CLUSTAL format seed alignment for MF_04200
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Features found in the protein:- The following colors are used to highlight features:
- blue indicates SIGNAL, PROPEP, TRANSMEM, DOMAIN, ZN_FING, REPEAT,
DNA_BIND and CA_BIND.
- magenta is used to display DISULFID, THIOLEST and THIOETH.
- red is used for all other features, such as INIT_MET, ACTIVE SITE,
METAL,BINDING, NP_BIND, SITE, REGION, etc.
- The ID of the sequence used as the template for feature propagation is
underlined.
- A '<' at the beginning of a sequence or '>' at the end indicate that
the protein is fused with another domain either at the N- or C-terminus.
_____________________________________________________________________________
SPIKE_CVHNL -MKLFLILLVLP---------LASCFF----TCNSNANLSMLQ-----LGVPDNSSTIVT
SPIKE_CVH22 MFVLLVAYALLH-----------------IAGCQ--------------------------
SPIKE_BC512 MKYTLLFCVVFA---------TVSFGFADNERCNKTVNLTRLFSK---FDIQPPSQVVLA
SPIKE_PEDV7 MRSLIYFWLLLP----VLPTLSLPQD---VTRCQSTTNFRRFFSK---FNVQAPAVVVLG
Q8JVL1_9ALPC MIVLIFALLSTARSEDAPHGVTLPQF---NTSSNNQKFELNFYNFLQTWDIPPNTETILG
I7H7U2_9ALPC MIFLILALLSVAKSEDAPHGVTLPQF---NTSYNNEKFELYFYNFLQTWDIPPNTETILG
SPIKE_CVPR8 MKKLFVVLVVMP--------------------------------------------LIYG
SPIKE_CVPRM MKKLFVVLVVMP--------------------------------------------LIYG
SPIKE_CVPPU MKKLFVVLVVMP----LIYGDNFPCSKLTNRTIGNQWNLIETFLLNYSSRLPPNSDVVLG
SPIKE_CVPRT MKKLFVVLVVMP----LIYGDNFPCSKLTNRTIGNQWNLIETFLLNYSSRLPPNSDVVLG
SPIKE_CVPMI MKKLFVVLVVMP----LIYGDNFPCSKLTNRTIGNHWNLIETFLLNYSSRLSPNSDVVLG
SPIKE_CVPFS MKKLFVVLVVMP----LIYGDNFPCSKLTNRTIGNHWNLIETFLLNYSSRLSPNSDVVLG
SPIKE_FIPV MIVLVTCLLLLCSYHTVLSTTNNECIQVNVTQLAGNENLIRDFLF---SNFKEEGSVVVG
SPIKE_CVCAK MIVLILCLLLFS-YNSVICTSNNDCVQGNVTQLPGNENIIKDFLF---HTFKEEPSVVVG
SPIKE_CVCBG MIVLTLCLFLVL-YNSVICTSNNECVQVNVTQLPGNENIIRDFLF---QNFKEEGTVVVG
SPIKE_CVCAI MIVLTLCLFLFL-YSSVSCTSNNDCVQVNVTQLPGNENIIKDFLF---QNFKEEGSLVVG
SPIKE_CVHNL GLLPT-------HWFCANQSTS----------------VYSANGFFYI-------DVGNH
SPIKE_CVH22 ------------------------------------------------------------
SPIKE_BC512 GLLPNQTA----QWKCTTETNK-------------RDEGVGVKGVFLSY------VSSGR
SPIKE_PEDV7 GYLPSMNS---SSWYCGTGIET----------------ASGVHGIFLSY------IDSGQ
Q8JVL1_9ALPC GYLPYCGDGPNCGWYNFVYSQNVGQNGRHSYINTKNLNIPNVHGVYFDVREHNSDGLWDA
I7H7U2_9ALPC GYLPYCGDGLNCGWYNFVYSQQVGQNGKYSYINTQNLNIPNVHGVYFDVREHDSDGVWDT
SPIKE_CVPR8 DKFPT-------------------------------------------------------
SPIKE_CVPRM DKFPT-------------------------------------------------------
SPIKE_CVPPU DYFPTVQP-----WFNCIRNNS----------NDLYVTLENLKALYWDY--ATENITWNH
SPIKE_CVPRT DYFPTVQP-----WFNCIRNNS----------NDLYVTLENLKALYWDY--ATENITWNH
SPIKE_CVPMI DYFPTVQP-----WFNCIRNNS----------NDLYVTLENLKALYWDY--ATENITLNH
SPIKE_CVPFS DYFPTVQP-----WFNCIHNNS----------NDLYVTLENLKALYWDY--ATENSTWNH
SPIKE_FIPV GYYPT------EVWYNCSRTAR----------TTAFQYFNNIHAFYFVMEAMENSTGNAR
SPIKE_CVCAK GYYPT------EVWYNCSRSAT----------TTAYKDFSNIHAFYFDMEAMENSTGNAR
SPIKE_CVCBG GYYPT------EVWYNCSRTAR----------TQAFKTFSNIHAFYFDMEAMENSTGDAR
SPIKE_CVCAI GYYPT------EVWYNCSTTQQ----------TTAYKYFSNIHAFYFDMEAMENSTGNAR
SPIKE_CVHNL RSAFALHTGYYDANQYYIYVTNEIGLNAS---VTLKICKF---SRNTTFDFLSNASSSFD
SPIKE_CVH22 ------------------------------------------------------------
SPIKE_BC512 GFTIGVSQYNFDPSTYQLYLHRDTNGNSNAF-AYLRICKWP--SKKWLQSTSNMDTSGRF
SPIKE_PEDV7 GFEIGISQEPFDPSGYQLYLHKATNGNTNAI-ARLRICQFP--DNKTLGPTVNDVTTGRN
Q8JVL1_9ALPC RDRVGLLIAIYGTSYYSLLMVLQDKVEENQPHVAVKICHWKPGNISSYHQFSVNLEDGGQ
I7H7U2_9ALPC RDRVGLLISIHGNSHYSLLMVLQDDVDENQPDVAVKICHWKPGNISSYHAFNVNLGDCGQ
SPIKE_CVPR8 ------------------------------------------------------------
SPIKE_CVPRM ------------------------------------------------------------
SPIKE_CVPPU RQRLNVVVNGYP---YSITVTTTRNFNSAEG-AIICICKGS--PPTTTTESSLTCNWGSE
SPIKE_CVPRT RQRLNVVVNGYP---YSITVTTTRNFNSAEG-AIICICKGS--PPTTTTESSLTCNWGSE
SPIKE_CVPMI KQRLNVVVNGYP---YSITVTTTRNFNSAEG-AIICICKGS--PPTTTTESSLTCNWGSE
