AC   MF_01695;
DC   Protein; auto
TR   HAMAP; MF_01695; -; 1; level=0
XX
Names: MshA
XX
ID   MSHA
DE   RecName: Full=D-inositol-3-phosphate glycosyltransferase;
DE            EC=2.4.1.250;
DE   AltName: Full=N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase;
DE            Short=GlcNAc-Ins-P N-acetylglucosaminyltransferase;
GN   Name=mshA;
XX
CC   -!- FUNCTION: Catalyzes the transfer of a N-acetyl-glucosamine moiety to
CC       1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-
CC       deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis
CC       pathway.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine
CC         = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-
CC         phosphate + H(+) + UDP; Xref=Rhea:RHEA:26188, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:58401,
CC         ChEBI:CHEBI:58892; EC=2.4.1.250;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family. MshA
CC       subfamily.
XX
DR   Pfam; PF08323; Glyco_transf_5; 1; trigger=no
DR   Pfam; PF00534; Glycos_transf_1; 1; trigger=no
DR   NCBIfam; TIGR03449; Mycothiol_MshA; 1; trigger=no
XX
KW   Glycosyltransferase
KW   Magnesium
KW   Metal-binding
KW   Transferase
XX
GO   GO:0000287; F:magnesium ion binding
GO   GO:0008375; F:acetylglucosaminyltransferase activity
GO   GO:0010125; P:mycothiol biosynthetic process
XX
FT   From: MSHA_CORGL (Q8NTA6)
FT   BINDING         15..16
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Condition: Q-P
FT   BINDING         20..25
FT                   /ligand="1D-myo-inositol 3-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58401"
FT   Condition: D-x-G-x-[ML]-N
FT   BINDING         303
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: [YFIM]
FT   BINDING         304
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: [RHQ]
FT   BINDING         306
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: [ACSV]
FT   BINDING         330
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: T
FT   BINDING         9
FT                   /ligand="1D-myo-inositol 3-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58401"
FT   Condition: H
FT   BINDING         23
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Condition: G
FT   BINDING         78
FT                   /ligand="1D-myo-inositol 3-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58401"
FT   Condition: [KR]
FT   BINDING         110
FT                   /ligand="1D-myo-inositol 3-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58401"
FT   Condition: [YH]
FT   BINDING         134
FT                   /ligand="1D-myo-inositol 3-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58401"
FT   Condition: [TS]
FT   BINDING         154
FT                   /ligand="1D-myo-inositol 3-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58401"
FT   Condition: [RQ]
FT   BINDING         231
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Condition: R
FT   BINDING         236
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Condition: K
FT   BINDING         294
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Condition: [RMQV]
FT   BINDING         316
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Condition: E
FT   BINDING         324
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Condition: E
XX
Size: 407-496;
Related: None;
Template: Q8NTA6; P9WMY7; A0QQZ8;
Scope:
 Bacteria; Actinomycetota
Fusion:
 Nter: None
 Cter: None
Duplicate: in CATAD
Plasmid: None
Comments: None
XX
# Revision 1.13 2023/06/01
//