HAMAP rule MF_01681
General rule information
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Accession | MF_01681 |
Dates | 24-OCT-2008 (Created)
1-JUN-2023 (Last updated, Version 16) |
Name | Salvage_MtnC |
Scope(s) |
Bacteria |
Template(s) | P0C8L5 (MTNC_KLEAE); [ Recover all ] |
Triggered by |
HAMAP; MF_01681 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MTNC |
Protein name | RecName: Full=Enolase-phosphatase E1; EC=3.1.3.77; AltName: Full=2,3-diketo-5-methylthio-1-phosphopentane phosphatase; |
Gene name | Name=mtnC; |
Comments
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FUNCTION | Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). |
CATALYTIC ACTIVITY | Reaction=5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2- dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate; Xref=Rhea:RHEA:21700, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:49252, ChEBI:CHEBI:58828; EC=3.1.3.77; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
PATHWAY | Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6. |
PATHWAY | Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. |
SUBUNIT | Monomer. |
SIMILARITY | Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. |
Keywords
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Gene Ontology
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GO:0000287; Molecular function:magnesium ion binding |
GO:0043715; Molecular function:2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity |
GO:0043716; Molecular function:2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity |
GO:0019284; Biological process:L-methionine salvage from S-adenosylmethionine |
Cross-references
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Pfam | PF00702; Hydrolase; 1; |
PRINTS | PR00413; HADHALOGNASE; 1; |
NCBIfam | TIGR01691; Enolase-ppase; 1; |
NCBIfam | TIGR01549; HAD-SF-IA-v1; 1; |
NCBIfam | TIGR01509; HAD-SF-IA-v3; 1; |
Features
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Additional information
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Size range | 221-253 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |