQKSGITPI
NPD_PYRFU LTTAFSLAKKAD---VVLVVGTSGVVYPAAYIPYIVKESG----GIVVEINIEPSAITPI
NPD_THEKO LEEAFSLAERAD---VVLVVGTSGVVYPAAYVPYIVKERG----GKVIEVNVERSGITPI
NPD_THESM LQKAFKLAERAD---VCLVVGTSAQVFPAAYVPYIVKDNG----GSVIEINTKESGITPI
NPD2_PYRAE WRAAVELASVSD---VLLVVGTSGVVYPAAYIPRIAKEAG----ARVVEINVEPSAITPI
NPD2_ARCFU LFEAIEEAKHCD---AFMVVGSSLVVYPAAELPYIAKKAG----AKMIIVNAEPTMADPI
NPD1_ARCFU LDRAMREVERAD---VIIVAGTSAVVQPAASLPLIVKQRG----GAIIEINPDETPLTPI
NPD_CORGL WDIAEQRIAEAD---LMIIVGTSGIVHPAAALPQLAQQRG----VPIVEISPTRTELSRI
NPD2_COREF WAVAERRMREAD---LVVIVGTSGIVYPAASLPVLAHQRG----VPILEITPKETDLSRI
NPD2_MYCA1 WRRAVEATESAD---VVVVVGTSAIVYPAAGLAELALSRG----AAVVEVNPEVTPLSAS
NPD_MYCPA WRRAVEATESAD---VMVVVGTSAIVYPAAGLAELALSRG----AAVVEVNPEVTPLSAS
NPD_MYCBO WRSAVEATGSAD---VMVVVGTSAIVYPAAGLPDLALARG----TAVIEVNPEPTPLSGS
NPD_MYCTU WRSAVEATGSAD---VMVVVGTSAIVYPAAGLPDLALARG----TAVIEVNPEPTPLSGS
NPD_MYCLE WRRAVEATETTD---VMVVVGTSAIVYPAAGLPELALSRG----AVVIEVNPEPTPLTKN
NPD_METCA WDAARQAAEDCD---LMFSIGTSALVWPAAQLPALVARRG----ATVVQVNPAETALDGH
NPD1_PSEAE LREAFAAACECD---LLLSVGTSGVVQPAARIPGLALEHG----ASVVHVNPQPVRTRHP
NPD1_PSESM WKSALSLVKSCD---VLISVGTSGIVTPAADLPNIALACG----ATVIHVNTVDVGMGAP
NPD4_PSESM WKNAVSLVKNCD---ALISVGTSGVVTPAADLPHIALASG----ATVIHVNTVDVGAQAA
NPD_PSEPK WRSAVRLVRACD---LLVSVGTSGVVMPAAGIPDMALAVG----ATVIHVNLEDVGMDGA
NPD_RALN1 NYRAEEAANTCD---VCLVVGTSGMVYPAAGLPGLAKDHG----ARVIVVNPEPSVLDET
NPD_THET2 WERAERAFAEAD---FALVVGTSAEVEPAASLGRIAFASG----AYLVEVNPEPTPLTPL
NPD_THET8 WERAERAFAEAD---FALVVGTSAEVEPAASLGRIAFASG----AYLVEVNPEPTPLTPL
NPD_DEIRA LDAAQRAFAGAE---VALVIGTSSVVYPAAGLAAETLRRG----GAVIEINPEATDLTPD
SIR2A_PLAF7 LKEAEEEIAKCD---LLLVIGTSSTVSTATNLCHFACKKK----KKIVEINISKTYITNK
NPD_LEPIN LNLSIQRMKHTD---LLLVLGTSGSVSMPVYLAQIAKDSG----ALLIEINPERSSFSSS
NPD_LEPIC LNFSIQRMKHTD---LLLVLGTSGSVSMPVYLAQIAKDSG----ALLVEINPERSSFSSS
SIR5_CANAL IDSFVESDPSVD---LILVIGTSGTVYPANSYVERVRLKGGKVAIFNTDIEDNILNGKVE
NPD_HELPY LKEAISLVKQAH---LLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAK--------NA
NPD_HELPJ LKEAVSLVKQVH---LLIIIGTSLQVYPAASLYTHANKDALIYYIDPKAK--------NA
NPD_AGGAC LEPAIDLVSQAD---IVLVIGTSLQVYPANGLVNEAPKNAQIYLIDPNPN--------TG
NPD_BACTN IETAVRYVEKAD---IFVIIGTSLNVYPAAGLLHYVPRGAEVYLIDPKPV--------DT
NPD_CAMJE YATLYSLLHQTS---LFISIGTSGAVLPVGQYASMCEKSILNIYEKDVNL-------ERY
NPD_CAMJR YATLYSLLNQTS---LFISIGTSGAVLPVGRYASMCEKSILNIYEKDANL-------ERY
NPD_HELHP YVIMHDIFSQLSSKDCVLVIGTSGNVVDISTILAFAESRARIGYKILNNLQYCPSIAESV
NPD_ECOLI MDEIYMALSMAD---IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP----SQVGNE
NPD_ECO57 MDEIYMALSMAD---IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP----SQVGNE
NPD_ECOL6 MDEIYMALSMAD---IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP----SQVGNE
NPD_SHIFL MDEIYMALSMAD---VFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP----SQVGNE
NPD_SALTI MDEIYMALSMAD---IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP----SQVGSE
NPD_SALTY MDEIYMALSMAD---IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP----SQVGSE
NPD_YERPE MDDIYQALAEAD---FFISIGTSGHVYPAAGFVHESHLHGAHTVELNLEP----SQVESQ
NPD_YERPS MDDIYQALAEAD---FFISIGTSGHVYPAAGFVHESHLHGAHTVELNLEP----SQVESQ
NPD_PASMU MEKIQTALSECD---YFISIGTSGNVYPAAGFVREALFYGAHTVELNLEP----SQVRSS
NPD_VIBVU MGEIYSALETAD---LFISIGTSGVVYPAAGFVHDAKMHGAHTIEINLEP----SAIESE
NPD_VIBVY MGEIYSALETAD---LFISIGTSGVVYPAAGFVHDAKMHGAHTIEINLEP----SAIESE
NPD_VIBPA MGEIYAALEEAD---LFVSIGTSGVVYPAAGFVHDAKMHGAHTIEINLEP----SAVESE
NPD_VIBCH MGDIYAALEQAD---LFVSIGTSGVVYPAAGFVHDARMHGAHTIEINLEP----SAVESE
NPD_SHEON MDRIHDALDNCD---LFIAIGTSGTVYPAAGFVDTANHHGAQTVEVNLQS----PDRHSQ
NPD_BDEBA MEEIYEALDKAD---YFISIGTSGNVYPAAGFVRLA--WKAKKIEINLKD----TEISPA
NPD_RHOBA LTQIEKAATKAD---LFIAIGTSGVVYPAAGIVAQTPPHCRR-IEVNLDD----TPASSA
NPD_CAUVC MDQIEDALSAAD---LFVSIGTSGSVYPAAGFVAEARAMGIATCEINLEP----SANAYV
*:* *
SIR5_HUMAN ---------------FRFHFQGPCGTTLPEALACHENETVS--------
SIR5_PONAB ---------------FRFHFQGPCGTTLPEALARHENETVS--------
SIR5_MACMU ---------------FRFHFQGPCGTTLPEALARHENETVS--------
SIR5_BOVIN ---------------FRFHFQGPCGTTLPEALAPHETETVS--------
SIR5_CANLF ---------------FRFHFQGPCGTTLPEALAPHETGNVS--------
SIR5_MOUSE ---------------FRFHFPGPCGKTLPEALAPHETERTS--------
SIR5_RAT ---------------FRFHFPGPCGVTLPEALAPHETERIS--------
SIR5A_XENLA ---------------FTFHFHGPCGTTLPPALARHETELIS--------
SIR5_XENTR ---------------FTFHFQGPCGTTLPPAIARHETELIS--------
SIR5B_XENLA ---------------FKFHFQGPCGTTLPPALARHETELIS--------
SIR5_CHICK ---------------FRFHFEGPCGTTLPPALARHESEIIA--------
SIR5_DANRE ---------------FKYHFEGPCGSTLPPALERHESEAV---------
SIR5_DAPPU ---------------FGFHFSGPCGELLPKALAP---------------
SIR5_MONDO ---------------FRFHFSGLCGTTIPEALSPHESEKTG--------
SIR5_COPC7 ---------------ADFLFLGGCEETLPKALGLPDKPASEGAPASSL-
SIR5_PHYPA GLALREKSQYLLVAFRRFKFQGPSSVKLPTALGIGEDELAEMKET----
NPD_AQUAE ---------------ADMHFKEKASTGLKKVYDYLREKYGSKG------
NPD1_CALS4 ---------------AHLFFQMGAVEFAMK----FEEKEG---------
NPD_AERPE ---------------ADIELRMRAVEFAERLSRAMGIDI----------
NPD_METKA ---------------MDVIIRERAASAMEALWNEIERLL----------
NPD_PYRAB ---------------ADFFLRGRAGEVLPRVVHEVRRLLQ---------
NPD_PYRHO ---------------ADFFLRGKAGEILPKLVQEVRRIL----------
NPD_PYRFU ---------------ADFFLRGKAGEVLPKLVEEIRRISK---------
NPD_THEKO ---------------ADVFIRGKAGEVMPELLRRVKDIMAERNHYG---
NPD_THESM ---------------ADVFIRGKAGEVMQSLLVKVKRCLENKKC-----
NPD2_PYRAE ---------------ADVFIQGRAGEVLPRLVEEVKRRLRTRQALTP--
NPD2_ARCFU ---------------FDVKIIGKAGEVLPKIVEEVKRLRSEK-------
