HAMAP rule MF_00649
General rule information
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Accession | MF_00649 |
Dates | 4-JUN-2003 (Created)
26-JAN-2023 (Last updated, Version 28) |
Name | DNA_gyrase_inhibitor_YacG |
Scope(s) |
Bacteria Pseudomonadota Planctomycetota |
Template(s) | P0A8H8 (YACG_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00649 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | YACG |
Protein name | RecName: Full=DNA gyrase inhibitor YacG; |
Gene name | Name=yacG; |
Comments
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FUNCTION | Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. |
case <FTGroup:1> | |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion.; |
end case | |
SUBUNIT | Interacts with GyrB. |
SIMILARITY | Belongs to the DNA gyrase inhibitor YacG family. |
Keywords
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case <FTGroup:1> | |
Zinc | |
Metal-binding | |
end case |
Gene Ontology
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GO:0008657; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity | |
case <FTGroup:1> | |
GO:0008270; Molecular function:zinc ion binding | |
end case |
Cross-references
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Pfam | PF03884; DUF329; 1; |
Features
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From: YACG_ECOLI (P0A8H8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 9 | 9 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 12 | 12 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 28 | 28 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 32 | 32 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 |
Additional information
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Size range | 48-82 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |