CLUSTAL format seed alignment for MF_01470
_____________________________________________________________________________
Features found in the protein:- The following colors are used to highlight features:
- blue indicates SIGNAL, PROPEP, TRANSMEM, DOMAIN, ZN_FING, REPEAT,
DNA_BIND and CA_BIND.
- magenta is used to display DISULFID, THIOLEST and THIOETH.
- red is used for all other features, such as INIT_MET, ACTIVE SITE,
METAL,BINDING, NP_BIND, SITE, REGION, etc.
- The ID of the sequence used as the template for feature propagation is
underlined.
- A '<' at the beginning of a sequence or '>' at the end indicate that
the protein is fused with another domain either at the N- or C-terminus.
_____________________________________________________________________________
Q3J7J6_NITOC ------------------------------------------------------------
CAS1_PECAS ------------------------------------------------------------
Q5NPQ6_ZYMMO ------------------------------------------------------------
CAS1_PSEAB ------------------------------------------------------------
E1V4T7_HALED ------------------------------------------------------------
Q6NEQ3_CORDI ------------------------------------------------------------
CAS1B_CHLTE ------------------------------------------------------------
I3Y7Y6_THIV6 ------------------------------------------------------------
CAS1A_RHORT ------------------------------------------------------------
CAS1C_METHJ ------------------------------------------------------------
CAS1_ECOLI ------------------------------------------------------------
CAS1_GEOSL ------------------------------------------------------------
CAS1B_THET8 ------------------------------------------------------------
C7QEM2_CATAD ------------------------------------------------------------
F4H8A4_CELFA ------------------------------------------------------------
CAS1_CLOSS ------------------------------------------------------------
Q03C58_LACP3 ------------------------------------------------------------
CAS1_STRTR ------------------------------------------------------------
Q73QW5_TREDE ------------------------------------------------------------
CAS1_NEIM8 ------------------------------------------------------------
A6GZS0_FLAPJ ------------------------------------------------------------
CAS1B_METHJ ------------------------------------------------------------
CAS1_THEPD ------------------------------------------------------------
CAS1_MYCTU ------------------------------------------------------------
CAS1_MYCTO ------------------------------------------------------------
CAS1A_METHJ ------------------------------------------------------------
Q8PS38_METMA ------------------------------------------------------------
CAS1B_SACS2 ------------------------------------------------------------
CAS1A_SACS2 ----------------------------------------MVHKVSQREFSRCYKRNCDC
CAS1_KORCO ------------------------------------------------------------
CAS1_HYPBU ------------------------------------------------------------
CAS1A_ARCFU ------------------------------------------------------------
CAS1B_METRM ------------------------------------------------------------
CAS1C_METRM ------------------------------------------------------------
Q7MR72_WOLSU ------------------------------------------------------------
G0GAL1_SPITZ ------------------------------------------------------------
CAS1A_PYRAE ------------------------------------------------------------
CAS1B_PYRAE ------------------------------------------------------------
CAS1A_THEYD ------------------------------------------------------------
CS4F1_LEPIN ------------------------------MGIHSLLYCERLFYLEEVEGILVADDRVYA
CS4F1_MYXXD MSVVVTRYRGGGPQYMNASSTSPKPVVGEPSIRTHALHALAYCERLFYLEEVEELRVADA
CAS1_HALVD ------------------------------------------------------------
CAS1_NANEQ ------------------------------------------------------------
CAS1B_THEYD ------------------------------------------------------------
CAS1_THEMA ------------------------------------------------------------
CAS1_FUSNN ------------------------------------------------------------
CAS1_THEKO ------------------------------------------------------------
CAS1_PYRHO ------------------------------------------------------------
D5VSN5_METIM ------------------------------------------------------------
CAS1_METJA ------------------------------------------------------------
CAS1B_ARCFU ------------------------------------------------------------
CAS1_METTH ------------------------------------------------------------
CAS1A_METRM ------------------------------------------------------------
CAS1_CLOPS ------------------------------------------------------------
CAS1C_THEYD ------------------------------------------------------------
CAS1B_MOOTA ------------------------------------------------------------
CAS1_AQUAE ------------------------------------------------------------
CAS1_METKA ------------------------------------------------------------
Q6ZEC7_SYNY3 ------------------------------------------------------------
CAS1A_THET8 ------------------------------------------------------------
CAS1C_RHORT ------------------------------------------------------------
CAS1D_METHJ ------------------------------------------------------------
CS4F1_GEOSL -------------------------MAETDGSIPLIPVRMLNEHVYCPRLAYLMWVQGEF
CS4F1_RHORT MAPSDTPPSAEDLPSQGELALFAPPATAEDALVPASMVNAWIYCPRLAVLEWGRGEKARS
CAS1C_THET8 ------------------------------------------------------------
CAS1A_MOOTA ------------------------------------------------------------
CAS1_LEPIN ------------------------------------------------------------
A6VNV5_ACTSZ ------------------------------------------------------------
CAS1B_RHORT ------------------------------------------------------------
Q0AZN9_SYNWW ------------------------------------------------------------
CAS1A_CHLTE ------------------------------------------------------------
Q3J7J6_NITOC ----------------------------MPILPSHRQ-----------------------
CAS1_PECAS ------------------MDNAFSPSDLKTILHSKRA-----------------------
Q5NPQ6_ZYMMO -------------------MKPITSGDLKTILHSKRA-----------------------
CAS1_PSEAB -------------------MDDISPSELKTILHSKRA-----------------------
E1V4T7_HALED -------------------MDDLSPSDLKTILHSKRA-----------------------
Q6NEQ3_CORDI ------------MPYSHDAIAFSTIPASHQIRLEDRL-----------------------
CAS1B_CHLTE ------MKSNTLGDEGNPARLLIKVTRETLPQVKEKY-----------------------
I3Y7Y6_THIV6 ------------------MLKGRLGLETSRMPHADRH-----------------------
CAS1A_RHORT -------------------MADPAFVPLRPIAIKDRS-----------------------
CAS1C_METHJ --------------------MTPTLPDIKPIPIKERS-----------------------
CAS1_ECOLI ----------------------MTWLPLNPIPLKDRV-----------------------
CAS1_GEOSL --------------------MQPQLPPLKPIPIKDRI-----------------------
CAS1B_THET8 -----------------MPPVSSARNLKELPKFRDGL-----------------------
C7QEM2_CATAD ---------------MAGPAQRGSSTPYQLPRIADRV-----------------------
F4H8A4_CELFA ---------------MTKIPGVRPPDLSELTRAQDRI-----------------------
CAS1_CLOSS -----------------------------MPRISDRV-----------------------
Q03C58_LACP3 -----------------MESGAKKADLTELSRVRERV-----------------------
CAS1_STRTR --------------------------------MAGWR-----------------------
Q73QW5_TREDE ---------------------------------MSWR-----------------------
CAS1_NEIM8 ---------------------------------MTWR-----------------------
A6GZS0_FLAPJ ---------------------------------MIKR-----------------------
CAS1B_METHJ ------------------------------------------------------------
CAS1_THEPD -----------------------------------MR-----------------------
CAS1_MYCTU ----------------------------------MVQ-----------------------
CAS1_MYCTO ----------------------------------MVQ-----------------------
CAS1A_METHJ ----------------------------------MNS-----------------------
Q8PS38_METMA ---------------------------MKLLLLNGHG-----------------------
CAS1B_SACS2 -------------------------------MISVRT-----------------------
CAS1A_SACS2 ICRKPKQRRNVYLNYSLELLITIFKEVIPNLPMDKKI-----------------------
CAS1_KORCO -----------------------------METTQYGH-----------------------
CAS1_HYPBU ---------------------------------MPEV-----------------------
CAS1A_ARCFU -----------------------------------MR-----------------------
CAS1B_METRM -----------------------------------MK-----------------------
CAS1C_METRM -----------------------------------MK-----------------------
Q7MR72_WOLSU ---------------------------------MTKH-----------------------
G0GAL1_SPITZ -------------------------------MAVLPH-----------------------
CAS1A_PYRAE -----------------------------------ME-----------------------
CAS1B_PYRAE -----------------------------------MQ-----------------------
CAS1A_THEYD ----------------------------------MST-----------------------
CS4F1_LEPIN GRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRI--------------QKRDGDWIP
CS4F1_MYXXD AVFAGRRLHVQLQEEGEHVELELASEALGLHGRVDAV--------------KTREGTLVV
CAS1_HALVD ---------------------------------MTKA-----------------------
CAS1_NANEQ -----------------------------------MK-----------------------
CAS1B_THEYD ----------------------------------MKK-----------------------
CAS1_THEMA -----------------------------------ME-----------------------
CAS1_FUSNN --------------------------MFCIGGVNMKR-----------------------
CAS1_THEKO ---------------------------------MRKR-----------------------
CAS1_PYRHO ---------------------------------MRKK-----------------------
D5VSN5_METIM ---------------------------------MRKK-----------------------
CAS1_METJA ---------------------------------MRKK-----------------------
CAS1B_ARCFU ---------------------------------MRKK-----------------------
CAS1_METTH ---------------------MNSAGLEQCGMIMTRK-----------------------
CAS1A_METRM ---------------------------------MSKK-----------------------
CAS1_CLOPS ----------------------------------MGR-----------------------
CAS1C_THEYD -----------------------------------MR-----------------------
CAS1B_MOOTA -----------------------------------MR-----------------------
CAS1_AQUAE ----------------------------------MGR-----------------------
CAS1_METKA -------------------------------MGAPND-----------------------
Q6ZEC7_SYNY3 ----------------------------------MTS-----------------------
CAS1A_THET8 -----------------------------------MT-----------------------
CAS1C_RHORT ------------------MVGSGGTGAPPPRSSPMTT-----------------------
CAS1D_METHJ -------MNIENEVHIENASESKREPKPPEGLLEDDT-----------------------
CS4F1_GEOSL SHNEFTVDGVIRHRRVDAGGGVLPSETQEDSRIHARSVSLSSERLGITAKIDLVEGEGAY
CS4F1_RHORT VDLIAGLRAHQATESGPTPALPDPMVLREDQSLKTRRLSLSSERLGLTAELDLLDVEEGM
CAS1C_THET8 ---------------------------MAEGGGGVGV-----------------------
CAS1A_MOOTA ------------------------------MHILLNT-----------------------
CAS1_LEPIN ------------------------------------------------------------
A6VNV5_ACTSZ ------------------------------MRKLQNT-----------------------
CAS1B_RHORT ------------------------------MKKLLNT-----------------------
Q0AZN9_SYNWW ------------------------------MRRLLNT-----------------------
CAS1A_CHLTE ------------------------------MKKHLNT-----------------------
Q3J7J6_NITOC ------------------------------------------------------------
CAS1_PECAS ------------------------------------------------------------
Q5NPQ6_ZYMMO ------------------------------------------------------------
CAS1_PSEAB ------------------------------------------------------------
E1V4T7_HALED ------------------------------------------------------------
Q6NEQ3_CORDI ------------------------------------------------------------
CAS1B_CHLTE ------------------------------------------------------------
I3Y7Y6_THIV6 ------------------------------------------------------------
CAS1A_RHORT ------------------------------------------------------------
CAS1C_METHJ ------------------------------------------------------------
CAS1_ECOLI ------------------------------------------------------------
CAS1_GEOSL ------------------------------------------------------------
CAS1B_THET8 ------------------------------------------------------------
C7QEM2_CATAD ------------------------------------------------------------
F4H8A4_CELFA ------------------------------------------------------------
CAS1_CLOSS ------------------------------------------------------------
Q03C58_LACP3 ------------------------------------------------------------
CAS1_STRTR ------------------------------------------------------------
Q73QW5_TREDE ------------------------------------------------------------
CAS1_NEIM8 ------------------------------------------------------------
A6GZS0_FLAPJ ------------------------------------------------------------
CAS1B_METHJ ------------------------------------------------------------
CAS1_THEPD ------------------------------------------------------------
CAS1_MYCTU ------------------------------------------------------------
CAS1_MYCTO ------------------------------------------------------------
CAS1A_METHJ ------------------------------------------------------------
Q8PS38_METMA ------------------------------------------------------------
CAS1B_SACS2 ------------------------------------------------------------
CAS1A_SACS2 ------------------------------------------------------------
CAS1_KORCO ------------------------------------------------------------
CAS1_HYPBU ------------------------------------------------------------
CAS1A_ARCFU ------------------------------------------------------------
CAS1B_METRM ------------------------------------------------------------
CAS1C_METRM ------------------------------------------------------------
Q7MR72_WOLSU ------------------------------------------------------------
G0GAL1_SPITZ ------------------------------------------------------------
CAS1A_PYRAE ------------------------------------------------------------
CAS1B_PYRAE ------------------------------------------------------------
CAS1A_THEYD ------------------------------------------------------------
CS4F1_LEPIN YEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDE
CS4F1_MYXXD YEHKRGRHAPGGDAPEAWPSDRLQAGAYALLVEERFPGAPVECRVRYHQTDTTVRFPLDA
CAS1_HALVD ------------------------------------------------------------
CAS1_NANEQ ------------------------------------------------------------
CAS1B_THEYD ------------------------------------------------------------
CAS1_THEMA ------------------------------------------------------------
CAS1_FUSNN ------------------------------------------------------------
CAS1_THEKO ------------------------------------------------------------
CAS1_PYRHO ------------------------------------------------------------
D5VSN5_METIM ------------------------------------------------------------
CAS1_METJA ------------------------------------------------------------
CAS1B_ARCFU ------------------------------------------------------------
CAS1_METTH ------------------------------------------------------------
CAS1A_METRM ------------------------------------------------------------
CAS1_CLOPS ------------------------------------------------------------
CAS1C_THEYD ------------------------------------------------------------
CAS1B_MOOTA ------------------------------------------------------------
CAS1_AQUAE ------------------------------------------------------------
CAS1_METKA ------------------------------------------------------------
Q6ZEC7_SYNY3 ------------------------------------------------------------
CAS1A_THET8 ------------------------------------------------------------
CAS1C_RHORT ------------------------------------------------------------
CAS1D_METHJ ------------------------------------------------------------
CS4F1_GEOSL VSPVDYKRGKRPHVAGGAYEPERVQLCAQGLLLREHGFASDGGALYFVASRERVPVAFDD
CS4F1_RHORT VIPVEIKVGKRPSVDEGAYLPERAQVCAQALLLREAGYTCLEGALWFAESRERVTVDLTE
CAS1C_THET8 ------------------------------------------------------------
CAS1A_MOOTA ------------------------------------------------------------
CAS1_LEPIN ------------------------------------------------------------
A6VNV5_ACTSZ ------------------------------------------------------------
CAS1B_RHORT ------------------------------------------------------------
Q0AZN9_SYNWW ------------------------------------------------------------
CAS1A_CHLTE ------------------------------------------------------------
Q3J7J6_NITOC ------------------------------------------------------------
CAS1_PECAS ------------------------------------------------------------
Q5NPQ6_ZYMMO ------------------------------------------------------------
CAS1_PSEAB ------------------------------------------------------------
E1V4T7_HALED ------------------------------------------------------------
Q6NEQ3_CORDI ------------------------------------------------------------
CAS1B_CHLTE ------------------------------------------------------------
I3Y7Y6_THIV6 ------------------------------------------------------------
CAS1A_RHORT ------------------------------------------------------------
CAS1C_METHJ ------------------------------------------------------------
CAS1_ECOLI ------------------------------------------------------------
CAS1_GEOSL ------------------------------------------------------------
CAS1B_THET8 ------------------------------------------------------------
C7QEM2_CATAD ------------------------------------------------------------
F4H8A4_CELFA ------------------------------------------------------------
CAS1_CLOSS ------------------------------------------------------------
Q03C58_LACP3 ------------------------------------------------------------
CAS1_STRTR ------------------------------------------------------------
Q73QW5_TREDE ------------------------------------------------------------
CAS1_NEIM8 ------------------------------------------------------------
A6GZS0_FLAPJ ------------------------------------------------------------
CAS1B_METHJ ------------------------------------------------------------
CAS1_THEPD ------------------------------------------------------------
CAS1_MYCTU ------------------------------------------------------------
CAS1_MYCTO ------------------------------------------------------------
CAS1A_METHJ ------------------------------------------------------------
Q8PS38_METMA ------------------------------------------------------------
CAS1B_SACS2 ------------------------------------------------------------
CAS1A_SACS2 ------------------------------------------------------------
CAS1_KORCO ------------------------------------------------------------
CAS1_HYPBU ------------------------------------------------------------
CAS1A_ARCFU ------------------------------------------------------------
CAS1B_METRM ------------------------------------------------------------
CAS1C_METRM ------------------------------------------------------------
Q7MR72_WOLSU ------------------------------------------------------------
G0GAL1_SPITZ ------------------------------------------------------------
CAS1A_PYRAE ------------------------------------------------------------
CAS1B_PYRAE ------------------------------------------------------------
CAS1A_THEYD ------------------------------------------------------------
CS4F1_LEPIN ELRSKALKTIDRAKGLSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLF
CS4F1_MYXXD ALRGAVVAAVARARLLRASRERPPVTQEERKCAKCSLAPVCLPEEERQVVGEERPRLFPE
CAS1_HALVD ------------------------------------------------------------
CAS1_NANEQ ------------------------------------------------------------
CAS1B_THEYD ------------------------------------------------------------
CAS1_THEMA ------------------------------------------------------------
CAS1_FUSNN ------------------------------------------------------------
CAS1_THEKO ------------------------------------------------------------
CAS1_PYRHO ------------------------------------------------------------
D5VSN5_METIM ------------------------------------------------------------
CAS1_METJA ------------------------------------------------------------
CAS1B_ARCFU ------------------------------------------------------------
CAS1_METTH ------------------------------------------------------------
CAS1A_METRM ------------------------------------------------------------
CAS1_CLOPS ------------------------------------------------------------
CAS1C_THEYD ------------------------------------------------------------
CAS1B_MOOTA ------------------------------------------------------------
CAS1_AQUAE ------------------------------------------------------------
CAS1_METKA ------------------------------------------------------------
Q6ZEC7_SYNY3 ------------------------------------------------------------
CAS1A_THET8 ------------------------------------------------------------
CAS1C_RHORT ------------------------------------------------------------
CAS1D_METHJ ------------------------------------------------------------
CS4F1_GEOSL ELIGRTLAAIDEMGRTALSGTMPPPLEDSPKCPRCSLVGICLPDEVRFLSHLSVEPRPII
CS4F1_RHORT ALVTATLVATSDLRLTVASGRLPPPLDHSAKCPRCSLLPICLPDEIAWFRKGSIARTPPP
CAS1C_THET8 ------------------------------------------------------------
CAS1A_MOOTA ------------------------------------------------------------
CAS1_LEPIN ------------------------------------------------------------
A6VNV5_ACTSZ ------------------------------------------------------------
CAS1B_RHORT ------------------------------------------------------------
Q0AZN9_SYNWW ------------------------------------------------------------
CAS1A_CHLTE ------------------------------------------------------------
Q3J7J6_NITOC --------GLYYLEHCRVMAKDERVVY--ACQEG--------------AFTKFFAIPPAN
CAS1_PECAS --------NVYYLQHCRILVNGGRVEY--VTEEG-----------NQSLYWNI---PIAN
Q5NPQ6_ZYMMO --------NIYYLEHCRVLVNGGRVEY--ITDRG-----------NKSLYWNI---PIAN
CAS1_PSEAB --------NLYYLQHCRVLVNGGRVEY--VTDEG-----------RHSHYWNI---PIAN
E1V4T7_HALED --------NLYYLQHCRVLVNGGRVEY--VTDEG-----------KQSRYWNI---PIAN
Q6NEQ3_CORDI --------SFLYLEYCLIRQDRTGVIA--IQNGHNESSDEEEKLEPQILRIQL---PVAS
CAS1B_CHLTE --------PFLYLEKGRIEIDDSSIKW--IDCDC--------------NVVRL---PVAM
I3Y7Y6_THIV6 --------GLIWFERGELCVIDGCLHF--FQGKD----------SLTPYSVQI---PHQT
CAS1A_RHORT --------SIVFLQRGQLDVVDGAFVL--IDQEG--------------VRVQI---PVGG
CAS1C_METHJ --------SVVFLGRGELDVIDGAFVL--VDTNG--------------IRMQI---PVGG
CAS1_ECOLI --------SMIFLQYGQIDVIDGAFVL--IDKTG--------------IRTHI---PVGS
CAS1_GEOSL --------SVLYVERGNLDVLDGAFVV--VDKTG--------------VRTHL---PVGG
CAS1B_THET8 --------SYLYVEHAVVEREAGGIGI--YDQEG---------------LTLA---PVAG
C7QEM2_CATAD --------SFVYLERCTVHRDANAITA--QDADG---------------ITHI---PSAT
F4H8A4_CELFA --------TFLYLERSVIHRDSNAITA--TDERG---------------TVHI---PAAS
CAS1_CLOSS --------TYIYVEHSKINRVDGSITV--AESRG---------------IVRI---PASM
Q03C58_LACP3 --------TFLYLEHAKINRQDSAIVV--IDTGG---------------TVAI---PAAL
CAS1_STRTR --------TVVVNIHSKLSYKNNHLIF--RNSYK---------------TEMI---HLSE
Q73QW5_TREDE --------TVVISNRAKLDLHLNHLVV--RGEKT----------------QKV---FIEE
CAS1_NEIM8 --------SLLIQNGGKLSLQRRQLLI--QQNGE---------------SHTV---PLED
A6GZS0_FLAPJ --------TLFFGNPAYLSTKNEQIVI--SYPNK------------EQETKTV---AIED
CAS1B_METHJ ----------MGGFGAHIKSNRTEITI--QHKGK---------------ITDI---PIKD
CAS1_THEPD --------LLVLRGVDEVTVSSRSTVV--IKSGN--------------RVFER---ALRD
CAS1_MYCTU --------LYVSDSVSRISFADGRVIV--WSEEL--------------GESQY---PIET
CAS1_MYCTO --------LYVSDSVSRISFADGRVIV--WSEEL--------------GESQY---PIET
CAS1A_METHJ --------VLITGAGYRIRKRGDVLTI--ETGKD---------SDTAEPPRTL---SPLG
Q8PS38_METMA --------INMHVDGAKLHIKDGRFST--TEEPQ----------------EYVFSPKRID
CAS1B_SACS2 --------LVISEYGAYVYVKKNMLVI--KKGDK---------------KVEI---SPSE
CAS1A_SACS2 --------AFVKDYGAYLKVEKGLITC--KIKNQ--------------VKWSI---APTE
CAS1_KORCO --------LLIDGFGVSLRKRRGRILI--LSKGE---------------KKEI---PMKS
CAS1_HYPBU --------LLVATPGTRIYVRRGVVYA--EAPSG---------------EKAV---VTAD
CAS1A_ARCFU --------LVVDGFGKYLGIENGLIVV--KEKGK--------------ALRKV---RPED
CAS1B_METRM --------LVVDGFGKSVAKRDNQIVI--KENGK--------------EINYY---LAKD
CAS1C_METRM --------ILIEGYNKSIHKRDNQILIMEKEG----------------ELEKI---NIKK
Q7MR72_WOLSU --------LYIDEYGSFVGKTSERLTV--SQGGE--------------LKAEI---PLSR
G0GAL1_SPITZ --------LIVDEYGAFIGKHSERLVV--TKDKE--------------RLAQV---PLIH
CAS1A_PYRAE --------VVVKDWGVSLGYSRGALVI--KKRGG---------------VDRI---PLFQ
CAS1B_PYRAE --------IVVASYGARIRAKKGLLIV--EGREG---------------RREY---PLHQ
CAS1A_THEYD --------VFIDRKDIEIRVDGNSISF--YAKGK--------------KDGSL---PLSP
CS4F1_LEPIN PEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETG-----------EKSKSEKI---PIQE
CS4F1_MYXXD DDVRQV--LHVATPGTRVGRAAEELVV--TPPEG------------EGAPSRQ---PGRM
CAS1_HALVD --------NHHIFADGELSRKEGTLRI--DTLEG--------------ETKYL---PVES
CAS1_NANEQ --------TIYILSIGKLYRGKNGLYF--INKDK--------------KKSPI---PLES
CAS1B_THEYD --------SLYIISDGELKRKDNTLYF--ETSEE---------------RKYI---PVEN
CAS1_THEMA --------SVYLFSSGTLKRKANTICL--ETESG---------------RKYI---PVEN
CAS1_FUSNN --------SFFLYSNGTLKRKDNTITF--INEKD--------------EKRDI---PIEM
CAS1_THEKO --------SLTLFSDGNLFRRENTLYF--ENAQG---------------RKPL---AVEG
CAS1_PYRHO --------PLTIFSDGTLTRRENTLYF--ESAKG---------------RKPL---AIEG
D5VSN5_METIM --------SLTLLTDGTLFRKENTIYF--ENKYG---------------KKPL---AIEG
CAS1_METJA --------SLTLLSDGYLFRKENTIYF--ENARG---------------KKPL---AIEG
CAS1B_ARCFU --------NYYLVSDGKLRRHENTIYF--ENEDG---------------KRPI---PINS
CAS1_METTH --------NYYITTDGLLKRNENTLYF--INKDL---------------KRPI---PINK
CAS1A_METRM --------NYYLLSEGILKRKENTIYF--VNEKG---------------SKPL---PINK
CAS1_CLOPS --------DYYIFSNGRIKRKENTIYF--EDFEG--------------NKKGL---PIED
CAS1C_THEYD --------NYYIFSNGRIRRKENTIYI--ENEQG--------------DRKAI---PIED
CAS1B_MOOTA --------TYYIFSSGRLRRMDNTLAL--ELETE---------------RRVV---PVED
CAS1_AQUAE --------VYYINSHGTLSRHENTLRF--ENAEV---------------KKDI---PVED
CAS1_METKA --------TVIFLRRGKIERREDAFRI---------------------GKSKY---SAVR
Q6ZEC7_SYNY3 --------IYLTEPGTKVSYHNQQLQI--KQKSR---------------QVIT---RLAE
CAS1A_THET8 --------LHLTRQGATLRLRQGRLLL--EEEGR--------------EVAGF---PARQ
CAS1C_RHORT --------LYVTQPGSVVRSEGGSLTV--WVETEADDPGPNDSPVRRKRLASV---EPHR
CAS1D_METHJ --------IYITTPYGKISLDGGRIQV--KDSDG-------------EIVASF---PLEK
CS4F1_GEOSL PADGRGLPLYVQSPKAYVRKDGDCLVI--EEERV--------------RVAEA---RLGE
CS4F1_RHORT PASPALP-LYGQTPGARIGKKDYTLVI--QVEGE--------------ADRSL---ALDE
CAS1C_THET8 --------VYVLENEAYLSKEGGTLKV--SRRAG------------REVLLQK---PLIA
CAS1A_MOOTA --------LYLMTPRTLVRLDHETVKI--EVEGE--------------LKMQI---PLHH
CAS1_LEPIN ------------------------------------------------------------
A6VNV5_ACTSZ --------LYITTQGSYLHKERETLVV--EQDRK--------------KVAQL---PVHS
CAS1B_RHORT --------VYVTTEGTGLRKDGENLVA--ELDGV--------------QKGRV---PLHM
Q0AZN9_SYNWW --------LYVTTPDSYLAREGENILI--RLEEK--------------IVFRI---PSHN
CAS1A_CHLTE --------LFVTTQGSYLSKEGECVLI--SIDRV--------------EKTRI---PLHM
Q3J7J6_NITOC TNVILLGSGT-SLTQAAARLLASEQVMVAFVGGG-----GSPLFL-----------ASQN
CAS1_PECAS TSVVMLGTGT-SVTQAAMREFARAGVMIGFCGGG-----GTPLFAANEAEVAVSWLSPQS
Q5NPQ6_ZYMMO TTTILLGTGT-SITQAAMRELGKAGVLVGFCGGG-----GTPLFSANEQETDVLWFSPQS
CAS1_PSEAB TTSLLLGTGT-SITQAAMRELARAGVLVGFCGGG-----GTPLFSANEVDVEVSWLTPQS
E1V4T7_HALED TTSLLLGTGT-SITQAAMRELAKAGVLVGFCGGG-----GTPLFAANEVDVDVAWLTPQS
Q6NEQ3_CORDI LAVLCLGPGT-SISNAAMTSCTRSGCTVIFTGGG-----GVNAYS-----------HATP
CAS1B_CHLTE LNCILLGPGT-TVTHEAVKVMAAANCGICWVGDD-----SLMFYA-----------SGQT
I3Y7Y6_THIV6 VSMILLGPGS-TVTHDALRLLARHGTLMAAVGED-----GVRCYT-----------APPL
CAS1A_RHORT LACLMLEPGT-RITHAAIVLCARVGCLVIWVGER-----GTRLYA-----------AGQP
CAS1C_METHJ LASLMLEPGS-RVSHAAVSLASKVGCLLVFVGEG-----GVRLYS-----------VGHP
CAS1_ECOLI VACIMLEPGT-RVSHAAVRLAAQVGTLLVWVGEA-----GVRVYA-----------SGQP
CAS1_GEOSL VACLMLEPGT-RVSHAAVTLASRIGCLLVWIGEA-----GVRLYA-----------SGQP
CAS1B_THET8 LGVLFLGPGT-RITHAAVRLLAENGCTVAWVGEG-----MARFYA-----------QGLG
C7QEM2_CATAD IGTLLLGPGT-RITHQAMAVLGDCGANVAWVGEH-----GARFYA-----------AARS
F4H8A4_CELFA LGALLLGPGT-TASHAAMTLLAESGSTAVWVGER-----GVRYYA-----------HGRS
CAS1_CLOSS IGILLLGPGT-DISHRAMELLGDSGTSVAWVGEQ-----GVRNYA-----------HGRS
Q03C58_LACP3 ISVLMLGPGV-DVTHRAMELMGDAGMSVVWVGER-----GVRQYA-----------PGRA
CAS1_STRTR IDILLLETTDIVLTTMLVKRLVDENILVIFCDDK-----RLPTAF----------LTPYY
Q73QW5_TREDE ISVLIIETTAVSITAALLNELIKQKVKVIFCDEK-----RNPASE----------LIGYY
CAS1_NEIM8 IAVIIIENRETLITAPLLSALAEHGATLLTCDEQ-----FLPCGQ----------WLPYA
A6GZS0_FLAPJ IGVIVLENQQITITNGLLEKLTNNNVALINCDQQ-----HLPIGL----------LMPL-
CAS1B_METHJ LSHFLLIGGH-TIQTSTITSLVKEGVFISFCESD-----GEPVGY----------ISPYD
CAS1_THEPD VDAVLVVGSGIKISSSLPPVLALHGIPLSILAKG-------HVAV----------LLNPV
CAS1_MYCTU LDGITLFGRP-TMTTPFIVEMLKRERDIQLFTTD-----GHYQGR-----------ISTP
CAS1_MYCTO LDGITLFGRP-TMTTPFIVEMLKRERDIQLFTTD-----GHYQGR-----------ISTP
CAS1A_METHJ LDLLAIAGDH-SISTAAVRLVTSHGGAIALMDGL-----GNPFGH----------FLP--
Q8PS38_METMA IDGIIIYGKSGNLTLEAIRWLIKHNVQVSILDWN-----GKLLTT-----------MLPP
CAS1B_SACS2 VDEILITVSC-SISTSALSLALTHGISVMFLNSR-----ETPWGI----------LLPSI
CAS1A_SACS2 LHSIVVLTNS-SISSEVVKVANEYGIEIVFFNKH------EPYAK----------LIPAK
CAS1_KORCO VKEVVIIGKA-ALSSELLKALAQSGTDLLIATPT-----GRPVAR----------LIPAK
CAS1_HYPBU TELVVLATGSVSVSGRALRRLAELGVRLVVLGQR-----GQVVAE----------HRPVD
CAS1A_ARCFU LKQVLIIGKA-AISSDAIKLLLKNRVDVVFLDFN-----GEILGR-----------LSHP
CAS1B_METRM ISQILLTGKG-SITFDALTLLAENDVDCVSINWK-----GHVDYR-----------LSAP
CAS1C_METRM IDDITIIGKG-SITFDALRLISENNVRLMSIDYF-----GKINYT-----------LEYP
Q7MR72_WOLSU LKSVNILKGGISLSSDIIEACSLRGIKIFFLDFR-----NVAHTA-----------ITST
G0GAL1_SPITZ LEAVLITGNGVGISSDAVHACTERGIPIHFLTRN-----GTPYAS----------LYSAG
CAS1A_PYRAE VDRIWILTGGVSISSRLVRALSHHFIDVVFFDAK-----GNPVAR----------LFPPE
CAS1B_PYRAE VDEVLLLTGGISISTRALRALLRAGAVVAVFDQR-----GEPLGI----------FMKPV
CAS1A_THEYD LKRVVIVGNV-KIETSVLYKLVNHGITVLFLTGK-----LKYSGI-----------LNGP
CS4F1_LEPIN IESVNIHGNC-QISSQMIKFLVSEEIPVHWFSGG-----GNYIGG------------INI
CS4F1_MYXXD VSALIAHGAV-QVSAQALAYCVENDIGVHWFTSG-----GRYLGG------------LGG
CAS1_HALVD IDALYLHGQI-SFNTRALGLLNKHGVPVHIFGWK-----DYYRGS----------YLPKR
CAS1_NANEQ IKEIFILNKV-SVTYNALKLLADRNIPIHFFYENTKKGISYYLGS----------FLPRQ
CAS1B_THEYD TREILIFGEV-SMNKRLLEFLTESEIIIHFFNYY-----GYYIGS----------FYPRE
CAS1_THEMA VMDIKVFGEV-DLNKRFLEFLSQKRIPIHFFNRE-----GYYVGT----------FYPRE
CAS1_FUSNN VDDFYVMSEM-NFNTKFINYISQFGIPIHFFNYY-----TFYTGS----------FYPRE
CAS1_THEKO IYDIYVYGHV-NISSQALHFLAQKGIPVHFFNHY-----GHYDGS----------FYPRE
CAS1_PYRHO IYDIYIYGHV-NITSQALHYIAQKGILIHFFNHY-----GYYDGT----------FYPRE
D5VSN5_METIM IYDIYIYGNV-NISSQALHYLAQKGIVVHFFNHY-----GYYDGT----------FYPRE
CAS1_METJA IYDIYIYGKV-SISSQALHYLAQKGIALHFFNHY-----GYYDGS----------FYPRE
CAS1B_ARCFU IYAIYALGSL-SITSKAISLLAKEGVCIHFFNRY-----GYYIGS----------FYPRE
CAS1_METTH IYSIYSYGAL-TISSQALNLLSKEGIPIHFFNRY-----GFYSGS----------FYPRE
CAS1A_METRM IYSMYAYGQI-TISSQVISLFAKEGIPIHFFNYY-----GYYNGS----------FYPRE
CAS1_CLOPS IERLHIFGEV-DLNTKFLNYISRYSVLISIYNYY-----GFYSGS----------YYSKK
CAS1C_THEYD VDTIHIFGEV-DLNTKLLNFICQQGKTVHFYNYY-----GFYSGS----------LMPRE
CAS1B_MOOTA IDHIYCFSEL-DLNTRLLDFLAQKQICLHFFNYY-----GHYSGS----------FIPRE
CAS1_AQUAE VEEIFVFAEL-SLNTKLLNFLASKGIPLHFFNYY-----GYYTGT----------FYPRE
CAS1_METKA TTGIIIAGGA-QITTQAVRLALRNEVPIVYL-GG-----NRILGV----------TVPFS
Q6ZEC7_SYNY3 IDLLVLFPGV-QLTDVAIAVLMDQGIETIFLRRD-----GQFRGR-----------LQGQ
CAS1A_THET8 VRSVALWGNV-RLSTPALVFLLRQGVPVFFYSLE-----GFLHGV----------AGAYP
CAS1C_RHORT LESLVLLGFT-TITANAMRLCMANKIAVSLLDGG-----GGLAAR-----------VVPP
CAS1D_METHJ VCTMNVFGSA-SVSTPLLKHCSDKEVVINYFTNF-----GKYFGS----------FVP--
CS4F1_GEOSL TSQVALFGNA-TLTTAALHECLRREIPVTWLSYG-----GWFMGH-----------TVST
CS4F1_RHORT ISEVVLAGPV-SLTTPAIHELLRREIPVAWMSSG-----FWFLGS-----------TGGQ
CAS1C_THET8 VEEIVILGNA-VVTPALLKHCAQEGVGIHYLSPT-----GTYYAG-----------LTRT
CAS1A_MOOTA LGSIVCFGDV-TLTTPLIMRCAEDKRLIVFHDQH-----GRFKAR-----------VEGP
CAS1_LEPIN ------------------------------------------------------------
A6VNV5_ACTSZ IGHIFCFGNV-LVSPFLMGFCGENNVNLAFFTEN-----GRFLGR-----------LQGR
CAS1B_RHORT VGSVVVFGGT-YVSPGLMGACAAHGITIVLLDRV-----GRFQAR-----------VEGP
Q0AZN9_SYNWW IEAIVYFGYP-GASPSLLGLCAEKGITVSFFSPN-----GRFLAR-----------VEGP
CAS1A_CHLTE LNGIVCFGQV-SCSPFLLGHCAQLGVAVTFLTEH-----GRFLCQ-----------MQGP
Q3J7J6_NITOC EYRPTEYCQAWMRLWQDNDQRLKVAKTFQRNRAEFLMQQWPKLAEPKP------------
CAS1_PECAS EYRPTEYLQDWVSFWFDDEKRLAAAIAFQQVRITQIRQHWLGSRLSRESRFTF-------
Q5NPQ6_ZYMMO EYRPTEYVQAWVKFWFDDEKRLRAAKALQLARSSRIKEQWLKPSLGKDGFLP--------
CAS1_PSEAB EYRPTEYLQRWVGFWFDEEKRLVAARHFQRARLERIRHSWLEDRVLRDAGFAV-------
E1V4T7_HALED EYRPTEYLQYWVRFWFDDEKRLDAARCFQLARLDRIEHLWGESRFQRDTGFTP-------
Q6NEQ3_CORDI LTSTAKWAIAQACLVSNTEYQKKAALAFYKRQFGGNA-----------------------
CAS1B_CHLTE PTSNTRNMTHQMKLAANPAKALEVARRLFAYRFPDAN-----------------------
I3Y7Y6_THIV6 MPDRSDIARRQAELWGSPRRRISVARQMYALRLGEVL-----------------------
CAS1A_RHORT GGARADRLLFQARNALDETARLNVVREMYRRRFDDDP-----------------------
CAS1C_METHJ GGARSDRLLYQARLALDEVLRLKVVKKMFSLRFGEDF-----------------------
CAS1_ECOLI GGARSDKLLYQAKLALDEDLRLKVVRKMFELRFGEPA-----------------------
CAS1_GEOSL GGARADRLLYQAKLALDDSARLKVVRKMYALRFREEP-----------------------
CAS1B_THET8 DTRSAARFYRQARAWADPALHLEVVMRLYRMRFSEPL-----------------------
C7QEM2_CATAD LNRSSALVEAQATLWANRRTRLDIARAMYRMRF---------------------------
F4H8A4_CELFA LARSSRLLLAQAELVTNQSSRLRVARQMYAMRF---------------------------
CAS1_CLOSS LSHTSRFLELQAKLVSNTRSRLQVARKMYQMRF---------------------------
Q03C58_LACP3 LTHSSALLVAQAKLVSNNRLRVGVARQMYQMRF---------------------------
CAS1_STRTR ARHDSSLQIARQIAWKENVKC-EVWTAIIAQKILNQSYYLGECSFFE-------------
Q73QW5_TREDE GSHDTSEKIRLQIKWDKNIKQL-VWTEVVTEKIRQQKYLLEKLNLPQASL----------
CAS1_NEIM8 QYHR-QLKILKLQLNISEPLKKQLWQHIVRQKILNQAFVADETGNDL-------------
A6GZS0_FLAPJ NGHTEQSERFKNQINASVPLKKNLWQQTISAKIMNQAGLLKEKGIPCRK-----------
CAS1B_METHJ YSLFKEIQNLQ-KTAAPYSYALACANESIKSRILAIEKYAEEIGPEI-------------
CAS1_THEPD GTKYNNYRALQY--TLPKNKALAIALEYLKSRVRGMASIIRNRGGRLPAL----------
CAS1_MYCTU DVSYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQD------------
CAS1_MYCTO DVSYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQD------------
CAS1A_METHJ LGRSALIEQYEAQASAPEERRLEIARSICTGALENKRTLLSNLERIRGFD----------
Q8PS38_METMA ESTNLRTKFAQYHAFEDKEARLEIAKKFIEAKFYKSKAVLDFLSQR--------------
CAS1B_SACS2 VTETVKTKKAQYEAIVV-RKDNRYGEEIISSKIYNQSVHLKYWAR---------------
CAS1A_SACS2 YAGSFKVWLKQLTAW--KRRKVEFAKAFIYGKVHNQWVTLRYYERKYGYNL---------
CAS1_KORCO AGGTARNRYEQYKSLED-RRGIEIARAVIVGKIRNQASNLSYYSKARRMDEELSSE----
CAS1_HYPBU RVNRTIEARMEQYRVKATGEALYYAAEMVYAKIVNQAKLLRYLAKSRREPWLRDAGYR--
CAS1A_ARCFU LIGTAKTRREQYLAYGD-KRGVHLAKEFIKAKMANQMAILTNLAKARKDSNPEVAESLLK
CAS1B_METRM DRKNAIVKKEQYFALTDSRSG-YLAKAFVRAKIENQKAVLGTLAKSREEKDYIIE-----
CAS1C_METRM SNENIFLRKQQYKTSEN-HKGLIIAREMIMSKMINQKSTIKTLNKNKKLENVKI---FER
Q7MR72_WOLSU ANHAVANVRKAQFLTIESNHGREIARTLIVGKLKNQRATLQYFYKYLKNTDKQSKK----
G0GAL1_SPITZ LTGTVATRRAQLLAYHN-GLGLALVVKIASGKLTNQAAFLKYLAKYRKETDPPTHEALTH
CAS1A_PYRAE ANGTVTHRRAQYEAYLT-GRGFELAKLVTYGKLINQARALRRLGQWKREHYGA-------
CAS1B_PYRAE GDATGAKRLCQYAAATD-GRGLQLAKKWVWLKIRGQLENLKRWRRRLGK-----------
CAS1A_THEYD LHNNGLLRVKQYQKSLS-GFSLKFAKELIKRKIVSQRDFLSEIREIKKALAMQ-------
CS4F1_LEPIN NPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNE-------
CS4F1_MYXXD GAGNVHRRLRQFEALRQASVCLGLARRLVAAKLEGQLRFLLRASRGDSESRQV-------
CAS1_HALVD SQLSGNTVVEQVRAYDNTERRLRIGHRIIEASIHNMRANLQYYSGRRG------------
CAS1_NANEQ KTKSGLVLVKQVEAYKDIEKRTEIALEIVDAIRYNCIKVLEKYHIDEVK-----------
CAS1B_THEYD HLNSGYMILKQAEHYLDTGKRLNLAEKFVSGAIENIKKVLIYYHNRGKE-----------
CAS1_THEMA YLNSGFLILKQAEHYINQEKRMLIAREIVSRSFQNMVDFLKKRKV---------------
CAS1_FUSNN MNISGQLLVKQVEHYTNEQKRVEIAREFIEGASFNIYRNLRYYNGRGKD-----------
CAS1_THEKO SLLSGDLIIKQAKHYLDQEKRLILAKLFVRGSALNMEKNLKRWK----------------
CAS1_PYRHO TLLSGDLIIRQAEHYLNKEKRLFLAKSFVTGGTKNMERNLKNWGIKAK------------
D5VSN5_METIM KLISGDLTVKQVEHYLNKEKRLELAKLFVFGAIKNIEHNLVKFKNKYK------------
CAS1_METJA SLHSGYLVVNQVEHYLDKDKRLELAKLFIIGGIKNMEWNLLKFKNKTK------------
CAS1B_ARCFU SLVSGEVVLRQAEHHLDSEKRLHLARAFVEGAILNMARVLKK------------------
CAS1_METTH TLLSGDVIIKQAEHVIDHDKRIELARSFVRGAALNMRRVLSYYGIENG------------
CAS1A_METRM SLLSGDLLIKQAEHNIDFSKRLKLAKLFVEGAAKNILKVLAYYKIENN------------
CAS1_CLOPS KNVSGVLLVNQALAYDNYEFRVAIAKTFIDSAMHHILRNLRRYKE---------------
CAS1C_THEYD RNVSGHIVVKQVEHFLDPERRFYLAYSFVEGAIFHMVRNLREYKN---------------
CAS1B_MOOTA SQLSGFLLVRQVEHYLDQAKRLELARTFVEGALHNIRRNLEKR-----------------
CAS1_AQUAE SSVSGHLLIKQVEHYLDAQKRLYLAKSFVIGSILNLEYVYKIS-----------------
CAS1_METKA ERYA-TLRLKQYEIASQPSARLAFARPLIASSILARAAVLEFLANETGITG---------
Q6ZEC7_SYNY3 FATNPLTRIAQYRV-LDSTFGTALAQRLILGKVTNQRAILQRRHRDTGKKNNA-------
CAS1A_THET8 DPHPAHLRAQFA------AEGLPLARAFVVGKLRSALALLERH-----------------
CAS1C_RHORT EARSADLRLHQYALHLDPPERLIRARAVVTAKLRNAAAVLRGIRSNQASSAA--------
CAS1D_METHJ -SRNTIALVRRHQAGITKEKSLAICREIIHAKLQNSCVFLAR------------------
CS4F1_GEOSL GHRNVETRTYQYQRSFDPETCLNLARRWIVAKIANCRTLLRRNWRGEGDEAKA-------
CS4F1_RHORT GPRSAAVRTAQYALAGDERRRQAFARDLVSAKIRNGRTLLRRNWRGAEAE----------
CAS1C_THET8 PSKNAPARVAQFKAYLEPTWKLALAQRFVLGKIRNGLVFLRRN-----------------
CAS1A_MOOTA VSGNVFLRHAQHEALSDSKKTTAIARNIVAGKIRNTRQVVLRGAREADNEDDRKA-----
CAS1_LEPIN -----MIRKAQFKKSEIEKFRLEIARSIVAGKLQNCRSVLSRTARKSKNESEKQD-----
A6VNV5_ACTSZ QSGNVLLRRAQYQRSESNP--VSIARNIIAAKIQASKRVLQRQIRNHGDNAE--------
CAS1B_RHORT VAGNVLLRRAQYKASEAPE---DIVKSLILGKVSNQRAVLLRALRDHGADFPAAEALA--
Q0AZN9_SYNWW QTGNVLLRRKQYRMADEENQVPVLAKYFIAAKILNSRAVLQRGRRDHPDKVGDS------
CAS1A_CHLTE VKGNILLRRAQYRMADNYDQTATLARLFVIGKIGNARVTLARALRDHPEKTDGEK-----
Q3J7J6_NITOC HKASLEKLAERYLADIELAGDN--------GTILAQEAKFAKKLYKFWANCTETE-----
CAS1_PECAS KSEHLQALLDRYQKGLTDCRTS--------NDVLVQEAMMTKALYRLAANAVSYG-----
Q5NPQ6_ZYMMO DERRLSALLHQSEHAIERASDI--------ATLLIEEARLTKALFKLASETVGY------
CAS1_PSEAB DATALAVAVEDSARALEQAPNH--------EHLLTEEARLSKRLFKLAAQATRYG-----
E1V4T7_HALED SKTELKALLTSSREAIGQAVDT--------TALLTEEARLTKKLFRLASHATDYG-----
Q6NEQ3_CORDI ----------------ITGGSI--------SVMRGLEGRIMRNTYRENAKKAGI------
CAS1B_CHLTE ----------------LENKTL--------PQMMGMEGLRVRKLYEEMAVKYKVG-----
I3Y7Y6_THIV6 PHRDL-------------------------DTLRGIEGSRVKATYQLMAQRYGIE-----
CAS1A_RHORT ----------------PARRSV--------DQLRGMEGVRVREIYRLLAKKYAVD-----
CAS1C_METHJ ----------------SDAYSV--------EQLRGLEGVRVREGYRKIARDTGVI-----
CAS1_ECOLI ----------------PARRSV--------EQLRGIEGSRVRATYALLAKQYGVT-----
CAS1_GEOSL ----------------PERRSV--------EQLRGIEGVRVRKMYELLARQHGVA-----
CAS1B_THET8 ----------------PEGLTL--------EQVRGLEGVRVRNAYARWSRETGVP-----
C7QEM2_CATAD PDEDPSGFMR--------------------QQLLGMEGRRLKDCYRQQSQRTGVP-----
F4H8A4_CELFA PGEDTSGLTM--------------------QQLRGREGARVRRTYREQAALHGIA-----
CAS1_CLOSS PEEDVSSLTM--------------------QQLRAKEGARIRKIYRKMSAEYGVD-----
Q03C58_LACP3 PDDDVSTLSM--------------------QELRGKEGARVRRIYREESRRTGVE-----
CAS1_STRTR KSQSIMELYHGLER----------------FDPSNREGHSARIYFNTL------------
Q73QW5_TREDE LAEYITDIDI--------------------NDKTNKEAHAAKAYFAA---LFGAG-----
CAS1_NEIM8 AAKRLRTLASEVRS----------------GDTGNREAQAAALYFQAL------------
A6GZS0_FLAPJ MELWAKEVTS--------------------GDALNHESRAAVFYWQSL------------
CAS1B_METHJ LFSGELDILTGYAKELENMVLI--------EELRRIEQLVRDMYYEILGRLISPT-----
CAS1_THEPD PEPPDPALYEDPARLE--------------SDIRSWEAAASNTLWDEVFKLLDPSAAREL
CAS1_MYCTU VAESIRTMKHSLAWV-DRSGSL--------AELNGFEGNAAKAYFTALGHLVPQE-----
CAS1_MYCTO VAESIRTMKHSLAWV-DRSGSL--------AELNGFEGNAAKAYFTALGHLVPQE-----
CAS1A_METHJ LSREIRLVEDAQDKA-LECQSL--------DSLRGVEGSGAHAYFQGFSLAFDEE-----
Q8PS38_METMA YPEINFDILDGLTKL-KDVKST--------REILGVEGTLAGKYWIEFSKAVPKE-----
CAS1B_SACS2 VTGTKNDYK---------------------ELLDKDEPAAARVYWQNISQLLPKD-----
CAS1A_SACS2 TSQELDRLAREITFVNTA------------EEVMQKEAEAAKVYWRGVKSLLPKS-----
CAS1_KORCO LYDAAQQLKREMEELKNEEFPDIDEAR---KRIMARESKCANIYWEKIASIMEE------
CAS1_HYPBU VEGHADRLRQIIENEEPTTP----------EVIRSIEAQAARDYWDAIAQIAPT------
CAS1A_ARCFU AKKEIDACLNELDGVEAEMIDKVR------ERLLGIEGKASKHYWDAISLVIPEE-----
CAS1B_METRM QREKVSEHIGKIEKLSNINSDNIR------NNILGIEGQASHEYWSAFASVLDEK-----
CAS1C_METRM NINEAIKQIGSLRFGERTDIEKSK------MKMMGIEGSASVDYWLAVNELLPKE-----
Q7MR72_WOLSU LESAIEKIKETIESLKNIELSNNKHWS---QIIMGKEGGMAAIYFDAIGAELLEE-----
G0GAL1_SPITZ AIETITTHRRQLSRILERTPSPGDHLTRLRSDIMGEEGRAANAYWEAIAHILPAS-----
CAS1A_PYRAE LAEAASKIADLAGRI-PSCADV--------QCVLGHEGAAASLYWDAVSKT---------
CAS1B_PYRAE YGTYAESISKAINALASAATP---------REVMEAEAAAAEAYWAAYREI---------
CAS1A_THEYD ADRAIEILNKAISNIEVTPISI--------DSLRGIEGAASSIYFITYSKIFPNS-----
CS4F1_LEPIN TESYLATIRSGLKNI-ESADSP--------SQLLGIEGSSARAYFSGLPALLKNSDP---
CS4F1_MYXXD LASAVRDLRALLPKC-EEAPSL--------EVLLGLEGAGAARYFGALPYLQGEDVDTR-
CAS1_HALVD DFDSVVETLRELKTAVSDTQRI--------DELRAVEGDARKRYYDCFDSILEAP-----
CAS1_NANEQ ELRKIDVWKMFEESLNDWKDAI--------NIIRGIESNIWNLFYQGLDKILKL------
CAS1B_THEYD LSEIISKIQEIATNI-PDCSTT--------DELMAIEGNIRDYYYQSFDIILDNEH----
CAS1_THEMA RADSLTRYKKKA----EEASNV--------SELMGIEGNAREEYYSMIDSLVSDER----
CAS1_FUSNN LKLYMDQIEELRKHL-KEVNNV--------EELMGYEGNIRKIYYEAWNIIVNQE-----
CAS1_THEKO VADGFSGLLDELFEELESARKI--------TEVMNVEARIRGEYYTRWDNALPEG-----
CAS1_PYRHO LSDYLDEL--------NDARKI--------TEIMNVEARIRQEYYAKWDENLPEE-----
D5VSN5_METIM FNNELKRL--------ESVKKI--------TEVMNIEGIVRAKYYSLWDETLKDE-----
CAS1_METJA FSSYIEEL--------NNCNKI--------TEVMNVEGRVRTEYYRLWDETLPDD-----
CAS1B_ARCFU AEQDDSDVIASLQHL-SSAKSI--------VELMGAEAAARNAYYTKFDEILKN------
CAS1_METTH ISDTLMDL--------DSSNSV--------TDVMNVEGRIRSDYYNAIDSILPEG-----
CAS1A_METRM IKNTLTEL--------NESSKI--------TEVMNVEGRIRAEYYQYFDDILPDE-----
CAS1_CLOPS KTSEFVKAIENERKIMKEAKTI--------EEVMGAEGRARKKYYESYNAFLKFLKND--
CAS1C_THEYD TDEFQEKIKKELSNA-VETTKI--------SELMGCEGRARDFYYEAFNTFLKSD-----
CAS1B_MOOTA EYDDICSKLDEIREGIGKTASI--------EELMSLEAHARKAYYDTWEEITG-------
CAS1_AQUAE ADTYLNKV--------KETNSI--------PELMSVEAEFRKLCYKKLEEVTG-------
CAS1_METKA LEDAADEVRSEAERA-LNAGST--------DALRGYEGRAACRYFRALAEVLPD------
Q6ZEC7_SYNY3 LAEAIDLIGAYRLSLRSGLGNSSR------DQLMGIEGICAKHYYQVFQFCLPEG-----
CAS1A_THET8 RLPEAGGVVEALARA-EGASEL--------ERLRGAEGEGSRVYFQGLARLLGP------
CAS1C_RHORT LASAITQTEASAEAAAAAVSA---------ESLLGIEGNGAHQYFAGLRTAFVGG-----
CAS1D_METHJ KRVEVPSLLKELRDRSLHAVSV--------DSLRGIEGEAASIYFPMLSSSLPDE-----
CS4F1_GEOSL PPGLLMSLQDDMRHA-MRAPSL--------EVLLGIEGASAGRYFQHFSRMLRGGDGEGM
CS4F1_RHORT RQIALDRLARLAERA-TTAETT--------ACLLGIEGEAAAVYFRAFPQLFTQAVTTLP
CAS1C_THET8 GAEGWERLKEALLEA-ERAQDE--------EALRGAEGRAADLYFRAFAELLPEE-----
CAS1A_MOOTA LQETARELAHGLDAL-SRSPDL--------EQIRGIEGNAARHYFATLDRMVRVNREA--
CAS1_LEPIN IKEAIGKIEKNISLL-EKAESI--------ESIRGYEGASAKTYFSVFDYCIIQQKED--
A6VNV5_ACTSZ IQTAVSALNSSLMQL-KKAENL--------ELIRGIEGDAASRYFGVFGQLLKAESG---
CAS1B_RHORT VKDAIDRMAHILRKVGASAEDA--------DHLRGAEGEAASLYFGVFGQLIRSPDGD--
Q0AZN9_SYNWW IERSIALLAGSVKKV-FDSENL--------NDIRGLEGDAAQRYFSEVDNLILEQKQD--
CAS1A_CHLTE LKNAQHVLAGCIRRL-QEATDQ--------ELIRGIEGEAAKAYFSVFDECITADDPA--
* :
Q3J7J6_NITOC ----NFTRDPGK------RDFNDPFNSYLDHGNY-LVYGIAAAVLWVLGIPHSLPVIH-G
CAS1_PECAS ----DFTR-AKR------GGGTDLANRFLDHGNY-LAYGLAAVSTWVLGLPHGLAVLH-G
Q5NPQ6_ZYMMO ---SDFTR-SKR------GTGIDPANRFLDHGNY-LAYGLGATATWVLGIPHGLAILH-G
CAS1_PSEAB ----EFVR-AKR------GSGGDPANRFLDHGNY-LAYGLAATATWVLGIPHGLAVLH-G
E1V4T7_HALED ----DFTR-VKR------GQGVDPANRFLDHGNY-LAYGLAATATWVLGIPHGLAVLH-G
Q6NEQ3_CORDI ---RGFKR-DTK--------AADPVNVGLNISNS-ILYGAAATVCTAIGVNPALGIIHRG
CAS1B_CHLTE ---WKGRR-FEP----GKFEMSDTTNKILTASNA-ALYSIILSAVHSMGYSPHIGFIHSG
I3Y7Y6_THIV6 ---WKGRH-YDR----ANPNATDIPNQAINHAAT-AVQAAAAIAVQAVAAIPQLGFIHED
CAS1A_RHORT ---WNARR-YDH----NDWDGADIPNRCLSAATA-CLYGLCEAAILAAGYAPAIGFLHRG
CAS1C_METHJ ---WNGRR-YDP----HSWGSADLPNRCLSAATA-SLYGICEAAVLAAGYSPSIGFLHTG
CAS1_ECOLI ---WNGRR-YDP----KDWEKGDTINQCISAATS-CLYGVTEAAILAAGYAPAIGFVHTG
CAS1_GEOSL ---WKARN-YDH----TQWESGDVPNRCLSSATA-CLYGICEAAILAAGYAPAVGFIHTG
CAS1B_THET8 ---WYGRS-YDR----GNWRAADPVNRALSAGAS-YLYGLAHAAIVSLGFSPALGFIHTG
C7QEM2_CATAD ---WHGRQ-YTP----GNFNAGDAINQAITAAAQ-CMYGVAHTIITALGCSPGLGFIHSG
F4H8A4_CELFA ---WEKRR-YDP----DDFTSGDPVNQALSAATT-ALYGIVHAVVVALGCSPGLGFVHTG
CAS1_CLOSS ---WNGRT-YDP----DDFEGGDPVNQALSAANV-ALYGLAYSAIAAMGLATGLGFVHTG
Q03C58_LACP3 ---WTHRE-YDP----ENYQSGSIINQALTAAHA-ALYGLSYSVIVALGASPGLGFVHTG
CAS1_STRTR -----FGNDFTR-------ESDNDINAALDYGYT-LLLSMFAREVVVCGCMTQIGLKHAN
Q73QW5_TREDE ---FS-------------RSLDIPINAALNYGYS-ILLSAFNREIIANGYITQLGIFHDN
CAS1_NEIM8 -----FGE-KFT------RNDNNAVNAALNYTYA-VLRAAVARTLTLYGWLPALGLFHRS
A6GZS0_FLAPJ ---ITVPN-FTR------GQKGIPPNNLLNYGYA-ILRAITARAIVSSGMLPTLGIFHRN
CAS1B_METHJ ---YLFKR-RTS------RPYLDPVNAIFSFGYG-MLSSACTRAVIGGHLDPGHGYLNR-
CAS1_THEPD RERYGFAG-RKP-------GHPDPLNKAISAMYA-VLYTLSTKALVAAGLDPTYGFLHRT
CAS1_MYCTU ---FAFQG-RST------RPPLDAFNSMVSLGYS-LLYKNIIGAIERHSLNAYIGFLHQD
CAS1_MYCTO ---FAFQG-RST------RPPLDAFNSMVSLGYS-LLYKNIIGAIERHSLNAYIGFLHQD
CAS1A_METHJ ---WGFLG-RSQ------NPATDPVNSLLSYGYG-MLYIQARQALVLSGYSPYYGAYHET
Q8PS38_METMA ---YDFCN-RID-QFRRAMGSGDMINTMLNYGYS-LLEAECLKAINSVGLDTHVGFLHEM
CAS1B_SACS2 ---IGFDG-RDV-------DGTDQFNMALNYSYA-ILYNTIFKYLVIAGLDPYLGFIHKD
CAS1A_SACS2 ---LGFKG-RMK----RVSDNLDPFNRALNIGYG-MLRKVVWGAVISVGLNPYIGFLHKF
CAS1_KORCO ---WKFRG-REK-RTDLEGNVIDPVNLCLNVCYN-LLSAQIWKNVLRFGLDPFLGYLHVE
CAS1_HYPBU ----PFPG-RQP------RG-EDHLNMALSYGYA-ILYSIAHDALTVAGLDPYAGFLHAD
CAS1A_ARCFU ---YRFNG-RRGIEIGSPRYAKDIVNAMLNYGYS-ILLAECVKAVELAGLDPYAGFLHVD
CAS1B_METRM ---WEFFG-RSG------RGAKDPVNSLLNYGYA-VIESEIWKSIYLAGLDPYCGFLHSE
CAS1C_METRM ---IGFFS-RNN------RHPNDITNASLNYAYA-ILASEVNKALVINGLDSYCGFLHFD
Q7MR72_WOLSU ---CDFTT-RIG------RGAEDIMNSALNYGYA-ILTSFVWQSIINAGLEAYAGVLHTN
G0GAL1_SPITZ ---LGFPG-RVR------RGARDPLNSALNYGYA-ILYGEAERALLLAGLDPYAGFLHAD
CAS1A_PYRAE ---TGLPG-RNP-------EAADPLNLALNYGYG-VLKYAVWRQAVIHGLDPYAGYIHAD
CAS1B_PYRAE ---TGFPG-RDQ-------EGRDPVNAGLNYGYG-ILKALCFKSILLAGLDPYVGFLHAD
CAS1A_THEYD ---LKFVR-RIK------RPPKDPVNAMLSLCYT-LLHYEIVREIQLIGLDPTIGFYHQF
CS4F1_LEPIN ---FLVPNGRSK------RPPKDPFNATLSFLYS-LLYKSVRQAIIAVGLDPSFGFYHTP
CS4F1_MYXXD ---LRFEG-RNR------RPPRDRFNAVLGFLFG-LVHREVEAAIRAVGLDVAFGFYHQP
CAS1_HALVD ---FRLAK-REY------NPPSNETNALISFLNG-MVYTSCVSAIRKTALDPTVGFVHEP
CAS1_NANEQ ---YKLER-RTR------RPPKNEANTIVSFANT-LLYGVTLTEIYKTHLDPTISFLHEL
CAS1B_THEYD ---FIFET-RTK------RPPKNRINALISFANS-LVYTTCLSEIYQTHLDPRIGYLHAT
CAS1_THEMA ---FRIEK-RTR------RPPKNFANTLISFGNS-LLYTTVLSLIYQTHLDPRIGYLHET
CAS1_FUSNN ---IDFEK-RVK------NPPDNMINSLISFVNT-LFYTKVLGEIYKTQLNPTVSYLHQP
CAS1_THEKO ---FKIVK-RTR------RPPENEMNALISFLNS-RLYATIVSELYNTQLAPTVSYLHEP
CAS1_PYRHO ---FKIVK-RTR------RPPKNEMNALISFLNS-RLYATIITEIYNTQLAPTISYLHEP
D5VSN5_METIM ---FKIVK-RTR------KPPKNEMNALISFLNS-RLYATIISEIYNTQLNPSVSYLHEV
CAS1_METJA ---FKIVK-RTR------RPPKNEMNALISFLNS-RLYPAIITELYNTQLTPTVSYLHEP
CAS1B_ARCFU ---FEFGK-RSR------MPPENEVNAMISFGNS-LLYSAVLSEIYHTQLNPAISYLHEP
CAS1_METTH ---FRIGK-RTR------RPPENMTNAMISFGNS-LLYSTVITELYNTQLNPTISYLHEP
CAS1A_METRM ---FKMEG-RSR------QPPTNMINSLISFGNS-MMYASVITELYNTQLNPTISYLHEP
CAS1_CLOPS ---FHFNK-REK------KPPNDPINALISFGNS-MMYTTVLGEIYKTQLDPTISYLHEP
CAS1C_THEYD ---FSMGK-REK------RPPRNPINALISFANS-MIYTTVLNEIYHTQLNPTVSYLHEP
CAS1B_MOOTA ---WEFGS-RSK------RPPANALNALISFGNA-MMYTVVLKEIYRTALNPTISYLHEP
CAS1_AQUAE ---WELEK-RTK------RPPQNPLNALISFGNS-LTYAKVLGEIYKTQLNPTVSYLHEP
CAS1_METKA ---WAFSGRRTR------RPPRDPFNAAISFGYAGVLLPVLLSRTVAAGLEPFLGFLHGP
Q6ZEC7_SYNY3 ---WSFTG-RNR------RPPKDPVNALLSWGYG-VLLARVFSAIVQAGLDPYLGFFHAT
CAS1A_THET8 ---YGFGG-RTR------RPPRDPVNAALSYGYA-LLLGRVLVAVRLAGLHPEVGFLHAE
CAS1C_RHORT ---IPFLG-RAQ------RPPPDPANSLLSFGYV-LLGNRLTGLLEARGVDPCLGFFHDL
CAS1D_METHJ ---WRSDK-RTR------RPPRDELNALLSLTYT-MVNTEVISALRQYNLDPFIGVMHVD
CS4F1_GEOSL G--FDFTT-RNR------RPPKDPVNALLSFAYA-MLTREWTVALAAVGLDPYRGFYHQP
CS4F1_RHORT A--FAFER-RNR------RPPADPVNACLSLCYA-VLTRTLSSALSIAGLDPWKGFYHTE
CAS1C_THET8 ---FAFGE-RSR------RPPRDPANSLLSLAYT-LLAKECESALLVAGLDPYVGYLHEV
CAS1A_MOOTA ---FKITH-RNR------RPPLDRMNALLSYIYA-LLLNDCLSAAEGVGLDPQIGYLHVL
CAS1_LEPIN ---FQFHK-RTR------RPPRSRTNALLSFLYS-LLTNDCIAVCQAVGLDPYIGFLHDE
A6VNV5_ACTSZ ---FVFDG-RNR------RPPRDGVNALLSFLYS-ILGKDISGALQGVGLDPQVGFLHAD
CAS1B_RHORT ---FAFRG-RSR------RPPLDPTNALLSFLYT-LLTHDCRSACESVGLDPAVGFLHRD
Q0AZN9_SYNWW ---FFMAA-RSR------RPPLDNVNALLSFFYT-LLVHECRAALESVGLDPAVGFLHRD
CAS1A_CHLTE ---FRFEG-RSR------RPPLDRVNCLLSFVYT-LMTHDIRSALESCGLDPAAGFLHKD
* . :
Q3J7J6_NITOC TTRRGALVFDVADIIKDTCVMPIAFQHAAAGRS-DQEM-------RQACIAWLDESHAMT
CAS1_PECAS KTRRGGLVFDVADLIKDALVLPQAFIAAMEGE--DEQE--F----RQRCLTAFQQSEALD
Q5NPQ6_ZYMMO KTRRGGLVFDVADLVKDATILPQAFLSAMAGD--EESS--F----RQKSIAALTHSESLD
CAS1_PSEAB KTRRGGLVFDVADLIKDSLILPQAFLSAMRGD--EEQD--F----RQACLDNLSRAQALD
E1V4T7_HALED KTRRGGLVFDVADLVKDAIILPQAFLSAMKGD--EEQE--F----RQACIERLTRTESLD
Q6NEQ3_CORDI DTR--SLLFDLADLYKASIVIPLVFSHA------KDED--PVTNIRRHLRREIHSRKIMA
CAS1B_CHLTE SP--LPFIYDLADLYKQQVSIDLAFSLTADMAGYYDRH--------------KIASEFRK
I3Y7Y6_THIV6 SGQ--SFILDIADLFREAITLKIAFTVAKKAET-DTQT--IDRLVRREAATVFRKQDVIP
CAS1A_RHORT KPQ--SFVYDVADLYKVETVVPTAFSIAAKIAAGKGDDSPPERQVRIACRDQFRKSGLLE
CAS1C_METHJ KP--LSFVYDIADLFKFETVVPAAFKTAALNPREPERE--V----RYACRDLFRETQLLK
CAS1_ECOLI KP--LSFVYDIADIIKFDTVVPKAFEIARRNPGEPDRE--V----RLACRDIFRSSKTLA
CAS1_GEOSL KPQ--SFVYDIADIFKFETVVPVAFRIAAKKPRDPERE--V----RLACRDAFRQSKILH
CAS1B_THET8 KL--LSFVYDIADLYKADYLVPAAFRTVAESEEAVERR--VRRALREAIQEGRLLERMAE
C7QEM2_CATAD HE--LSFVMDIADLYKTEIGIPVAFDTAAE----DSTD--IGPRTRRALREQIRTTRLLE