NPD1_ARCFU ---------------ADYSLRGKAGEVMDELVRHVRKALS---------
NPD_CORGL ---------------ADFTWMSTAAQALPALMRGLSA------------
NPD2_COREF ---------------ATYSWRATAAEGLPALVRRLGV------------
NPD2_MYCA1 ---------------ATLSIRETASQALPGLLQRLPALLN---------
NPD_MYCPA ---------------ATLSIRETASQALPGLLQRLPALLN---------
NPD_MYCBO ---------------ATISIRESASQALPGLLERLPALLK---------
NPD_MYCTU ---------------ATISIRESASQALPGLLERLPALLK---------
NPD_MYCLE ---------------ATISIRETASQALPGLLQRLPALLK---------
NPD_METCA ---------------AGYNLRGAAGKVMPLLLQALRRSRP---------
NPD1_PSEAE ---------------REHCLVGPAGEVLPELL---RRAFPG--------
NPD1_PSESM ---------------NEIMLIGRATQILSHLSAFLSRELNSP-------
NPD4_PSESM ---------------NELMLVGRATDVLAKIHESLSTGKNNDNG-----
NPD_PSEPK ---------------DEIMLEGPAGVVLPALLQATGVAALSPPGVPT--
NPD_RALN1 ---------------ADLVIHQPAGVCLPAMLA----------------
NPD_THET2 ---------------AHLSLRTGAVEGMALLLPPSPEDQAEGHLS----
NPD_THET8 ---------------AHLSLRTGAVEGMALLLPPSPEDQAEGHLS----
NPD_DEIRA ---------------ATFSLRESASRGLELLL----EDD----------
SIR2A_PLAF7 ---------------MSDYHVCAKFSELTKVANILKGSSEKNKKIM---
NPD_LEPIN ---------------VDLFLQGKTGEVLPELIREILDNPS---------
NPD_LEPIC ---------------VDLFLQGKTGEVLPELIREILDNPS---------
SIR5_CANAL ---------------DTWGFKGDAAELLPIALKPLIGDI----------
NPD_HELPY HLP---------------QNVQCINESAVHAMQDLMPKLIEMAS-----
NPD_HELPJ RLP---------------QNVQCINENAVHAMQDLMPKLIEMASQEMLK
NPD_AGGAC FNP---------------VTGW---------------------------
NPD_BACTN HTS---------------RSIHVLRKGASEGVEELKQLLIPAP------
NPD_CAMJE FDK---------------IYIEDIISAIDKIALDIENFMKDGNV-----
NPD_CAMJR FDK---------------IYIEDIINAIDKIALDIENFMKDGNV-----
NPD_HELHP FDK---------------IFYKPTTQAIAEIEQELEQFFIS--------
NPD_ECOLI FAE---------------KYYGPASQVVPEFVEKLLKGLKAGSIA----
NPD_ECO57 FAE---------------KYYGPASQVVPEFVEKLLKGL----------
NPD_ECOL6 FAE---------------KYYGPASQVVPEFVEKLLKGL----------
NPD_SHIFL FAE---------------KYYGPASQVVPEFVEKLLEGL----------
NPD_SALTI FEE---------------KHYGPASQVVPEFVDKFLKGL----------
NPD_SALTY FEE---------------KHYGPASQVVPEFVDKFLKGL----------
NPD_YERPE FDE---------------KHYGLASKVVPEYIREFLTTCGENRQGD---
NPD_YERPS FDE---------------KHYGLASKVVPEYIREFLTTCGENRQGD---
NPD_PASMU FDE---------------CHYGKATELVPHYLAQFL-------------
NPD_VIBVU FVE---------------KRYGKASVEVPKLVEELLAHLESNVESA---
NPD_VIBVY FVE---------------KRYGKASVEVPKLVEELLAHLESNVENA---
NPD_VIBPA FEE---------------KRYGKASVEVPKLVDEILA-LDTKA------
NPD_VIBCH FAE---------------KRYGKASIEVPRLVEEILAAQARAKESAA--
NPD_SHEON FQY---------------HLTGRAGELVPKLVDTILAGRVIGSDLAE--
NPD_BDEBA FDE---------------HFVGPASTEVPRFITQFLE------------
NPD_RHOBA FDE---------------TIRGAASVEIPKLLNHFSAM-----------
NPD_CAUVC FDE---------------KVYGPATEVVPAWVERLLARL----------