CONSTRUCT { _:215668 up:source unirule:MF_00553 . _:215669 up:source unirule:MF_00553 . _:215670 up:source unirule:MF_00553 . _:215671 up:source unirule:MF_00553 . _:215672 up:source unirule:MF_00553 . _:215673 up:source unirule:MF_00553 . _:215674 up:source unirule:MF_00553 . _:215675 up:source unirule:MF_00553 . _:215676 up:source unirule:MF_00553 . _:215677 up:source unirule:MF_00553 . _:215678 up:source unirule:MF_00553 . _:215679 up:source unirule:MF_00553 . _:215680 up:source unirule:MF_00553 . _:215681 up:source unirule:MF_00553 . _:215682 up:source unirule:MF_00553 . _:215683 up:source unirule:MF_00553 . _:215684 up:source unirule:MF_00553 . _:215685 up:source unirule:MF_00553 . _:215686 up:source unirule:MF_00553 . _:215687 up:source unirule:MF_00553 . _:215688 up:source unirule:MF_00553 . _:215689 up:source unirule:MF_00553 . _:215690 up:source unirule:MF_00553 . _:215691 up:source unirule:MF_00553 . _:215692 up:source unirule:MF_00553 . _:215693 up:source unirule:MF_00553 . _:215694 up:source unirule:MF_00553 . _:215695 up:source unirule:MF_00553 . _:215696 up:source unirule:MF_00553 . _:215697 up:source unirule:MF_00553 . _:215698 up:source unirule:MF_00553 . _:215699 up:source unirule:MF_00553 . _:215700 up:source unirule:MF_00553 . ?this up:alternativeName ?name1 , ?name2 , ?name3 ; up:annotation ?annotation5 , ?annotation6 , ?annotation8 , ?annotation9 , ?annotation11 , ?annotation12 ; up:classifiedWith GO:0000502 , GO:0005524 , GO:0005737 , GO:0010498 , GO:0016887 , GO:0022623 , GO:0043335 , keyword:143 , keyword:378 , keyword:547 , keyword:647 , keyword:67 , keyword:963 ; up:recommendedName ?name0 . ?name0 up:ecName '3.6.1.-' ; up:fullName 'Proteasome-activating nucleotidase' ; up:shortName 'PAN' ; rdf:type up:Structured_Name . ?name1 up:fullName 'Proteasomal ATPase' ; rdf:type up:Structured_Name . ?name2 up:fullName 'Proteasome regulatory ATPase' ; rdf:type up:Structured_Name . ?name3 up:fullName 'Proteasome regulatory particle' ; rdf:type up:Structured_Name . ?gene4 skos:prefLabel 'pan' . ?annotation5 a up:Function_Annotation ; rdfs:comment "ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates." . ?annotation6 up:activity ?activity7 ; rdf:type up:Catalytic_Activity_Annotation . ?activity7 up:catalyticActivity <http://rdf.rhea-db.org/13065>. ?annotation8 a up:Subunit_Annotation ; rdfs:comment 'Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.' . ?annotation9 a up:Subcellular_Location_Annotation . ?annotation9li10 up:cellularComponent <http://purl.uniprot.org/locations/null>. ?annotation11 a up:Domain_Annotation ; rdfs:comment 'Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.' . ?annotation12 a up:Similarity_Annotation ; rdfs:comment 'Belongs to the AAA ATPase family.' . ?pfs13 up:annotation ?annotation14 . ?annotation14 faldo:begin ?pfsb15 ; faldo:end ?pfse16 ; rdf:type up:Region_Annotation ; rdfs:comment 'Docks into pockets in the proteasome alpha-ring to cause gate opening' . ?pfsb15 faldo:position ?thisPositionOn17 ; rdf:type faldo:ExactPosition . ?pfse16 faldo:position ?thisPositionOn18 ; rdf:type faldo:ExactPosition . ?pfs19 up:annotation ?annotation20 . ?annotation20 faldo:begin ?pfsb21 ; faldo:end ?pfse22 ; up:ligand ?ligand23 ; rdf:type up:Binding_Site_Annotation . ?pfsb21 faldo:position ?thisPositionOn24 ; rdf:type faldo:ExactPosition . ?pfse22 faldo:position ?thisPositionOn25 ; rdf:type faldo:ExactPosition . ?ligand23 rdfs:subClassOf chebi:30616 . ?pfs26 up:annotation ?annotation27 . ?annotation27 faldo:begin ?pfsb28 ; faldo:end ?pfse29 ; up:ligand ?ligand30 ; rdf:type up:Binding_Site_Annotation . ?pfsb28 faldo:position ?thisPositionOn31 ; rdf:type faldo:ExactPosition . ?pfse29 faldo:position ?thisPositionOn32 ; rdf:type faldo:ExactPosition . ?ligand30 rdfs:subClassOf chebi:30616 . ?pfs33 up:annotation ?annotation34 . ?annotation34 faldo:begin ?pfsb35 ; faldo:end ?pfse36 ; up:ligand ?ligand37 ; rdf:type up:Binding_Site_Annotation . ?pfsb35 faldo:position ?thisPositionOn38 ; rdf:type faldo:ExactPosition . ?pfse36 faldo:position ?thisPositionOn39 ; rdf:type faldo:ExactPosition . ?ligand37 rdfs:subClassOf chebi:30616 . ?pfs40 up:annotation ?annotation41 . ?annotation41 faldo:begin ?pfsb42 ; faldo:end ?pfse43 ; up:ligand ?ligand44 ; rdf:type up:Binding_Site_Annotation . ?pfsb42 faldo:position ?thisPositionOn45 ; rdf:type faldo:ExactPosition . ?pfse43 faldo:position ?thisPositionOn46 ; rdf:type faldo:ExactPosition . ?ligand44 rdfs:subClassOf chebi:30616 . ?pfs47 up:annotation ?annotation48 . ?annotation48 faldo:begin ?pfsb49 ; faldo:end ?pfse50 ; up:ligand ?ligand51 ; rdf:type up:Binding_Site_Annotation . ?pfsb49 faldo:position ?thisPositionOn52 ; rdf:type faldo:ExactPosition . ?pfse50 faldo:position ?thisPositionOn53 ; rdf:type faldo:ExactPosition . ?ligand51 rdfs:subClassOf chebi:30616 . ?pfs54 up:annotation ?annotation55 . ?annotation55 faldo:begin ?pfsb56 ; faldo:end ?pfse57 ; up:ligand ?ligand58 ; rdf:type up:Binding_Site_Annotation . ?pfsb56 faldo:position ?thisPositionOn59 ; rdf:type faldo:ExactPosition . ?pfse57 faldo:position ?thisPositionOn60 ; rdf:type faldo:ExactPosition . ?ligand58 rdfs:subClassOf chebi:30616 . ?pfs61 up:annotation ?annotation62 . ?annotation62 faldo:begin ?pfsb63 ; faldo:end ?pfse64 ; up:ligand ?ligand65 ; rdf:type up:Binding_Site_Annotation . ?pfsb63 faldo:position ?thisPositionOn66 ; rdf:type faldo:ExactPosition . ?pfse64 faldo:position ?thisPositionOn67 ; rdf:type faldo:ExactPosition . ?ligand65 rdfs:subClassOf chebi:30616 . ?sam68 up:classifiedWith keyword:175 . ?coiledCoil69 faldo:begin ?coiledCoilb70 ; faldo:end ?coiledCoile71 . ?coiledCoilb70 faldo:position ?coiledCoilbp72 . ?coiledCoile71 faldo:position ?coiledCoilep73 . ?keyword74 up:range ?coiledCoil69 . _:215701 a rdf:Statement ; up:attribution _:215668 ; rdf:subject ?this ; rdf:predicate up:recommendedName ; rdf:object ?name0 . _:215702 a rdf:Statement ; up:attribution _:215669 ; rdf:subject ?this ; rdf:predicate up:alternativeName ; rdf:object ?name1 . _:215703 a rdf:Statement ; up:attribution _:215670 ; rdf:subject ?this ; rdf:predicate up:alternativeName ; rdf:object ?name2 . _:215704 a rdf:Statement ; up:attribution _:215671 ; rdf:subject ?this ; rdf:predicate up:alternativeName ; rdf:object ?name3 . _:215705 a rdf:Statement ; up:attribution _:215672 ; rdf:subject ?gene4 ; rdf:predicate up:encodedBy ; rdf:object ?gene4 . _:215706 a rdf:Statement ; up:attribution _:215673 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation5 . _:215707 a rdf:Statement ; up:attribution _:215674 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation6 . _:215708 a rdf:Statement ; up:attribution _:215675 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation8 . _:215709 a rdf:Statement ; up:attribution _:215676 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation9 . _:215710 a rdf:Statement ; up:attribution _:215677 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation11 . _:215711 a rdf:Statement ; up:attribution _:215678 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation12 . _:215712 a rdf:Statement ; up:attribution _:215679 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:143 . _:215713 a rdf:Statement ; up:attribution _:215680 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:963 . _:215714 a rdf:Statement ; up:attribution _:215681 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:647 . _:215715 a rdf:Statement ; up:attribution _:215682 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:67 . _:215716 a rdf:Statement ; up:attribution _:215683 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:547 . _:215717 a rdf:Statement ; up:attribution _:215684 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:378 . _:215718 a rdf:Statement ; up:attribution _:215685 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0005524 . _:215719 a rdf:Statement ; up:attribution _:215686 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0016887 . _:215720 a rdf:Statement ; up:attribution _:215687 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0010498 . _:215721 a