SPIKE_CVPFS KQRLNVVVNGYP---YSITVTTTRNFNSAEG-AIICICKGS--PPTTTTESSLTCNWGSE
SPIKE_FIPV GKPLLFHVHGEPVS--VIISAYRDDVQQRPLLKHGLVCITK--NRHINYEQFTSNQWNST
SPIKE_CVCAK GKPLLVHVHGDPVSIIIYISAYRDDVQPRPLLKHGLLCITK--NKIIDYNTFTSAQWSAI
SPIKE_CVCBG GKPLLVHVHGNPVSIIVYISAYRHDVQGRPKLKHGLLCITK--NSTTDYDRFTANQWRDI
SPIKE_CVCAI GKPLLVHVHGNPVSIIVYISAYRDDVQFRPLLKHGLLCITK--NDTVDYNSFTINQWRDI
SPIKE_CVHNL CI-------VNLLFTEQ----LGAPLGITISGETVRLHLYNVTRTFYVPAAYKLTKLSVK
SPIKE_CVH22 ------------------------------------------------------------
SPIKE_BC512 CLVNKK---IPAAFTDH----ANMVVGITWDQDRVTFY-TDKVYHFYVPNN-RWSRVVSW
SPIKE_PEDV7 CLFNKA---IPAYMRDG----KDIVVGITWDNDRVTVF-ADKIYHFYLKND--WSRVATR
Q8JVL1_9ALPC CVFNQR---FSLDTVLT----ANDFYGFQWTDTYVDIYLGGTITKVWVNND--WSSVEAS
I7H7U2_9ALPC CVFNRR---FALDVKLT----ANHFYGFQWTDTYVDIYLGGTITKVWVDND--WSVVEAS
SPIKE_CVPR8 ------------------------------------------------------------
SPIKE_CVPRM ------------------------------------------------------------
SPIKE_CVPPU CRLNHK---FPICPSNSEANCGNMLYGLQWFADEVVAYLHGASYRISFENQ--WSGTVTF
SPIKE_CVPRT CRLNHK---FPICPSNSEANCGNMLYGLQWFADEVVAYLHGASYRISFENQ--WSGTVTF
SPIKE_CVPMI CRLNHK---FPICPSNSEANCGNMLYGLQWFADAVVAYLHGASYRISFENQ--WSGTVTL
SPIKE_CVPFS CRLNHK---FPICPSNSEANCGNMLYGLQWFADAVVAYLHGASYRISFENQ--WSGTVTL
SPIKE_FIPV CTGADRKIPFSVIPTDN----GTKIYGLEWNDDFVTAYISGRSYHLNINTN--WFNNVTL
SPIKE_CVCAK CLGDDRKIPFSVIPTDN----GTKIFGLEWNDDYVTAYISDRSHHLNINNN--WFNNVTI
SPIKE_CVCBG CLGEDRKIPFSVVPTDN----GTKLFGLEWNDDYVTAYISDDSHYLNINNN--WFNNVTL
SPIKE_CVCAI CLGDDRKIPFSVVPTDN----GTKLFGLEWNDDYVTAYISDESHRLNINNN--WFNNVTL
SPIKE_CVHNL CYFNYS-----------CVFSVVNATVTVNVTTHNGRV---VNYTVCDD---CNGYTDNI
SPIKE_CVH22 --------------------------------TTNGLN---TSYSVCNG---CVGYSENV
SPIKE_BC512 CSAADS-----------CAMQYINSTIYYNLNVTTPGP-GGITYSVCTK--HCTGLADNV
SPIKE_PEDV7 CYNRRS-----------CAMQYVYTPTYYMLNVTSAGE-DGIYYEPCTA--NCTGYAANV
Q8JVL1_9ALPC ISYHWNQINYG------YYIQFVNRTTYYTYNNTGGSNYTHLQLAECHS-EYCAGYAKNV
I7H7U2_9ALPC ISYHWNNLNYG------YYMQFVNRTTYYAYNNTGGANYTHLQLSECRS-DYCAGYAKNV
SPIKE_CVPR8 -----------------------------------------SVVSNCTD--QCASYVANV
SPIKE_CVPRM -----------------------------------------SVVSNCTD--QCASYVANV
SPIKE_CVPPU GDMRATTLEVAGTLVDLWWFNPVYDVSYYRVNNKNGTT----VVSNCTD--QCASYVANV
SPIKE_CVPRT GDMRATTLEVSGTLVDLWWFNPVYDVSYYRVNNKNGTT----VVSNCTD--QCASYVANV
SPIKE_CVPMI GDMRATTLETAGTLVDLWWFNPVYDVSYYRVNNKNGTT----VVSNCTD--QCASYVANV
SPIKE_CVPFS GDMRATTLETAGTLVDLWWFNPVYDVSYYRVNNKNGTT----VVSNCTD--QCASYVANV
SPIKE_FIPV LYSRSSTATWEYSAA--YAYQGVSNFTYYKLNNTNGLK----TYELCEDYEHCTGYATNV
SPIKE_CVCAK LYSRSSSATWQKSAA--YVYQGVSNFTYYKLNNTNGLK----SYELCEDYEYCTGYATNV
SPIKE_CVCBG LYSRSSTATWQHSAA--YVYQGVSNFTYYKLNNTNGLK----SYELCEDYEYCTGYATNV
SPIKE_CVCAI LYSRTSTATWQHSAA--YVYQGVSNFTYYKLNKTAGLK----SYELCEDYEYCTGYATNV
* * . *:
SPIKE_CVHNL FSVQQDGRIPNGFPFNNWFLLTNGSTLVDGVSRLYQPLRLTCLWPVPGLKSSTGFVYFNA
SPIKE_CVH22 FAVESGGYIPSDFAFNNWFLLTNTSSVVDGVVRSFQPLLLNCLWSVSGLRFTTGFVYFNG
SPIKE_BC512 FSTDQGGHIPPIFPYNNWFLLTNTSTLVQGVTRVFQPFLVNCLVALPKLQGLTTTLSFDS
SPIKE_PEDV7 FATDSNGHIPEGFSFNNWFLLSNDSTLLHGKVVSNQPLLVNCLLAIPKIYGLGQFFSFNH
Q8JVL1_9ALPC FVP-IDGKIPESFSFSNWFLLSDKSTLVQGRVLSRQPVLVQCLRPVPTWSNNSAVVFFSN
I7H7U2_9ALPC FVP-IDGKIPESFSFSNWFLLSDKSTLVQGRVLSSQPVFVQCLRPVPTWSNNTAVVHFNN
SPIKE_CVPR8 FTTQPGGFIPSDFSFNNWFILTNSSTLVSGKLVTKQPLLVNCLWPVPSFEEAASTFCFEG
SPIKE_CVPRM FTILPGGFIPSDFSFNNWFLLTNSSTLVNGKLVTKQPLLVNCLWPVPSFEEVASTFCFEG
SPIKE_CVPPU FTTQPGGFIPSDFSFNNWFLLTNSSTLVSGKLVTKQPLLVNCLWPVPSFEEAASTFCFEG
SPIKE_CVPRT FTTQPGGFIPSDFSFNNWFLLTNSSTLVSGKLVTKQPLLVNCLWPVPSFEEAASTFCFEG
SPIKE_CVPMI FTTQPGGFIPSDFSFNNWFLLTNSSTLVSGKLVTKQPLLVNCLWPVPSFEEAASTLCFEG
SPIKE_CVPFS FTTQPGGFIPSDFSFNNWFLLTNSSTLVSGKLVTKQPLLVNCLWPVPSFEEAASTFCFEG
SPIKE_FIPV FAPTSGGYIPDGFSFNNWFLLTNSSTFVSGRFVTNQPLLINCLWPVPSFGVAAQEFCFEG
SPIKE_CVCAK FAPTVGGYIPHGFSFNNWFMRTNSSTFVSGRFVTNQPLLVNCLWPVPSFGVAAQQFCFEG
SPIKE_CVCBG FAPTPGGYIPEGFSFNNWFMLTNSSTFVSGRFVTNQPLLVNCLWPVPSFGVAAQEFCFEG
SPIKE_CVCAI FAPTSGGYIPDGFSFNNWFMLTNSSTFVSGRFVTNQPLLVNCLWPVPSFGVAAQEFCFEG
* .* ** *.:.***: :: *:.: * **. : ** .:. . *.
SPIKE_CVHNL TGSDVN--CNGYQHNSVVDVMRYNLNFSANSLDNLKSGV-----IVFKTLQYDVL-FYC-
SPIKE_CVH22 TGRGD---CKGFSSDVLSDVIRYNLNFE----ENLRRGT-----ILFKTSYGVVV-FYC-
SPIKE_BC512 PLNVPGFSCNGANGSSSAEAFRFNVNDTK---LFVGAGA-----VTLNTVDGVNVSIVC-
SPIKE_PEDV7 TMDGV---CNGAAVDRAPEALRFNINDTS---VILAEGS-----IVLHTALGTNLSFVC-
Q8JVL1_9ALPC DLY-----CPG----VTAEVLRFNLNFSD---SDVYTDLTNDDQFYFTFEDNTTASIACY
I7H7U2_9ALPC DPF-----CP----NVTADVLRFNLNFSD---TDVYTDSTNDDQLYFTFEDNTTASIACY
SPIKE_CVPR8 ADFDQ---CNGAVLNNTVDVIRFNLNFT----TNVQSGK-GATVFSLNTTGGVTLEISCY
SPIKE_CVPRM ADFDQ---CNGAVLNNTVDVIRFNLNFT----TNVQSGK-GATVFSLNTTGGVTLEISCY
SPIKE_CVPPU AGFDQ---CNGAVLNNTVDVIRFNLNFT----TNVQSGK-GATVFSLNTTGGVTLEISCY
SPIKE_CVPRT AGFDQ---CNGAVLNNTVDVIRFNLNFT----TNVQSGK-GATVFSLNTTGGVTLEISCY
SPIKE_CVPMI AGFDQ---CNGPVLNNTVDVIRFNLNFT----TNVQSGK-GATVFSLNTTGGVTLEISCY
SPIKE_CVPFS AGFDQ---CNGAVLNNTVDVIRFNLNFT----TNVQSGK-GATVFSLNTTGGVTLEISCY
SPIKE_FIPV AQFSQ---CNGVSLNNTVDVIRFNLNFT----ADVQSGM-GATVFSLNTTGGVILEISCY
SPIKE_CVCAK AQFSQ---CNGVSLNNTVDVIRFNLNFT----ALVQSGM-GATVFSLNTTGGVILEISCY
SPIKE_CVCBG AQFSQ---CNGVSLNNTVDVIRFNLNFT----TDVQSGM-GATVFSLNTTGGVILDISCY
SPIKE_CVCAI AQFSQ---CNGVSLNNTVDVIRFNLNFT----TDVQSGM-GATVFSLNTTGGVILEISCY
* :.:*:*:* : . . : : *
SPIKE_CVHNL ------SNSSSGVLDTTIPFGPSSQPYYCFINSTINTTHVSTFVGILPPTVREIVVARTG
SPIKE_CVH22 ------TNNTLVSGDAHIPFGTVLGNFYCFVNTTIGNETTSAFVGALPKTVREFVISRTG
SPIKE_BC512 -----SNNATQPTRSNNL---QEDLPYYCFTNTSSGTNHTVKFLSVFPPIIREFVITKYG
SPIKE_PEDV7 -----SNSSDPHLAIFAIPLGATEVPYYCFLKVDTYNSTVYKFLAVLPPTVREIVITKYG
Q8JVL1_9ALPC SSANVTDFQPANSSVSHIPLGKTI----CFANFS-HSVVSRQVLGILPPTVREFAFGRDG
I7H7U2_9ALPC SSANVTDFQPAINSVSHIPFGKTVHSYFCFANFS-HSIVSRQFLGILPPTVRELAFGRDG
SPIKE_CVPR8 ND---TVSDSSFSSYGEIPFGVTNGPRYCYVL---YNGTALKYLGTLPPSVKEIAISKWG
SPIKE_CVPRM ND---TVSDSSFSSYGEIPFGVTNGPRYCYVL---YNGTALKYLGTLPPSVKEIAISKWG
SPIKE_CVPPU -----TVSDSSFFSYGEIPFGVTDGPRYCYVH---YNGTALKYLGTLPPSVKEIAISKWG
SPIKE_CVPRT -----TVSDSSFFSYGEIPFGVTDGPRYCYVH---YNGTALKYLGTLPPSVKEIAISKWG
SPIKE_CVPMI ND---TVSDSSFSSYGEMPFGVTDGPRYCYVL---YNGTALKYLGTLPPSVKEIAISKWG
SPIKE_CVPFS ND---TVSDSSFSSYGEIPFGVTDGPRYCYVL---YNGTALKYLGTLPPSVKEIAISKWG
SPIKE_FIPV SD---TVSESSSYSYGEIPFGITDGPRYCYVL---YNGTALKYLGTLPPSVKEIAISKWG
SPIKE_CVCAK ND---TVSESSFYSYGEISFGVTDGPRYCFAL---YNGTALKYLGTLPPSVKEIAISKWG
SPIKE_CVCBG ND---TVSESSFYSYGEIPFGVIDGPRYCYVL---YNGTALKYLGTLPPSVKEIAISKWG
SPIKE_CVCAI ND---TVSESSFYSYGEIPFGVTDGPRYCYVL---YNGTALKYLGTLPPSVKEIAISKWG
: *: . :. :* :.*:.. . *
SPIKE_CVHNL QFYINGFKYFDLGFIEAVNFNVTT----ASATDFWTVAFATFVDVLVNVSATNIQNLLYC
SPIKE_CVH22 HFYINGYRYFTLGNVEAVNFNVTT----AETTDFCTVALASYADVLVNVSQTSIANIIYC
SPIKE_BC512 NVYVNGYIYLRTRPLTAVHLNASSHS--QDVAGFWTIAATNFTDVLVEVNNTGIQRLLYC
SPIKE_PEDV7 DVYVNGFGYLHLGLLDAVTINFTGHGTDDDVSGFWTIASTNFVDALIEVQGTSIQRILYC
Q8JVL1_9ALPC SVFVNGYKYFSLPPIKSVNFSISS----VEQYGFWTIAYTNYTDVMVDVNGTGISRLFYC
I7H7U2_9ALPC SIFVNGYKYFSLPPIRSVKFSISS----VEEYGFWTIAYTNYTDVMVDVNGTGITRLFYC
SPIKE_CVPR8 HFYINGYNFFSTFPIDCISFNLTT----GDSDVFWTIAYTSYTEALVQVENTAITNVTYC
SPIKE_CVPRM HFYINGYNFFSTFPIDCISFNLTT----GDSDVFWTIAYTSYTEALVQVENTAITNVTYC
SPIKE_CVPPU HFYINGYNFFSTFPIDCISFNLTT----GDSDVFWTIAYTSYTEALVQVENTAITKVTYC
SPIKE_CVPRT HFYINGYNFFSTFPIDCISFNLTT----GDSDVFWTIAYTSYTEALVQVENTAITKVTYC
SPIKE_CVPMI HFYINGYNFFSTFPIDCISFNLTT----GDSDVFWTIAYTSYTEALVQVENTAITKVTYC
SPIKE_CVPFS HFYINGYNFFSTFPIDCISFNLTT----GDSDVFWTIAYTSYTEALVQVENTAITKVTYC
SPIKE_FIPV HFYINGYNFFSTFPIGCISFNLTT----GVSGAFWTIAYTSYTEALVQVENTAIKNVTYC
SPIKE_CVCAK HFYINGYNFFSTFPIDCISFNLTT----GDSGAFWTIAYTSYTDALVQVENTAIKKVTYC
SPIKE_CVCBG HFYINGYNFFSTFPIDCISFNLTT----GASGAFWTIAYTSYTEALVQVENTAIKKVTYC
SPIKE_CVCAI HFYINGYNFFSTFPIDCIAFNLTT----GASGAFWTIAYTSYTEALVQVENTAIKKVTYC
.::**: :: : .: :. : * *:* :.:.:.:::*. * * .: **
SPIKE_CVHNL DSPFEKLQCEHLQFGLQDGFYSANF--LDDNVLPETYVALPIYYQHTDINFTA----TAS
SPIKE_CVH22 NSVINRLRCDQLSFDVPDGFYSTSP--IQSVELPVSIVSLPVYHKHTFIVLYVDFK-PQS
SPIKE_BC512 DTPENSVKCSQLSFELEDGFYSMTADNVYAVTKPHTFVTLPTFNDHGFVNVTV-------
SPIKE_PEDV7 DDPVSQLKCSQVAFDLDDGFYPISSRNLLSHEQPISFVTLPSFNDHSFVNITVSAA----
Q8JVL1_9ALPC DSPLNRIKCQQLKHVLPDGFYSASM--LVKNDLPKTFVTMPQFYNWMHITLHVVLNDTAK
I7H7U2_9ALPC DSPLNRIKCQQLKHELPDGFYSATR--LVKKDLPKTFVTMPQFYNWMNVTLHVVLNDTEK
SPIKE_CVPR8 NSYVNNIKCSQLTANLNNGFYPVSS--SEVGSVNKSVVLLPSFLTHTIVNITIGLGMKRS
SPIKE_CVPRM NSYVNNIKCSQLTANLNNGFYPVSS--SEVGSVNKSVVLLPSFLTHTIVNITIGLGMKRS
SPIKE_CVPPU NSHVNNIKCSQITANLNNGFYPVSS--SEVGLVNKSVVLLPSFYTHTIVNITIGLGMKRS
SPIKE_CVPRT NSHVNNIKCSQITANLNNGFYPVSS--SEVGLVNKSVVLLPSFYTHTIVNITIGLGMKRS
SPIKE_CVPMI NSYVNNIKCSQLTANLNNGFYPVSS--SEVGLVNKSVVLLPSFYTHTIVNITIGLGMKRS
SPIKE_CVPFS NSYVNNIKCSQLTANLNNGFYPVSS--SEVGFVNKSVVLLPTFYTHTIVNITIGLGMKRS
SPIKE_FIPV NSHINNIKCSQLTANLNNGFYPVAS--SEVGFVNKSVVLLPSFFTYTAVNITIDLGMKLS
SPIKE_CVCAK NSHINNIKCSQLTANLQNGFYPVAS--SEVGLVNKSVVLLPSFYSHTSVNITIDLGMKRS
SPIKE_CVCBG NSHVNSIKCSQLTANLQNGFYPVAS--SEVGLVNKSVVLLPSFYSHTSVNITIDLGMRRS
SPIKE_CVCAI NSHINNIKCSQLTANLQNGFYPVAS--SEVGLVNKSVVLLPSFYSHTSVNITIDLGMKRS
: . :.*.:: : :***. : * :* : : .
SPIKE_CVHNL FGGSCYVCKPHQV------------NISLNGNTSV----CVRTSHFSIRYIYNRVKS---
SPIKE_CVH22 GGGKCFNCYPAGV------------NITLANFNETKGPLCVDTSHFTTKYVA--------
SPIKE_BC512 -GGNFDSSYPPKFTA----------NGTLVNNGTVV---CVTSNQFTLRHDFMV------
SPIKE_PEDV7 FGGLSSANLVAS-------------DTTINGFSSF----CVDTRQFTITLFY--------
Q8JVL1_9ALPC KEDIILAKAPELASLADVHFEILQANGSVVNVTSL----CVQAKQLALFYKYTSLQGLY-
I7H7U2_9ALPC KADIILAKAPELASLADVHFEIAQANGSVTNVTSL----CVQTRQLALFYKYTSLQGLY-
SPIKE_CVPR8 GYGQPIASTLSNITL----------PMQDNNTDVY----CVRSDQFSVYVHSTCKSALWD
SPIKE_CVPRM GYGQPIASTLSNITL----------PMQDNNNDVY----CVRSDQFSVYVHSTCKSVLWD
SPIKE_CVPPU GYGQPIASTLSNITL----------PMQDHNTDVY----CIRSDQFSVYVHSTCKSALWD
SPIKE_CVPRT GYGQPIASTLSNITL----------PMQDHNTDVY----CIRSDQFSVYVHSTCKSALWD
SPIKE_CVPMI GYGQPIASTLSNITL----------PMQDNNTDVY----CIRSDQFSVYVHSTCKSSLWD
SPIKE_CVPFS GYGQPIASTLSNITL----------PMQDNNIDVY----CIRSDQFSVYVHSTCKSALWD
SPIKE_FIPV GYGQPIASTLSNITL----------PMQDNNTDVY----CIRSNQFSVYVHSTCKSSLWD
SPIKE_CVCAK GYGQPIASTLSNITL----------PMQDNNTDVY----CIRSNRFSVYFHSTCKSSLWD
SPIKE_CVCBG GYGQPVASSLSNISL----------PMQDNNTDVY----CIRSNQFSFYVHSNCKSASWD
SPIKE_CVCAI -VTVTIASPLSNITL----------PMQDNNIDVY----CIRSNQFSVYVHSTCKSSLWD
. *: : .::
SPIKE_CVHNL -----GSPGDSSWHIYLKSGTCPFSFSKLNNFQKFKTICFSTVEVPGSCNFPLEATWHYT
SPIKE_CVH22 -----VYANVGRWSASINTGNCPFSFGKVNNFVKFGSVCFSLKDIPGGCAMPIVANWAYS
SPIKE_BC512 -----GYSADMRKGIFEYSSTCPFNRETINNYLTFGRICFSTSPADGACELKYYVWNTIG
SPIKE_PEDV7 -----NVTNSYGYVSKSQDSNCPFTLQSVNDYLSFSKFCVSTSLLAGACTIDLFGYPAFG
Q8JVL1_9ALPC -----TYSNLVE----LQNYDCPFSPQHFNNYLQFETLCFDVNPAVAGCKWSLVHDVNWR
I7H7U2_9ALPC -----TYSNLVE----LQNYDCPFSPQQFNNYLQFETLCFDVNPAVAGCKWSLVHDVKWR
SPIKE_CVPR8 NVFKRNCTDVLDATAVIKTGTCPFSFDKLNNYLTFNKFCLSLSPVGANCKFDVAARTRTN
SPIKE_CVPRM NVFKRNCTDVLDATAVIKTGTCPFSFDKLNNYLTFNKFCLSLSPVGANCKFDVAARTRTN
SPIKE_CVPPU NIFKRNCTDVLDATAVIKTGTCPFSFDKLNNYLTFNKFCLSLSPVGANCKFDVAARTRTN
SPIKE_CVPRT NIFKRNCTDVLDATAVIKTGTCPFSFDKLNNYLTFNKFCLSLSPVGANCKFDVAARTRTN
SPIKE_CVPMI NVFKRNCTDVLDATAVIKTGTCPFSFDKLNNYLTFNKFCLSLSPVGANCKFDVAARTRTN
SPIKE_CVPFS NVFKRNCTDVLDATAVIKTGTCPFSFDKLNNYLTFNKFCLSLSPVGANCKFDVAARTRAN
SPIKE_FIPV NIFNQDCTDVLEATAVIKTGTCPFSFDKLNNYLTFNKFCLSLSPVGANCKFDVAARTRTN
SPIKE_CVCAK DVFNSDCTDVLYATAVIKTGTCPFSFDKLNNYLTFNKFCLSLNPVGANCKFDVAARTRTN
SPIKE_CVCBG NIFNSACTDVLEATAVIKTGTCPFSFDKLNNYLTFNKFCLSLNPTGANCKFDVVARTRTN
SPIKE_CVCAI NNFNSACTDVLDATAVIKTGTCPFSFDKLNNYLTFNKFCLSLNPVGANCKLDVAARTRTN
. ***. .*:: * .*.. . *
SPIKE_CVHNL SYTIV-GALYVTWSEGNSITGVPYPVSGIREFSNLVLNNCTKYNIYDYVGTGIIRSSNQS
SPIKE_CVH22 KYYTI-GSLYVSWSDGDGITGVPQPVEGVSSFMNVTLDKCTKYNIYDVSGVGVIRVSNDT
SPIKE_BC512 AVSHLAGTLYVQHTKGDIITGTPKPLQGLNDISELHLDTCTTYTIYGFRGDGVIRLTNQT
SPIKE_PEDV7 SGVKL-TSLYFQFTKGELITGTPKPLEGITDVSFMTLDVCTKYTIYGFKGEGIITLTNSS
Q8JVL1_9ALPC TQF---ATITVSYKDGAMITTMPRAQLGFKDISNLVKDECTDYNIYGFQGTGIIRSTTSR
I7H7U2_9ALPC IQF---ATITVSYKYGSMITTTPKVRLGFQDISVLVKDECTAYNIYGLQGTGIIRNTTSM
SPIKE_CVPR8 DQFV--RSLYVIYEEGDSIVGVPSDNSGLHDLSVLHLDSCTDYNIYGRTGVGIIRQTNRT
SPIKE_CVPRM DQVV--RSLYVIYEEGDSIVGVPSDNSGLHDLSVLHLDSCTDYNIYGRTGVGIIRQTNRT
SPIKE_CVPPU EQVV--RSLYVIYEEGDNIVGVPSDNSGVHDLSVLHLDSCTDYNIYGRTGVGIIRQTNRT
SPIKE_CVPRT EQVV--RSLYVIYEEGDNIVGVPSDNSGVHDLSVLHLDSCTDYNIYGRTGVGIIRKTNRT
SPIKE_CVPMI DQVV--RSLYVIYEEGDNIVGVPSDNSGLHDLSVLHLDSCTDYNIYGRTGVGIIRQTNRT
SPIKE_CVPFS DQVV--RSLYVIYEEGDNIVGVPSDNSGLHDLSVLHLDSCTDYNIYGRSGVGIIRQTNRT
SPIKE_FIPV EQVV--RSLYVIYEEGDNIVGVPSDNSGLHDLSVLHLDSCTDYNIYGRTGVGIIRRTNST
SPIKE_CVCAK EQVV--RSLYVIYEEGDNIVGVPSDNSGLHDLSVLHLDSCTDYNIYGITGVGIIRQTNST
SPIKE_CVCBG EQGV--GSLYVIYEEGDNIVGVPSDNSGLHDLSVLHLDSCTDYNIYGRNGVGIIRKTNST
SPIKE_CVCAI EQVF--GSLYVIYEEGDNIVGVPSDNSGLHDLSVLHLDSCTDYNIYGRTGVGIIRKTNST
:: . * *. * *. .. : : ** *.**. * *:* :.
SPIKE_CVHNL LAGGITYVSNSGNLLGFKNVSTGNIFIVTPCNQPDQVAVYQQSIIGAMTAVNES-RYGLQ
SPIKE_CVH22 FLNGITYTSTSGNLLGFKDVTKGTIYSITPCNPPDQLVVYQQAVVGAMLSENFT-SYGFS
SPIKE_BC512 FLSGVYYTSESGQLLAFKNVTTGQIYSVTPCQLVQQVAFVEDRIVGVISSANNT---GFF
SPIKE_PEDV7 ILAGVYYTSDSGQLLAFKNVTSGAVYSVTPCSFSEQAAYVNDDIVGVISSLSNS---TFN
Q8JVL1_9ALPC LVAGLYYTSISGDLLAFKNSTTGEIFTVVPCDLTVLAAVINDEIVGAITSVNQTDLFEFV
I7H7U2_9ALPC LVAGLYYTSISGDLLAFKNSTTGEIFTVVPCDLTAQAVIINDEIVGAITAVNQTDLFEFV
SPIKE_CVPR8 LLSGLYYTSLSGDLLGFKNVSDGVIYSVTPCDVSAQAAIIDGAIVGAITSINSE-LLALT
SPIKE_CVPRM ILSGLYYTSLSGDLLGFTNVSDGVIYSVTPCDVSAQAAIIDGTIVGAITSINSE-LLGLT
SPIKE_CVPPU LLSGLYYTSLSGDLLGFKNVSDGVIYSVTPCDVSAQAAVIDGTIVGAITSINSE-LLGLT
SPIKE_CVPRT LLSGLYYTSLSGDLLGFKNVSDGVIYSVTPCDVSAQAAVIDGTIVGAITSINSE-LLGLT
SPIKE_CVPMI LLSGLYYTSLSGDLLGFKNVSDGVIYSVTPCDVSAQAAVIDGTIVGAITSINSE-LLGLT
SPIKE_CVPFS LLSGLYYTSLSGDLLGFKNVSDGVIYSVTPCDVSAQAAVIDGTIVGAITSINSE-LLGLT
SPIKE_FIPV LLSGLYYTSLSGDLLGFKNVSDGVIYSVTPCDVSAQAAVIDGAIVGAMTSINSE-LLGLT
SPIKE_CVCAK LLSGLYYTSLSGDLLGFKNVSDGVIYSVTPCDVSAHAAVIDGAIVGAMTSINSE-LLGLT
SPIKE_CVCBG LLSGLYYTSLSGDLLGFKNVSDGVVYSVTPCEVSAQAAVIDGAIVGAMTSINSE-LLGLT
SPIKE_CVCAI LLSGLYYTSLSGDLLGFKNVSDGVVYSVTPCDVSAQAAVIDGAIVGAMTSINSE-LLGLT
: *: *.* **:**.*.: : * :: :.**. . : ::*.: : . :
SPIKE_CVHNL NLLQ---------------L-PNFYYVS--------------NGGNNCTTAVMTYSNFGI
SPIKE_CVH22 NVVE---------------L-PKFFYAS--------------NGTYNCTDAVLTYSSFGV
SPIKE_BC512 NSTR---------------TFPGFYYHS--------------NDTTNCTSPRLVYSNIGV
SPIKE_PEDV7 NTRE---------------L-PGFFYHS--------------NDGSNCTEPVLVYSNIGV
Q8JVL1_9ALPC NHTQAKRSRRPTSHSVTTYNMPQFYYITRWN-----------NDTSTNCTSVITYSSFAI
I7H7U2_9ALPC NHTQSRRLLRLTHNSVTTYTMPQFYYITKWN-----------NDTSNNCTSVITYSSFAI
SPIKE_CVPR8 HWTI---------------T-PNFYYYSIYNYTNDKTRGTPIGSNDVDCEPVITYSNIGV
SPIKE_CVPRM HWTT---------------T-PNFYYYSIYNYTNDKTRGTPIGSNDVDCEPVITYSNIGV
SPIKE_CVPPU HWTT---------------T-PNFYYYSIYNYTNDRTRGTAIDSNDVDCEPVITYSNIGV
SPIKE_CVPRT HWTT---------------T-PNFYYYSIYNYTNDRTRGTAIDSNDVDCEPVITYSNIGV
SPIKE_CVPMI HWTT---------------T-PNFYYYSIYNYTNDRTRGTAIDSNDVDCEPVITYSNIGV
SPIKE_CVPFS HWTT---------------T-PNFYYYSIYNYTNDMTRGTAIDSNDVDCEPVITYSNIGV
SPIKE_FIPV HWTT---------------T-PNFYYYSIYNYTSERTRGTAIDSNDVDCEPVITYSNIGV
SPIKE_CVCAK HWTT---------------T-PNFYYYSIYNYTNERTRGTAIDSNDVDCEPIITYSNIGV
SPIKE_CVCBG HWTT---------------T-PNFYYYSIYNYTNERVRGTVTDSNDVDCEPIITYSNIGV
SPIKE_CVCAI HWTT---------------T-PNFYYYSIYNYTNVMNRGTA-IDNDIDCEPIITYSNIGV
: * *:* : . . :.**.:.:
SPIKE_CVHNL CADGSLIPVRPRNSS-----DNGISAIITANLSIPSNWTTSVQVEYLQITSTPIVVDCAT
SPIKE_CVH22 CADGSIIAVQPRNVS-----YDSVSAIVTANLSIPSNWTTSVQVEYLQITSTPIVVDCST
SPIKE_BC512 CTSGAIGLLSPKAAQ------PQVQPMFQGNISIPTNFTMSVRTEYIQLFNKPVSVDCAM
SPIKE_PEDV7 CKSGSIGYVPSQYGQ------VKIAPTVTGNISIPTNFSMSIRTEYLQLYNTPVSVDCAT
Q8JVL1_9ALPC CNTGEIKYVNVTHVETVDD-IGVIKPISTGNILIPKNFTVAVQAEYIQIQVKPVVVDCAK
I7H7U2_9ALPC CNTGEIKYVNVTHVEVVDDSIGVIKPVSTGNISIPKNFTVAVQAEYIQIQVKPVVVDCAK
SPIKE_CVPR8 CKNGALVFINVTHSD------GDVQPISTGNVTIPTNFTISVQVEYIQVYTTPVSIDCSR
SPIKE_CVPRM CKNGALVFINVTHSD------GDVQPISTGNVTIPTNFTISVQVEYIQVYTTPVSIDCSR
SPIKE_CVPPU CKNGAFVFINVTHSD------GDVQPISTGNVTIPTNFTISVQVEYIQVYTTPVSIDCSR
SPIKE_CVPRT CKNGAFVFINVTHSD------GDVQPISTGNVTIPTNFTISVQVEYIQVYTTPVSIDCSR
SPIKE_CVPMI CKNGALVFINVTHSD------GDVQPISTGNVTIPTNFTISVQVEYIQVYTTPVSIDCSR
SPIKE_CVPFS CKNGALVFINVTHSD------GDVQPISTGNVTIPTNFTISVQVEYIQVYTTPVSIDCSR
SPIKE_FIPV CKNGALVFINVTHSD------GDVQPISTGNVTIPTNFTISVQVEYMQVYTTPVSIDCAR
SPIKE_CVCAK CKNGALVFINVTHSD------GDVQPISTGNVTIPTNFTISVQVEYIQVYTTPVSIDCSR
SPIKE_CVCBG CKNGALVFINVTHSD------GDVQPISTGNVTIPTNFTISVQVEYIQVYTTPVSIDCSR
SPIKE_CVCAI CKNGALVFINVTHSD------GDVQPISTGNVTIPTNFTISVQVEYIQVYTTPVSIDCAR
* * : : . : . .*: **.*:: ::..**:*: .*: :**:
SPIKE_CVHNL YVCNGNPRCKNLLKQYTSACKTIEDALRLSAHLETNDVSSMLTFDSNAFSLANVTSF---
SPIKE_CVH22 YVCNGNVRCVELLKQYTSACKTIEDALRNSARLESADVSEMLTFDKKAFTLANVSSF---
SPIKE_BC512 YVCNGNDRCKQLLSQYTSACKNIESALQLSARLESMEVNSMLTVSDEALKLATISQFP--
SPIKE_PEDV7 YVCNGNSRCKQLLTQYTAACKTIESALQLSARLESVEVNSMLTISEEALQLATISSFN--
Q8JVL1_9ALPC YVCNGNTHCRSLLTQYTSACQTIENALNLGARLESLMLNDMITVSDRSLELATIEKFNAT
I7H7U2_9ALPC YVCNGNRHCLKLLTQYTSACQTIENALNLGARLESLMLNDMITVSDRSLELATVEKFNST
SPIKE_CVPR8 YVCNGNPRCNKLLTQYVSACQTIEQALAMGARLENMEVDSMLFVSENALKLASVEAFNSS
SPIKE_CVPRM YVCNGNPRCNKLLTQYVSACQTIEQALAMGARLENMEVDSMLFVSENALKLASVEAFNSS
SPIKE_CVPPU YVCNGNPRCNKLLTQYVSACQTIEQALAMGARLENMEVDSMLFVSENALKLASVEAFNSS
SPIKE_CVPRT YVCNGNPRCNKLLTQYVSACQTIEQALAMGARLENMEVDSMLFVSENALKLASVEAFNSS
SPIKE_CVPMI YVCNGNPRCNKLLTQYVSACQTIEQALAMGARLENMEVGSMLFVSENALKLASVEAFNSS
SPIKE_CVPFS YVCNGNPRCNKLLTQYVSACQTIEQALAVGARLENMEVDSMLFVSENALKLASVEAFNSS
SPIKE_FIPV YVCNGNPRCNKLLTQYVSACQTIEQALAMGARLENMEVDSMLFVSENALKLASVEAFNST
SPIKE_CVCAK YVCNGNPRCNKLLTQYVSACQTIEQALAMGARLENMEIDSMLFVSENALKLASVEAFNST
SPIKE_CVCBG YVCNGNSRCNKLLTQYVSACHTIEQALAMGARLENMEIDSMLFVSENALKLASVEAFNST
SPIKE_CVCAI YVCNGNPRCNKLLTQYVSACQTIEQALAMGARLENMEIDSMLFVSENALKLASVEAFNST
****** .* .**.**.:**:.**.** .*.**. :..*: ... :: **.: *
SPIKE_CVHNL -------------G-DY--NLSSVLPQR---NIRSSRIAGRSALEDLLFSKVVTSGLGTV
SPIKE_CVH22 -------------G-DY--NLSSVIPSL---PTSGSRVAGRSAIEDILFSKLVTSGLGTV
SPIKE_BC512 -------------GGGY--NFTNIL------P---ANPGARSVIEDILFDKVVTSGLGTV
SPIKE_PEDV7 -------------GDGY--NFTNVLGASVYDPASGRVVQKRSVIEDLLFNKVVTNGLGTV
Q8JVL1_9ALPC AT------GGVKLGGLYLDGLSSLL------P---PKIGARSAVEDLLFNKVVTSGLGTV
I7H7U2_9ALPC AV------GGEKLGGFYFDGLSNLL------P---PRVGMRSAVEDLLFNKVVTSGLGTV
SPIKE_CVPR8 ETLDPIYKEWPNIGGFWLEGLKYIL------PSDNSKRKYRSAIEDLLFSKVVTSGLGTV
SPIKE_CVPRM ETLDPIYKEWPNIGGFWLEGLKYIL------PSDNSKRKYRSAIEDLLFSKVVTSGLGTV
SPIKE_CVPPU ETLDPIYKEWPNIGGSWLEGLKYIL------PSHNSKRKYRSAIEDLLFDKVVTSGLGTV
SPIKE_CVPRT ETLDPIYKEWPNIGGSWLEGLKYIL------PSHNSKRKYRSAIEDLLFDKVVTSGLGTV
SPIKE_CVPMI ETLDPIYKEWPNIGGSWLEGLKYIL------PSDNSKRKYRSAIEDLLFAKVVTSGLGTV
SPIKE_CVPFS ETLDPIYKEWPNIGGSWLEGLKYIL------PSDNSKRKYRSAIEDLLFSKVVTSGLGTV
SPIKE_FIPV ENLDPIYKEWPSIGGSWLGGLKDIL------PSHNSKRKYGSAIEDLLFDKVVTSGLGTV
SPIKE_CVCAK ETLDPIYKEWPNIGGSWLGGLKDIL------PSHNSKRKYRSAIEDLLFDKVVTSGLGTV
SPIKE_CVCBG DNLDPIYREWPNIGGSWLGGLKDIL------PSHNSKRKYRSAIEDLLFDKVVTSGLGTV
SPIKE_CVCAI ENLDPIYKEWPNIGGSWLGGLKDIL------PSHNSKRKYRSAIEDLLFDKVVTSGLGTV
* : .:. :: *.:**:** *:**.*****
SPIKE_CVHNL DVDYKSCTKGLSIADLACAQYYNGIMVLPGVADAERMAMYTGSLIGGMVLGGLT-SAAAI
SPIKE_CVH22 DADYKKCTKGLSIADLACAQYYNGIMVLPGVADAERMAMYTGSLIGGIALGGLT-SAVSI
SPIKE_BC512 DEDYKRCSNGLSIADLACAQHYNGIMVLPGVADWEKVHMYSASLVGGMTLGGIT-SAAAL
SPIKE_PEDV7 DEDYKRCSNGRSVADLVCAQYYSGVMVLPGVVDAEKLHMYSASLIGGMALGGIT-AAAAL
Q8JVL1_9ALPC DDDYKKCSAGTDVADLVCAQYYNGIMVLPGIVDGNKMAMYTASLIGGMALGSIT-SAVAV
I7H7U2_9ALPC DDDYKKCSAGTDVADLVCAQYYNGIMVLPGVVDANKMAMYTASLIGGMALGSIT-SAVAV
SPIKE_CVPR8 DEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANADKMTMYTASLAGGITLGALGGGAVAI
SPIKE_CVPRM DEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANADKMTMYTASLAGGITLGALGGGAVAI
SPIKE_CVPPU DEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANADKMTMYTASLAGGITLGALGGGAVAI
SPIKE_CVPRT DEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANADKMTMYTASLAGGITLGALGGGAVAI
SPIKE_CVPMI DEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANADKMTMYTASLAGGITLGALGGGAVAI
SPIKE_CVPFS DEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANADKMTMYTASLAGGITLGALGGGAVAI
SPIKE_FIPV DEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANADKMTMYTASLAGGITLGALGGGAVAI
SPIKE_CVCAK DEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANDDKMAMYTASLAGGITLGSLGGGAVSI
SPIKE_CVCBG DEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANDDKMAMYTASLAGGITLGALGGGAVSI
SPIKE_CVCAI DEDYKRSAGGYDIADLVCARYYNGIMVLPGVANDDKMTMYTASLTGGITLGALSGGAVAI
* *** .: * .:***.**.:*.*:*****:.: :.: **:.** **:.**.: .*.::
SPIKE_CVHNL PFSLALQARLNYVALQTDVLQENQKILAASFNKAINNIVASFSSVNDAITQTAEAIHTVT
SPIKE_CVH22 PFSLAIQARLNYVALQTDVLQENQKILAASFNKAMTNIVDAFTGVNDAITQTSQALQTVA
SPIKE_BC512 PFSYAVQARLNYVALQTDVLQRNQQMLANSFNSAISNITLAFESVNNAIYQTSAGLNTVA
SPIKE_PEDV7 PFSYAVQARLNYLALQTDVLQRNQQLLAESFNSAIGNITSAFESVKEAISQTSKGLNTVA
Q8JVL1_9ALPC PFSMQVQARLNYVALQTDVLQENQKILANAFNNAIGNITLALGKVSNAVTTISDGFNTMA
I7H7U2_9ALPC PFAMQVQARLNYVALQTDVLQENQKILANAFNNAIGNITLALGKVSNAITTISDGFTTMA
SPIKE_CVPR8 PFAVAVQARLNYVALQTDVLNKNQQILASAFNQAIGNITQSFGKVNDAIHQTSRGLTTVA
SPIKE_CVPRM PFAVAVQARLNYVALQTDVLNKNQQILASAFNQAIGNITQSFGKVNDAIHQTSRGLTTVA
SPIKE_CVPPU PFAVAVQARLNYVALQTDVLNKNQQILASAFNQAIGNITQSFGKVNDAIHQTSRGLATVA
SPIKE_CVPRT PFAVAVQARLNYVALQTDVLNKNQQILASAFNQAIGNITQSFGKVNDAIHXTSRGLATVA
SPIKE_CVPMI PFAVAVQARLNYVALQTDVLNKNQQILASAFNQAIGNITQSFGKVNDAIHQTSRGLATVA
SPIKE_CVPFS PFAVAVQARLNYVALQTDVLNKNQQILASAFNQAIGNITQSFGKVNDAIHQTSRGLATVA
SPIKE_FIPV PFAVAVQARLNYVALQTDVLNKNQQILANAFNQAIGNITQAFGKVNDAIHQTSQGLATVA
SPIKE_CVCAK PFAIAVQARLNYVALQTDVLNKNQQILANAFNQAIGNITQAFGKVNDAIHQTSQGLATVA
SPIKE_CVCBG PFAVAVQARLNYVALQTDVLNKNQQILANAFNQAIGNITQAFGNVNDAIHQTSKGLATVA
SPIKE_CVCAI PFAVAVQARLNYVALQTDVLNKNQQILANAFNQAIGNITQAFGKVNDAIHQTSKGLATVA
**: :******:*******: **::** :**.*: **. :: *.:*: : .: *::
SPIKE_CVHNL IALNKIQDVVNQQGSALNHLTSQLRHNFQAISNSIQAIYDRLDSIQADQQVDRLITGRLA
SPIKE_CVH22 TALNKIQDVVNQQGNSLNHLTSQLRQNFQAISSSIQAIYDRLDTIQADQQVDRLITGRLA
SPIKE_BC512 EALSKVQDVVNGQGNALSQLTVQLQNNFQAISNSIGDIYSRLDQITADAQVDRLITGRLA
SPIKE_PEDV7 HALTKVQEVVNSQGSALNQLTVQLQHNFQAISSSIDDIYSRLDILSADVQVDRLITGRLS
Q8JVL1_9ALPC SALTKIQSVVNQQGEALSQLTSQLQKNFQAISSSIAEIYNRLEKAEADAQVDRLITGRLA
I7H7U2_9ALPC SALTKIQSVVNQQGEALSQLTSQLQKNFQAISSSIAEIYNRFDKVEADSQVDRLITGRLA
SPIKE_CVPR8 KALAKVQDVVNTQGQALRHLTVQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLT
SPIKE_CVPRM KALAKVQDVVNTQGQALRHLTVQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLT
SPIKE_CVPPU KALAKVQDVVNIQGQALSHLTVQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLT
SPIKE_CVPRT KALAKVQDVVXIQGQALSHLTVQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLT
SPIKE_CVPMI KALAKVQDVVNTQGQALSHLTVQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLT
SPIKE_CVPFS KALAKVQDVVNTQGQALSHLTVQLQNNFQAISSSISDIYNRLDELSADAHVDRLITGRLT
SPIKE_FIPV KALAKVQDVVNTQGQALSHLTVQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLT
SPIKE_CVCAK KVLAKVQDVVNTQGQALSHLTLQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLT
SPIKE_CVCBG KALAKVQDVVNTQGQALSHLTVQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLT
SPIKE_CVCAI KALAKVQDVVNTQGQALSHLTVQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLT
.* *:*.** **.:* :** **.:******.** **.*:: ** :*********:
SPIKE_CVHNL ALNAFVSQVLNKYTEVRGSRRLAQQKINECVKSQSNRYGFCG-NGTHIFSIVNSAPDGLL
SPIKE_CVH22 ALNVFVSHTLTKYTEVRASRQLAQQKVNECVKSQSKRYGFCG-NGTHIFSIVNAAPEGLV
SPIKE_BC512 ALNAFVAQSLTKYAEVQASRTLAKQKVNECVKSQSPRYGFCGDEGEHIFSLTQAAPQGLM
SPIKE_PEDV7 ALNAFVAQTLTKYTEVQASRKLAQQKVNECVKSQSQRYGFCGGDGEHIFSLVQAAPQGLL
Q8JVL1_9ALPC ALNAYVSQTLTQYAEVKASRQLAMEKVNECVKSQSDRYGFCG-NGTHLFSLVNSAPDGLL
I7H7U2_9ALPC ALNAYVSQTLTQYAEVKASRQLALEKVNECVKSQSNRYGFCG-NGTHLLSLVNSAPDGLL
SPIKE_CVPR8 ALNAFVSQTLTRQAEVRASRQLAKDKVNECVKSQSHRFGFCG-NGTHLFSLANAAPNGMI
SPIKE_CVPRM ALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCG-NGTHLFSLANAAPNGMI
SPIKE_CVPPU ALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCG-NGTHLFSLANAAPNGMI
SPIKE_CVPRT ALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCG-NGTHLFSLANAAPNGMI
SPIKE_CVPMI ALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCG-NGTHLFSLANAAPNGMI
SPIKE_CVPFS ALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCG-NGTHLFSLANAAPNGMI
SPIKE_FIPV ALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCG-NGTHLFSLANAAPNGMI
SPIKE_CVCAK ALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCG-NGTHLFSLANAAPNGMI
SPIKE_CVCBG ALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCG-NGTHLFSLANAAPNGMI
SPIKE_CVCAI ALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCG-NGTHLFSLANAAPNGMI
***.:*:: *.. :**..** ** :*:****.*** *:**** :* *::*:.::**:*::
SPIKE_CVHNL FLHTVLLPTDYKNVKAWSGICV---DGIYGYVLRQPNLVLYSD------NGVFRVTSRVM
SPIKE_CVH22 FLHTVLLPTQYKDVEAWSGLCV---DGTNGYVLRQPNLALYKE------GNYYRITSRIM
SPIKE_BC512 FLHTVLVPNGFINVTAVTGLCV---DETIAMTLRQSGFVLFVQ------NGNYLVSPRKM
SPIKE_PEDV7 FLHTVLVPGDFVNVLAIAGLCV---NGEIALTLREPGLVLFTHELQTYTATEYFVSSRRM
Q8JVL1_9ALPC FFHTVLLPTEWEEVTAWSGICV---NHTYAYVLKDFDHSIFSY------NNTYMVTPRNM
I7H7U2_9ALPC FFHTVLLPTEWEEVTAWSGICV---NDTYAYVLKDFDHSIFSY------NGTYMVTPRNM
SPIKE_CVPR8 FFHTVLLPTAYETVTAWSGICALDGDRTFGLVVKDVQLTLFRN-----LDDNFYLTPRTM
SPIKE_CVPRM FFHTVLLPTAYETVTAWSGICALDVDRTFGLVVKDVQLTLFRN-----LDDKFYLTPRTM
SPIKE_CVPPU FFHTVLLPTAYETVTAWPGICASDGDRTFGLVVKDVQLTLFRN-----LDDKFYLTPRTM
SPIKE_CVPRT FFHTVLLPTAYETVTAWPGICASDGDRTFGLVVKDVQLTLFRN-----LDDKFYLTPRTM
SPIKE_CVPMI FFHTVLLPTAYETVTAWAGICALDGDRTFGLVVKDVQLTLFRN-----LDDKFYLTPRTM
SPIKE_CVPFS FFHAVLLPTAYETVTAWAGICALDGDRTFGLVVKDVQLTLFRN-----LDDKFYLTPRTM
SPIKE_FIPV FFHTVLLPTAYETVTAWSGICASDGDRTFGLVVKDVQLTLFRN-----LDDKFYLTPRTM
SPIKE_CVCAK FFHTVLLPTAYETVTAWSGICASDGDRTFGLVVKDVQLTLFRN-----LDDKFYLTPRTM
SPIKE_CVCBG FFHTVLLPTAYETVTAWSGICASDGNRTFGLVVKDVQLTLFRN-----LDYKFYLTPRTM
SPIKE_CVCAI FFHTVLLPTAYETVTAWSGICASDGSRTFGLVVEDVQLTLFRN-----LDEKFYLTPRTM
*:*:**:* : * * .*:*. . . .: : :: : ::.* *
SPIKE_CVHNL FQPRLPVLSDFVQIYNCNVTFVNISRVELHTVIPDYVDVNKTLQEFAQNL-PKYVKPNFD
SPIKE_CVH22 FEPRIPTMADFVQIENCNVTFVNISRSELQTIVPEYIDVNKTLQELSYKL-PNYTVPDLV
SPIKE_BC512 FEPRRPEVADFVQVKTCTISYVNITNNQLPDIIPDYVDVNKTIDEILANL-PNNTVPDLP
SPIKE_PEDV7 FEPRKPTVSDFVQIESCVVTYVNLTSDQLPDVIPDYIDVNKTLDEILASL-PNRTGPSLP
Q8JVL1_9ALPC FQPRKPQMSDFVQITSCEVTFLNTTYTMFQNIVVDYIDINKTIADMLEQYYSNYTTPELE
I7H7U2_9ALPC FQPRKPQMSDFVQITSCEVTFLNTTYTTFQEIVVDYIDINKTIADMLEQYNHNYTSPELD
SPIKE_CVPR8 YQPRVATSSDFVQIEGCDVLFVNTTVSDLPSIIPDYIDINQTVQDILENFRPNWTVPELT
SPIKE_CVPRM YQPRVATSSDFVQIEGCDVLFVNTTVSDLPSIIPDYIDINQTVQDILENFRPNWTVPELT
SPIKE_CVPPU YQPRVATSSDFVQIEGCDVLFVNATVSDLPSIIPDYIDINQTVQDILENFRPNWTVPELT
SPIKE_CVPRT YQPRVATSSDFVQIEGCDVLFVNATVSDLPSIIPDYIDINQTVQDILENFRPNWTVPELT
SPIKE_CVPMI YQPRVATSSDFVQIEGCDVLFVNATVSDLPSIIPDYIDINQTVQDILENFRPNWTVPELT
SPIKE_CVPFS YQPRVATSSDFVQIEGCDVLFVNATLSDLPSIIPDYIDINQTVQDILENFRPNWTVPELT
SPIKE_FIPV YQPRVATSSDFVQIEGCDVLFVNATVIDLPSIIPDYIDINQTVQDILENYRPNWTVPEFT
SPIKE_CVCAK YQPIVATSSDFVQIEGCDVLFVNATVIDLPSIIPDYIDINQTVQDILENFRPNWTVPELP
SPIKE_CVCBG YQPRVATSSDFVQIEGCDVLFVNATVIELPSIIPDYIDINQTVQDILENFRPNWTVPELP
SPIKE_CVCAI YQPRVATSSDFVQIEGCDVLFVNGTVIELPSIIPDYIDINQTVQDILENFRPNWTVPELP
::* . :****: * : ::* : : :: :*:*:*:*: :: . : . *.:
SPIKE_CVHNL --LTPFNLTYLNLSSELKQLEAKTASLFQTTVELQGLIDQINSTYVDLKLLNRFENYIKW
SPIKE_CVH22 --VEQYNQTILNLTSEISTLENKSAELNYTVQKLQTLIDNINSTLVDLKWLNRVETYIKW
SPIKE_BC512 --LDVFNQTFLNLTGEIADLEARSESLKNTSEELRQLIQNINNTLVDLQWLNRVETFIKW
SPIKE_PEDV7 --LDVFNATYLNLTGEIADLEQRSESLRNTTEELRSLINNINNTLVDLEWLNRVETYIKW
Q8JVL1_9ALPC LQLEIFNQTKLNLTAEIDQLEQRADNLTTIAHELQQYIDNLNKTLVDLEWLNRIETYVKW
I7H7U2_9ALPC LHLEIFNQTKLNLTAEIDQLEQRSVNLTTIVHELQQYIDNLNKTLVDLEWLNRIETYVKW
SPIKE_CVPR8 --MDVFNATYLNLTGEIDDLEFRSEKLHNTTVELAILIDNINNTLVNLEWLNRIETYVKW
SPIKE_CVPRM --LDVFNATYLNLTGEIDDLEFRSEKLHNTTVELAILIDNINNTVVNLEWLNRIETYVKW
SPIKE_CVPPU --FDIFNATYLNLTGEIDDLEFRSEKLHNTTVELAILIDNINNTLVNLEWLNRIETYVKW
SPIKE_CVPRT --FDIFNATYLNLTGEIDDLEFRSEKLHNTTVELAILIDNINNTLVNLEWLNRIETYVKW
SPIKE_CVPMI --FDIFNATYLNLTGEIDDLEFRSEKLHNTTVELAILIDNINNTLVNLEWLNRIETYVKW
SPIKE_CVPFS --FDIFNATYLNLTGEIDDLEFRSEKLHNTTVELAILIDNINNTLVNLEWLNRIETYVKW
SPIKE_FIPV --LDIFNATYLNLTGEIDDLEFRSEKLHNTTVELAILIDNINNTLVNLEWLNRIETYVKW
SPIKE_CVCAK --LDIFNATYLNLTGEINDLEFRSEKLHNTTVELAILIDNINNTLVNLEWLNRIETYVKW
SPIKE_CVCBG --LDIFNATYLNLTGEINDLEFRSEKLHNTTLELATLIDNINNTLVNLEWLNRIETYVKW
SPIKE_CVCAI --LDIFHATYLNLTGEINDLEFRSEKLHNTTVELAILIDNINNTLVNLEWLNRIETYVKW
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SPIKE_CVHNL PWWVWLIISVVFVVLLSLLVFCCLSTGCCGCCNCLTSSMRGCCDCGSTKLPYYE-FEKVH
SPIKE_CVH22 PWWVWLCISVVLIFVVSMLLLCCCSTGCCGFFSCFASSIRGCCE--STKLPYYD-VEKIH
SPIKE_BC512 PWYVWLAIVIALILVVSLLVFCCISTGCCGCCGCCGSCFSGCCR--GTKLQHYEPIEKVH
SPIKE_PEDV7 PWWVWLIIVIVLIFVVSLLVFCCISTGCCGCCGCCGACFSGCCR--GPRLQPYEAFEKVH
Q8JVL1_9ALPC PWYVWLLIGLVIVFCIPLLLFCCLSTGCCGCFGCLGSCCHSLCS--RRQFENYEPIEKVH
I7H7U2_9ALPC PWYVWLLIGLVVVFCIPLLLFCCLSTGCCGCFVCIGSCCHSLCS--RRQFENYEPIEKVH
SPIKE_CVPR8 PWYVWLLIGLVVIFCIPLLLFCCCSTGCCGCIGCLGSCCHSIFS--RRQFENYEPIEKVH
SPIKE_CVPRM PWYVWLLIGLVVIFCIPLLLFCCCSTGCCGCIGCLGSCCHSIFS--RRQFENYEPIEKVH
SPIKE_CVPPU PWYVWLLIGLVVIFCIPLLLFCCCSTGCCGCIGCLGSCCHSICS--RRQFENYEPIEKVH
SPIKE_CVPRT PWYVWLLIGLVVIFCIPLLLFCCCSTGCCGCIGCLGSCCHSICS--RRQFENYEPIEKVH
SPIKE_CVPMI PWYVWLLIGLVVIFCIPLLLFCCCSTGCCGCIGCLGSCCHSICS--RRQFENYEPIEKVH
SPIKE_CVPFS PWYVWLLIGLVVIFCIPLLLFCCCSTGCCGCIGCLGSCCHSICS--RRQFENYEPIEKVH
SPIKE_FIPV PWYVWLLIGLVVVFCIPLLLFCCFSTGCCGCIGCLGSCCHSICS--RRQFENYEPIEKVH
SPIKE_CVCAK PWYVWLLIGLVVIFCIPILLFCCCSTGCCGCIGCLGSCCHSICS--RRQFESYEPIEKVH
SPIKE_CVCBG PWYVWLLIGLVVIFCIPLLLFCCCSTGCCGCFGCIGSCCHSMCS--RRQFESYEPIEKVH
SPIKE_CVCAI PWYVWLLIGLVVIFCIPILLFCCCSTGCCGCIGCLGSCCHSICS--RGQFESYEPIEKVH
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SPIKE_CVHNL VQ
SPIKE_CVH22 IQ
SPIKE_BC512 VQ
SPIKE_PEDV7 VQ
Q8JVL1_9ALPC IH
I7H7U2_9ALPC IH
SPIKE_CVPR8 VH
SPIKE_CVPRM VH
SPIKE_CVPPU VH
SPIKE_CVPRT VH
SPIKE_CVPMI VH
SPIKE_CVPFS IH
SPIKE_FIPV VH
SPIKE_CVCAK VH
SPIKE_CVCBG VH
SPIKE_CVCAI VH
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