AC MF_01510; DC Protein; auto TR HAMAP; MF_01510; -; 1; level=0 XX Names: GMP_synthase_A XX ID GUAAA DE RecName: Full=GMP synthase [glutamine-hydrolyzing] subunit A; DE EC=6.3.5.2; DE AltName: Full=Glutamine amidotransferase; GN Name=guaAA; XX CC -!- FUNCTION: Catalyzes the synthesis of GMP from XMP. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 CC H(+) + L-glutamate; Xref=Rhea:RHEA:11680, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:58115, CC ChEBI:CHEBI:58359, ChEBI:CHEBI:456215; EC=6.3.5.2; CC -!- PATHWAY: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln CC route): step 1/1. CC -!- SUBUNIT: Heterodimer composed of a glutamine amidotransferase subunit CC (A) and a GMP-binding subunit (B). XX DR Pfam; PF00117; GATase; 1; trigger=no DR PRINTS; PR00096; GATASE; 1; trigger=no DR NCBIfam; TIGR00888; GuaA_Nterm; 1; trigger=no DR PROSITE; PS51273; GATASE_TYPE_1; 1; trigger=yes XX KW ATP-binding KW GMP biosynthesis KW Glutamine amidotransferase KW Ligase KW Nucleotide-binding KW Purine biosynthesis XX GO GO:0003922; F:GMP synthase (glutamine-hydrolyzing) activity GO GO:0006177; P:GMP biosynthetic process XX FT From: GUAAA_METJA (Q58970) FT ACT_SITE 76 FT /note="Nucleophile" FT Condition: C FT ACT_SITE 163 FT Condition: H FT ACT_SITE 165 FT Condition: E XX Size: 181-202; Related: MF_00344!; Template: P04079; Scope: Archaea Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: Sequences from AERPE and PYRAE are like that of Eubacteria composed of two domains, while other archaea have separate proteins that correspond to each domain XX # Revision 1.24 2023/06/01 //