CLUSTAL format seed alignment for MF_03021
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Features found in the protein:- The following colors are used to highlight features:
- blue indicates SIGNAL, PROPEP, TRANSMEM, DOMAIN, ZN_FING, REPEAT,
DNA_BIND and CA_BIND.
- magenta is used to display DISULFID, THIOLEST and THIOETH.
- red is used for all other features, such as INIT_MET, ACTIVE SITE,
METAL,BINDING, NP_BIND, SITE, REGION, etc.
- The ID of the sequence used as the template for feature propagation is
underlined.
- A '<' at the beginning of a sequence or '>' at the end indicate that
the protein is fused with another domain either at the N- or C-terminus.
_____________________________________________________________________________
D3BA00_POLPP -MRRQISNDRDWVIIKLKKSDKQLSRTS--------------------------------
SPAST_DICDI -------MLFDLINSFLKNGINN-------------------------------------
F0ZEB6_DICPU ------MLGHLVQLFFEDKFEDE-------------------------------------
SPAST_NEMVE ------------------------------------------------------------
SPAST_IXOSC ------MASTVALLRDSSDDREN-------------------------------------
SPAST_DANRE -------------MNSGHKARLR-------------------------------------
SPAST_XENLA ------------MNSPGGRNDKKKPV----------------------------------
SPAST_XENTR ------------MNSPGGRNNKKKPV----------------------------------
SPAST_CHICK ------------MNSPGGRGKKK-------------------------------------
SPAST_MOUSE ------------MSSPAGRRKKK-------------------------------------
SPAST_RAT ------------MSSPAGRRKKK-------------------------------------
SPAST_BOVIN ------------MNSPGGRGKKK-------------------------------------
SPAST_PIG ------------MNSPGGRGKKK-------------------------------------
H0X267_OTOGA ------------MNSPGGRGKKK-------------------------------------
SPAST_HUMAN ------------MNSPGGRGKKK-------------------------------------
G1S0D4_NOMLE ------------MNSPGGRGKKK-------------------------------------
SPAST_DROME MVRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGLGGRQSTHRSSSASNVAAVVAGGSSA
SPAST_DROPS MVRTKNQSSSSSASSSSHKSPIKSHGGSGSAAAGTAGHPVSRSSSSHRTSIDDRKSATNV
SPAST_ANOGA ------MVRNKYTLTTAGKSPSKKSRTGSLSKQHDATG----------------------
E0VYI4_PEDHC -----------MLRKDNSRIPKRI------------------------------------
D6WR93_TRICA ------MVRKTQTKSPGKKSRKS-------------------------------------
F4W8A4_ACREC ---MSCSDGARPTRKFGTKSPKKLCVTKS-------------------------------
E2AI24_CAMFO ---MSYSDGARPIRKFGTKSPKKLCVTK--------------------------------
D3BA00_POLPP --QAVNLDHILNDKVISDH---IDNNNSKTK-----TTDNNNIE----SIELNKNNIITT
SPAST_DICDI --SNNNNNNNNNKNNF--------YNSLEDD-----DYLLNNQT----TKVSLYLYFFIF
F0ZEB6_DICPU --YSYNRYLPLEEEPYVDN---Q-------------------------VKVSLFNFFFIF
SPAST_NEMVE --MPNNDIL---------------------------------------RPLAIPAKYVGS
SPAST_IXOSC --FDDGETDCVQ------------------------------------VGRKRKLTVFFY
SPAST_DANRE ---GGRACGPVSDGS---------------------------------ARGNRLLFYTRS
SPAST_XENLA --TPAAETGPGSPTTPPSTETQVVLAPP--------------------SPHKRNLHLFSY
SPAST_XENTR --TPAAETGPGPPTPPPP--------PAETQ-----VLLAPP------SLHKRNLYLFSY
SPAST_CHICK --GSAGSSSAPPAAGASPSAPSGPAPPAPPA-----GAAAAAAA----SPHKRNLYYFSY
SPAST_MOUSE --GSGGAS-PAPARPPPPA------AVPAPA-----AGPAPAAG----SPPKRNPSSFSS
SPAST_RAT --GSGGAS-PAPARPPPPA------AVPAPA-----AGPAPAPG----SPHKRNLYYFSY
SPAST_BOVIN --GSGGPSSPVPPRPPPPC-----QARSRPA-----PKPAPPPQ----SPHKRNLYYFSY
SPAST_PIG --GSGGPSSPVPPRPPPPC-----LASSRPA-----PRPAPPPQ----SPHKRNLYYFSY
H0X267_OTOGA --GSGGPSSPVPPRPPPPC-----LAPAPPA-----AGRAPARE----SPHKQNLYYFSY
SPAST_HUMAN --GSGGASNPVPPRPPPPC-----LAPAPPA-----AGPAPPPE----SPHKRNLYYFSY
G1S0D4_NOMLE --GSGGASNPVPPRPPPPC-----LAPAPPA-----AGPAPPPE----SPHKRNLYYFSY
SPAST_DROME AGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSF
SPAST_DROPS SSSSNRRTTPGSSPDGDGDDDTTTTDDLTPT-----STSAPRSAGGPSSVHKQNLYVVSF
SPAST_ANOGA --DDDGETGTLDGSGSAAG---SPVGGGTDA-----AAKRCDGG----SVHKQNLYIISF
E0VYI4_PEDHC --KKFDNSKPQEESI---------------------------------SVQKKNLFIISY
D6WR93_TRICA --DPDISRSDVMFTSYSET-----------------------------SVHKRNLCIVSF
F4W8A4_ACREC --ENGDKTTTTISCVGHRHNHHYHHGHHRFL-----DGSSQP------SVHKRNLYIVSF
E2AI24_CAMFO --SENGEKTTTTVNCGGHHHNHYHHSHHRFL-----DGPQP-------SVHKRNLYVVSF
D3BA00_POLPP TASKRLSSSNSNSNNSSSVGTN----INKRNSVSITTPS---------------------
SPAST_DICDI AFMFLVVDLIMLYYKHRENIESRETDLSLKLNKMLIDFENDNKIKSSPTTSTTTTTITPT
F0ZEB6_DICPU TFIFLIVDIIISCYQHKENIRQREIHLSSKLNKIINDFE---------------------
SPAST_NEMVE FLVFLYNGL----YFVFVVNLW--SRLFGKATKTEVPPL---------------------
SPAST_IXOSC PLLLVFWLLRWVFYQFFLVLCF----VCRGFVP---------------------------
SPAST_DANRE LSRVPEWLLRVLL----LLLRW----LFQPIRRAMAARA---------------------
SPAST_XENLA PLLAVFSLLRFLAFQLGLLFVW----CCELLSRSVMADK---------------------
SPAST_XENTR PLLAAFSLLRFLAFQLGLLFVW----FCERLSRRVMADK---------------------
SPAST_CHICK PLFAAFALLRFVAFQLGLLVAW----LCERLSRGALMAA---------------------
SPAST_MOUSE PLVVGFALLRLLACHLGLLFAW----LCQRFSRALMAAK---------------------
SPAST_RAT PLVVGFALLRLLACHLGLLFVW----LCQRFSRALMAAK---------------------
SPAST_BOVIN PLFLGFALLRLVAFHLGLLFVW----LCQRFSRALMAAK---------------------
SPAST_PIG PLFLGFALLRLVAFHLGLLFVW----LCQRFSRALMAAK---------------------
H0X267_OTOGA PLFVGFALLRLVAFHLGLLFVW----LCQRFSRALMAAK---------------------
SPAST_HUMAN PLFVGFALLRLVAFHLGLLFVW----LCQRFSRALMAAK---------------------
G1S0D4_NOMLE PLFVGFALLRLVAFHLGLLFVW----LCQRFSRALMAAK---------------------
SPAST_DROME PIIFLFNVLRSLIYQLFCIFRY----LYGASTKVIYRPH--RRDCNIEIVVQNSSKEQQ-
SPAST_DROPS PIIFLFNVLRSLIYQLFCIFRY----LYGASTKVIYRPH--RRDCNIEIVVQNNSNNKDQ
SPAST_ANOGA PVIFVFNVLRSLLYQLFIVFRY----VYNFTTKVVYRPV--RKECGLEIVINTDQHGHHH
E0VYI4_PEDHC PVVFLFVIFRSILHHLFLLLKA----LGTLITSNKFKFKSNSEKNN--------------
D6WR93_TRICA PIIFLFNILRTLLYQIFVILRF----VYCSSSNYLVKKR---------------------
F4W8A4_ACREC PLILLFNVLRTLLYQLFVVFKY----LYTSTSQLIQRRQTSKQACQLEIVVG--------
E2AI24_CAMFO PLILLFNVLRTLLYQLFMVFKY----LYTSTSQLIQRRQASKQVCQLEIVVG--------
D3BA00_POLPP -------------------------SSIPTPTSTTNCSNNRRSLTLERQNSINNNIN---
SPAST_DICDI TTS-------------------------SSQLRQPSTPKTTTKTINSPPSTPKSPPP---
F0ZEB6_DICPU -----------------------------------NQNHQKQSQISPSPSTSLSPSP---
SPAST_NEMVE --------------------------------PKIRKLGKDMASRAPPRRGQSSEDN---
SPAST_IXOSC ----------------------------------------RRHLATAETTTTMATAE---
SPAST_DANRE ----------------------------------------------------KECGP---
SPAST_XENLA ----------------------------------------GRTVASTAAAQDRPQEP---
SPAST_XENTR -------------------------------------------GSTAARTAAAPAQD---
SPAST_CHICK ------------------------------------------------KSSRAGDAP---
SPAST_MOUSE ----------------------------------------RSSGTAPAPASPSPPEP---
SPAST_RAT ----------------------------------------RSSGTAPAPASPSTPAP---
SPAST_BOVIN ----------------------------------------RSSGAA--PASASPPAP---