F4H8A4_CELFA HVR--SFVFDIADLYKADYAIPCAFETAAA----GYSD--IGAETRRAMRDRFRDGHLLE
CAS1_CLOSS HD--LSFVYDIADLYKADITVPVAFEIASEYE--EGDN--VGKISRQKVRDKFIGGKLFA
Q03C58_LACP3 HD--LSFVYDFADLYKAEVTIPIAFTVAANAT--EQDD--IGQLTRLAVRDAFVDGKLMI
CAS1_STRTR QFNQFNLASDIMEPFRP-IIDRIVYQ-------------------NRHNNFVKIKKELFS
Q73QW5_TREDE MFNPFNLGSDLMEPFRP-LVDAEVFKL-------NPQK--F----EHEEKLKIVSVINKK
CAS1_NEIM8 ELNPFNLADDFIEPLRP-LADLTVIHLYEQGRLKAELTPGIKQHLIKTLHYQISIERQHF
A6GZS0_FLAPJ KYNAYCLADDIMEPYRP-YVDLIVCHIID-----TEDS--YD----------ELTIEIKK
CAS1B_METHJ --GNQALVQDLMNCWKPKMIDNHAIGFLRSGRL-HQNG--YE---RTKDRC-ILHDEVIE
CAS1_THEPD QYSVP-LAFDYAEAFKPLAVE-AALDLVNEEGL------------PTLSEDGDLDKDSLN
CAS1_MYCTU SRGHATLASDLMEVWRAPIIDDTVLRLIADGVV-DTRA--FSK--NSDTGAVFATREATR
CAS1_MYCTO SRGHATLASDLMEVWRAPIIDDTVLRLIADGVV-DTRA--FSK--NSDTGAVFATREATR
CAS1A_METHJ YKKQEALVYDLVEEFRQPVVDRTVVTFLAKHMA-TPDD--FT---YPDEGGCMIGTMAKK
Q8PS38_METMA APSKNSLAYDLQEPFR-FIVDLAVISLIESGAM-ESKD--FI---RTENYNLRLKPTGAR
CAS1B_SACS2 RPGNESLVYDFSEMFKP-YIDFLLVRALRSG---------F----RLKVKGGLIEENSRG
CAS1A_SACS2 RSGRISLVFDLMEEFRSPFVDRKLIGLARESAD-KVTD--------------------LK
CAS1_KORCO RPGRISLVYDLMEPFRP-MVDRFVFSYLRGM---SPSL--F----SSNIVSGTIASLRSR
CAS1_HYPBU RSGRPSLTYDYADTYKPIAVDKPLLTAP------RKTD-------CLDTYMGALTYNARR
CAS1A_ARCFU VSGRSSLAIDLMENFRQQVVDRVVLRLISYRQI-KPED---C---EKRNMVCQLSDNARR
CAS1B_METRM RYGRASLVYDLIEEFRQQIVDKTVLSIVNRNQI-TPDD--F----EEDGNYIKIHERARR
CAS1C_METRM RQKRTSLTFDLMEEFRQQLVDKVVFSLVNTKQI-SNDD--------LDKRNNSISLDVRK
Q7MR72_WOLSU RPGKPSLVLDVMEEYRAWVVDRNIIKLR-----------------SSLAGKKELDAELKK
G0GAL1_SPITZ RPGKPAMVLDFVEEFRTPVVDRTIIGLATKGVSFDQEE------------DGLLARETRL
CAS1A_PYRAE KSGRPSLVLDLMEEFRP-HVDLLVIRLRPSADW---------------ADGGVLKREIRA
CAS1B_PYRAE KSGRPSLVLDFMEQWRPR-VDAVVAQLAE----------------ELEAENGLLTHKSRL
CAS1A_THEYD EYGRESLACDLVELFR-VNVDRFVYELFKAKHL-GNRD--FMKD-EESGGV-YLKKTGRK
CS4F1_LEPIN RSSAEPLVLDLMELFRVSLCDMTLIGSINRKSW-IDED--F----EITKNKVWLSESGRK
CS4F1_MYXXD RGTAGPLGLDVMELFRVPLADMPLVASVNRRAWDADAD--F----EVTSEHVWLSKAGRA
CAS1_HALVD GERRFTLSLDIADIFKPILADRLVFRLVNRKQI-TTDD--F----ETELAGCLLTEQGRL
CAS1_NANEQ RDTRYSLALDLSENFKPIITFRILIWLVNQGII-KDTH--F----VKGLNGVLLNEQGKK
CAS1B_THEYD NFRRFTLNLDVAEIFKPIIADRAIFSIVNKRIV-KPQH--F----EKKLDGIVLNDKGKQ
CAS1_THEMA NFRRFSLNLDIAELFKPAVVDRLFLNLVNTRQI-NEKH--F----DEISEGLMLNDEGKS
CAS1_FUSNN STRRFSLSLDISEVFKPLIVDRLIFSLLNKNQI-TEKS--F----VKDFEYLRLKEDVSK
CAS1_THEKO GERRFSLALDLSEIFKPIIADRIANRLVKQGII-KREH--F----RGELNGVLLTKEGMK
CAS1_PYRHO SERRFSLSLDLSEIFKPIIADRVANRLVKKGSL-KKEH--F----REDLNGVLLTEEGMK
D5VSN5_METIM GTRRFSLALDLSEIFKPIYVDRLANRLVKQNII-KKSH--F----RDDLNGMLLTDEGMR
CAS1_METJA HERRFSLALDLSEIFKPMIADRLANRLVKQGII-QKKH--F----RDDLNGVLLNKEGMK
CAS1B_ARCFU SERRFSLALDIAELFKPVIVDRLIFYLVNNGIV-TESD--F----DSRLGGILLSEEGKK
CAS1_METTH FERRYSLALDLSEIFKPTLIDRMIISLIKKKAI-KAED--F----EHGMNHCLLNNSGKR
CAS1A_METRM AERRFSLALDLSEIFKPIIVDRVIFYLVNKKMI-TEKD--F----NQDLNCCLLNDKGRA
CAS1_CLOPS STKRFSLSLDLAEIFKPLIVDSVIFNMINKGMI-KKSD--F----DTDEGICYLNENGRK
CAS1C_THEYD SERRYSLSLDIAEIFKPLLADAIIFKLINNNMI-KLDD--F----EEDVNYCYLNESGRK
CAS1B_MOOTA SERRYSLALDVAEIFKPVFVDRLIFRLINLNML-KETH--F----DTNVNFVYLTEGGRK
CAS1_AQUAE STKRFSLSLDVAEVFKPIFVDNLIIRLIQENKI-DKTH--F----STELNMTFLNEIGRK
CAS1_METKA RGRRPGLILDLMEEWRALAVDVPVLRRFLDGSL-SREM--FR---WKGDAVLLRDLDAVS
Q6ZEC7_SYNY3 QPYRPNLALDLMEEFRPVVVDQAIVRLLRSGIL-DPLD--FEP--SYDGLGIWLGITAKK
CAS1A_THET8 GRRSPALALDLMEEFRVPVVDQVVLSAFRRGLL-TPSH--AE---VREGGV-YLNEEGRR
CAS1C_RHORT RPGRPSLALDLLEELRHPVVDRLALRICNLRKI-QPQH--FEPD-AERPGGVKLTVDGRK
CAS1D_METHJ RHGKPALALDLLEEFRPVFCDAFVARLINKRMI-TKDD--F-------TQGSRLNDTAFK
CS4F1_GEOSL RFGRPALALDMMEPFRPLIADSTVLMAINNGEI-RTGD--F----VRSAGGCNLTDSARK
CS4F1_RHORT RPGRPALALDLIESFRPVLADSTVLMVLNNGEI-GTND--F----LYAGGGCALKPNARR
CAS1C_THET8 RYGRPSLALDLMEEFRSVLADSVVLSLLNNRRV-TLED--F----DDSEGFPRLRKEAWP
CAS1A_MOOTA RSGRPALALDLMEEFRAILADRLALTLVNRRQI-DERD--FV---ERPGGAVHINDNARK
CAS1_LEPIN RPGRPSLALDMMEEFRP-FIDRLVFTLINRKQI-QVSD--FL---EKPGSVFFINDDSRK
A6VNV5_ACTSZ RPGRDSLAQDILEEFRAWWVDRMVLSLINRGQI-KPDD--FT---QEAGGAVNIKPDVRK
CAS1B_RHORT RPGRPSLALDLMEELRPVLVDRLALSLINRRQL-RATD--FQ---RLDGGAVLLTDEARK
Q0AZN9_SYNWW RPGRPSLALDLMEELRPYLGDRMVLSLINRKQI-NKDD--FI---TKENGAVYVLPDTRK
CAS1A_CHLTE RPGRPSLALDMLEEFRSYIGDRLVLSLINRGQI-HAKD--FD---ISETGAVAMKDDARK
: * : .
Q3J7J6_NITOC FLFQ-SIKRVAQL-----------------------------------------------
CAS1_PECAS VMIG-SLQDVASKL-----------------------SQVVR------------------
Q5NPQ6_ZYMMO FMID-TIKKIALSMEAEPAL----------------------------------------
CAS1_PSEAB FMID-TLKDVAQRSTVSA------------------------------------------
E1V4T7_HALED FMID-TLKAVALD---------------------------------LGGP-EA-------
Q6NEQ3_CORDI GMLE-ALMEVLTPYLPNR----NDDRLIGDSDEVKGHIQYGKEIN---------------
CAS1B_CHLTE RVIEIDLLGKIGPDIE---------------------TILGKKQ----------------
I3Y7Y6_THIV6 AMID-RIKKVIRMEETDA----------------------------SGHDRDP-------
CAS1A_RHORT KIIP-DIEEILRAGGLEPPL--DAPEAVDPVIPPEE-PSGDDGH--RG------------
CAS1C_METHJ RIIP-TIEEVLTAGGISAPAPPDWVVPPAIPVDEEG------------------------
CAS1_ECOLI KLIP-LIEDVLAAGEIQPPAPPEDAQPVAIPLPVSLGDAGHRSS----------------
CAS1_GEOSL RIIP-TIEQVLAAG--------GMDVPTPPPESVEAVIPNKEGI--GDAGHRG-------
CAS1B_THET8 DLLN-LFRGLGLPEEEDPVE--EDPTRPGGLWDLEG-EVEGGVA--YGGDDPG-------
C7QEM2_CATAD RCVD-DVKALLTTPNNEPGSSDATDTGFFDQVQLQS--DRETEV--EGGRNYA-------
F4H8A4_CELFA RCSS-DIHNLLLPAEPDEATA-DLGPDVVRLWDGGTRTVAGGTS--WGDEVDW-------
CAS1_CLOSS TIVR-DIQLLFGIKEEEQLN--VEPLSLWDNREGNIKYGINYSN--ENED----------
Q03C58_LACP3 RMVA-DLKMLLGDVDDDLDA--DVVNLWDDKLGLQK-FGVSYRE--STEDGQS-------
CAS1_STRTR IFSE-TYLYN------------GKEMYLSNIVSDYT-KKVIKALNQLGEEIPE-------
Q73QW5_TREDE VLIN-NKEHYLNKAIE------IFVHSIFDALNEKD-ISQINFY--RNEL----------
CAS1_NEIM8 STLA-AIDKMVSSFQAGVTDKNAKQLKLPEILPLKE-YQYE-------------------
A6GZS0_FLAPJ HLLS-IATIDVCID--------GKNSPLMVAMSRTT-HSLQECF--AGAARKI-------
CAS1B_METHJ ELIH-LFSKSIQEE----------------LINTQI-DVLIQSL--RGEA-QF-------
CAS1_THEPD KAMK-RLYRYLSAKHRE-----TGKTPYQQ-IHLKA-FCLAKHL--EGKCSRE-------
CAS1_MYCTU SIAR-AFGNRIARTATYIKGD-PHRYTFQYALDLQL-QSLVRVI--EAGH-PSRLVDIDI
CAS1_MYCTO SIAR-AFGNRIARTATYIKGD-PHRYTFQYALDLQL-QSLVRVI--EAGH-PSRLVDIDI
CAS1A_METHJ KYAA-AVLTRIHGKVKYEEQ------TFQDIFKRQA-ERIGKAL--TEGD-EY-------
Q8PS38_METMA KIVN-EFSNTLNKKVSYQ----GKESTWSYVIFLKV-RELAHYL--TSKKEKLDFTKPEY
CAS1B_SACS2 DLAK-LIRKGMEENVKEESD--HNPKTLIQAIRAHA-VKLASSI--REGK-EY-------
CAS1A_SACS2 TVYS-LFSDVKEDE-----------------IYTQA-RRLVNAI--LNDE-EY-------
CAS1_KORCO FFSD-FMNWRLDYK--------GRKLGMETIMFLYV-RDIVSFL--RGGKEPT-------
CAS1_HYPBU CIATLVLENIYKTPYPDSR---GRKKTLRDHIYTYA-WNLAAAI--RQHK-PY-------
CAS1A_ARCFU LLLA-SLLERLDSKTQYR----GRNLAYSSIILLHA-RDVVAFL--RGER-RY-------
CAS1B_METRM LLIA-KILDKLNSKIMFH----SKNISYSDIILYQG-KLMADYL--TNGV-PY-------
CAS1C_METRM LIIG-RVLDKVNSNINYE----GENLSYAQIIDKQA-KKIVNYL--INGE-KY-------
Q7MR72_WOLSU KIIT-EINATMNKKHLYN----GKNLSLQGVMQRQV-YRLVGAF--MQQN-RY-------
G0GAL1_SPITZ MIAE-KILERLETPAPFR----GKRHPLRAIIQIQA-RSIATFF--RGERKDY-------
CAS1A_PYRAE MLVE-EWTGERLEPVIARQV-----------------GLAVAHL--HGQR-AY-------
CAS1B_PYRAE RLAA-AVLEEFN----------ATGRPLSAEIHREA-RSIAKAL--CTS-----------
CAS1A_THEYD KFYP-LYEQWVQQQ--------------RTIWRGEV-QGFARRI--LEEK-DI-------
CS4F1_LEPIN KATQ-LYETRLDDTWKHPVV--NYSLSYYRMIELEV-RLLEKEW--SGEANIF-------
CS4F1_MYXXD KAIE-LYERRKRETWKNNVL--GYSLSYARLVELEV-RLLEKEW--TGKPGLF-------
CAS1_HALVD TVLE-EFERSLDQTVQHPRL--KRKVSFKTLIQTDV-YSLKKHL--LTGE-PY-------
CAS1_NANEQ LVIK-EFNKRLDETIKLKS---GLKRSMRWYIKAQA-YNLERFL--LDGR-KF-------
CAS1B_THEYD ILLQ-EMDERLRSTIQHKKL--GRHVSYRQLIRLEL-YKIQKHL--MEEE-EY-------
CAS1_THEMA LFVK-NYEQALRETVFHKKL--NRYVSMRSLIKMEL-HKLEKHL--IGEQ-VF-------
CAS1_FUSNN LIVQ-EFEDRLKQIITHKDL--NRKISYQYLVRLEC-YKLIKHL--LGEK-KY-------
CAS1_THEKO VVLK-AYNEELGRSVKHPGL--KKNVTKQRLIRLEA-YKLIKHL--VGVK-DY-------
CAS1_PYRHO IVTK-AYNEELQKSVKHPKI--GSNVTRQRLIRLEA-YKLIKHL--VGVE-EY-------
D5VSN5_METIM LVIK-FFNELLESTVKHPKL--NKNVSKKRLIRLEC-YKLIKHL--LEVN-KY-------
CAS1_METJA VVLE-HFNKEMDKTVNHKKL--KKNVSKRRLIRLEA-YKLVKHL--VGQK-RY-------
CAS1B_ARCFU KFVR-HFNERLEKTVKHRKL--NRKVSYQRLIRLEC-YKLVKHF--TAVE-KY-------
CAS1_METTH KFLA-EYDRRLGKTVKHREL--GRKVSYRRLIRLEA-YKLIKHL--IGQK-SY-------
CAS1A_METRM TFVK-EYNKRLETTIKHKDL--GRKVSYQRLIRLEA-YKLKKHV--FGMK-EY-------
CAS1_CLOPS KFIK-EYENKLSTTVRHRTL--NRNVSYRELIRLEC-YKLIKML--LGDE-DY-------
