AC   MF_00491;
DC   Protein; auto
TR   HAMAP; MF_00491; -; 1; level=0
XX
Names: NDH1_NuoM
XX
ID   NU4C
case not <OG:Chloroplast>
DE   RecName: Full=NAD(P)H-quinone oxidoreductase chain 4;
DE            EC=7.1.1.-;
DE   AltName: Full=NAD(P)H dehydrogenase I, chain 4;
DE   AltName: Full=NDH-1, chain 4;
end case
case <OG:Chloroplast>
DE   RecName: Full=NAD(P)H-quinone oxidoreductase chain 4, chloroplastic;
DE            EC=7.1.1.-;
DE   AltName: Full=NAD(P)H dehydrogenase, chain 4;
DE   AltName: Full=NADH-plastoquinone oxidoreductase chain 4;
end case
GN   Name=ndhD;
XX
case not <OG:Chloroplast>
CC   -!- FUNCTION: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-
CC       sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC       immediate electron acceptor for the enzyme in this species is believed
CC       to be plastoquinone. Couples the redox reaction to proton translocation
CC       (for every two electrons transferred, four hydrogen ions are
CC       translocated across the cytoplasmic membrane), and thus conserves the
CC       redox energy in a proton gradient.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n
CC         H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561,
CC         Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n
CC         H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561,
CC         Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192;
case <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Multi-
CC       pass membrane protein.
else case <OC:Gloeobacter>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
else
CC   -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane; Multi-pass membrane
CC       protein.
end case
CC   -!- SIMILARITY: Belongs to the complex I subunit 4 family.
XX
DR   Pfam; PF00361; Oxidored_q1; 1; trigger=no
DR   PRINTS; PR01437; NUOXDRDTASE4; 1; trigger=no
DR   NCBIfam; TIGR01972; NDH_I_M; 1; trigger=no
DR   General; Transmembrane; -; 12-15; trigger=yes
XX
KW   NAD
KW   NADP
KW   Quinone
KW   Plastoquinone
case <OC:Gloeobacter>
KW   Cell membrane
KW   Cell inner membrane
else
KW   Thylakoid
end case
KW   Membrane
KW   Transmembrane
KW   Transmembrane helix
KW   Translocase
XX
GO   GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
case <OG:Chloroplast>
GO   GO:0009535; C:chloroplast thylakoid membrane
else case <OC:Gloeobacter>
GO   GO:0005886; C:plasma membrane
else
GO   GO:0042651; C:thylakoid membrane
end case
XX
FT   None
XX
Size: 493-563;
Related: None;
Template: P72823;
Scope:
 Bacteria; Cyanobacteriota
 Plastid
Fusion:
 Nter: None
 Cter: None
Duplicate: in NOSS1, TRIV2, MICAN, SYNJA, SYNJB, PICP2, SYNP6, SYNE7, SYNY3,
 TRIEI
Plasmid: None
Comments: In dicots the initiation codon seems to be created by RNA editing (has
 been proven for TOBAC, ARATH, SPIOL, OENEH and snapdragon).
XX
# Revision 1.42 2023/12/07
//