SPAST_PIG ----------------------------------------RSSRAAPAPASASPPAP---
H0X267_OTOGA ----------------------------------------RSSRAAPTPSSASPPAP---
SPAST_HUMAN ----------------------------------------RSSGAAPAPASASAPAP---
G1S0D4_NOMLE ----------------------------------------RSSGAAPAPASASAPAP---
SPAST_DROME -------------------------QSLNHPSELNREGDGQEQQLSNQPQRFRPIQP---
SPAST_DROPS KHQQLTSSQSLNYPLEVTSGEAASEQQVQQPLPQQRYRALQPLEMAGANRSGSGYSP---
SPAST_ANOGA HHHHRHSSHSIHSTAAAHQLQQHQQQQQHQYSLLQQEQHGVTEPQQQQQQQHQAAHPLQC
E0VYI4_PEDHC ----------------------------KEGVINDAVKDETSIVETEKMSNINKHQL---
D6WR93_TRICA --------------------------QFECGESDQQVATCVIEEITEMTHVQRVTGP---
F4W8A4_ACREC ----------------------------QKPTDGRLINGNRIEGEAMSQVPRRPIGP---
E2AI24_CAMFO ----------------------------QKPTDGRLTNSGQVEGEIMSQLPRRPIGP---
D3BA00_POLPP -------------------------NNSTNNNS-NNSNSNNNNLQVENNM---SEIQKGR
SPAST_DICDI -------------------------LPSLESKL-LYKDDIKQQLSLNEAK---SQIDSAK
F0ZEB6_DICPU -------------------------SISSTISS-PVNKRSISVPNLISQAKNELLLKESK
SPAST_NEMVE -------------------------EDGLPAEIFNVRRHHKQAYAYIARA---LEVDEGQ
SPAST_IXOSC -------------------------EPDANLLI-RQKQHHKKAFDFISKA---LKYDE--
SPAST_DANRE -------------------------DGSEETGE-RIRNYHKQAFEFISVA---LQIDE--
SPAST_XENLA -------------------------E--------VVRSYHQQAFQYISLA---LRVDE--
SPAST_XENTR -------------------------RPQEPE---VVRSYHQQAFQYISMA---LRIDE--
SPAST_CHICK -------------------------EPGGAAE--RVRACHKRAFECISMA---LRIDED-
SPAST_MOUSE -------------------------GPGGEAE--SVRVFHKQAFEYISIA---LRIDEE-
SPAST_RAT -------------------------GPGGEAE--SVRVFHKQAFEYISIA---LRIDE--
SPAST_BOVIN -------------------------VPGGEAE--RVRAFHKQAFEYISVA---LRIDED-
SPAST_PIG -------------------------VPGGEVE--RVRAFHKQAFEYISVA---LRIDED-
H0X267_OTOGA -------------------------VPGGETE--SVRAFHKQAFEYISIA---LRIDED-
SPAST_HUMAN -------------------------VPGGEAE--RVRVFHKQAFEYISIA---LRIDED-
G1S0D4_NOMLE -------------------------VPGGEAE--RVRVFHKQAFEYISIA---LRIDED-
SPAST_DROME -----------LEMAANRPGGGYSPGPGDPLLA-KQKHHHRRAFEYISKA---LKIDE--
SPAST_DROPS -------------------------GPGDPLLA-KQKHHHRRAFEYISKA---LKIDE--
SPAST_ANOGA SQSGILVNGEGREMSIQRSASGSQVGPGDPLLA-KQKHHHRRAFEYISKA---LKIDE--
E0VYI4_PEDHC -------------------------GPGDPLLV-KQKQHHRRAFEYISKA---LKIDE--
D6WR93_TRICA -------------------------GPGDPLLA-KQKHHHRRAFEYISKA---LKIDE--
F4W8A4_ACREC -------------------------GPGDPLLA-KQKHHHRRAFEFISKA---LKIDE--
E2AI24_CAMFO -------------------------GPGDPLLA-KQKHHHRRAFEFISKA---LKIDE--
..
D3BA00_POLPP HFIEEGKLKDEKGEYDKALQYYTDGIEKL---IPL---CKSSKELKNYVMFYMDRAEYLK
SPAST_DICDI QL-------DESLKYNSCIKLYIDGIEKL---MALFS-SYNSKEYRDYIDFYLKRAEYLK
F0ZEB6_DICPU EQIEKAKKYDQSLDYQKSLELYIEGIGKL---MSINSSFKDSKEFKNYIDFYLKRAEYIK
SPAST_NEMVE ---------GSLETKKRAVEFYNRGIEEMEAGLLIPC-IDEGEEWDKARRLQEKMEANLE
SPAST_IXOSC ---------ENEDFKEMSIDLYRKGIEELQKGIAIDFSKGQGTTWERAHRLSDKMKVNLE
SPAST_DANRE ---------DEKGDKQKAVQWYRKGIAELEKGIQIQV-TGAGEKADRARKLQDKMITNLS
SPAST_XENLA ---------EEKDQKEQAVQWYKKGIEELEKGIAVPI-SGKGEQYDRARRLQAKMSTNLI
SPAST_XENTR ---------EEKDQKEQAIQWYKKGIEELEKGIAVTI-TGKGEQYDRARRLQAKMSTNLL
SPAST_CHICK ---------ERAGQKEQAVEWYKKGIEELERGIAVLV-VGQGDQCERARRLQSKMMTNLA
SPAST_MOUSE ---------EKAGQKEQAVEWYKKGIEELEKGIAVIV-TGQGEQYERARRLQAKMMTNLV
SPAST_RAT ---------EEKGQKEQAVEWYKKGIEELEKGIAVIV-TGQGEQYERARRLQAKMMTNLV
SPAST_BOVIN ---------EKVGQKDQAVEWYKKGIEELEKGIAVVV-TGQGEQCERARRLQAKMMTNLV
