CONSTRUCT { _:187249 up:source unirule:MF_00465 . _:187250 up:source unirule:MF_00465 . _:187251 up:fullName 'S-adenosylmethionine decarboxylase beta chain' ; rdf:type up:Structured_Name . _:187252 up:source unirule:MF_00465 . _:187253 up:fullName 'S-adenosylmethionine decarboxylase alpha chain' ; rdf:type up:Structured_Name . _:187254 up:source unirule:MF_00465 . _:187255 up:source unirule:MF_00465 . _:187256 up:source unirule:MF_00465 . _:187257 up:source unirule:MF_00465 . _:187258 up:source unirule:MF_00465 . _:187259 up:source unirule:MF_00465 . _:187260 up:source unirule:MF_00465 . _:187261 up:source unirule:MF_00465 . _:187262 up:source unirule:MF_00465 . _:187263 up:source unirule:MF_00465 . _:187264 up:source unirule:MF_00465 . _:187265 up:source unirule:MF_00465 . _:187266 up:source unirule:MF_00465 . _:187267 up:source unirule:MF_00465 . _:187268 up:source unirule:MF_00465 . _:187269 up:source unirule:MF_00465 . _:187270 up:source unirule:MF_00465 . _:187271 up:source unirule:MF_00465 . _:187272 up:source unirule:MF_00465 . _:187273 up:source unirule:MF_00465 . _:187274 up:source unirule:MF_00465 . _:187275 up:source unirule:MF_00465 . _:187276 up:source unirule:MF_00465 . _:187277 up:source unirule:MF_00465 . _:187278 up:source unirule:MF_00465 . _:187279 up:source unirule:MF_00465 . _:187280 up:source unirule:MF_00465 . _:187281 up:source unirule:MF_00465 . ?this up:annotation ?annotation4 , ?annotation5 , ?annotation7 , ?annotation8 , ?annotation9 , ?annotation10 , ?annotation11 ; up:classifiedWith GO:0004014 , GO:0006596 , GO:0008295 , keyword:210 , keyword:456 , keyword:620 , keyword:670 , keyword:68 , keyword:704 , keyword:745 , keyword:865 , keyword:949 ; up:component ?namedpart1 , ?namedpart2 ; up:precursor "true"^^xsd:boolean ; up:recommendedName ?name0 . ?name0 up:ecName '4.1.1.50' ; up:fullName 'S-adenosylmethionine decarboxylase proenzyme' ; up:shortName 'AdoMetDC' , 'SAMDC' ; rdf:type up:Structured_Name . ?namedpart1 up:recommendedName _:187251 . ?namedpart2 up:recommendedName _:187253 . ?gene3 skos:prefLabel 'speD' . ?annotation4 a up:Function_Annotation ; rdfs:comment 'Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.' . ?annotation5 up:activity ?activity6 ; rdf:type up:Catalytic_Activity_Annotation . ?activity6 up:catalyticActivity <http://rdf.rhea-db.org/15981>; up:enzymeClass <http://purl.uniprot.org/enzyme/4.1.1.50>. ?annotation7 up:cofactor chebi:15361 ; rdf:type up:Cofactor_Annotation ; rdfs:comment 'Binds 1 pyruvoyl group covalently per subunit.' . ?annotation8 a up:Pathway_Annotation ; rdfs:comment 'Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.' . ?annotation9 a up:Subunit_Annotation ; rdfs:comment 'Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.' . ?annotation10 a up:PTM_Annotation ; rdfs:comment 'Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.' . ?annotation11 a up:Similarity_Annotation ; rdfs:comment 'Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.' . ?pfs12 up:annotation ?annotation13 . ?annotation13 faldo:begin ?pfsb14 ; faldo:end ?pfse15 ; rdf:type up:Chain_Annotation ; rdfs:comment 'S-adenosylmethionine decarboxylase beta chain' . ?pfsb14 faldo:position ?thisPositionOn16 ; rdf:type faldo:ExactPosition . ?pfse15 faldo:position ?thisPositionOn17 ; rdf:type faldo:ExactPosition . ?pfs18 up:annotation ?annotation19 . ?annotation19 faldo:begin ?pfsb20 ; faldo:end ?pfse21 ; rdf:type up:Chain_Annotation ; rdfs:comment 'S-adenosylmethionine decarboxylase alpha chain' . ?pfsb20 faldo:position ?thisPositionOn22 ; rdf:type faldo:ExactPosition . ?pfse21 faldo:position ?thisPositionOn23 ; rdf:type faldo:ExactPosition . ?pfs24 up:annotation ?annotation25 . ?annotation25 faldo:begin ?pfsb26 ; faldo:end ?pfse27 ; rdf:type up:Active_Site_Annotation ; rdfs:comment 'Schiff-base intermediate with substrate; via pyruvic acid' . ?pfsb26 faldo:position ?thisPositionOn28 ; rdf:type faldo:ExactPosition . ?pfse27 faldo:position ?thisPositionOn29 ; rdf:type faldo:ExactPosition . ?pfs30 up:annotation ?annotation31 . ?annotation31 faldo:begin ?pfsb32 ; faldo:end ?pfse33 ; rdf:type