CLUSTAL format seed alignment for MF_01967
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Features found in the protein:- The following colors are used to highlight features:
- blue indicates SIGNAL, PROPEP, TRANSMEM, DOMAIN, ZN_FING, REPEAT,
DNA_BIND and CA_BIND.
- magenta is used to display DISULFID, THIOLEST and THIOETH.
- red is used for all other features, such as INIT_MET, ACTIVE SITE,
METAL,BINDING, NP_BIND, SITE, REGION, etc.
- The ID of the sequence used as the template for feature propagation is
underlined.
- A '<' at the beginning of a sequence or '>' at the end indicate that
the protein is fused with another domain either at the N- or C-terminus.
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SIR4_BOVIN ---------------------MRMSFGLTFKRTAKVHWRANFSQQCSLRST---------
SIR4_HUMAN ---------------------MKMSFALTF-RSAKGRWIANPSQPCSKASI---------
SIR4_MOUSE ------------------------MSGLTF-RPTKGRWITHLSRPRSCGPS---------
SIR41_CAEEL -------------------------------------------------MA---------
SIR42_CAEEL -------------------------------------------------MA---------
SIR4_DROME -------------------------------MRVGQLLRFRSTSLRSSTAR---------
SIR4_ARATH MNMRRVFGGVSTDLFPSRSMYRPLQSGGNLVMLFKGCRRFVRTTCRVSIPGGSLGNESKA
NPD_BORBR ------------------------------------------------------------
NPD_BORPE ------------------------------------------------------------
NPD_XANAC ------------------------------------------------------------
NPD_XANCP ------------------------------------------------------------
NPD2_BRADU ------------------------------------------------------------
NPD3_PSESM ------------------------------------------------------------
SIR4_BATDJ ------------------------------------------------------------
NPD1_COREF ------------------------------------------------------------
NPD1_STRCO ------------------------------------------------------------
NPD1_MYCA1 ------------------------------------------------------------
SIR4_MONBE ---------------------------------------------------MAATKLHPA
SIR4_LEIMA ------------------------------------------------------------
SIR4_TRYB2 ------------------------------------------------------------
SIR4_BOVIN -------GLFVPPSPPLDPEKVKELQRFITLSK----RLLVMTGAGISTESGIPDYRSEK
SIR4_HUMAN -------GLFVPASPPLDPEKVKELQRFITLSK----RLLVMTGAGISTESGIPDYRSEK
SIR4_MOUSE -------GLFVPPSPPLDPEKIKELQRFISLSK----KLLVMTGAGISTESGIPDYRSEK
SIR41_CAEEL -------QKFVPEAAELCENSLKKFISLIGTVD----KLLVISGAGISTESGIPDYRSKD
SIR42_CAEEL -------RKYVPHTTELCENSLKKFKSLVGTVD----KLLIITGAGISTESGIPDYRSKD
SIR4_DROME -------QEYVPHHKPVVEDDIKRLEDFLLSKP----NVLVLTGAGISTESGIPDYRSEG
SIR4_ARATH PPRFLRDRKIVPDADPPNMEDIHKLYRLFEQSS----RLTILTGAGVSTECGIPDYRSP-
NPD_BORBR --------------MDSRMSDLQALRGFLGGSE----RLFVLTGAGCSTASGIPDYRDG-
NPD_BORPE --------------MDSRMSDLQALRGFLGGSE----RLFVLTGAGCSTASGIPDYRDG-
NPD_XANAC -------------MTAVPAHDHHTLQDFIERHQ----RLFVLTGAGCSTDSGIPDYRDL-
NPD_XANCP -------------MTVAITQTGPALQEFVERHQ----RLFVLSGAGCSTDSGIPDYRDL-
NPD2_BRADU --------------MSNAPLANQSLQDFVARHQ----RLFVLTGAGCSTNSGIPDYRDS-
NPD3_PSESM -------------MLDSPTLDLLDSLRRTMAEK----SFLVVTGAGISTASGIPDYRDK-
SIR4_BATDJ ----MSAQVMHNRVMGTVKDSASKLVDFLMRHHG---QTVLLTGAGVSTDSGIPDYRGP-
NPD1_COREF ---------------MEEGAALEGVVKLLEA-----GSVLAVTGAGVSTDSGIPDYRSPR
NPD1_STRCO MRMRPTLSWTPGADLPPGTTDLAPVADALRA-----GGVLVLSGAGISTESGIPDYRGEG
NPD1_MYCA1 --------------MTVGRAESPELVAVLAG-----RRIAVLTGAGISTDSGIPDYRGPE
SIR4_MONBE LRNAIRAGANLPTEVISATFDVQEGIKLLSAFLLRHEPVCVLTGAGISTDSGIPDYRSPG
SIR4_LEIMA ---------------MRPAGTLASFLERCSARKRG-RGCVVLTGAGCSTESGIPDYRGPN
SIR4_TRYB2 -----------------MADRLAIFIKQCGLQR-----CVILTGAGCSTESGVPDYRGPN
::*** ** .*:****.
SIR4_BOVIN VGLYAR-TDRRPIQHGDFVRSAPVRQRYWARNFVGWPQFSSRQPNPAHWALSNWERLGKL
SIR4_HUMAN VGLYAR-TDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKL
SIR4_MOUSE VGLYAR-TDRRPIQHIDFVRSAPVRQRYWARNFVGWPQFSSHQPNPAHWALSNWERLGKL
SIR41_CAEEL VGLYAR-IAHKPIYFQDYMRSNRCRQRYWSRNFLAWPRFGQAAPNINHYALSKWEASDRF
SIR42_CAEEL VGLYTK-TALEPIYFQDFMKSKKCRQRYWSRSYLNWPRFAQALPNFNHYALSKWEAANKF
SIR4_DROME VGLYAR-SNHKPVQHMEFVKSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREERV
SIR4_ARATH NGAYS--SGFKPITHQEFTRSSRARRRYWARSYAGWRRFTAAQPGPAHTALASLEKAGRI
NPD_BORBR QGQWK---RKPPIDFQAFMGGQPARARYWARSMVGWRHFGQARPNAAHHALARLAQRGQV
NPD_BORPE QGQWK---RKPPIDFQAFMGGQPARARYWARSMVGWRHFGQARPNAAHHALARLAQRGQV
NPD_XANAC QGGWK---RPQPVTFQAFMGELSTRQRYWARSLVGWPRFGLAQPNATHHALAALEARGQL
NPD_XANCP QGGWK---RPQPVTFQAFMGELSTRQRYWARSLVGWPRFGLARPNATHHALAALEARGQL
NPD2_BRADU HGNWK---RTQPVNFQAFMSEEHTRRRYWARSLIGWRRFGQARPNDAHHALARLEANGRC
NPD3_PSESM DGVRR---GAQPMMYQEFVGNPAARQRYWARAMLGWPRISASQANAAHRALAALQAENLI
SIR4_BATDJ QGIYSRNKDFKPIQYQQFVGPHEFRQRYWARSFLGWPKVSQAQPNASHHAIAALESRSHI
NPD1_COREF GSLNQG----RPMTYQEFRFDPVASHRYWARSFVGWRVMADAQPNRTHYALVELERAGLL
NPD1_STRCO GSLSRH----TPMTYQDFTAHPEARRRYWARSHLGWRTFGRARPNAGHRSVAAFGRHGLL
NPD1_MYCA1 SPPSN------PMTIRQFTGDPAFRQRYWARNHVGWRHMDDTLPNAGHRALAALEDAAVV
SIR4_MONBE RPPHR------PLQHLEFLGSHERQQRYWARSLYGYPRIRDTMPNVGHQAINELQRRGLV
SIR4_LEIMA GQYHRA--DFVLLTFQKFMRDDNEKRRYWARSMLGYSTMCGASCNAAHMALQAFTKSGAV
SIR4_TRYB2 GLYRRP--NFVPLTRQVFLSGSEHRKRYWARSMFGYNTVSGASCNDTHMGLYELYRAGVV
: : ***:* : . . * .:
SIR4_BOVIN HWLVTQNVDALHTKA------------------GSQRLTELHGCMHRVLCLDCGEQTPRG
SIR4_HUMAN YWLVTQNVDALHTKA------------------GSRRLTELHGCMDRVLCLDCGEQTPRG
SIR4_MOUSE HWLVTQNVDALHSKA------------------GSQRLTELHGCMHRVLCLNCGEQTARR
SIR41_CAEEL QWLITQNVDGLHLKA------------------GSKMVTELHGSALQVKCTTCDYIESRQ
SIR42_CAEEL HWLITQNVDGLHLKA------------------GSKMITELHGNALQVKCTSCEYIETRQ
SIR4_DROME QAVVTQNVDRLHTKA------------------GSRNVVEVHGSGYVVKCLSCEYRIDRH
SIR4_ARATH NFMITQNVDRLHHRA------------------GSD-PLELHGTVYTVMCLECGFSFPRD
NPD_BORBR DLLVTQNVDRLHQAA------------------GGREVLDLHGRLDEVRCMQCDWRGPRG
NPD_BORPE DLLVTQNVDRLHQAA------------------GGREVLDLHGRLDEVRCMQCDWRGPRG
NPD_XANAC EVLLTQNVDRLHQAA------------------GSQAVIDLHGRLDVVRCMGCERRMPRT
NPD_XANCP ELLLTQNVDRLHQAA------------------GSQAVIDLHGRLDVVRCMGCEQRMPRT
NPD2_BRADU GMLLTQNVDRLHQSA------------------GHRQVIDLHGRLDLVRCMGCGAKTPRS
NPD3_PSESM KGLITQNVDALHTQA------------------GSQDVIELHGSLHRVLCLDCQQRSDRT
SIR4_BATDJ AGCITQNVDGLHRRAV---------------VIENPNLLEIHGTLHWVNCISCGYKLQRS
NPD1_COREF SGIVTQNVDGLHRRA------------------GSENLVALHGDLATIVCLQCGHREARE
NPD1_STRCO TGVITQNVDGLHQAA------------------GSEGVVELHGSLDRVVCLSCGVLSPRR
NPD1_MYCA1 TGVITQNVDLLHTKA------------------GSRNVIDLHGSYARVICLGCGDTTSRA
SIR4_MONBE GAIITQNVDGLHQRA------------------GSQHVIDLHGRLDQVKCMNCHSITTRD
SIR4_LEIMA AHILTQNVDGLHHLATYGGVGDAEEEHYYKYTTSDAPLKELHGNIHNVICTSCGFFMPRA
SIR4_TRYB2 NRLLTQNVDGLHHLAAHGGTGSKTVEAYAKYTSSNSGVLELHGNIHQVCCMQCGDVSPRR
:***** ** * :** : * * *
SIR4_BOVIN VLQERFQVLNP---TWSAEAHG---------------LAPDGDVFLTEEE-VQSFQVPSC
SIR4_HUMAN VLQERFQVLNP---TWSAEAHG---------------LAPDGDVFLSEEQ-VRSFQVPTC
SIR4_MOUSE VLQERFQALNP---SWSAEAQG---------------VAPDGDVFLTEEQ-VRSFQVPCC
SIR41_CAEEL TYQDRLDYANP---GFKEEHVAPGE------------LAPDGDIILPLGT-EKGFQIPEC
SIR42_CAEEL TYQDRLNYANP---GFKEQFVSPGQ------------QELDADTALPLGS-EQGFKIPEC
SIR4_DROME EFQSILASLNP---AFKDAPDM---------------IRPDGDVEIPLEY-IENFRIPEC
SIR4_ARATH LFQDQLKAINP---KWAEAIESIDHGDPGSEKSFGMKQRPDGDIEIDEKFWEEGFHIPVC
NPD_BORBR PWQHTLELANP---QWAALQAG---------------AAPDGDADLEGQD-FSRFVVPSC
NPD_BORPE PWQHTLELANP---QWAALQAG---------------AAPDGNADLEGQD-FSRFVVPSC
NPD_XANAC EFQVLLEQANP---GWAALEAA---------------QAPDGDADLDDVA-FEHFVVPPC
NPD_XANCP EFQLLLERDNP---GWADLEAA---------------QAPDGDADLDNVA-FDNFVVPAC
NPD2_BRADU EFQDTLGRANA---EWLALDAS---------------DAPDGDADLEHAD-FSSFKVPAC
NPD3_PSESM AIQEQMLAHNL---YLADVHAT---------------QAPDGDTLLDPAY-EAGFKVPEC
SIR4_BATDJ AMQEQLQKINPIVYEWQRLNPEKSN------ADVASSLNPDGDVEIKWDY--NHFKYPHC
NPD1_COREF LLDARLDHLNP---GYFD-SIALDP----------SAVNPDGDVTLDDHH-VQRFTMAGC
NPD1_STRCO ELARRLEEANA---GFSP-VAA--------------GINPDGDADLTDEQ-VGDFRVVPC
NPD1_MYCA1 ALAERLEALNP---GFIERTEAIGG----------LAVAPDADAVVAE---TASFRYVDC
SIR4_MONBE ELQSRLLADNK---ALLDQFSVVHD----------EAVRPDGDAVLDEDL-YGRFTVAAC
SIR4_LEIMA RLQRELRERNP---GFYEQYGADVS-----------RTRPDGDYSAPTEA-VNAMHLVMC
SIR4_TRYB2 RLQQRLCEANY---QLCRDYEAEFS-----------EVRPDGDYEVPDRV-VQAMQLVCC
: * *.: : *
SIR4_BOVIN SRCGGP-LKPDVVFFGDTVKPDKVDFVHKRVK-EADSLLVVGSSLQVYSGYRFILTAREK
SIR4_HUMAN VQCGGH-LKPDVVFFGDTVNPDKVDFVHKRVK-EADSLLVVGSSLQVYSGYRFILTAWEK
SIR4_MOUSE DRCGGP-LKPDVVFFGDTVNPDKVDFVHRRVK-EADSLLVVGSSLQVYSGYRFILTAREQ
SIR41_CAEEL PSCGGL-MKTDVTFFGENVNMDKVNFCYEKVN-ECDGILSLGTSLAVLSGFRFIHHANMK
SIR42_CAEEL LNCGGL-MKTDVTLFGENLNTDKIKVCGKKVN-ECNGVLTLGTSLEVLSGYQIVNHAHMQ
SIR4_DROME TQCGGD-LKPEIVFFGDSVPRPRVDQIAGMVY-NSDGLLVLGSSLLVFSGYRVVLQTKDL
SIR4_ARATH EKCKGV-LKPDVIFFGDNIPKERATQAMEVAK-QSDAFLVLGSSLMTMSAFRLCRAAHEA
NPD_BORBR PRCGGI-VKPDVVFFGETVPRERVQRAYAALE-HADAVLVVGSSLMLYSGYRFVQAAARA
NPD_BORPE PRCGGI-VKPDVVFFGETVPRERVQRAYAALE-HADAVLVVGSSLMLYSGYRFVQAAARA
NPD_XANAC PVCGGV-LKPNVVFFGENVPRARVERAFAHLQ-AADAVLVVGSSLMVYSGFRFVQTAARN
NPD_XANCP PACGGV-LKPDVVFFGENVPRERVERAFAHLQ-AADAVLVVGSSLMVYSGFRFVQAAARA
NPD2_BRADU EACGGI-LKPDVVFFGENVPRDVVATAQDHLS-QADAMLIVGSSLMVYSGFRFVQAAAQR
NPD3_PSESM PHCQGKRLKPDVVFFGENVASHTAARATLSVE-QAEGLLVVGTSLMAWSAFRLCKAMAEQ
SIR4_BATDJ PECNGL-LKPNVVFFGENMPMTVRDTSFKMID-DAKALLVVGSSLQVYSALRLVKRAAST
NPD1_COREF ARCGSVLLKPDVVYFGEPVPSIRKTRVAQLLD-GADAVVVAGSSLAVMSGYRIVIEAQRA
NPD1_STRCO AVCGGVL-KPDVVFFGENVPPRRVEHCRELVR-GASSLLVLGSSLTVMSGLRFVRQAAEA
NPD1_MYCA1 ARCAGML-KPDIVYFGESVPKDVVAAAYRLID-ESDTLLVAGSSLTVFSGYRFVRHAAAR
SIR4_MONBE ASCGGVL-KPNVVFFGGSLDPEDVKRASTAVS-EASALFVVGTSLATWSAFRIVRQAVEE
SIR4_LEIMA PRCNGF-FKPHVVLFGENVPKPIVEATMSLVRDKASCLLCLGTSLQVYSAYRYVLQANQL
SIR4_TRYB2 EHCGGL-LKPHVVLFGENVPKECVREAYTAVR-AASCLICLGTSLQVFSALRFVLAARES
* . *..: ** : .. .. *:** *. :
SIR4_BOVIN KLPIVILNIGPTRSDD--LASLKLDSRCGELLPLIDPR----------------------
SIR4_HUMAN KLPIAILNIGPTRSDD--LACLKLNSRCGELLPLIDPC----------------------
SIR4_MOUSE KLPIAILNIGPTRSDD--LACLKLDSRCGELLPLIDPRRQHSDVQRLEMNFPLSSAAQDP
SIR41_CAEEL KKPIFIVNIGPTRADH--MATMKLDYKISDVLKEM-------------------------
SIR42_CAEEL NKPIFIVNIGPTRADQ--MATMKLDYRISDVLKEM-------------------------
SIR4_DROME KLPVGIVNIGETRADH--LADIKISAKCGDVIPKLFDFRNSKSVS---------------
SIR4_ARATH GAMTAIVNIGETRADD--IVPLKINARVGEILHRVLDVGSLSVPAL--------------
NPD_BORBR GLPIAAINLGRTRADD--MLALKVSRPCDEVLAEVVS-----------------------
NPD_BORPE GLPIAAINLGRTRADD--MLALKVSRPCDEVLAEVVP-----------------------
NPD_XANAC GLPIAALNFGRTRADE--LLTLKVEQSCAQALAFLHAPPHLPRARSVNDASARSA-----
NPD_XANCP GLPIAALNFGRTRADD--LLSLKVEQSCAQALAFLQQPPDPLHTATARYHSARSA-----
NPD2_BRADU QIPIAAVNLGRTRADD--LLTLKVEERCEAALAFLL------------------------
NPD3_PSESM GKPVIAINHGKTRADE--LLRMKIEAPCEQVLPWLAEQLITR------------------
SIR4_BATDJ GKPIAILNLGFTRGDE--LAQIRINLGSSAVLEELASTIR--------------------
NPD1_COREF GKPVAVINGGPGRADH--RVDILWRTRVGPAFDQILDALDL-------------------
NPD1_STRCO GKPVLIVNRDATRGDR--LAVTRVALPLGPALTTVADRLGLRVGDAATA-----------
NPD1_MYCA1 GIPIAIVNRGDTRGDH--LATVKVDGGCSELLALLADELSPLPTH---------------
SIR4_MONBE AKPVCVLNSGPTRADGVIPEYLRLCMPIGEVLPAALRQL---------------------
SIR4_LEIMA GIPVAIVNAGTTRGDAIADLKLDVESVGSVLAETAHEMLGVPASMFFRRKTIQL------
SIR4_TRYB2 GVPIAIVTAGRTRADGLEELKVDTNSTAATMRGVVKQLLGFELGGTK-------------
:. . *.*