SPAST_PIG ---------EKVGQKEQAVEWYKKGIEELEKGIAVVV-TGQGEQCERARRLQAKMMTNLV
H0X267_OTOGA ---------EKAGQKEQAVEWYKKGIEELEKGIAVII-TGQGEQCERARRLQAKMMTNLV
SPAST_HUMAN ---------EKAGQKEQAVEWYKKGIEELEKGIAVIV-TGQGEQCERARRLQAKMMTNLV
G1S0D4_NOMLE ---------EKAGQKEQAVEWYKKGIEELEKGIAVIV-TGQGEQCERARRLQAKMMTNLV
SPAST_DROME ---------ENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLS
SPAST_DROPS ---------ENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLS
SPAST_ANOGA ---------DNEDQKELAIELYRKGILELERGIAVECWGGRGEVWERAQRLHDKMQTNLS
E0VYI4_PEDHC ---------ENDGHKDLAIELYKKGILELEKGVAVECNGGKGELWERAQRLHEKMKTNLS
D6WR93_TRICA ---------ENEGQKDLAIELYRKGITELELGIAVQCWGGRGEVWERAQRLHEKMKTNLA
F4W8A4_ACREC ---------DNEGQKEMAIELYKKGIGELEKGIAVECTGGHGEVWEHAQRLHDKMCTNLA
E2AI24_CAMFO ---------DNEGQKEMAIELYKKGIGELEKGIAVECNGGHGEVWEHAQRLHDKMCTNLA
. .:. * ** :: : : . : . :
D3BA00_POLPP SELSKSTSFTLIEPFNIFVQ--------------------KNVNSTTSTTTTTSSSSSTS
SPAST_DICDI NELKKGTNLKSITNFNNFSK-------------------------EYQINYNNKILEQQQ
F0ZEB6_DICPU QELSKNTNEKLIINFEKFQK--------------------------------EHQQQQQQ
SPAST_NEMVE NTRERMDELVIIFFIIVVAL----------------------------LVSAGMMDDQPL
SPAST_IXOSC MARDRLDFLESMVKIEHLGD-----HLPWHGGVAPAQRGQRRRAWQKAAPSAPSEPGTGP
SPAST_DANRE MAEDRLKLLGNL-----LSQ------------------------------------SPAE
SPAST_XENLA MAKDRLQLLAKLQADIQGPH------------------------------------SQME
SPAST_XENTR MAKDRLQLLAKLKADIQGQH------------------------------------SQME
SPAST_CHICK MAKDRLQLLEKLQADLQISK------------------------------------PQME
SPAST_MOUSE MAKDRLQLLEKLQPVLQFSK------------------------------------SQTD
SPAST_RAT MAKDRLQLL---------------------------------------------------
SPAST_BOVIN MAKDRLQLLEKLQPSLQFSK------------------------------------SQTD
SPAST_PIG MAKDRLQLLEKLQPVLQFSK------------------------------------SQMD
H0X267_OTOGA MAKDRLQLLEKLQPVLSFTK------------------------------------SQPE
SPAST_HUMAN MAKDRLQLLEKMQPVLPFSK------------------------------------SQTD
G1S0D4_NOMLE MAKDRLQLLEKMQPVLPFSK------------------------------------SQTD
SPAST_DROME MARDRLHFLALREQDLQMQR---------------LSLKEKQKEEAQSKPQKTREPMLAG
SPAST_DROPS MARDRLHFLALREEDFQMHRLSLKEEQKPNPSREQHQKPQKAREAADKPMLTNLTNDPVK
SPAST_ANOGA MARDRLQFLGMLCVCVSVQR-------KHLHPTRTTLPYRDVKSKLHTTPTENRMVSFNE
E0VYI4_PEDHC MAKDRLEFLSSSQKILTEKR----------------------------------------
D6WR93_TRICA MAKDRLQFLESMDMLHRQDV-------------------------------QKEPKEAPK
F4W8A4_ACREC MAKDRLDFLVSVRELRKLGINNNINNRAPGNKTDGEHPGKHLRARRNTHTFQNARTSPNI
E2AI24_CAMFO MAKDRLDFLVSVCELRKLGI--NNQYRAAGNKMDGKHLGKHLRARRNIHTFQTAQTSFNA
..
D3BA00_POLPP SSSANSKPSFFSSWFGGGSSN-----------------NSTATASSSAAKKKQPDIIDLT
SPAST_DICDI QQQQQSSSTYRNSL------------------------NLSSSKSNSTINNRHSISSLSS
F0ZEB6_DICPU VQQQQRKSGMFSLF------------------------SKPSATLSTTTNKS------LG
SPAST_NEMVE LSARKTSSEPSQAWDV----------------------SKPTGPSYKQSKSYKN----ST
SPAST_IXOSC SWLKMAENGPAKGGPCPTS-------------------PRLQRSNTGVTLRRQQQQQLGG
SPAST_DANRE SSSDDSFYSFSNGN------------------------LRPAPASGAVSKKKDT----L-
SPAST_XENLA VCSDNTNLPCRNGL------------------------LKP--EKGAVPKKKDP------
SPAST_XENTR VCSDNTNLPCRNGL------------------------LKP--EKGAVPKKKDP------
SPAST_CHICK VYNDSTNLACRNGH------------------------LQS--ESGAVPKKKDP----L-
SPAST_MOUSE VYNESTNLTCRNGH------------------------LQS--ESGAVPKRKDP----L-
SPAST_RAT -------------------------------------------ESGAVPKKKDP----L-
SPAST_BOVIN VYNDSTNLTCRNGH------------------------LQS--ESGAVPKRKDP----L-