up:Active_Site_Annotation ; rdfs:comment 'Proton acceptor; for processing activity' . ?pfsb32 faldo:position ?thisPositionOn34 ; rdf:type faldo:ExactPosition . ?pfse33 faldo:position ?thisPositionOn35 ; rdf:type faldo:ExactPosition . ?pfs36 up:annotation ?annotation37 . ?annotation37 faldo:begin ?pfsb38 ; faldo:end ?pfse39 ; rdf:type up:Active_Site_Annotation ; rdfs:comment 'Proton donor; for catalytic activity' . ?pfsb38 faldo:position ?thisPositionOn40 ; rdf:type faldo:ExactPosition . ?pfse39 faldo:position ?thisPositionOn41 ; rdf:type faldo:ExactPosition . ?pfs42 up:annotation ?annotation43 . ?annotation43 faldo:begin ?pfsb44 ; faldo:end ?pfse45 ; rdf:type up:Site_Annotation ; rdfs:comment 'Cleavage (non-hydrolytic); by autolysis' . ?pfsb44 faldo:position ?thisPositionOn46 ; rdf:type faldo:ExactPosition . ?pfse45 faldo:position ?thisPositionOn47 ; rdf:type faldo:ExactPosition . ?pfs48 up:annotation ?annotation49 . ?annotation49 faldo:begin ?pfsb50 ; faldo:end ?pfse51 ; rdf:type up:Modified_Residue_Annotation ; rdfs:comment 'Pyruvic acid (Ser); by autocatalysis' . ?pfsb50 faldo:position ?thisPositionOn52 ; rdf:type faldo:ExactPosition . ?pfse51 faldo:position ?thisPositionOn53 ; rdf:type faldo:ExactPosition . _:187282 a rdf:Statement ; up:attribution _:187249 ; rdf:subject ?this ; rdf:predicate up:recommendedName ; rdf:object ?name0 . _:187283 a rdf:Statement ; up:attribution _:187250 ; rdf:subject ?this ; rdf:predicate up:precursor ; rdf:object "true"^^xsd:boolean . _:187284 a rdf:Statement ; up:attribution _:187252 ; rdf:subject ?this ; rdf:predicate up:component ; rdf:object ?namedpart1 . _:187285 a rdf:Statement ; up:attribution _:187254 ; rdf:subject ?this ; rdf:predicate up:component ; rdf:object ?namedpart2 . _:187286 a rdf:Statement ; up:attribution _:187255 ; rdf:subject ?gene3 ; rdf:predicate up:encodedBy ; rdf:object ?gene3 . _:187287 a rdf:Statement ; up:attribution _:187256 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation4 . _:187288 a rdf:Statement ; up:attribution _:187257 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation5 . _:187289 a rdf:Statement ; up:attribution _:187258 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation7 . _:187290 a rdf:Statement ; up:attribution _:187259 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation8 . _:187291 a rdf:Statement ; up:attribution _:187260 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation9 . _:187292 a rdf:Statement ; up:attribution _:187261 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation10 . _:187293 a rdf:Statement ; up:attribution _:187262 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation11 . _:187294 a rdf:Statement ; up:attribution _:187263 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:68 . _:187295 a rdf:Statement ; up:attribution _:187264 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:210 . _:187296 a rdf:Statement ; up:attribution _:187265 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:456 . _:187297 a rdf:Statement ; up:attribution _:187266 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:620 . _:187298 a rdf:Statement ; up:attribution _:187267 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:670 . _:187299 a rdf:Statement ; up:attribution _:187268 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:949 . _:187300 a rdf:Statement ; up:attribution _:187269 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:704 . _:187301 a rdf:Statement ; up:attribution _:187270 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:745 . _:187302 a rdf:Statement ; up:attribution _:187271 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:865 . _:187303 a rdf:Statement ; up:attribution _:187272 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0004014 . _:187304 a rdf:Statement ; up:attribution _:187273 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0006596 . _:187305 a rdf:Statement ; up:attribution _:187274 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0008295 . _:187306 a rdf:Statement ; up:source unirule:MF_00465 ; rdf:subject ?pfs12 ; rdf:predicate up:annotation ; rdf:object ?annotation13 . _:187307 a rdf:Statement ; up:attribution _:187275 ; rdf:subject ?pfs12 ; rdf:predicate up:annotation ; rdf:object ?annotation13 . _:187308 a rdf:Statement ; up:source unirule:MF_00465 ; rdf:subject ?pfs18 ; rdf:predicate up:annotation ; rdf:object ?annotation19 . _:187309 a rdf:Statement ; up:attribution _:187276 ; rdf:subject ?pfs18 ; rdf:predicate up:annotation ; rdf:object ?annotation19 . _:187310 a rdf:Statement ; up:source unirule:MF_00465 ; rdf:subject ?pfs24 ; rdf:predicate up:annotation ; rdf:object ?annotation25 . _:187311 a rdf:Statement ; up:attribution _:187277 ; rdf:subject ?pfs24 ; rdf:predicate up:annotation ; rdf:object ?annotation25 . _:187312 a rdf:Statement ; up:source unirule:MF_00465 ; rdf:subject ?pfs30 ; rdf:predicate up:annotation ; rdf:object ?annotation31 . _:187313 a rdf:Statement ; up:attribution _:187278 ; rdf:subject ?pfs30 ; rdf:predicate up:annotation ; rdf:object ?annotation31 . _:187314 a rdf:Statement ; up:source unirule:MF_00465 ; rdf:subject ?pfs36 ; rdf:predicate up:annotation ; rdf:object ?annotation37 . _:187315 a rdf:Statement ; up:attribution _:187279 ; rdf:subject ?pfs36 ; rdf:predicate up:annotation ; rdf:object ?annotation37 . _:187316 a rdf:Statement ; up:source unirule:MF_00465 ; rdf:subject ?pfs42 ; rdf:predicate up:annotation ; rdf:object ?annotation43 . _:187317 a rdf:Statement ; up:attribution _:187280 ; rdf:subject ?pfs42 ; rdf:predicate up:annotation ; rdf:object ?annotation43 . _:187318 a rdf:Statement ; up:source unirule:MF_00465 ; rdf:subject ?pfs48 ; rdf:predicate up:annotation ; rdf:object ?annotation49 . _:187319 a rdf:Statement ; up:attribution _:187281 ; rdf:subject ?pfs48 ; rdf:predicate up:annotation ; rdf:object ?annotation49 . } WHERE { #baseURI: http://purl.uniprot.org/unirule/MF_00465 #Rule MF_00465 Created by:? on:2005-02-28 Modified by:Edouard de Castro on:2024-09-03 VALUES ?supertaxon54 {taxon:1239 taxon:1236} ?this up:organism ?thisOrganism ; rdfs:seeAlso signature:MF_00465 . ?thisOrganism rdfs:subClassOf+ ?supertaxon54 . BIND(URI(CONCAT(STR(?this), '#MF_00465a0')) AS ?name0) . BIND(URI(CONCAT(STR(?this), '#MF_00465a1')) AS ?namedpart1) . BIND(URI(CONCAT(STR(?this), '#MF_00465a2')) AS ?namedpart2) . BIND(URI(CONCAT(STR(?this), '#MF_00465a4')) AS ?annotation4) . BIND(URI(CONCAT(STR(?this), '#MF_00465a5')) AS ?annotation5) . BIND(URI(CONCAT(STR(?this), '#MF_00465a7')) AS ?annotation7) . BIND(URI(CONCAT(STR(?this), '#MF_00465a8')) AS ?annotation8) . BIND(URI(CONCAT(STR(?this), '#MF_00465a9')) AS ?annotation9) . BIND(URI(CONCAT(STR(?this), '#MF_00465a10')) AS ?annotation10) . BIND(URI(CONCAT(STR(?this), '#MF_00465a11')) AS ?annotation11) . OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch59 faldo:location ?templateMotifSequenceMatchRegionP0A7F660 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP0A7F662 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP0A7F6MF_0046555 . ?templateMotifSequenceMatchRegionP0A7F660 faldo:begin ?templateMotifSequenceMatchBeginP0A7F661 . ?templateMotifSequenceMatchBeginP0A7F661 faldo:position ?templateMotifSequenceMatchBeginPositionP0A7F656 ; faldo:reference isoform:P0A7F6-1 . ?templateMotifSequenceProfileAlignmentOperationP0A7F662 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . ?targetMotifMatch63 faldo:location ?targetMotifMatchRegionMatch64 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0046566 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP0A7F6MF_0046557 . ?targetMotifMatchRegionMatch64 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0046565 . ?targetMotifMatchRegionMatchBeginMF_0046565 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0046558 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_0046566 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . BIND(1 AS ?thisPositionOn16) . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP0A7F6MF_0046555, 1, (STRLEN(?templateMotifCigarP0A7F6MF_0046555) - STRLEN(REPLACE(?templateMotifCigarP0A7F6MF_0046555, CONCAT('^(?:-*[^-]){', STR(((111 - ?templateMotifSequenceMatchBeginPositionP0A7F656) + 1)), '}'), '')))), '[a-z]', '')) AS ?step167) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP0A7F6MF_0046557, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_0046557) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_0046557, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step167), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP0A7F6MF_0046557, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_0046557) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_0046557, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step167), '}'), '')))), '[^-]', ''))) AS ?step268) . BIND(((?step268 + ?targetMotifMatchRegionMatchBeginPositionMF_0046558) - 1) AS ?thisPositionOn17) . BIND(?this AS ?pfs1t69) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn16))) AS ?pfsb14) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn17))) AS ?pfse15) . FILTER ((BOUND(?thisPositionOn16) && BOUND(?thisPositionOn17))) . BIND(URI(CONCAT(STR(?this), '#MF_00465a13')) AS ?annotation13) . BIND(?this AS ?pfs12) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch74 faldo:location ?templateMotifSequenceMatchRegionP0A7F675 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP0A7F677 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP0A7F6MF_0046570 . ?templateMotifSequenceMatchRegionP0A7F675 faldo:begin ?templateMotifSequenceMatchBeginP0A7F676 . ?templateMotifSequenceMatchBeginP0A7F676 faldo:position ?templateMotifSequenceMatchBeginPositionP0A7F671 ; faldo:reference isoform:P0A7F6-1 . ?templateMotifSequenceProfileAlignmentOperationP0A7F677 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . ?targetMotifMatch78 faldo:location ?targetMotifMatchRegionMatch79 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0046581 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP0A7F6MF_0046572 . ?targetMotifMatchRegionMatch79 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0046580 . ?targetMotifMatchRegionMatchBeginMF_0046580 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0046573 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_0046581 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP0A7F6MF_0046570, 1, (STRLEN(?templateMotifCigarP0A7F6MF_0046570) - STRLEN(REPLACE(?templateMotifCigarP0A7F6MF_0046570, CONCAT('^(?:-*[^-]){', STR(((112 - ?templateMotifSequenceMatchBeginPositionP0A7F671) + 1)), '}'), '')))), '[a-z]', '')) AS ?step182) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP0A7F6MF_0046572, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_0046572) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_0046572, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step182), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP0A7F6MF_0046572, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_0046572) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_0046572, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step182), '}'), '')))), '[^-]', ''))) AS ?step283) . BIND(((?step283 + ?targetMotifMatchRegionMatchBeginPositionMF_0046573) - 1) AS ?thisPositionOn22) . BIND(STRLEN(?thisSequenceValue) AS ?thisPositionOn23) . BIND(?this AS ?pfs1t84) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn22))) AS ?pfsb20) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn23))) AS ?pfse21) . FILTER ((BOUND(?thisPositionOn22) && BOUND(?thisPositionOn23))) . BIND(URI(CONCAT(STR(?this), '#MF_00465a19')) AS ?annotation19) . BIND(?this AS ?pfs18) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch89 faldo:location ?templateMotifSequenceMatchRegionP0A7F690 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP0A7F692 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP0A7F6MF_0046585 . ?templateMotifSequenceMatchRegionP0A7F690 faldo:begin ?templateMotifSequenceMatchBeginP0A7F691 . ?templateMotifSequenceMatchBeginP0A7F691 faldo:position ?templateMotifSequenceMatchBeginPositionP0A7F686 ; faldo:reference isoform:P0A7F6-1 . ?templateMotifSequenceProfileAlignmentOperationP0A7F692 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . ?targetMotifMatch93 faldo:location ?targetMotifMatchRegionMatch94 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0046596 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP0A7F6MF_0046587 . ?targetMotifMatchRegionMatch94 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0046595 . ?targetMotifMatchRegionMatchBeginMF_0046595 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0046588 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_0046596 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP0A7F6MF_0046585, 1, (STRLEN(?templateMotifCigarP0A7F6MF_0046585) - STRLEN(REPLACE(?templateMotifCigarP0A7F6MF_0046585, CONCAT('^(?:-*[^-]){', STR(((112 - ?templateMotifSequenceMatchBeginPositionP0A7F686) + 1)), '}'), '')))), '[a-z]', '')) AS ?step197) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP0A7F6MF_0046587, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_0046587) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_0046587, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step197), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP0A7F6MF_0046587, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_0046587) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_0046587, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step197), '}'), '')))), '[^-]', ''))) AS ?step298) . BIND(((?step298 + ?targetMotifMatchRegionMatchBeginPositionMF_0046588) - 1) AS ?thisPositionOn28) . BIND(?thisPositionOn28 AS ?thisPositionOn29) . BIND(?this AS ?pfs1t99) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn28))) AS ?pfsb26) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn29))) AS ?pfse27) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn28, 1) = 'S')) . BIND(URI(CONCAT(STR(?this), '#MF_00465a25')) AS ?annotation25) . BIND(?this AS ?pfs24) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch104 faldo:location ?templateMotifSequenceMatchRegionP0A7F6105 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP0A7F6107 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP0A7F6MF_00465100 . ?templateMotifSequenceMatchRegionP0A7F6105 faldo:begin ?templateMotifSequenceMatchBeginP0A7F6106 . ?templateMotifSequenceMatchBeginP0A7F6106 faldo:position ?templateMotifSequenceMatchBeginPositionP0A7F6101 ; faldo:reference isoform:P0A7F6-1 . ?templateMotifSequenceProfileAlignmentOperationP0A7F6107 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . ?targetMotifMatch108 faldo:location ?targetMotifMatchRegionMatch109 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_00465111 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP0A7F6MF_00465102 . ?targetMotifMatchRegionMatch109 faldo:begin ?targetMotifMatchRegionMatchBeginMF_00465110 . ?targetMotifMatchRegionMatchBeginMF_00465110 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_00465103 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_00465111 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP0A7F6MF_00465100, 1, (STRLEN(?templateMotifCigarP0A7F6MF_00465100) - STRLEN(REPLACE(?templateMotifCigarP0A7F6MF_00465100, CONCAT('^(?:-*[^-]){', STR(((117 - ?templateMotifSequenceMatchBeginPositionP0A7F6101) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1112) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP0A7F6MF_00465102, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_00465102) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_00465102, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1112), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP0A7F6MF_00465102, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_00465102) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_00465102, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1112), '}'), '')))), '[^-]', ''))) AS ?step2113) . BIND(((?step2113 + ?targetMotifMatchRegionMatchBeginPositionMF_00465103) - 1) AS ?thisPositionOn34) . BIND(?thisPositionOn34 AS ?thisPositionOn35) . BIND(?this AS ?pfs1t114) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn34))) AS ?pfsb32) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn35))) AS ?pfse33) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn34, 1) = 'H')) . BIND(URI(CONCAT(STR(?this), '#MF_00465a31')) AS ?annotation31) . BIND(?this AS ?pfs30) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch119 