AC MF_01260; DC Protein; auto TR HAMAP; MF_01260; -; 1; level=0 XX Names: Carboxylester XX ID BIOH DE RecName: Full=Pimeloyl-[acyl-carrier protein] methyl ester esterase; DE EC=3.1.1.85; DE AltName: Full=Biotin synthesis protein BioH; DE AltName: Full=Carboxylesterase BioH; GN Name=bioH; XX CC -!- FUNCTION: The physiological role of BioH is to remove the methyl group CC introduced by BioC when the pimeloyl moiety is complete. It allows to CC synthesize pimeloyl-ACP via the fatty acid synthetic pathway through CC the hydrolysis of the ester bonds of pimeloyl-ACP esters. CC -!- CATALYTIC ACTIVITY: CC Reaction=6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6- CC carboxyhexanoyl-[ACP] + H(+) + methanol; Xref=Rhea:RHEA:42700, CC Rhea:RHEA-COMP:9955, Rhea:RHEA-COMP:10186, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:78846, CC ChEBI:CHEBI:82735; EC=3.1.1.85; CC -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis. CC -!- SUBUNIT: Monomer. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Carboxylesterase CC BioH family. XX DR Pfam; PF00561; Abhydrolase_1; 1; trigger=no DR Pfam; PF00975; Thioesterase; 1; trigger=no DR PRINTS; PR00111; ABHYDROLASE; 1; trigger=no DR PRINTS; PR00412; EPOXHYDRLASE; 1; trigger=no DR NCBIfam; TIGR01738; BioH; 1; trigger=no XX KW Cytoplasm KW Biotin biosynthesis KW Hydrolase KW Serine esterase XX GO GO:0052689; F:carboxylic ester hydrolase activity GO GO:0009102; P:biotin biosynthetic process GO GO:0005737; C:cytoplasm XX FT From: BIOH_ECOLI (P13001) FT BINDING 82..83 FT /ligand="substrate" FT Condition: S-[LM] FT BINDING 143..147 FT /ligand="substrate" FT Condition: F-x-x-x-[QD] FT ACT_SITE 82 FT /note="Nucleophile" FT Condition: S FT ACT_SITE 207 FT Condition: D FT ACT_SITE 235 FT Condition: H FT BINDING 22 FT /ligand="substrate" FT Condition: W FT BINDING 235 FT /ligand="substrate" FT Condition: H XX Size: 239-312; Related: None; Template: P13001; Q9K197; Q8GHL1; Scope: Bacteria; Pseudomonadota Fusion: Nter: None Cter: MF_00835 (BioC) Duplicate: None Plasmid: None Comments: Longer C-terminal in NEIMA; sequence not shown in alignment and not taken into account in size range XX # Revision 1.26 2023/06/01 //