CONSTRUCT { _:434534 up:source unirule:MF_01253 . _:434535 up:source unirule:MF_01253 . _:434536 up:source unirule:MF_01253 . _:434537 up:source unirule:MF_01253 . _:434538 up:source unirule:MF_01253 . _:434539 up:source unirule:MF_01253 . _:434540 up:source unirule:MF_01253 . _:434541 up:source unirule:MF_01253 . _:434542 up:source unirule:MF_01253 . _:434543 up:source unirule:MF_01253 . _:434544 up:source unirule:MF_01253 . _:434545 up:source unirule:MF_01253 . _:434546 up:source unirule:MF_01253 . _:434547 up:source unirule:MF_01253 . _:434548 up:source unirule:MF_01253 . _:434549 up:source unirule:MF_01253 . _:434550 up:source unirule:MF_01253 . _:434551 up:source unirule:MF_01253 . _:434552 up:source unirule:MF_01253 . _:434553 up:source unirule:MF_01253 . _:434554 up:source unirule:MF_01253 . _:434555 up:source unirule:MF_01253 . _:434556 up:source unirule:MF_01253 . _:434557 up:source unirule:MF_01253 . _:434558 up:source unirule:MF_01253 . _:434559 up:source unirule:MF_01253 . _:434560 up:source unirule:MF_01253 . _:434561 up:source unirule:MF_01253 . _:434562 up:source unirule:MF_01253 . _:434563 up:source unirule:MF_01253 . _:434564 up:source unirule:MF_01253 . ?this up:alternativeName ?name1 , ?name2 , ?name3 ; up:annotation ?annotation5 , ?annotation6 , ?annotation8 , ?annotation9 ; up:classifiedWith GO:0000703 , GO:0003906 , GO:0006281 , keyword:227 , keyword:234 , keyword:238 , keyword:326 , keyword:378 , keyword:456 , keyword:511 ; up:recommendedName ?name0 . ?name0 up:fullName 'Endonuclease 8' ; rdf:type up:Structured_Name . ?name1 up:ecName '3.2.2.-' , '4.2.99.18' ; up:fullName 'DNA glycosylase/AP lyase Nei' ; rdf:type up:Structured_Name . ?name2 up:fullName 'DNA-(apurinic or apyrimidinic site) lyase Nei' ; rdf:type up:Structured_Name . ?name3 up:fullName 'Endonuclease VIII' ; rdf:type up:Structured_Name . ?gene4 skos:prefLabel 'nei' . ?annotation5 a up:Function_Annotation ; rdfs:comment "Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates." . ?annotation6 up:activity ?activity7 ; rdf:type up:Catalytic_Activity_Annotation . ?activity7 up:catalyticActivity <http://rdf.rhea-db.org/66592>; up:enzymeClass <http://purl.uniprot.org/enzyme/4.2.99.18>. ?annotation8 up:cofactor chebi:29105 ; rdf:type up:Cofactor_Annotation ; rdfs:comment 'Binds 1 zinc ion per subunit.' . ?annotation9 a up:Similarity_Annotation ; rdfs:comment 'Belongs to the FPG family.' . ?case10 up:classifiedWith GO:0008270 , keyword:479 , keyword:862 , keyword:863 . ?pfs11 up:annotation ?annotation12 . ?annotation12 faldo:begin ?pfsb13 ; faldo:end ?pfse14 ; rdf:type up:Initiator_Methionine_Annotation ; rdfs:comment 'Removed' . ?pfsb13 faldo:position ?thisPositionOn15 ; rdf:type faldo:ExactPosition . ?pfse14 faldo:position ?thisPositionOn16 ; rdf:type faldo:ExactPosition . ?pfs17 up:annotation ?annotation18 . ?annotation18 faldo:begin ?pfsb19 ; faldo:end ?pfse20 ; rdf:type up:Active_Site_Annotation ; rdfs:comment 'Schiff-base intermediate with DNA' . ?pfsb19 faldo:position ?thisPositionOn21 ; rdf:type faldo:ExactPosition . ?pfse20 faldo:position ?thisPositionOn22 ; rdf:type faldo:ExactPosition . ?pfs23 up:annotation ?annotation24 . ?annotation24 faldo:begin ?pfsb25 ; faldo:end ?pfse26 ; rdf:type up:Active_Site_Annotation ; rdfs:comment 'Proton donor' . ?pfsb25 faldo:position ?thisPositionOn27 ; rdf:type faldo:ExactPosition . ?pfse26 faldo:position ?thisPositionOn28 ; rdf:type faldo:ExactPosition . ?pfs29 up:annotation ?annotation30 . ?annotation30 faldo:begin ?pfsb31 ; faldo:end ?pfse32 ; rdf:type up:Active_Site_Annotation ; rdfs:comment 'Proton donor; for beta-elimination activity' . ?pfsb31 faldo:position ?thisPositionOn33 ; rdf:type faldo:ExactPosition . ?pfse32 faldo:position ?thisPositionOn34 ; rdf:type faldo:ExactPosition . ?pfs35 up:annotation ?annotation36 . ?annotation36 faldo:begin ?pfsb37 ; faldo:end ?pfse38 ; rdf:type up:Active_Site_Annotation ; rdfs:comment 'Proton donor; for delta-elimination activity' . ?pfsb37 faldo:position ?thisPositionOn39 ; rdf:type faldo:ExactPosition . ?pfse38 faldo:position ?thisPositionOn40 ; rdf:type faldo:ExactPosition . ?pfs41 up:annotation ?annotation42 . ?annotation42 faldo:begin ?pfsb43 ; faldo:end ?pfse44 ; up:ligand ?ligand45 ; rdf:type up:Binding_Site_Annotation . ?pfsb43 faldo:position ?thisPositionOn46 ; rdf:type faldo:ExactPosition . ?pfse44 faldo:position ?thisPositionOn47 ; rdf:type faldo:ExactPosition . ?ligand45 rdfs:subClassOf chebi:16991 . ?pfs48 up:annotation ?annotation49 . ?annotation49 faldo:begin ?pfsb50 ; faldo:end ?pfse51 ; up:ligand ?ligand52 ; rdf:type up:Binding_Site_Annotation . ?pfsb50 faldo:position ?thisPositionOn53 ; rdf:type faldo:ExactPosition . ?pfse51 faldo:position ?thisPositionOn54 ; rdf:type faldo:ExactPosition . ?ligand52 rdfs:subClassOf chebi:16991 . ?pfs55 up:annotation ?annotation56 . ?annotation56 faldo:begin ?pfsb57 ; faldo:end ?pfse58 ; up:ligand ?ligand59 ; rdf:type up:Binding_Site_Annotation . ?pfsb57 faldo:position ?thisPositionOn60 ; rdf:type faldo:ExactPosition . ?pfse58 faldo:position ?thisPositionOn61 ; rdf:type faldo:ExactPosition . ?ligand59 rdfs:subClassOf chebi:16991 . _:434565 a rdf:Statement ; up:attribution _:434534 ; rdf:subject ?this ; rdf:predicate up:recommendedName ; rdf:object ?name0 . _:434566 a rdf:Statement ; up:attribution _:434535 ; rdf:subject ?this ; rdf:predicate up:alternativeName ; rdf:object ?name1 . _:434567 a rdf:Statement ; up:attribution _:434536 ; rdf:subject ?this ; rdf:predicate up:alternativeName ; rdf:object ?name2 . _:434568 a rdf:Statement ; up:attribution _:434537 ; rdf:subject ?this ; rdf:predicate up:alternativeName ; rdf:object ?name3 . _:434569 a rdf:Statement ; up:attribution _:434538 ; rdf:subject ?gene4 ; rdf:predicate up:encodedBy ; rdf:object ?gene4 . _:434570 a rdf:Statement ; up:attribution _:434539 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation5 . _:434571 a rdf:Statement ; up:attribution _:434540 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation6 . _:434572 a rdf:Statement ; up:attribution _:434541 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation8 . _:434573 a rdf:Statement ; up:attribution _:434542 ; rdf:subject ?this ; rdf:predicate up:annotation ; rdf:object ?annotation9 . _:434574 a rdf:Statement ; up:attribution _:434543 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:227 . _:434575 a rdf:Statement ; up:attribution _:434544 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:234 . _:434576 a rdf:Statement ; up:attribution _:434545 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:238 . _:434577 a rdf:Statement ; up:attribution _:434546 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:326 . _:434578 a rdf:Statement ; up:attribution _:434547 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:378 . _:434579 a rdf:Statement ; up:attribution _:434548 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:456 . _:434580 a rdf:Statement ; up:attribution _:434549 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object keyword:511 . _:434581 a rdf:Statement ; up:attribution _:434550 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0003906 . _:434582 a rdf:Statement ; up:attribution _:434551 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0000703 . _:434583 a rdf:Statement ; up:attribution _:434552 ; rdf:subject ?this ; rdf:predicate up:classifiedWith ; rdf:object GO:0006281 . _:434584 a rdf:Statement ; up:attribution _:434553 ; rdf:subject ?case10 ; rdf:predicate up:classifiedWith ; rdf:object keyword:479 . _:434585 a rdf:Statement ; up:attribution _:434554 ; rdf:subject ?case10 ; rdf:predicate up:classifiedWith ; rdf:object keyword:862 . _:434586 a rdf:Statement ; up:attribution _:434555 ; rdf:subject ?case10 ; rdf:predicate up:classifiedWith ; rdf:object keyword:863 . _:434587 a rdf:Statement ; up:attribution _:434556 ; rdf:subject ?case10 ; rdf:predicate up:classifiedWith ; rdf:object GO:0008270 . _:434588 a rdf:Statement ; up:source unirule:MF_01253 ; rdf:subject ?pfs11 ; rdf:predicate up:annotation ; rdf:object ?annotation12 . _:434589 a rdf:Statement ; up:attribution _:434557 ; rdf:subject ?pfs11 ; rdf:predicate up:annotation ; rdf:object ?annotation12 . _:434590 a rdf:Statement ; up:source unirule:MF_01253 ; rdf:subject ?pfs17 ; rdf:predicate up:annotation ; rdf:object ?annotation18 . _:434591 a rdf:Statement ; up:attribution _:434558 ; rdf:subject ?pfs17 ; rdf:predicate up:annotation ; rdf:object ?annotation18 . _:434592 a rdf:Statement ; up:source unirule:MF_01253 ; rdf:subject ?pfs23 ; rdf:predicate up:annotation ; rdf:object ?annotation24 . _:434593 a rdf:Statement ; up:attribution _:434559 ; rdf:subject ?pfs23 ; rdf:predicate up:annotation ; rdf:object ?annotation24 . _:434594 a rdf:Statement ; up:source unirule:MF_01253 ; rdf:subject ?pfs29 ; rdf:predicate up:annotation ; rdf:object ?annotation30 . _:434595 a rdf:Statement ; up:attribution _:434560 ; rdf:subject ?pfs29 ; rdf:predicate up:annotation ; rdf:object ?annotation30 . _:434596 a rdf:Statement ; up:source unirule:MF_01253 ; rdf:subject ?pfs35 ; rdf:predicate up:annotation ; rdf:object ?annotation36 . _:434597 a rdf:Statement ; up:attribution _:434561 ; rdf:subject ?pfs35 ; rdf:predicate up:annotation ; rdf:object ?annotation36 . _:434598 a rdf:Statement ; up:source unirule:MF_01253 ; rdf:subject ?pfs41 ; rdf:predicate up:annotation ; rdf:object ?annotation42 . _:434599 a rdf:Statement ; up:attribution _:434562 ; rdf:subject ?pfs41 ; rdf:predicate up:annotation ; rdf:object ?annotation42 . _:434600 a rdf:Statement ; up:source unirule:MF_01253 ; rdf:subject ?pfs48 ; rdf:predicate up:annotation ; rdf:object ?annotation49 . _:434601 a rdf:Statement ; up:attribution _:434563 ; rdf:subject ?pfs48 ; rdf:predicate up:annotation ; rdf:object ?annotation49 . _:434602 a rdf:Statement ; up:source unirule:MF_01253 ; rdf:subject ?pfs55 ; rdf:predicate up:annotation ; rdf:object ?annotation56 . _:434603 a rdf:Statement ; up:attribution _:434564 ; rdf:subject ?pfs55 ; rdf:predicate up:annotation ; rdf:object ?annotation56 . } WHERE { #baseURI: http://purl.uniprot.org/unirule/MF_01253 #Rule MF_01253 Created by:coudert on:2004-12-09 Modified by:ecoudert on:2024-01-30 ?this up:organism ?thisOrganism ; rdfs:seeAlso signature:MF_01253 . ?thisOrganism rdfs:subClassOf+ taxon:91347 . BIND(URI(CONCAT(STR(?this), '#MF_01253a0')) AS ?name0) . BIND(URI(CONCAT(STR(?this), '#MF_01253a1')) AS ?name1) . BIND(URI(CONCAT(STR(?this), '#MF_01253a2')) AS ?name2) . BIND(URI(CONCAT(STR(?this), '#MF_01253a3')) AS ?name3) . BIND(URI(CONCAT(STR(?this), '#MF_01253a5')) AS ?annotation5) . BIND(URI(CONCAT(STR(?this), '#MF_01253a6')) AS ?annotation6) . BIND(URI(CONCAT(STR(?this), '#MF_01253a8')) AS ?annotation8) . BIND(URI(CONCAT(STR(?this), '#MF_01253a9')) AS ?annotation9) . OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch66 faldo:location ?templateMotifSequenceMatchRegionP5046567 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP5046569 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP50465MF_0125362 . ?templateMotifSequenceMatchRegionP5046567 faldo:begin ?templateMotifSequenceMatchBeginP5046568 . ?templateMotifSequenceMatchBeginP5046568 faldo:position ?templateMotifSequenceMatchBeginPositionP5046563 ; faldo:reference isoform:P50465-1 . ?templateMotifSequenceProfileAlignmentOperationP5046569 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . ?targetMotifMatch70 faldo:location ?targetMotifMatchRegionMatch71 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0125373 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP50465MF_0125364 . ?targetMotifMatchRegionMatch71 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0125372 . ?targetMotifMatchRegionMatchBeginMF_0125372 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0125365 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_0125373 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . BIND(1 AS ?thisPositionOn15) . BIND(?thisPositionOn15 AS ?thisPositionOn16) . BIND(?this AS ?pfs1t74) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn15))) AS ?pfsb13) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn16))) AS ?pfse14) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn15, 1) = 'M')) . BIND(URI(CONCAT(STR(?this), '#MF_01253a12')) AS ?annotation12) . BIND(?this AS ?pfs11) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch79 faldo:location ?templateMotifSequenceMatchRegionP5046580 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP5046582 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP50465MF_0125375 . ?templateMotifSequenceMatchRegionP5046580 faldo:begin ?templateMotifSequenceMatchBeginP5046581 . ?templateMotifSequenceMatchBeginP5046581 faldo:position ?templateMotifSequenceMatchBeginPositionP5046576 ; faldo:reference isoform:P50465-1 . ?templateMotifSequenceProfileAlignmentOperationP5046582 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . ?targetMotifMatch83 faldo:location ?targetMotifMatchRegionMatch84 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0125386 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP50465MF_0125377 . ?targetMotifMatchRegionMatch84 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0125385 . ?targetMotifMatchRegionMatchBeginMF_0125385 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0125378 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_0125386 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP50465MF_0125375, 1, (STRLEN(?templateMotifCigarP50465MF_0125375) - STRLEN(REPLACE(?templateMotifCigarP50465MF_0125375, CONCAT('^(?:-*[^-]){', STR(((2 - ?templateMotifSequenceMatchBeginPositionP5046576) + 1)), '}'), '')))), '[a-z]', '')) AS ?step187) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP50465MF_0125377, 1, (STRLEN(?targetMotifMatchCigarP50465MF_0125377) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_0125377, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step187), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP50465MF_0125377, 1, (STRLEN(?targetMotifMatchCigarP50465MF_0125377) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_0125377, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step187), '}'), '')))), '[^-]', ''))) AS ?step288) . BIND(((?step288 + ?targetMotifMatchRegionMatchBeginPositionMF_0125378) - 1) AS ?thisPositionOn21) . BIND(?thisPositionOn21 AS ?thisPositionOn22) . BIND(?this AS ?pfs1t89) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn21))) AS ?pfsb19) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn22))) AS ?pfse20) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn21, 1) = 'P')) . BIND(URI(CONCAT(STR(?this), '#MF_01253a18')) AS ?annotation18) . BIND(?this AS ?pfs17) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch94 faldo:location ?templateMotifSequenceMatchRegionP5046595 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP5046597 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP50465MF_0125390 . ?templateMotifSequenceMatchRegionP5046595 faldo:begin ?templateMotifSequenceMatchBeginP5046596 . ?templateMotifSequenceMatchBeginP5046596 faldo:position ?templateMotifSequenceMatchBeginPositionP5046591 ; faldo:reference isoform:P50465-1 . ?templateMotifSequenceProfileAlignmentOperationP5046597 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . ?targetMotifMatch98 faldo:location ?targetMotifMatchRegionMatch99 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_01253101 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP50465MF_0125392 . ?targetMotifMatchRegionMatch99 faldo:begin ?targetMotifMatchRegionMatchBeginMF_01253100 . ?targetMotifMatchRegionMatchBeginMF_01253100 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0125393 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_01253101 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP50465MF_0125390, 1, (STRLEN(?templateMotifCigarP50465MF_0125390) - STRLEN(REPLACE(?templateMotifCigarP50465MF_0125390, CONCAT('^(?:-*[^-]){', STR(((3 - ?templateMotifSequenceMatchBeginPositionP5046591) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1102) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP50465MF_0125392, 1, (STRLEN(?targetMotifMatchCigarP50465MF_0125392) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_0125392, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1102), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP50465MF_0125392, 1, (STRLEN(?targetMotifMatchCigarP50465MF_0125392) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_0125392, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1102), '}'), '')))), '[^-]', ''))) AS ?step2103) . BIND(((?step2103 + ?targetMotifMatchRegionMatchBeginPositionMF_0125393) - 1) AS ?thisPositionOn27) . BIND(?thisPositionOn27 AS ?thisPositionOn28) . BIND(?this AS ?pfs1t104) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn27))) AS ?pfsb25) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn28))) AS ?pfse26) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn27, 1) = 'E')) . BIND(URI(CONCAT(STR(?this), '#MF_01253a24')) AS ?annotation24) . BIND(?this AS ?pfs23) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch109 faldo:location ?templateMotifSequenceMatchRegionP50465110 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP50465112 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP50465MF_01253105 . ?templateMotifSequenceMatchRegionP50465110 faldo:begin ?templateMotifSequenceMatchBeginP50465111 . ?templateMotifSequenceMatchBeginP50465111 faldo:position ?templateMotifSequenceMatchBeginPositionP50465106 ; faldo:reference isoform:P50465-1 . ?templateMotifSequenceProfileAlignmentOperationP50465112 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . ?targetMotifMatch113 faldo:location ?targetMotifMatchRegionMatch114 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_01253116 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP50465MF_01253107 . ?targetMotifMatchRegionMatch114 faldo:begin ?targetMotifMatchRegionMatchBeginMF_01253115 . ?targetMotifMatchRegionMatchBeginMF_01253115 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_01253108 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_01253116 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP50465MF_01253105, 1, (STRLEN(?templateMotifCigarP50465MF_01253105) - STRLEN(REPLACE(?templateMotifCigarP50465MF_01253105, CONCAT('^(?:-*[^-]){', STR(((53 - ?templateMotifSequenceMatchBeginPositionP50465106) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1117) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP50465MF_01253107, 1, (STRLEN(?targetMotifMatchCigarP50465MF_01253107) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_01253107, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1117), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP50465MF_01253107, 1, (STRLEN(?targetMotifMatchCigarP50465MF_01253107) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_01253107, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1117), '}'), '')))), '[^-]', ''))) AS ?step2118) . BIND(((?step2118 + ?targetMotifMatchRegionMatchBeginPositionMF_01253108) - 1) AS ?thisPositionOn33) . BIND(?thisPositionOn33 AS ?thisPositionOn34) . BIND(?this AS ?pfs1t119) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn33))) AS ?pfsb31) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn34))) AS ?pfse32) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn33, 1) = 'K')) . BIND(URI(CONCAT(STR(?this), '#MF_01253a30')) AS ?annotation30) . BIND(?this AS ?pfs29) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch124 faldo:location ?templateMotifSequenceMatchRegionP50465125 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP50465127 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP50465MF_01253120 . ?templateMotifSequenceMatchRegionP50465125 faldo:begin ?templateMotifSequenceMatchBeginP50465126 . ?templateMotifSequenceMatchBeginP50465126 faldo:position ?templateMotifSequenceMatchBeginPositionP50465121 ; faldo:reference isoform:P50465-1 . ?templateMotifSequenceProfileAlignmentOperationP50465127 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . ?targetMotifMatch128 faldo:location ?targetMotifMatchRegionMatch129 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_01253131 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP50465MF_01253122 . ?targetMotifMatchRegionMatch129 faldo:begin ?targetMotifMatchRegionMatchBeginMF_01253130 . ?targetMotifMatchRegionMatchBeginMF_01253130 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_01253123 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_01253131 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP50465MF_01253120, 1, (STRLEN(?templateMotifCigarP50465MF_01253120) - STRLEN(REPLACE(?templateMotifCigarP50465MF_01253120, CONCAT('^(?:-*[^-]){', STR(((253 - ?templateMotifSequenceMatchBeginPositionP50465121) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1132) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP50465MF_01253122, 1, (STRLEN(?targetMotifMatchCigarP50465MF_01253122) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_01253122, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1132), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP50465MF_01253122, 1, (STRLEN(?targetMotifMatchCigarP50465MF_01253122) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_01253122, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1132), '}'), '')))), '[^-]', ''))) AS ?step2133) . BIND(((?step2133 + ?targetMotifMatchRegionMatchBeginPositionMF_01253123) - 1) AS ?thisPositionOn39) . BIND(?thisPositionOn39 AS ?thisPositionOn40) . BIND(?this AS ?pfs1t134) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn39))) AS ?pfsb37) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn40))) AS ?pfse38) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn39, 1) = 'R')) . BIND(URI(CONCAT(STR(?this), '#MF_01253a36')) AS ?annotation36) . BIND(?this AS ?pfs35) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch139 faldo:location ?templateMotifSequenceMatchRegionP50465140 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP50465142 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP50465MF_01253135 . ?templateMotifSequenceMatchRegionP50465140 faldo:begin ?templateMotifSequenceMatchBeginP50465141 . ?templateMotifSequenceMatchBeginP50465141 faldo:position ?templateMotifSequenceMatchBeginPositionP50465136 ; faldo:reference isoform:P50465-1 . ?templateMotifSequenceProfileAlignmentOperationP50465142 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . ?targetMotifMatch143 faldo:location ?targetMotifMatchRegionMatch144 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_01253146 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP50465MF_01253137 . ?targetMotifMatchRegionMatch144 faldo:begin ?targetMotifMatchRegionMatchBeginMF_01253145 . ?targetMotifMatchRegionMatchBeginMF_01253145 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_01253138 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_01253146 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP50465MF_01253135, 1, (STRLEN(?templateMotifCigarP50465MF_01253135) - STRLEN(REPLACE(?templateMotifCigarP50465MF_01253135, CONCAT('^(?:-*[^-]){', STR(((70 - ?templateMotifSequenceMatchBeginPositionP50465136) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1147) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP50465MF_01253137, 1, (STRLEN(?targetMotifMatchCigarP50465MF_01253137) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_01253137, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1147), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP50465MF_01253137, 1, (STRLEN(?targetMotifMatchCigarP50465MF_01253137) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_01253137, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1147), '}'), '')))), '[^-]', ''))) AS ?step2148) . BIND(((?step2148 + ?targetMotifMatchRegionMatchBeginPositionMF_01253138) - 1) AS ?thisPositionOn46) . BIND(?thisPositionOn46 AS ?thisPositionOn47) . BIND(?this AS ?pfs1t149) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn46))) AS ?pfsb43) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn47))) AS ?pfse44) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn46, 1) = 'Q')) . BIND(URI(CONCAT(STR(?this), '#MF_01253a42')) AS ?annotation42) . BIND(?this AS ?pfs41) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch154 faldo:location ?templateMotifSequenceMatchRegionP50465155 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP50465157 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP50465MF_01253150 . ?templateMotifSequenceMatchRegionP50465155 faldo:begin ?templateMotifSequenceMatchBeginP50465156 . ?templateMotifSequenceMatchBeginP50465156 faldo:position ?templateMotifSequenceMatchBeginPositionP50465151 ; faldo:reference isoform:P50465-1 . ?templateMotifSequenceProfileAlignmentOperationP50465157 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . ?targetMotifMatch158 faldo:location ?targetMotifMatchRegionMatch159 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_01253161 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP50465MF_01253152 . ?targetMotifMatchRegionMatch159 faldo:begin ?targetMotifMatchRegionMatchBeginMF_01253160 . ?targetMotifMatchRegionMatchBeginMF_01253160 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_01253153 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_01253161 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP50465MF_01253150, 1, (STRLEN(?templateMotifCigarP50465MF_01253150) - STRLEN(REPLACE(?templateMotifCigarP50465MF_01253150, CONCAT('^(?:-*[^-]){', STR(((125 - ?templateMotifSequenceMatchBeginPositionP50465151) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1162) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP50465MF_01253152, 1, (STRLEN(?targetMotifMatchCigarP50465MF_01253152) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_01253152, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1162), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP50465MF_01253152, 1, (STRLEN(?targetMotifMatchCigarP50465MF_01253152) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_01253152, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1162), '}'), '')))), '[^-]', ''))) AS ?step2163) . BIND(((?step2163 + ?targetMotifMatchRegionMatchBeginPositionMF_01253153) - 1) AS ?thisPositionOn53) . BIND(?thisPositionOn53 AS ?thisPositionOn54) . BIND(?this AS ?pfs1t164) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn53))) AS ?pfsb50) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn54))) AS ?pfse51) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn53, 1) = 'R')) . BIND(URI(CONCAT(STR(?this), '#MF_01253a49')) AS ?annotation49) . BIND(?this AS ?pfs48) . } OPTIONAL { ?this up:sequence ?thisSequence . ?thisSequence rdf:value ?thisSequenceValue . ?templateMotifMatch169 faldo:location ?templateMotifSequenceMatchRegionP50465170 ; edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationP50465172 ; rdf:type edam:data_0869 ; rdf:value ?templateMotifCigarP50465MF_01253165 . ?templateMotifSequenceMatchRegionP50465170 faldo:begin ?templateMotifSequenceMatchBeginP50465171 . ?templateMotifSequenceMatchBeginP50465171 faldo:position ?templateMotifSequenceMatchBeginPositionP50465166 ; faldo:reference isoform:P50465-1 . ?templateMotifSequenceProfileAlignmentOperationP50465172 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . ?targetMotifMatch173 faldo:location ?targetMotifMatchRegionMatch174 ; edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_01253176 ; rdf:type edam:data_0869 ; rdf:value ?targetMotifMatchCigarP50465MF_01253167 . ?targetMotifMatchRegionMatch174 faldo:begin ?targetMotifMatchRegionMatchBeginMF_01253175 . ?targetMotifMatchRegionMatchBeginMF_01253175 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_01253168 ; faldo:reference ?thisSequence . ?targetMotifSequenceAlignmentOperationMF_01253176 edam:has_input signature:MF_01253 ; rdf:type edam:operation_0300 . BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarP50465MF_01253165, 1, (STRLEN(?templateMotifCigarP50465MF_01253165) - STRLEN(REPLACE(?templateMotifCigarP50465MF_01253165, CONCAT('^(?:-*[^-]){', STR(((169 - ?templateMotifSequenceMatchBeginPositionP50465166) + 1)), '}'), '')))), '[a-z]', '')) AS ?step1177) . BIND((STRLEN(SUBSTR(?targetMotifMatchCigarP50465MF_01253167, 1, (STRLEN(?targetMotifMatchCigarP50465MF_01253167) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_01253167, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1177), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarP50465MF_01253167, 1, (STRLEN(?targetMotifMatchCigarP50465MF_01253167) - STRLEN(REPLACE(?targetMotifMatchCigarP50465MF_01253167, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step1177), '}'), '')))), '[^-]', ''))) AS ?step2178) . BIND(((?step2178 + ?targetMotifMatchRegionMatchBeginPositionMF_01253168) - 1) AS ?thisPositionOn60) . BIND(?thisPositionOn60 AS ?thisPositionOn61) . BIND(?this AS ?pfs1t179) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn60))) AS ?pfsb57) . BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn61))) AS ?pfse58) . FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn60, 1) = 'N')) . BIND(URI(CONCAT(STR(?this), '#MF_01253a56')) AS ?annotation56) . BIND(?this AS ?pfs55) . } OPTIONAL { ?this a up:Protein . ?this rdfs:seeAlso <http://purl.uniprot.org/prosite/PS51066>. BIND(?this AS ?case10) . } }