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HAMAP rule MF_01681

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General rule information [?]

Accession MF_01681
Dates 24-OCT-2008 (Created)
1-JUN-2023 (Last updated, Version 16)
Name Salvage_MtnC
Scope(s) Bacteria
Template(s) P0C8L5 (MTNC_KLEAE); [ Recover all ]
Triggered by HAMAP; MF_01681 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MTNC
Protein name RecName: Full=Enolase-phosphatase E1;
                 EC=3.1.3.77;
AltName: Full=2,3-diketo-5-methylthio-1-phosphopentane phosphatase;
Gene name Name=mtnC;

Comments [?]

FUNCTIONBifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
CATALYTIC ACTIVITY Reaction=5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2- dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate; Xref=Rhea:RHEA:21700, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:49252, ChEBI:CHEBI:58828; EC=3.1.3.77;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
PATHWAYAmino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.
PATHWAYAmino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.
SUBUNITMonomer.
SIMILARITYBelongs to the HAD-like hydrolase superfamily. MasA/MtnC family.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0043715; Molecular function:2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity
GO:0043716; Molecular function:2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity
GO:0019284; Biological process:L-methionine salvage from S-adenosylmethionine

Cross-references [?]

Pfam PF00702; Hydrolase; 1;
PRINTS PR00413; HADHALOGNASE; 1;
NCBIfam TIGR01691; Enolase-ppase; 1;
NCBIfam TIGR01549; HAD-SF-IA-v1; 1;
NCBIfam TIGR01509; HAD-SF-IA-v3; 1;

Features [?]


Additional information [?]

Size range 221-253 amino acids
Related rules None
Fusion Nter: None Cter: None



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