SPAST_PIG VYNDSTNLTCRNGH------------------------LQS--ESGAVPKRKDP----L-
H0X267_OTOGA VYNDSTNLTCRNGH------------------------LQSV-ESGAIPKRKDP----L-
SPAST_HUMAN VYNDSTNLACRNGH------------------------LQS--ESGAVPKRKDP----L-
G1S0D4_NOMLE VYNDSTNLACRNGH------------------------LQS--ESGAVPKRKDP----L-
SPAST_DROME MTNEPMKLRVRSSGYGPKATTSAQ--------------PTASGRKLTIGSKR-P----VN
SPAST_DROPS LKTRSSGYGPKNGLTTPRISATATTPTSSS--------SLASGRKLTIGTKRPG----NL
SPAST_ANOGA NCTITTNHHPARGTAASSRPTTAATAPATPSLPIKQTASEASGRKLTVGYKR-P----GN
E0VYI4_PEDHC ------------------------------------------------PSLQ--------
D6WR93_TRICA LSYTTNIPTPKLCF------------------------NKASGKKLSVASKRPP----N-
F4W8A4_ACREC NHNKNTNNIHTTINAGQTMCTQIPKLRPRSPKNCFAHTIEASGRKLSVPGKR------II
E2AI24_CAMFO NHTKNTNSINATVNSGQTICTQIPKLKPRSPKNCHT--TEASGRKLSVPGKR------IT
D3BA00_POLPP TTTTATPTPLSKSTASTTTSTNRLNSNLSNSLRLTPSSSLST------------VNKSSS
SPAST_DICDI LNSTTATTTTPSNTSTIT-----------------SPGNKYG------------LQKSL-
F0ZEB6_DICPU LSTTETTNRVPLTKSSSQTLI--------------SNPPSST------------------
SPAST_NEMVE TVTTKRSQASPSFSSSSS-----------------SVNSTAG------------SSRTKP
SPAST_IXOSC VSTVSRSQTLPRNSVPCPRMSARSPSRKAGNNEAVPTPNTAR------------RRASQP
SPAST_DANRE ---TITNQTSLRPKNPPK-----------------STPNASG------------LNCTPS
SPAST_XENLA --PPITSNSYSRTKAPPKSGSLGN-----------RIPNCTS------------VPTSAR
SPAST_XENTR --PSISSNSYSRVKAAPKSGSLGN-----------RIPNCTG------------VSSSAR
SPAST_CHICK ---THTSNSLPRSKTVAKTGSTGLSGHH-------RTPSYSG------------ISTASV
SPAST_MOUSE ---THASNSLPRSKTVLKSGSAGLSGHH-------RAPSCSG------------LSMVSG
SPAST_RAT ---THASNSLPRSKTVMKSGSTGLSGHH-------RAPSCSG------------LSMVSG
SPAST_BOVIN ---THASNSLPRSKTVMKTGPTGLSGHH-------RAPSCSG------------LSMVSG
SPAST_PIG ---THPSNSLPRSKAIMKTGSTGLSGHH-------RAPSCSG------------LSIVSG
H0X267_OTOGA ---THTSNSLPRSKTVMKTGSTGLSGHH-------RAPSFSG------------LSMVSG
SPAST_HUMAN ---THTSNSLPRSKTVMKTGSAGLSGHH-------RAPSYSG------------LSMVSG
G1S0D4_NOMLE ---THTSNSLPRSKTVMKTGSAGLSGHH-------RAPSYSG------------LSMVSG
SPAST_DROME LAVANKSQTLPRNLGSKT-----------------SVGAVQR------------QPAKTA
SPAST_DROPS AVAANKSQTLPRNLGSKT-----------------SVGAVRQ-------------PGKTA
SPAST_ANOGA LGVMNKSQTLPRSMGGTRTTPTGTGGAGGIAGGLGNGGTYGGSIVGGGAGMPKIVPKPAA
E0VYI4_PEDHC ---GTRSHTLPRNMGSRSNP---------------NIGGSAS------------RSYKPA
D6WR93_TRICA -ATLAKSQTLPRSMGSRTA----------------PIQPVRP------------FNKLSS
F4W8A4_ACREC GTPLSKSQTLPRSMGRSM-----------------PIQPCHR-----------TMPIKPS
E2AI24_CAMFO GTPLSKSQTLPRSMGRST-----------------PIQPCHR-----------TMPIKPS
D3BA00_POLPP STSS---------SSSGILSKTFTGIT-GSKSSNSPLRSTTSTTTTTQQQPIP----GQI
SPAST_DICDI -------------------SSTTLSLK-KSSNSTNFQQPSPPSMVIP-------------
F0ZEB6_DICPU -------------------NVNRRSVNLSPKSN-NTNNNVINLNNIP-------------
SPAST_NEMVE AKPA---------------PMAAPRRY-NPQVR-RTKSTKPAMMAKQSCVDEQ---KKKI
SPAST_IXOSC QVP----------------PVHPRGRQ-PTTRGGAAHRGGPPTVSQRSLLSSR------V
SPAST_DANRE AAQS---------SRTG--PQNNQKGP-TVKGKNNVKASTTATASPQRKRDMK-------
SPAST_XENLA QAG----------------AHTPSNRGATGKNNTRTNKPATPTTAVR-KKDMK-------
SPAST_XENTR QAG----------------PNAPSNRGAAGKNNTRTNKPTTPTTAVR-KKDMK-------
SPAST_CHICK SRPA---------A--N--PATSTHKA-APKNS-RTNKPSTPTPAARKKKDTK-------
SPAST_MOUSE ARPG---------P--G--PAATTHKG-TPKPN-RTNKPSTPTTAVRKKKDLK-------
SPAST_RAT ARPG---------S--G--PAATTHKG-TSKPN-RTNKPSTPTTAVRKKKDLK-------
SPAST_BOVIN VRQG---------P--G--SAAATHKS-TPKTN-RTNKPSTPTTAARKKKDLK-------