CAS1C_THEYD KFIR-EFDQKLSTTIKHRKL--KRNVSYRTIIRIEC-YKLIKHF--IGDE-VY-------
CAS1B_MOOTA VFVK-EFEETLEKTILHRKL--KRNIRYKSLVRLDL-YKLIKHL--LGEE-KY-------
CAS1_AQUAE VFLK-AFNELLETTIFYPKL--NRKVSHRTLIKLEL-YKLIKHL--LEEE-VY-------
CAS1_METKA APVL-TVLSRVRGGLLEAVD--RRIREVRDGVSRQSPPEPLEFD--PEDV----------
Q6ZEC7_SYNY3 LFLT-ELESILQTSFLYSPQ--SRRLKLQQIILEQA-RCLGRCC--LESSLDY-------
CAS1A_THET8 RLIQ-LFEERLLEGVSHPL---GFRKPLGETIEVQA-QRLKAAL--LGRG-RY-------
CAS1C_RHORT IFLE-EWEGHLARPLREPGVAAEHRLDVHRLLQRQV-DRLVSDL--RGGE-PY-------
CAS1D_METHJ KYLG-FYHDFMEESLKHPRF--KYSVSRKKAIQIQA-IIFRKAI--CGELKGY-------
CS4F1_GEOSL RFIA-GFERRMEQEVTHPIF--KYTISYRRLLEVQA-RLLTRYL--SGEIPAY-------
CS4F1_RHORT GLIA-AYERRLDQETTHPVF--GYQLSMRRLIQVQA-RLLARFV--SGDIPRY-------
CAS1C_THET8 KFLR-AWEGRLNERIQHPLL--GKRLAYREILLAQA-RILVKHL--LGELPRY-------
CAS1A_MOOTA EIAI-AYQKRKQEEVLHPVL--NRKVPLGLVPHIQA-RLLARVL--RGDAEEY-------
CAS1_LEPIN ELIK-SYQERKKEEIFHPWL--NIKSTVGELPYLQA-RIFARTL--RGDLKYY-------
A6VNV5_ACTSZ LIFQ-TLQAKKQEKITHPFL--GEEVEIGLLPYIQS-MLLARHL--RGDLAEY-------
CAS1B_RHORT TVLS-AWQERKKQERRHPFL--EESAPLGLVPYLQA-QMLARHL--RGDLDAY-------
Q0AZN9_SYNWW MLLT-VWQKRKQEEIIHPYL--EEKIPIGLLPYTQA-LLLARFL--RGDLDAY-------
CAS1A_CHLTE TLIT-AYQQRKQEEIEHPFV--GEKMAVGLLWHMQA-MLLARYI--RGDIDMY-------
Q3J7J6_NITOC ------------------------------------------------------------
CAS1_PECAS ------------------------------------------------------------
Q5NPQ6_ZYMMO ------------------------------------------------------------
CAS1_PSEAB ------------------------------------------------------------
E1V4T7_HALED ------------------------------------------------------------
Q6NEQ3_CORDI ------------------------------------------------------------
CAS1B_CHLTE ------------------------------------------CSS---------------
I3Y7Y6_THIV6 ------------------------------------------------------------
CAS1A_RHORT ------------------------------------------------------------
CAS1C_METHJ ------------------------------------------------------------
CAS1_ECOLI ------------------------------------------------------------
CAS1_GEOSL ------------------------------------------------------------
CAS1B_THET8 ------------------------------------------EGAEEPEG----------
C7QEM2_CATAD ------------------------------------------DEL------------GTT
F4H8A4_CELFA ------------------------------------------------------------
CAS1_CLOSS ------------------------------------------------------------
Q03C58_LACP3 ------------------------------------------------------------
CAS1_STRTR ------------------------------------------FRI---------------
Q73QW5_TREDE ------------------------------------------------------------
CAS1_NEIM8 ------------------------------------------------------------
A6GZS0_FLAPJ -----------------------------------------LYPI------------YV-
CAS1B_METHJ ------------------------------------------SII------------KP-
CAS1_THEPD ------------------------------------------KLA------------FT-
CAS1_MYCTU TS----------------------------------------EPS------------GA-
CAS1_MYCTO TS----------------------------------------EPS------------GA-
CAS1A_METHJ ------------------------------------------VPY------------RYR
Q8PS38_METMA EIERIDSYDIRQKILSISYVDWKKLGFSKGTLHYMKQNAKSDKPFTLNAHVLERVNKWE-
CAS1B_SACS2 ------------------------------------------RGF------------KLV
CAS1A_SACS2 ------------------------------------------RPY------------LAK
CAS1_KORCO ------------------------------------------MPY-------------IP
CAS1_HYPBU ------------------------------------------KPF------------IVG
CAS1A_ARCFU ------------------------------------------EGF------------VQK
CAS1B_METRM ------------------------------------------EGF------------SLR
CAS1C_METRM ------------------------------------------TGF------------SLR
Q7MR72_WOLSU ------------------------------------------KSY------------IFK
G0GAL1_SPITZ ------------------------------------------TPY------------RMR
CAS1A_PYRAE ------------------------------------------TPH------------QL-
CAS1B_PYRAE ------------------------------------------------------------
CAS1A_THEYD ------------------------------------------ISG---------------
CS4F1_LEPIN ------------------------------------------AQA------------RLR
CS4F1_MYXXD ------------------------------------------ATF------------RLR
CAS1_HALVD ------------------------------------------HAT------------EK-
CAS1_NANEQ ------------------------------------------KAF------------RLI
CAS1B_THEYD ------------------------------------------KPF------------VTG
CAS1_THEMA ------------------------------------------GSE------------E--
CAS1_FUSNN ------------------------------------------KSF------------QM-
CAS1_THEKO ------------------------------------------EPL------------VA-
CAS1_PYRHO ------------------------------------------KPL------------VA-
D5VSN5_METIM ------------------------------------------SPL------------IA-
CAS1_METJA ------------------------------------------EPL------------VA-
CAS1B_ARCFU ------------------------------------------SPF------------VM-
CAS1_METTH ------------------------------------------EPF------------VM-
CAS1A_METRM ------------------------------------------DPF------------VI-
CAS1_CLOPS ------------------------------------------KPL------------KA-
CAS1C_THEYD ------------------------------------------APF------------KA-
CAS1B_MOOTA ------------------------------------------SPM------------KV-
CAS1_AQUAE ------------------------------------------LPL------------NYG
CAS1_METKA ---------------------------------------------------------GVV
Q6ZEC7_SYNY3 ------------------------------------------EPF------------TLS
CAS1A_THET8 ------------------------------------------TPF------------YL-
CAS1C_RHORT ------------------------------------------RPF------------RFG
CAS1D_METHJ ------------------------------------------YPF------------IYA
CS4F1_GEOSL ------------------------------------------PNF------------VTR
CS4F1_RHORT ------------------------------------------PHY------------CPR
CAS1C_THET8 ------------------------------------------EPF------------AVR
CAS1A_MOOTA ------------------------------------------LPF------------MYR
CAS1_LEPIN ------------------------------------------IPF--------------I
A6VNV5_ACTSZ ------------------------------------------PPF------------LMR
CAS1B_RHORT ------------------------------------------PPW--------------F
Q0AZN9_SYNWW ------------------------------------------PAF--------------I
CAS1A_CHLTE ------------------------------------------PPF--------------V
Q3J7J6_NITOC ----------
CAS1_PECAS ----------
Q5NPQ6_ZYMMO ----------
CAS1_PSEAB ----------
E1V4T7_HALED ----------
Q6NEQ3_CORDI ----------
CAS1B_CHLTE ----------
I3Y7Y6_THIV6 ----------
CAS1A_RHORT ----------
CAS1C_METHJ ----------
CAS1_ECOLI ----------
CAS1_GEOSL ----------
CAS1B_THET8 ----------
C7QEM2_CATAD W---------
F4H8A4_CELFA ----------
CAS1_CLOSS ----------
Q03C58_LACP3 ----------
CAS1_STRTR ----------
Q73QW5_TREDE ----------
CAS1_NEIM8 ----------
A6GZS0_FLAPJ ----------
CAS1B_METHJ ----------
CAS1_THEPD WDKKRYIIHE
CAS1_MYCTU ----------
CAS1_MYCTO ----------
CAS1A_METHJ T---------
Q8PS38_METMA ALVSSQR---
CAS1B_SACS2 M---------
CAS1A_SACS2 ----------
CAS1_KORCO W---------
CAS1_HYPBU RL--------
CAS1A_ARCFU W---------
CAS1B_METRM W---------
CAS1C_METRM W---------
Q7MR72_WOLSU W---------
G0GAL1_SPITZ W---------
CAS1A_PYRAE ----------
CAS1B_PYRAE ----------
CAS1A_THEYD ----------
CS4F1_LEPIN ----------
CS4F1_MYXXD ----------
CAS1_HALVD WW--------
CAS1_NANEQ Y---------
CAS1B_THEYD W---------
CAS1_THEMA ----------
CAS1_FUSNN WW--------
CAS1_THEKO WF--------
CAS1_PYRHO WF--------
D5VSN5_METIM WF--------
CAS1_METJA WF--------
CAS1B_ARCFU WW--------
CAS1_METTH WW--------
CAS1A_METRM WW--------
CAS1_CLOPS WW--------
CAS1C_THEYD WW--------
CAS1B_MOOTA WW--------
CAS1_AQUAE GLK-------
CAS1_METKA WDALEV----
Q6ZEC7_SYNY3 ----------
CAS1A_THET8 W-R-------
CAS1C_RHORT TSRPG-----
CAS1D_METHJ R---------
CS4F1_GEOSL ----------
CS4F1_RHORT ----------
CAS1C_THET8 ----------
CAS1A_MOOTA ----------
CAS1_LEPIN WK--------
A6VNV5_ACTSZ ----------
CAS1B_RHORT WK--------
Q0AZN9_SYNWW WK--------
CAS1A_CHLTE WR--------