AC   MF_01356;
DC   Protein; auto
TR   HAMAP; MF_01356; -; 1; level=0
XX
Names: NDH1_NuoB
XX
case <OG:Chloroplast>
ID   NDHK
DE   RecName: Full=NAD(P)H-quinone oxidoreductase subunit K, chloroplastic;
DE            EC=7.1.1.-;
DE   AltName: Full=NAD(P)H dehydrogenase subunit K;
DE   AltName: Full=NADH-plastoquinone oxidoreductase subunit K;
GN   Name=ndhK;
else case <OC:Cyanobacteriota>
ID   NDHK
DE   RecName: Full=NAD(P)H-quinone oxidoreductase subunit K;
DE            EC=7.1.1.-;
DE   AltName: Full=NAD(P)H dehydrogenase I subunit K;
DE   AltName: Full=NDH-1 subunit K;
DE            Short=NDH-K;
GN   Name=ndhK;
else
ID   NUOB
DE   RecName: Full=NADH-quinone oxidoreductase subunit B;
DE            EC=7.1.1.-;
DE   AltName: Full=NADH dehydrogenase I subunit B;
DE   AltName: Full=NDH-1 subunit B;
GN   Name=nuoB;
end case
XX
case <OG:Chloroplast>
CC   -!- FUNCTION: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN
CC       and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain
CC       and possibly in a chloroplast respiratory chain. The immediate electron
CC       acceptor for the enzyme in this species is believed to be
CC       plastoquinone. Couples the redox reaction to proton translocation, and
CC       thus conserves the redox energy in a proton gradient.
else case <OC:Cyanobacteriota>
CC   -!- FUNCTION: NDH-1 shuttles electrons from an unknown electron donor, via
CC       FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory
CC       and/or the photosynthetic chain. The immediate electron acceptor for
CC       the enzyme in this species is believed to be plastoquinone. Couples the
CC       redox reaction to proton translocation, and thus conserves the redox
CC       energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in
CC       inorganic carbon-concentration.
else case <OC:Actinomycetota> or <OC:Bacteroidota> or <OC:Chlorobiota> or <OC:Deinococcota> or <OC:Bacillota>
CC   -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur
CC       (Fe-S) centers, to quinones in the respiratory chain. The immediate
CC       electron acceptor for the enzyme in this species is believed to be a
CC       menaquinone. Couples the redox reaction to proton translocation (for
CC       every two electrons transferred, four hydrogen ions are translocated
CC       across the cytoplasmic membrane), and thus conserves the redox energy
CC       in a proton gradient.
else
CC   -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur
CC       (Fe-S) centers, to quinones in the respiratory chain. The immediate
CC       electron acceptor for the enzyme in this species is believed to be
CC       ubiquinone. Couples the redox reaction to proton translocation (for
CC       every two electrons transferred, four hydrogen ions are translocated
CC       across the cytoplasmic membrane), and thus conserves the redox energy
CC       in a proton gradient.
end case
case <OG:Chloroplast> or <OC:Cyanobacteriota>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n
CC         H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561,
CC         Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n
CC         H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561,
CC         Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192;
else
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124;
end case
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster.;
end case
case <OG:Chloroplast>
CC   -!- SUBUNIT: NDH is composed of at least 16 different subunits, 5 of which
CC       are encoded in the nucleus.
else case <OC:Cyanobacteriota>
CC   -!- SUBUNIT: NDH-1 can be composed of about 15 different subunits;
CC       different subcomplexes with different compositions have been identified
CC       which probably have different functions.
else case <OC:Enterobacterales> or <OC:Shewanellaceae> or <OC:Pseudomonadaceae>
CC   -!- SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD,
CC       E, F, and G constitute the peripheral sector of the complex.
else case <OC:Deinococci>
CC   -!- SUBUNIT: NDH-1 is composed of 15 different subunits. Subunits NuoB, C,
CC       D, E, F, and G constitute the peripheral sector of the complex.
else
CC   -!- SUBUNIT: NDH-1 is composed of 14 different subunits. Subunits NuoB, C,
CC       D, E, F, and G constitute the peripheral sector of the complex.
end case
case <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane;
CC       Peripheral membrane protein; Stromal side.
else case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
CC   -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane; Peripheral membrane
CC       protein; Cytoplasmic side.
else case <OC:Gloeobacter>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein;
CC       Cytoplasmic side.
else case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein;
CC       Cytoplasmic side.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein;
CC       Cytoplasmic side.
end case
CC   -!- SIMILARITY: Belongs to the complex I 20 kDa subunit family.
XX
DR   PROSITE; PS01150; COMPLEX1_20K; 1; trigger=no
DR   Pfam; PF01058; Oxidored_q6; 1; trigger=no
DR   NCBIfam; TIGR01957; NuoB_fam; 1; trigger=no
XX
case <FTGroup:1>
KW   4Fe-4S
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
end case
KW   NAD
case <OG:Chloroplast> or <OC:Cyanobacteriota>
KW   NADP
KW   Plastoquinone
else case not <OC:Actinomycetota> and not <OC:Bacteroidota> and not <OC:Chlorobiota> and not <OC:Deinococcota> and not <OC:Bacillota>
KW   Ubiquinone
end case
KW   Quinone
KW   Membrane
KW   Translocase
KW   Transport
case <OG:Chloroplast> or <OC:Cyanobacteriota> and not <OC:Gloeobacter>
KW   Thylakoid
else case <OC:Gloeobacter>
KW   Cell membrane
KW   Cell inner membrane
else case not defined <Property:Membrane> or <Property:Membrane=1>
KW   Cell membrane
else case <Property:Membrane=2>
KW   Cell membrane
KW   Cell inner membrane
end case
XX
GO   GO:0005506; F:iron ion binding
case <OG:Chloroplast> or <OC:Cyanobacteriota>
GO   GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO   GO:0019684; P:photosynthesis, light reaction
else
GO   GO:0050136; F:NADH dehydrogenase (quinone) activity
end case
case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
GO   GO:0042651; C:thylakoid membrane
else case <OG:Chloroplast>
GO   GO:0009535; C:chloroplast thylakoid membrane
else
GO   GO:0005886; C:plasma membrane
end case
XX
FT   From: NQO6_THET8 (Q56218)
FT   BINDING         45
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         46
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         111
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         140
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
XX
Size: 158-281;
Related: None;
Template: Q56218;
Scope:
 Bacteria
 Plastid
Fusion:
 Nter: None
 Cter: MF_01359 (nuoCD)
Duplicate: in ACAM1, KORVE, ACICJ, ANADE, ANADF, ANASK, AZOSB, BURMA, BURM7,
 BURM9, BURMS, BURP0, BURP1, BURP6, BURPS, CHLAA, CHLAD, CHLSY, CHLT3, CHRVO,
 CYAP4, CYTH3, CITBB, GEOMG, GEOSL, GEOUR, GLOVI, GLUDA, HERA2, NITMU, NITOC,
 OPITP, PELPD, RHIME, RHIE6, RHIEC, RHOP5, RHOPA, RHOPB, RHOPS, RHOPT, CERS1,
 CERS4, CERS5, CERSK, ROSCS, ROSS1, SALAI, SALTO, SOLUE, SORC5, STRAW, STRCO,
 STRGG, SYMTH, SYNY3, THEYD
Plasmid: in ACAM1, RHIME
Comments: 14 proteins form the NDH-1 complex in most bacteria, there are
 at least 15 subunits in cyanobacteria and chloroplasts. PARDE and
 THET8 are annotated with another nomenclature.
 In the Geobacter there is also a fusion with nuoCD.
XX
# Revision 1.32 2023/06/15
//