AC   MF_01903;
DC   Protein; auto
TR   HAMAP; MF_01903; -; 1; level=0
XX
Names: XGPRT
XX
ID   XGPT
DE   RecName: Full=Xanthine-guanine phosphoribosyltransferase;
DE            Short=XGPRT;
DE            EC=2.4.2.-;
DE            EC=2.4.2.22;
DE   AltName: Full=Xanthine phosphoribosyltransferase;
GN   Name=gpt;
XX
CC   -!- FUNCTION: Purine salvage pathway enzyme that catalyzes the transfer of
CC       the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-
CC       diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and
CC       xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-
CC       monophosphate) and XMP (xanthosine 5'-monophosphate), with the release
CC       of PPi. To a lesser extent, also acts on hypoxanthine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         guanine; Xref=Rhea:RHEA:25424, ChEBI:CHEBI:16235, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58017, ChEBI:CHEBI:58115;
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:25426;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         xanthine; Xref=Rhea:RHEA:10800, ChEBI:CHEBI:17712, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57464, ChEBI:CHEBI:58017; EC=2.4.2.22;
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:10802;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         hypoxanthine; Xref=Rhea:RHEA:17973, ChEBI:CHEBI:17368,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58053;
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17975;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- PATHWAY: Purine metabolism; GMP biosynthesis via salvage pathway; GMP
CC       from guanine: step 1/1.
CC   -!- PATHWAY: Purine metabolism; XMP biosynthesis via salvage pathway; XMP
CC       from xanthine: step 1/1.
CC   -!- SUBUNIT: Homotetramer.
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. XGPT subfamily.
XX
DR   PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1; trigger=no
DR   Pfam; PF00156; Pribosyltran; 1; trigger=no
XX
KW   Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Glycosyltransferase
KW   Magnesium
KW   Metal-binding
KW   Membrane
KW   Purine salvage
KW   Transferase
XX
GO   GO:0000287; F:magnesium ion binding
GO   GO:0000310; F:xanthine phosphoribosyltransferase activity
GO   GO:0006166; P:purine ribonucleoside salvage
GO   GO:0005886; C:plasma membrane
XX
FT   From: XGPT_ECOLI (P0A9M5)
FT   BINDING         92..96
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT   Condition: D-[TS]-G-x-T
FT   BINDING         134..135
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT   Optional; Condition: W-[IV]
FT   BINDING         37..38
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT   Condition: R-G
FT   BINDING         88..96
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT   BINDING         89
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: D
FT   BINDING         69
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT   Optional; Condition: [RKQ]
FT   BINDING         69
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT   Optional; Condition: [RKQ]
FT   BINDING         92
FT                   /ligand="guanine"
FT                   /ligand_id="ChEBI:CHEBI:16235"
FT   Condition: D
FT   BINDING         92
FT                   /ligand="xanthine"
FT                   /ligand_id="ChEBI:CHEBI:17712"
FT   Condition: D
FT   BINDING         135
FT                   /ligand="guanine"
FT                   /ligand_id="ChEBI:CHEBI:16235"
FT   Optional; Condition: [IV]
FT   BINDING         135
FT                   /ligand="xanthine"
FT                   /ligand_id="ChEBI:CHEBI:17712"
FT   Optional; Condition: [IV]
XX
Size: 152-176;
Related: None;
Template: P0A9M5; Q8ZC05;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: in HAEIN, HAEI8
Plasmid: None
Comments: None
XX
# Revision 1.32 2023/01/26
//