AC MF_00295; DC Protein; auto TR HAMAP; MF_00295; -; 1; level=0 XX Names: MetA_acyltransf XX case and (( and ) or ) ID METAS DE RecName: Full=Homoserine O-succinyltransferase; DE Short=HST; DE EC=2.3.1.46; DE AltName: Full=Homoserine transsuccinylase; DE Short=HTS; GN Name=metAS; else case and and and not ( or ) ID METAA DE RecName: Full=Homoserine O-acetyltransferase; DE Short=HAT; DE EC=2.3.1.31; DE AltName: Full=Homoserine transacetylase; DE Short=HTA; GN Name=metAA; else case and and and not ( or ) ID SAT DE RecName: Full=Serine O-acetyltransferase; DE Short=SAT; DE EC=2.3.1.30; else ID META DE RecName: Full=Probable acyltransferase; DE EC=2.3.1.-; end case XX case and (( and ) or ) CC -!- FUNCTION: Transfers a succinyl group from succinyl-CoA to L-homoserine, CC forming succinyl-L-homoserine. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine; CC Xref=Rhea:RHEA:22008, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, CC ChEBI:CHEBI:57476, ChEBI:CHEBI:57661; EC=2.3.1.46; CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo CC pathway; O-succinyl-L-homoserine from L-homoserine: step 1/1. else case and and and not ( or ) CC -!- FUNCTION: Transfers an acetyl group from acetyl-CoA to L-homoserine, CC forming acetyl-L-homoserine. CC -!- CATALYTIC ACTIVITY: CC Reaction=acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine; CC Xref=Rhea:RHEA:13701, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, CC ChEBI:CHEBI:57476, ChEBI:CHEBI:57716; EC=2.3.1.31; CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo CC pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1. else case and and and not ( or ) CC -!- FUNCTION: Transfers an acetyl group from acetyl-CoA to L-serine, CC forming acetyl-L-serine. CC -!- CATALYTIC ACTIVITY: CC Reaction=acetyl-CoA + L-serine = CoA + O-acetyl-L-serine; CC Xref=Rhea:RHEA:24560, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:57288, ChEBI:CHEBI:58340; EC=2.3.1.30; CC -!- PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine CC from L-serine: step 1/2. end case case or or CC -!- SUBUNIT: Homodimer. end case CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the MetA family. XX DR Pfam; PF04204; HTS; 1; trigger=no DR PIRSF; PIRSF000450; H_ser_succinyltr; 1; trigger=no DR NCBIfam; TIGR01001; MetA; 1; trigger=no XX KW Cytoplasm KW Amino-acid biosynthesis case and (( and ) or ) KW Methionine biosynthesis else case and and and not ( or ) KW Methionine biosynthesis else case and and and not ( or ) KW Cysteine biosynthesis end case KW Transferase KW Acyltransferase XX case and (( and ) or ) GO GO:0004414; F:homoserine O-acetyltransferase activity GO GO:0009086; P:methionine biosynthetic process else case and and and not ( or ) GO GO:0008899; F:homoserine O-succinyltransferase activity GO GO:0009086; P:methionine biosynthetic process else case and and and not ( or ) GO GO:0009001; F:serine O-acetyltransferase activity GO GO:0006535; P:cysteine biosynthetic process from serine end case GO GO:0005737; C:cytoplasm XX FT From: METAA_BACC1 (Q72X44) FT ACT_SITE 142 FT /note="Acyl-thioester intermediate" FT Group: 1; Condition: C FT ACT_SITE 235 FT /note="Proton acceptor" FT Group: 1; Condition: H FT ACT_SITE 237 FT Condition: E FT BINDING 163 FT /ligand="substrate" FT Group: 1; Condition: K FT BINDING 192 FT /ligand="substrate" FT Optional; Condition: S FT BINDING 249 FT /ligand="substrate" FT Group: 1; Condition: R FT SITE 109 FT /note="Important for acyl-CoA specificity" FT Tag: P4; Optional; Condition: [NE] FT SITE 111 FT /note="Important for acyl-CoA specificity" FT Tag: P5a; Optional; Condition: [GA] FT SITE 111 FT /note="Important for acyl-CoA specificity" FT Tag: P5b; Optional; Condition: [ED] FT SITE 143 FT /note="Important for acyl-CoA specificity" FT Tag: P7; Optional; Condition: L FT SITE 192 FT /note="Important for substrate specificity" FT Tag: P10a; Optional; Condition: A FT SITE 192 FT /note="Important for substrate specificity" FT Tag: P10b; Optional; Condition: S XX Size: 250-385; Related: None; Template: Q72X44; P07623; Q9WZY3; A0A1D3PCK2; Scope: Bacteria Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: Classification as HST, HAT or SAT was done according to Bastard et al. (2017) (PubMed:28581482). XX # Revision 1.35 2023/06/01 //