HAMAP rule MF_01482
General rule information
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Accession | MF_01482 |
Dates | 13-JUN-2013 (Created)
1-JUN-2023 (Last updated, Version 12) |
Name | Mca |
Scope(s) |
Bacteria Actinomycetota |
Template(s) | A0R2W9 (MCA_MYCS2); P9WJN1 (MCA_MYCTU); Q9ADK0 (MCA_STRCO); [ Recover all ] |
Triggered by |
HAMAP; MF_01482 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MCA |
Protein name | RecName: Full=Mycothiol S-conjugate amidase; EC=3.5.1.115; |
Gene name | Name=mca; |
Comments
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FUNCTION | A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics. |
CATALYTIC ACTIVITY | Reaction=H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy- alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate; Xref=Rhea:RHEA:36543, ChEBI:CHEBI:15377, ChEBI:CHEBI:58718, ChEBI:CHEBI:58886, ChEBI:CHEBI:59633; EC=3.5.1.115; |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
SUBUNIT | Monomer. |
SIMILARITY | Belongs to the MshB deacetylase family. Mca subfamily. |
Keywords
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Gene Ontology
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GO:0008270; Molecular function:zinc ion binding |
GO:0010126; Biological process:mycothiol metabolic process |
GO:0010127; Biological process:mycothiol-dependent detoxification |
Cross-references
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Features
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From: MCA_MYCTU (P9WJN1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 12 | 12 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
BINDING | 15 | 15 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
D | ||||||||
BINDING | 142 | 142 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H |
Additional information
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Size range | 255-420 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |