AC   MF_00272;
DC   Protein; auto
TR   HAMAP; MF_00272; -; 1; level=0
XX
Names: GcvH
XX
ID   GCSH
case <OC:Bacteria> and not <OC:Bacillales>
DE   RecName: Full=Glycine cleavage system H protein;
end case
case <OC:Bacillales>
DE   RecName: Full=Glycine cleavage system H protein;
DE   AltName: Full=Octanoyl/lipoyl carrier protein;
end case
case <OC:Archaea>
DE   RecName: Full=Probable glycine cleavage system H protein;
end case
GN   Name=gcvH;
XX
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. The H protein shuttles the methylamine group of glycine from
CC       the P protein to the T protein.
case <OC:Bacillales>
CC   -!- FUNCTION: Is also involved in protein lipoylation via its role as an
CC       octanoyl/lipoyl carrier protein intermediate.
end case
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC       Note=Binds 1 lipoyl cofactor covalently.;
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins: P,
CC       T, L and H.
CC   -!- SIMILARITY: Belongs to the GcvH family.
XX
DR   Pfam; PF01597; GCV_H; 1; trigger=no
DR   NCBIfam; TIGR00527; GcvH; 1; trigger=no
DR   PROSITE; PS00189; LIPOYL; 1; trigger=no
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1; trigger=yes
XX
KW   Lipoyl
XX
GO   GO:0019464; P:glycine decarboxylation via glycine cleavage system
case <OC:Bacillales>
GO   GO:0009249; P:protein lipoylation
end case
XX
FT   From: GCSH_ECOLI (P0A6T9)
FT   MOD_RES         65
FT                   /note="N6-lipoyllysine"
FT   Condition: K
XX
Size: 115-171;
Related: None;
Template: P0A6T9; O32174;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in AQUAE, PSEAE, SACS2, SULTO, CALS4
Plasmid: None
Comments: The role of GcvH as an octanoyl/lipoyl carrier protein intermediate during
 protein lipoylation has been shown in Bacillus subtilis (PubMed=21338421, AC:O32174).
 There are five potential gcvH in AQUAE.
XX
# Revision 1.35 2023/06/01
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