rdf:Statement ; up:attribution _:215688 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0043335 . _:215722 a rdf:Statement ; up:attribution _:215689 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0000502 . _:215723 a rdf:Statement ; up:attribution _:215690 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0005737 . _:215724 a rdf:Statement ; up:attribution _:215691 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0022623 . _:215725 a rdf:Statement ; up:source unirule:MF_00553 ; rdf:subject ?pfs13 ; rdf:predicate up:annotation ; rdf:object ?annotation14 . _:215726 a rdf:Statement ; up:attribution _:215692 ; rdf:subject ?pfs13 ; rdf:predicate up:annotation ; rdf:object ?annotation14 . _:215727 a rdf:Statement ; up:source unirule:MF_00553 ; rdf:subject ?pfs19 ; rdf:predicate up:annotation ; rdf:object ?annotation20 . _:215728 a rdf:Statement ; up:attribution _:215693 ; rdf:subject ?pfs19 ; rdf:predicate up:annotation ; rdf:object ?annotation20 . _:215729 a rdf:Statement ; up:source unirule:MF_00553 ; rdf:subject ?pfs26 ; rdf:predicate up:annotation ; rdf:object ?annotation27 . _:215730 a rdf:Statement ; up:attribution _:215694 ; rdf:subject ?pfs26 ; rdf:predicate up:annotation ; rdf:object ?annotation27 . _:215731 a rdf:Statement ; up:source unirule:MF_00553 ; rdf:subject ?pfs33 ; rdf:predicate up:annotation ; rdf:object ?annotation34 . _:215732 a rdf:Statement ; up:attribution _:215695 ; rdf:subject ?pfs33 ; rdf:predicate up:annotation ; rdf:object ?annotation34 . _:215733 a rdf:Statement ; up:source unirule:MF_00553 ; rdf:subject ?pfs40 ; rdf:predicate up:annotation ; rdf:object ?annotation41 . _:215734 a rdf:Statement ; up:attribution _:215696 ; rdf:subject ?pfs40 ; rdf:predicate up:annotation ; rdf:object ?annotation41 . _:215735 a rdf:Statement ; up:source unirule:MF_00553 ; rdf:subject ?pfs47 ; rdf:predicate up:annotation ; rdf:object ?annotation48 . _:215736 a rdf:Statement ; up:attribution _:215697 ; rdf:subject ?pfs47 ; rdf:predicate up:annotation ; rdf:object ?annotation48 . _:215737 a rdf:Statement ; up:source unirule:MF_00553 ; rdf:subject ?pfs54 ; rdf:predicate up:annotation ; rdf:object ?annotation55 . _:215738 a rdf:Statement ; up:attribution _:215698 ; rdf:subject ?pfs54 ; rdf:predicate up:annotation ; rdf:object ?annotation55 . _:215739 a rdf:Statement ; up:source unirule:MF_00553 ; rdf:subject ?pfs61 ; rdf:predicate up:annotation ; rdf:object ?annotation62 . _:215740 a rdf:Statement ; up:attribution _:215699 ; rdf:subject ?pfs61 ; rdf:predicate up:annotation ; rdf:object ?annotation62 . _:215741 a rdf:Statement ; up:attribution _:215700 ; rdf:subject ?sam68 ; rdf:predicate up:classifiedWith ; rdf:object keyword:175 . } WHERE { #baseURI: http://purl.uniprot.org/unirule/MF_00553 #Rule MF_00553 Created by:? on:2005-02-28 Modified by:Elisabeth Coudert on:2025-06-20 ?this up:organism ?thisOrganism ; rdfs:seeAlso signature:MF_00553 . ?thisOrganism rdfs:subClassOf+ taxon:2157 . BIND(URI(CONCAT(STR(?this), '#MF_00553a0')) AS ?name0) . BIND(URI(CONCAT(STR(?this), '#MF_00553a1')) AS ?name1) . BIND(URI(CONCAT(STR(?this), '#MF_00553a2')) AS ?name2) . BIND(URI(CONCAT(STR(?this), '#MF_00553a3')) AS ?name3) . BIND(URI(CONCAT(STR(?this), '#MF_00553a5')) AS ?annotation5) . BIND(URI(CONCAT(STR(?this), '#MF_00553a6')) AS ?annotation6) . BIND(URI(CONCAT(STR(?this), '#MF_00553a8')) AS ?annotation8) . BIND(URI(CONCAT(STR(?this), '#MF_00553a9')) AS ?annotation9) . BIND(URI(CONCAT(STR(?this), '#MF_00553a11')) AS ?annotation11) . BIND(URI(CONCAT(STR(?this), '#MF_00553a12')) AS ?annotation12) . OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch79 faldo:location ?templateMotifSequenceMatchRegionQ8U4H380 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ8U4H382 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarQ8U4H3MF_0055375 . ?templateMotifSequenceMatchRegionQ8U4H380 faldo:begin ?templateMotifSequenceMatchBeginQ8U4H381 . ?templateMotifSequenceMatchBeginQ8U4H381 faldo:position ?templateMotifSequenceMatchBeginPositionQ8U4H376 ; faldo:reference isoform:Q8U4H3-1 . ?templateMotifSequenceProfileAlignmentOperationQ8U4H382 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . ?targetMotifMatch83 faldo:location ?targetMotifMatchRegionMatch84 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0055386 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarQ8U4H3MF_0055377 . ?targetMotifMatchRegionMatch84 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0055385 . ?targetMotifMatchRegionMatchBeginMF_0055385 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0055378 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_0055386 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ8U4H3MF_0055375, 1, (STRLEN(?templateMotifCigarQ8U4H3MF_0055375) - STRLEN(REPLACE(?templateMotifCigarQ8U4H3MF_0055375, CONCAT('^(?:-*[^-]){', STR(((394 - ?templateMotifSequenceMatchBeginPositionQ8U4H376) + 1)), '}'), '')))), '[a-z]', '')) AS ?step187) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_0055377, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_0055377) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_0055377, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step187), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_0055377, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_0055377) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_0055377, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step187), '}'), '')))), '[^-]', ''))) AS ?step288) . BIND(((?step288 + ?targetMotifMatchRegionMatchBeginPositionMF_0055378) - 1) AS ?thisPositionOn17) . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ8U4H3MF_0055375, 1, (STRLEN(?templateMotifCigarQ8U4H3MF_0055375) - STRLEN(REPLACE(?templateMotifCigarQ8U4H3MF_0055375, CONCAT('^(?:-*[^-]){', STR(((396 - ?templateMotifSequenceMatchBeginPositionQ8U4H376) + 1)), '}'), '')))), '[a-z]', '')) AS ?step189) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_0055377, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_0055377) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_0055377, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step189), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_0055377, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_0055377) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_0055377, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step189), '}'), '')))), '[^-]', ''))) AS ?step290) . BIND(((?step290 + ?targetMotifMatchRegionMatchBeginPositionMF_0055378) - 1) AS ?thisPositionOn18) . BIND(?this AS ?pfs1t91) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn17))) AS ?pfsb15) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn18))) AS ?pfse16) . FILTER (REGEX('[ARNDCQEGHILKMFPSTWYVBZJUOX][YF][ARNDCQEGHILKMFPSTWYVBZJUOX]', SUBSTR(?thisSequenceValue, ?thisPositionOn17, (?thisPositionOn18 - ?thisPositionOn17)))) . BIND(URI(CONCAT(STR(?this), '#MF_00553a14')) AS ?annotation14) . BIND(?this AS ?pfs13) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch96 faldo:location ?templateMotifSequenceMatchRegionQ8U4H397 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ8U4H399 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarQ8U4H3MF_0055392 . ?templateMotifSequenceMatchRegionQ8U4H397 faldo:begin ?templateMotifSequenceMatchBeginQ8U4H398 . ?templateMotifSequenceMatchBeginQ8U4H398 faldo:position ?templateMotifSequenceMatchBeginPositionQ8U4H393 ; faldo:reference isoform:Q8U4H3-1 . ?templateMotifSequenceProfileAlignmentOperationQ8U4H399 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . ?targetMotifMatch100 faldo:location ?targetMotifMatchRegionMatch101 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_00553103 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarQ8U4H3MF_0055394 . ?targetMotifMatchRegionMatch101 faldo:begin ?targetMotifMatchRegionMatchBeginMF_00553102 . ?targetMotifMatchRegionMatchBeginMF_00553102 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0055395 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_00553103 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ8U4H3MF_0055392, 1, (STRLEN(?templateMotifCigarQ8U4H3MF_0055392) - STRLEN(REPLACE(?templateMotifCigarQ8U4H3MF_0055392, CONCAT('^(?:-*[^-]){', STR(((140 - ?templateMotifSequenceMatchBeginPositionQ8U4H393) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1104) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_0055394, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_0055394) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_0055394, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1104), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_0055394, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_0055394) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_0055394, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1104), '}'), '')))), '[^-]', ''))) AS ?step2105) . BIND(((?step2105 + ?targetMotifMatchRegionMatchBeginPositionMF_0055395) - 1) AS ?thisPositionOn24) . BIND(?thisPositionOn24 AS ?thisPositionOn25) . BIND(?this AS ?pfs1t106) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn24))) AS ?pfsb21) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn25))) AS ?pfse22) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn24, 1) = 'G')) . BIND(URI(CONCAT(STR(?this), '#MF_00553a20')) AS ?annotation20) . BIND(?this AS ?pfs19) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch111 faldo:location ?templateMotifSequenceMatchRegionQ8U4H3112 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ8U4H3114 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarQ8U4H3MF_00553107 . ?templateMotifSequenceMatchRegionQ8U4H3112 faldo:begin ?templateMotifSequenceMatchBeginQ8U4H3113 . ?templateMotifSequenceMatchBeginQ8U4H3113 faldo:position ?templateMotifSequenceMatchBeginPositionQ8U4H3108 ; faldo:reference isoform:Q8U4H3-1 . ?templateMotifSequenceProfileAlignmentOperationQ8U4H3114 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . ?targetMotifMatch115 faldo:location ?targetMotifMatchRegionMatch116 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_00553118 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarQ8U4H3MF_00553109 . ?targetMotifMatchRegionMatch116 faldo:begin ?targetMotifMatchRegionMatchBeginMF_00553117 . ?targetMotifMatchRegionMatchBeginMF_00553117 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_00553110 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_00553118 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ8U4H3MF_00553107, 1, (STRLEN(?templateMotifCigarQ8U4H3MF_00553107) - STRLEN(REPLACE(?templateMotifCigarQ8U4H3MF_00553107, CONCAT('^(?:-*[^-]){', STR(((181 - ?templateMotifSequenceMatchBeginPositionQ8U4H3108) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1119) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_00553109, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_00553109) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_00553109, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1119), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_00553109, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_00553109) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_00553109, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1119), '}'), '')))), '[^-]', ''))) AS ?step2120) . BIND(((?step2120 + ?targetMotifMatchRegionMatchBeginPositionMF_00553110) - 1) AS ?thisPositionOn31) . BIND(?thisPositionOn31 AS ?thisPositionOn32) . BIND(?this AS ?pfs1t121) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn31))) AS ?pfsb28) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn32))) AS ?pfse29) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn31, 1) = 'G')) . BIND(URI(CONCAT(STR(?this), '#MF_00553a27')) AS ?annotation27) . BIND(?this AS ?pfs26) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch126 faldo:location ?templateMotifSequenceMatchRegionQ8U4H3127 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ8U4H3129 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarQ8U4H3MF_00553122 . ?templateMotifSequenceMatchRegionQ8U4H3127 faldo:begin ?templateMotifSequenceMatchBeginQ8U4H3128 . ?templateMotifSequenceMatchBeginQ8U4H3128 faldo:position ?templateMotifSequenceMatchBeginPositionQ8U4H3123 ; faldo:reference isoform:Q8U4H3-1 . ?templateMotifSequenceProfileAlignmentOperationQ8U4H3129 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . ?targetMotifMatch130 faldo:location ?targetMotifMatchRegionMatch131 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_00553133 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarQ8U4H3MF_00553124 . ?targetMotifMatchRegionMatch131 faldo:begin ?targetMotifMatchRegionMatchBeginMF_00553132 . ?targetMotifMatchRegionMatchBeginMF_00553132 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_00553125 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_00553133 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ8U4H3MF_00553122, 1, (STRLEN(?templateMotifCigarQ8U4H3MF_00553122) - STRLEN(REPLACE(?templateMotifCigarQ8U4H3MF_00553122, CONCAT('^(?:-*[^-]){', STR(((182 - ?templateMotifSequenceMatchBeginPositionQ8U4H3123) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1134) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_00553124, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_00553124) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_00553124, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1134), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_00553124, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_00553124) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_00553124, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1134), '}'), '')))), '[^-]', ''))) AS ?step2135) . BIND(((?step2135 + ?targetMotifMatchRegionMatchBeginPositionMF_00553125) - 1) AS ?thisPositionOn38) . BIND(?thisPositionOn38 AS ?thisPositionOn39) . BIND(?this AS ?pfs1t136) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn38))) AS ?pfsb35) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn39))) AS ?pfse36) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn38, 1) = 'C')) . BIND(URI(CONCAT(STR(?this), '#MF_00553a34')) AS ?annotation34) . BIND(?this AS ?pfs33) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch141 faldo:location ?templateMotifSequenceMatchRegionQ8U4H3142 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ8U4H3144 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarQ8U4H3MF_00553137 . ?templateMotifSequenceMatchRegionQ8U4H3142 faldo:begin ?templateMotifSequenceMatchBeginQ8U4H3143 . ?templateMotifSequenceMatchBeginQ8U4H3143 faldo:position ?templateMotifSequenceMatchBeginPositionQ8U4H3138 ; faldo:reference isoform:Q8U4H3-1 . ?templateMotifSequenceProfileAlignmentOperationQ8U4H3144 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . ?targetMotifMatch145 faldo:location ?targetMotifMatchRegionMatch146 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_00553148 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarQ8U4H3MF_00553139 . ?targetMotifMatchRegionMatch146 faldo:begin ?targetMotifMatchRegionMatchBeginMF_00553147 . ?targetMotifMatchRegionMatchBeginMF_00553147 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_00553140 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_00553148 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ8U4H3MF_00553137, 1, (STRLEN(?templateMotifCigarQ8U4H3MF_00553137) - STRLEN(REPLACE(?templateMotifCigarQ8U4H3MF_00553137, CONCAT('^(?:-*[^-]){', STR(((183 - ?templateMotifSequenceMatchBeginPositionQ8U4H3138) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1149) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_00553139, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_00553139) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_00553139, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1149), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_00553139, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_00553139) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_00553139, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1149), '}'), '')))), '[^-]', ''))) AS ?step2150) . BIND(((?step2150 + ?targetMotifMatchRegionMatchBeginPositionMF_00553140) - 1) AS ?thisPositionOn45) . BIND(?thisPositionOn45 AS ?thisPositionOn46) . BIND(?this AS ?pfs1t151) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn45))) AS ?pfsb42) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn46))) AS ?pfse43) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn45, 1) = 'G')) . BIND(URI(CONCAT(STR(?this), '#MF_00553a41')) AS ?annotation41) . BIND(?this AS ?pfs40) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch156 faldo:location ?templateMotifSequenceMatchRegionQ8U4H3157 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ8U4H3159 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarQ8U4H3MF_00553152 . ?templateMotifSequenceMatchRegionQ8U4H3157 faldo:begin ?templateMotifSequenceMatchBeginQ8U4H3158 . ?templateMotifSequenceMatchBeginQ8U4H3158 faldo:position ?templateMotifSequenceMatchBeginPositionQ8U4H3153 ; faldo:reference isoform:Q8U4H3-1 . ?templateMotifSequenceProfileAlignmentOperationQ8U4H3159 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . ?targetMotifMatch160 faldo:location ?targetMotifMatchRegionMatch161 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_00553163 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarQ8U4H3MF_00553154 . ?targetMotifMatchRegionMatch161 faldo:begin ?targetMotifMatchRegionMatchBeginMF_00553162 . ?targetMotifMatchRegionMatchBeginMF_00553162 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_00553155 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_00553163 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ8U4H3MF_00553152, 1, (STRLEN(?templateMotifCigarQ8U4H3MF_00553152) - STRLEN(REPLACE(?templateMotifCigarQ8U4H3MF_00553152, CONCAT('^(?:-*[^-]){', STR(((184 - ?templateMotifSequenceMatchBeginPositionQ8U4H3153) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1164) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_00553154, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_00553154) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_00553154, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1164), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_00553154, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_00553154) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_00553154, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1164), '}'), '')))), '[^-]', ''))) AS ?step2165) . BIND(((?step2165 + ?targetMotifMatchRegionMatchBeginPositionMF_00553155) - 1) AS ?thisPositionOn52) . BIND(?thisPositionOn52 AS ?thisPositionOn53) . BIND(?this AS ?pfs1t166) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn52))) AS ?pfsb49) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn53))) AS ?pfse50) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn52, 1) = 'K')) . BIND(URI(CONCAT(STR(?this), '#MF_00553a48')) AS ?annotation48) . BIND(?this AS ?pfs47) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch171 faldo:location ?templateMotifSequenceMatchRegionQ8U4H3172 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ8U4H3174 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarQ8U4H3MF_00553167 . ?templateMotifSequenceMatchRegionQ8U4H3172 faldo:begin ?templateMotifSequenceMatchBeginQ8U4H3173 . ?templateMotifSequenceMatchBeginQ8U4H3173 faldo:position ?templateMotifSequenceMatchBeginPositionQ8U4H3168 ; faldo:reference isoform:Q8U4H3-1 . ?templateMotifSequenceProfileAlignmentOperationQ8U4H3174 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . ?targetMotifMatch175 faldo:location ?targetMotifMatchRegionMatch176 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_00553178 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarQ8U4H3MF_00553169 . ?targetMotifMatchRegionMatch176 faldo:begin ?targetMotifMatchRegionMatchBeginMF_00553177 . ?targetMotifMatchRegionMatchBeginMF_00553177 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_00553170 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_00553178 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ8U4H3MF_00553167, 1, (STRLEN(?templateMotifCigarQ8U4H3MF_00553167) - STRLEN(REPLACE(?templateMotifCigarQ8U4H3MF_00553167, CONCAT('^(?:-*[^-]){', STR(((185 - ?templateMotifSequenceMatchBeginPositionQ8U4H3168) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1179) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_00553169, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_00553169) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_00553169, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1179), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_00553169, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_00553169) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_00553169, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1179), '}'), '')))), '[^-]', ''))) AS ?step2180) . BIND(((?step2180 + ?targetMotifMatchRegionMatchBeginPositionMF_00553170) - 1) AS ?thisPositionOn59) . BIND(?thisPositionOn59 AS ?thisPositionOn60) . BIND(?this AS ?pfs1t181) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn59))) AS ?pfsb56) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn60))) AS ?pfse57) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn59, 1) = 'T')) . BIND(URI(CONCAT(STR(?this), '#MF_00553a55')) AS ?annotation55) . BIND(?this AS ?pfs54) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch186 faldo:location ?templateMotifSequenceMatchRegionQ8U4H3187 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ8U4H3189 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarQ8U4H3MF_00553182 . ?templateMotifSequenceMatchRegionQ8U4H3187 faldo:begin ?templateMotifSequenceMatchBeginQ8U4H3188 . ?templateMotifSequenceMatchBeginQ8U4H3188 faldo:position ?templateMotifSequenceMatchBeginPositionQ8U4H3183 ; faldo:reference isoform:Q8U4H3-1 . ?templateMotifSequenceProfileAlignmentOperationQ8U4H3189 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . ?targetMotifMatch190 faldo:location ?targetMotifMatchRegionMatch191 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_00553193 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarQ8U4H3MF_00553184 . ?targetMotifMatchRegionMatch191 faldo:begin ?targetMotifMatchRegionMatchBeginMF_00553192 . ?targetMotifMatchRegionMatchBeginMF_00553192 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_00553185 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_00553193 edam:has_input signature:MF_00553 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ8U4H3MF_00553182, 1, (STRLEN(?templateMotifCigarQ8U4H3MF_00553182) - STRLEN(REPLACE(?templateMotifCigarQ8U4H3MF_00553182, CONCAT('^(?:-*[^-]){', STR(((186 - ?templateMotifSequenceMatchBeginPositionQ8U4H3183) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1194) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_00553184, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_00553184) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_00553184, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1194), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ8U4H3MF_00553184, 1, (STRLEN(?targetMotifMatchCigarQ8U4H3MF_00553184) - STRLEN(REPLACE(?targetMotifMatchCigarQ8U4H3MF_00553184, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1194), '}'), '')))), '[^-]', ''))) AS ?step2195) . BIND(((?step2195 + ?targetMotifMatchRegionMatchBeginPositionMF_00553185) - 1) AS ?thisPositionOn66) . BIND(?thisPositionOn66 AS ?thisPositionOn67) . BIND(?this AS ?pfs1t196) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn66))) AS ?pfsb63) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn67))) AS ?pfse64) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn66, 1) = 'L')) . BIND(URI(CONCAT(STR(?this), '#MF_00553a62')) AS ?annotation62) . BIND(?this AS ?pfs61) . } OPTIONAL { ?this up:annotation ?samcc197 ; up:sequence ?thisSequence . ?samcc197 up:range ?samccr198 ; rdf:type up:Coiled_Coil_Annotation . ?samccr198 faldo:begin ?samccb199 ; faldo:end ?samcce200 . ?samccb199 faldo:position ?samccbp201 ; faldo:reference ?thisSequence . ?samcce200 faldo:position ?samccep202 ; faldo:reference ?thisSequence . BIND(?this AS ?sam68) . } BIND(URI(CONCAT(STR(?this), '#MF_00553a74')) AS ?keyword74) . }