SPAST_PIG MRQG---------P--G--PTTATHKS-TPKTN-RTNKPSTPTTAPRKKKDLK-------
H0X267_OTOGA VRQA---------P--G--PTITTHKG-TPKTN-RTNKPSTPTTAARKKKDLK-------
SPAST_HUMAN VKQG---------S--G--PAPTTHKG-TPKTN-RTNKPSTPTTATRKKKDLK-------
G1S0D4_NOMLE VKQG---------P--G--PAPTTHKG-TPKTN-RTNKPSTPTTATRKKKDLK-------
SPAST_DROME ATP----------------PAVRRQFS--SGRNTPPQRSRTPINNNGPSGSGA---STPV
SPAST_DROPS ATP----------------PAVRRQFS--SGRNTPPQRSRTPINNNGASGSGS-GASTPV
SPAST_ANOGA TPPAIRRQFSVSIPIPGSSPVRKASNG-YGSKNTPPPRSKTPLAGQQPQQPQQQQQQQPQ
E0VYI4_PEDHC STP----------------PAVKRQLS-GPGSS-PVHKPGNTTKTKPGQKIQK------A
D6WR93_TRICA TP-----------------PAVKKQLS-VPGTAGSPARKTTASLATPSKSTSR---GGKS
F4W8A4_ACREC STP----------------PSVKRQLS-VPGNGSPIRRPGTPTTSNSNRSTPT----RKV
E2AI24_CAMFO STP----------------PSVKRQLS-VPGNGSPIRRPGTPTTSNSNRSTPT----RKV
D3BA00_POLPP PDIKGVDKAALQIIMNEIIDTKHPVTWDDVVGLDKVKQSLMEAVILPNLRPDVFVGLRSP
SPAST_DICDI -DIKGIDKSMVTLIMNEIMDRKNPVKWDDVVGLDKVKQSLMESVILPNLRPDVFTGLRAP
F0ZEB6_DICPU -EIKGVDKAMISIIMNEILDRKNPVTWNDVVGLDKVKQSLMESVILPNLRPDVFTGLRAP
SPAST_NEMVE SHLKGIDPKLANIIMDEILESGPAVHFSDIAGVDNAKKALQEIVILPSLRPELWRGDPTL
SPAST_IXOSC PPLKGVDSRLAHLILDEVVDGAPPVLFSDIAGQEVAKQALSEMVILPTDRPELFTGLRAP
SPAST_DANRE -NFKNVDSKLASLILNEIVDSGSVVRFDDIAGQDLAKQALQEIVILPALRPELFTGLRAP
SPAST_XENLA -NLRNVDSNLANLILNEIVDSGPSVKFADIAGQDLAKQALQEIVILPSIRPELFTGLRAP
SPAST_XENTR -NLRNVDSNLANLILNEIVDSGPTVKFADIAGQDLAKQALQEIVILPSIRPELFTGLRAP
SPAST_CHICK -VFRNVDSNLANLILNEIVDSGPAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAP
SPAST_MOUSE -NFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAP
SPAST_RAT -NFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAP
SPAST_BOVIN -NFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAP
SPAST_PIG -NFRNVDSNLANFIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAP
H0X267_OTOGA -NFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAP
SPAST_HUMAN -NFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAP
G1S0D4_NOMLE -NFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAP
SPAST_DROME VSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAP
SPAST_DROPS VTVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQEVAKQALQEMVILPSVRPELFTGLRAP
SPAST_ANOGA ISVKGVEPKLVQIIMDEIVEGGAKVQWQDIAGQEVAKQALQEMVILPSVRPELFTGLRTP
E0VYI4_PEDHC ECLKGVNSKLAHTILDEIQDNVCGVKWDDIAGQHAAKQALQEMVILPSLRPELFTGLRTP
D6WR93_TRICA PNLRGVDTKLAQCILDEIVEGGLQVQWEDIIGQDAAKQALQEMVILPSLRPELFTGLRTP
F4W8A4_ACREC PILKGVDPKLAQVILDEILEGGAPVQWEDIAGQETAKQALQEMVILPSLRPELFTGLRTP
E2AI24_CAMFO PILKGVDPKLTQVILDEILEGGAPVQWEDIAGQETAKQALQEMVILPSLRPELFTGLRTP
...:: *::*: : * : *: * .*::* * **** **::: * :
D3BA00_POLPP PKGLLLFGPPGNGKTMIAKA-VAYESKATFFSISA-SSLTSKYVGEGEKLVRALFAVAGY
SPAST_DICDI PKGLLLFGPPGNGKTMIAKA-VAYESKVTFFSISS-SSLTSKYVGDGEKLVRALFAVATH
F0ZEB6_DICPU PRGLLLFGPPGTGKSMIAKA-VAYESKVTFFSISA-SSLTSKYVGDGEKLARALFAVATH
SPAST_NEMVE VLFQVLPYPPGSSHITLPRASTATSFTSCFFSISKRSSLVHPVVAS--FFVKSLEDLASI
SPAST_IXOSC PKGLLLFGPPGNGKTMLAKA-VAHESNSTFLNISA-ASLTSKYVGEGEKLVRALFAVARE
SPAST_DANRE ARGLLLFGPPGNGKTMLAKA-VAMESNATFFNISA-ATLTSKYVGEGEKLVRALFAVARE
SPAST_XENLA ARGLLLFGPPGNGKTMLAKA-VAAESNATFFNISA-ASLTSKYVGEGEKLVRALFSVARE
SPAST_XENTR ARGLLLFGPPGNGKTMLAKA-VAAESNATFFNISA-ASLTSKYVGEGEKLVRALFSVARE
SPAST_CHICK ARGLLLFGPPGNGKTMLAKA-VAAESNATFFNISA-ASLTSKYVGEGEKLVRALFAVARE
SPAST_MOUSE ARGLLLFGPPGNGKTMLAKA-VAAESNATFFNISA-ASLTSKYVGEGEKLVRALFAVARE
SPAST_RAT ARGLLLFGPPGNGKTMLAKA-VAAESNATFFNISA-ASLTSKYVGEGEKLVRALFAVARE
SPAST_BOVIN ARGLLLFGPPGNGKTMLAKA-VAAESNATFFNISA-ASLTSKYVGEGEKLVRALFAVARE
SPAST_PIG ARGLLLFGPPGNGKTMLAKA-VAAESNATFFNISA-ASLTSKYVGEGEKLVRALFAVARE
H0X267_OTOGA ARGLLLFGPPGNGKTMLAKA-VAAESNATFFNISA-ASLTSKYVGEGEKLVRALFAVARE
SPAST_HUMAN ARGLLLFGPPGNGKTMLAKA-VAAESNATFFNISA-ASLTSKYVGEGEKLVRALFAVARE
G1S0D4_NOMLE ARGLLLFGPPGNGKTMLAKA-VAAESNATFFNISA-ASLTSKYVGEGEKLVRALFAVARE
SPAST_DROME AKGLLLFGPPGNGKTLLARA-VATECSATFLNISA-ASLTSKYVGDGEKLVRALFAVARH
SPAST_DROPS AKGLLLFGPPGNGKTLLARA-VATECSATFLNISA-ASLTSKYVGDGEKLVRALFAVARH
SPAST_ANOGA AKGLLLFGPPGNGKTLLARA-VATECSATFFSISA-ATLTSKYVGDGEKLVRALFAVARE
E0VYI4_PEDHC SRGLLLFGPPGNGKTLLARA-VASECNATFFSISA-ASLTSKYVGEGEKLVRALFAVARE
D6WR93_TRICA ARGLLLFGPPGNGKTLLARA-VATECRATFFSISA-ASLTSKYVGEGEKMVRALFAIARE
F4W8A4_ACREC ARGLLLFGPPGNGKTLLARA-VATQCNATFFSISA-ASLTSKYVGEGEKLVRALFAIARE
E2AI24_CAMFO ARGLLLFGPPGNGKTLLARA-VATQCHATFFSISA-ASLTSKYVGEGEKLVRALFAIARE
:* ***..: :..* .* . *:.** ::*. *.. :..:* :*
D3BA00_POLPP YQPSIIFIDEVDSLLTERSEGESDHTRRLKTEILIQFDGVKTNGA-ERILVMGATNRPEE
SPAST_DICDI FQPSIIFIDEIDSLLTERSSNESEASRRLKTEILVQFDGARTNGD-ERVLVMGATNRPED
F0ZEB6_DICPU FQPSIIFIDEIDSLLTERSSNESEASRRLKTEILLQFDGVRTSGS-ERVLVMGATNRPED
SPAST_NEMVE LTTSLFTIDEVDSLLTERREGEHEHSRRLKTEFLVSFDGVVADPE-ERILVMGATNRPQE
SPAST_IXOSC LQPSIIFIDEVDSLLSERKDNEHEATRRLKTEFLVEFDGLHTGSE-ERVLVMGATNRPQE
SPAST_DANRE LQPSIIFIDEIDSLLCERREGEHDASRRLKTEFLIEFDGVQSGGD-ERVLVMGATNRPQE
SPAST_XENLA LQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSGGD-DRVLVMGATNRPQE
SPAST_XENTR LQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSGGD-DRVLVMGATNRPQE
SPAST_CHICK LQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSSGE-DRILVMGATNRPQE
SPAST_MOUSE LQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGD-DRVLVMGATNRPQE
SPAST_RAT LQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGD-DRVLVMGATNRPQE
SPAST_BOVIN LQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGD-DRVLVMGATNRPQE
SPAST_PIG LQPSIIFIDEVDSLLRERREGEHDASRRLKTEFLIEFDGVQSAGD-DRVLVMGATNRPQE
H0X267_OTOGA LQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGD-DRVLVMGATNRPQE
SPAST_HUMAN LQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGD-DRVLVMGATNRPQE
G1S0D4_NOMLE LQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGD-DRVLVMGATNRPQE
SPAST_DROME MQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQE
SPAST_DROPS LQPSIIFIDEVDSLLSERSSGEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQE
SPAST_ANOGA LQPSIIFIDEVDSVLSERSSNEHEATRRLKTEFLVQFDGLPANSEADRIVVMAATNRPQE
E0VYI4_PEDHC LQPSIIFIDEVDSLLCERRENEHEASRRLKTEFLVEFDGLPSSPD-ERVLVMAATNRPQE
D6WR93_TRICA LQPSIIFIDEVDSLLSERSNNEHEASRRLKTEFLVEFDGLPSNPDSERVVVMAATNRPQE
F4W8A4_ACREC FQPSVIFIDEVDSLLSERKDNEHEASRRLKTEFLVEFDGLPCNPE-ERVLVMAATNRPQE
E2AI24_CAMFO LQPSVIFIDEVDSLLSERKDNEHEASRRLKTEFLVEFDGLPCNPE-ERVLVMAATNRPQE
.*:: ***:**:* ** ..* : :******:*:.*** :*::*:.*****::
D3BA00_POLPP LDEAALRRFVKRIYVGLPEKSTRLDILKHLLRDQNHNLTNSQMSAIADATSGYSAFDLNA
SPAST_DICDI LDDAALRRLVKRIYVGLPELETRLQIIQHLLVGQRHSLTKQQINSLAEVTQGYSGFDLAA
F0ZEB6_DICPU LDDAALRRLVKRIYVCLPEYETRLQIIQHLLKDQRHSLSDAQLGELANLTNGYSGFDLTS
SPAST_NEMVE LDDAALRRMVKRIHIPLPDKETRKVLLTKLLAKHHNPLSGAEIDRLARMTEHYSGSDLTA
SPAST_IXOSC LDDAALRRFTKRVYVTLPDHNTRVILLEKLLKKHNNPLSADKLKYLARLTEGYSGSDLTA
SPAST_DANRE LDEAVLRRFAKRIYVALPTEETRLKLLKNLLSKHRNPLSQKELSQLARLTDGYSGSDLTS
SPAST_XENLA LDDAVLRRFTKRVYVALPNEETRLVLLKNLLSKQGNPLSEKELTQLSRLTEGYSGSDITA
SPAST_XENTR LDDAVLRRFTKRVYVSLPNEETRLLLLKNLLSKQGNPLNEKELTQLSRLTEGYSGSDITA
SPAST_CHICK LDDAVLRRFTKRVYVSLPNEETRLILLKNLLSKQGSPLTQKELAQLARMTDGYSGSDLTA
SPAST_MOUSE LDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTA
SPAST_RAT LDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTA
SPAST_BOVIN LDEAVLRRFTKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTNGYSGSDLTA
SPAST_PIG LDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARLTDGYSGSDLTA
H0X267_OTOGA LDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTA
SPAST_HUMAN LDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTA
G1S0D4_NOMLE LDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTA
SPAST_DROME LDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTA
SPAST_DROPS LDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTDALRRLSKITDGYSGSDLTA
SPAST_ANOGA LDEAALRRFPKRVYVTLPDRDTRELLLRRLLQKQGSPLSDADLAHLAQLTEGYSGSDLTA
E0VYI4_PEDHC LDEAALRRFSKRIYVTLPDHSTRKELLKHLLSKHDNPLSDYELEKLANLTVSYSGSDLTA
D6WR93_TRICA LDEAALRRFPKRVYVTLPDLETRIRLFKMLLAKQGCSLTQQELKRLATLTEGYSASDLTA
F4W8A4_ACREC LDEAALRRFTKRVYVTLPDSQTRIVLLRRLLAKHNDPLTLEELNEMAVLTEGYSGSDLTG
E2AI24_CAMFO LDEAALRRFTKRVYVTLPDLQTRIVLLQRLLAKHNDPLTPEELNEMAVLTEGYSGSDLTG
**:*.***: **::: ** .** :: ** : * : :: * **. *: .
D3BA00_POLPP LCKDAAYEPIRQLGME-IKDLKLNQIRPISCKDFKNSLKQIRASVSQDSLTGYEQWNMTF
SPAST_DICDI LCKDAAYEPIRRLGIG-IKDLELNEISLISFKDFANSLKQIRPSVTSQSLKSFEKWNQKF
F0ZEB6_DICPU LCKDAAYEPIRRLGTD-IKDLDLNKISLISFKDFRSSLKQIRPSVSAQSLKSYEKWNSKY
SPAST_NEMVE LARDAALGPIRDLNSDQLKSMAANEVRNITFQDFVNSLQIIRPSVGPETLKAYDDWNRLY
SPAST_IXOSC LAKDAALGPIRELNPEQVRCVDPKKMRNISLQDFLDSLKKVRRSVTPQSLDFFDRWNREF
SPAST_DANRE LAKDAALGPIRELKPEQVRNMSAHEMRDIRISDFLESLKRIKRSVSPQTLDQYVRWNREY
SPAST_XENLA LAKDAALGPIRELKPEQVKNMAASEMRNMKYSDFLGSLKKIKCSVSHSTLESYIRWNQDF
SPAST_XENTR LAKDAALGPIRELKPEQVKNMAASEMRNIKYSDFLSSLKKIKCSVSPSTLESYIRWNKEF
SPAST_CHICK LAKDAALGPIRELKPEQVKNMSASEMRNIKLSDFTESLKKIKRSLSPQTLEAYIRWNKDF
SPAST_MOUSE LAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDF
SPAST_RAT LAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDF
SPAST_BOVIN LAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDF
SPAST_PIG LAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDF
H0X267_OTOGA LAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDF
SPAST_HUMAN LAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDF
G1S0D4_NOMLE LAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDF
SPAST_DROME LAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDY
SPAST_DROPS LAKDAALEPIRELNVEQVKCLDINAMRHITEKDFHNSLKRIRRSVAQQSLSSYEKWSSDY
SPAST_ANOGA LARDAALEPIRELNVEEVKNMDPTKLRSIRESDFHNSLKRIRRSVAPQSLAAYEKWLQDF
E0VYI4_PEDHC LAKDAALGPIREISAEQMKTLDPKTVRNITFQDFKNSLKRIRPSLSNSSLSAYEKWNSQY
D6WR93_TRICA LAKDAALGPIRELQPEQVKEMDPSALRSITINDFLDSLKRIRRSVSPQSLVAYEKWSLQY
F4W8A4_ACREC LAKDAALGPIRELNPDQVKELDLNSVRNITMQDFRDSLKRIRRSVSPASLAAYEKWNFEY
E2AI24_CAMFO LAKDAALGPIRELNPDQVKELDLNSVRNITMQDFRDSLRRIRRSVSPASLTTYEKWNFEY
* .*** *** : :. : : : .** **. :. *: :* : * :
D3BA00_POLPP GTI---
SPAST_DICDI GTI---
F0ZEB6_DICPU GLI---
SPAST_NEMVE GSNA--
SPAST_IXOSC GDITV-
SPAST_DANRE GDTTGV
SPAST_XENLA GDTTV-
SPAST_XENTR GDTTV-
SPAST_CHICK GDTTV-
SPAST_MOUSE GDTTV-
SPAST_RAT GDTTV-
SPAST_BOVIN GDTTV-
SPAST_PIG GDTTV-
H0X267_OTOGA GDTTV-
SPAST_HUMAN GDTTV-
G1S0D4_NOMLE GDTTV-
SPAST_DROME GDITI-
SPAST_DROPS GDITI-
SPAST_ANOGA GDVTL-
E0VYI4_PEDHC GDVSL-
D6WR93_TRICA GDMSI-
F4W8A4_ACREC GDVSL-
E2AI24_CAMFO GDVSL-
*