HAMAP rule MF_00701
General rule information
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Accession | MF_00701 |
Dates | 28-AUG-2003 (Created)
19-NOV-2022 (Last updated, Version 21) |
Name | DNA_primase_lrg_arc |
Scope(s) |
Archaea |
Template(s) | Q9UWW1 (PRIL_SACS2); Q8U4H7 (PRIL_PYRFU); O57935 (PRIL_PYRHO); Q5JJ73 (PRIL_THEKO); Q9V291 (PRIL_PYRAB); [ Recover all ] |
Triggered by |
HAMAP; MF_00701 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | PRIL |
Protein name | RecName: Full=DNA primase large subunit PriL; |
Gene name | Name=priL; |
Comments
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FUNCTION | Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. |
case <FTGroup:1> | |
COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster.; |
end case | |
SUBUNIT | Heterodimer of a small subunit (PriS) and a large subunit (PriL). |
SIMILARITY | Belongs to the eukaryotic-type primase large subunit family. |
Keywords
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DNA replication | |
Primosome | |
case <FTGroup:1> | |
4Fe-4S | |
Iron | |
Iron-sulfur | |
Metal-binding | |
end case |
Gene Ontology
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case <FTGroup:1> | |
GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding | |
end case | |
GO:0006269; Biological process:DNA replication, synthesis of RNA primer |
Cross-references
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Pfam | PF04104; DNA_primase_lrg; 1; |
Features
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From: PRIL_SACS2 (Q9UWW1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 216 | 216 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
BINDING | 280 | 280 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
BINDING | 289 | 289 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
BINDING | 293 | 293 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 |
Additional information
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Size range | 295-500 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |