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HAMAP rule MF_00005

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General rule information [?]

Accession MF_00005
Dates 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 44)
Name Arg_succ_synth_type1
Scope(s) Bacteria
Archaea
Template(s) P59846 (ASSY_THET8); Q9X2A1 (ASSY_THEMA); [ Recover all ]
Triggered by HAMAP; MF_00005 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ASSY
Protein name RecName: Full=Argininosuccinate synthase;
                 EC=6.3.4.5;
AltName: Full=Citrulline--aspartate ligase;
Gene name Name=argG;

Comments [?]

CATALYTIC ACTIVITY Reaction=ATP + L-aspartate + L-citrulline = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:10932, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57472, ChEBI:CHEBI:57743, ChEBI:CHEBI:456215; EC=6.3.4.5;
PATHWAYAmino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
SUBUNITHomotetramer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the argininosuccinate synthase family. Type 1 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004055; Molecular function:argininosuccinate synthase activity
GO:0005524; Molecular function:ATP binding
GO:0006526; Biological process:arginine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00764; Arginosuc_synth; 1;
NCBIfam TIGR00032; argG; 1;
PROSITE PS00564; ARGININOSUCCIN_SYN_1; 1;
PROSITE PS00565; ARGININOSUCCIN_SYN_2; 1;

Features [?]

From: ASSY_THET8 (P59846)
Key From To Description Tag Condition FTGroup
BINDING 6 14 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
BINDING 33 33 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
A
BINDING 84 84 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
Y
BINDING 89 89 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
S
BINDING 114 114 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G
BINDING 116 116 /ligand="L-aspartate"
/ligand_id="ChEBI:CHEBI:29991"
T
BINDING 120 120 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
N
BINDING 120 120 /ligand="L-aspartate"
/ligand_id="ChEBI:CHEBI:29991"
N
BINDING 121 121 /ligand="L-aspartate"
/ligand_id="ChEBI:CHEBI:29991"
D
BINDING 124 124 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
R
BINDING 173 173 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
S
BINDING 182 182 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
S
BINDING 258 258 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
E
BINDING 270 270 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
Y

Additional information [?]

Size range 390-447 amino acids
Related rules MF_00581
Fusion Nter: None Cter: None
Comments Argininosuccinate synthase type 2 subfamily in MF_00581.



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