faldo:location ?templateMotifSequenceMatchRegionP0A7F6120 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP0A7F6122 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP0A7F6MF_00465115 . ?templateMotifSequenceMatchRegionP0A7F6120 faldo:begin ?templateMotifSequenceMatchBeginP0A7F6121 . ?templateMotifSequenceMatchBeginP0A7F6121 faldo:position ?templateMotifSequenceMatchBeginPositionP0A7F6116 ; faldo:reference isoform:P0A7F6-1 . ?templateMotifSequenceProfileAlignmentOperationP0A7F6122 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . ?targetMotifMatch123 faldo:location ?targetMotifMatchRegionMatch124 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_00465126 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP0A7F6MF_00465117 . ?targetMotifMatchRegionMatch124 faldo:begin ?targetMotifMatchRegionMatchBeginMF_00465125 . ?targetMotifMatchRegionMatchBeginMF_00465125 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_00465118 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_00465126 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP0A7F6MF_00465115, 1, (STRLEN(?templateMotifCigarP0A7F6MF_00465115) - STRLEN(REPLACE(?templateMotifCigarP0A7F6MF_00465115, CONCAT('^(?:-*[^-]){', STR(((140 - ?templateMotifSequenceMatchBeginPositionP0A7F6116) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1127) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP0A7F6MF_00465117, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_00465117) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_00465117, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1127), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP0A7F6MF_00465117, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_00465117) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_00465117, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1127), '}'), '')))), '[^-]', ''))) AS ?step2128) . BIND(((?step2128 + ?targetMotifMatchRegionMatchBeginPositionMF_00465118) - 1) AS ?thisPositionOn40) . BIND(?thisPositionOn40 AS ?thisPositionOn41) . BIND(?this AS ?pfs1t129) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn40))) AS ?pfsb38) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn41))) AS ?pfse39) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn40, 1) = 'C')) . BIND(URI(CONCAT(STR(?this), '#MF_00465a37')) AS ?annotation37) . BIND(?this AS ?pfs36) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch134 faldo:location ?templateMotifSequenceMatchRegionP0A7F6135 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP0A7F6137 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP0A7F6MF_00465130 . ?templateMotifSequenceMatchRegionP0A7F6135 faldo:begin ?templateMotifSequenceMatchBeginP0A7F6136 . ?templateMotifSequenceMatchBeginP0A7F6136 faldo:position ?templateMotifSequenceMatchBeginPositionP0A7F6131 ; faldo:reference isoform:P0A7F6-1 . ?templateMotifSequenceProfileAlignmentOperationP0A7F6137 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . ?targetMotifMatch138 faldo:location ?targetMotifMatchRegionMatch139 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_00465141 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP0A7F6MF_00465132 . ?targetMotifMatchRegionMatch139 faldo:begin ?targetMotifMatchRegionMatchBeginMF_00465140 . ?targetMotifMatchRegionMatchBeginMF_00465140 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_00465133 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_00465141 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP0A7F6MF_00465130, 1, (STRLEN(?templateMotifCigarP0A7F6MF_00465130) - STRLEN(REPLACE(?templateMotifCigarP0A7F6MF_00465130, CONCAT('^(?:-*[^-]){', STR(((111 - ?templateMotifSequenceMatchBeginPositionP0A7F6131) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1142) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP0A7F6MF_00465132, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_00465132) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_00465132, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1142), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP0A7F6MF_00465132, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_00465132) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_00465132, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1142), '}'), '')))), '[^-]', ''))) AS ?step2143) . BIND(((?step2143 + ?targetMotifMatchRegionMatchBeginPositionMF_00465133) - 1) AS ?thisPositionOn46) . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP0A7F6MF_00465130, 1, (STRLEN(?templateMotifCigarP0A7F6MF_00465130) - STRLEN(REPLACE(?templateMotifCigarP0A7F6MF_00465130, CONCAT('^(?:-*[^-]){', STR(((112 - ?templateMotifSequenceMatchBeginPositionP0A7F6131) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1144) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP0A7F6MF_00465132, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_00465132) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_00465132, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1144), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP0A7F6MF_00465132, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_00465132) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_00465132, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1144), '}'), '')))), '[^-]', ''))) AS ?step2145) . BIND(((?step2145 + ?targetMotifMatchRegionMatchBeginPositionMF_00465133) - 1) AS ?thisPositionOn47) . BIND(?this AS ?pfs1t146) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn46))) AS ?pfsb44) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn47))) AS ?pfse45) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn46, (?thisPositionOn47 - ?thisPositionOn46)) = 'KS')) . BIND(URI(CONCAT(STR(?this), '#MF_00465a43')) AS ?annotation43) . BIND(?this AS ?pfs42) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch151 faldo:location ?templateMotifSequenceMatchRegionP0A7F6152 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP0A7F6154 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP0A7F6MF_00465147 . ?templateMotifSequenceMatchRegionP0A7F6152 faldo:begin ?templateMotifSequenceMatchBeginP0A7F6153 . ?templateMotifSequenceMatchBeginP0A7F6153 faldo:position ?templateMotifSequenceMatchBeginPositionP0A7F6148 ; faldo:reference isoform:P0A7F6-1 . ?templateMotifSequenceProfileAlignmentOperationP0A7F6154 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . ?targetMotifMatch155 faldo:location ?targetMotifMatchRegionMatch156 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_00465158 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP0A7F6MF_00465149 . ?targetMotifMatchRegionMatch156 faldo:begin ?targetMotifMatchRegionMatchBeginMF_00465157 . ?targetMotifMatchRegionMatchBeginMF_00465157 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_00465150 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_00465158 edam:has_input signature:MF_00465 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP0A7F6MF_00465147, 1, (STRLEN(?templateMotifCigarP0A7F6MF_00465147) - STRLEN(REPLACE(?templateMotifCigarP0A7F6MF_00465147, CONCAT('^(?:-*[^-]){', STR(((112 - ?templateMotifSequenceMatchBeginPositionP0A7F6148) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1159) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP0A7F6MF_00465149, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_00465149) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_00465149, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1159), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP0A7F6MF_00465149, 1, (STRLEN(?targetMotifMatchCigarP0A7F6MF_00465149) - STRLEN(REPLACE(?targetMotifMatchCigarP0A7F6MF_00465149, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1159), '}'), '')))), '[^-]', ''))) AS ?step2160) . BIND(((?step2160 + ?targetMotifMatchRegionMatchBeginPositionMF_00465150) - 1) AS ?thisPositionOn52) . BIND(?thisPositionOn52 AS ?thisPositionOn53) . BIND(?this AS ?pfs1t161) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn52))) AS ?pfsb50) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn53))) AS ?pfse51) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn52, 1) = 'S')) . BIND(URI(CONCAT(STR(?this), '#MF_00465a49')) AS ?annotation49) . BIND(?this AS ?pfs48) . } }