AC   MF_01959;
DC   Protein; auto
TR   HAMAP; MF_01959; -; 1; level=0
XX
Names: CcmE
XX
ID   CCME
DE   RecName: Full=Cytochrome c-type biogenesis protein CcmE;
DE   AltName: Full=Cytochrome c maturation protein E;
DE   AltName: Full=Heme chaperone CcmE;
GN   Name=ccmE; Synonyms=cycJ;
XX
CC   -!- FUNCTION: Heme chaperone required for the biogenesis of c-type
CC       cytochromes. Transiently binds heme delivered by CcmC and transfers the
CC       heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane
CC       protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type II membrane
CC       protein; Periplasmic side.
end case
CC   -!- SIMILARITY: Belongs to the CcmE/CycJ family.
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DR   Pfam; PF03100; CcmE; 1; trigger=no
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KW   Cytochrome c-type biogenesis
KW   Heme
KW   Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Iron
KW   Membrane
KW   Metal-binding
KW   Transmembrane
KW   Signal-anchor
KW   Transmembrane helix
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GO   GO:0017003; P:protein-heme linkage
GO   GO:0005886; C:plasma membrane
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FT   From: CCME_ECOLI (P69490)
FT   TOPO_DOM        Nter..8
FT                   /note="Cytoplasmic"
FT   TRANSMEM        9..29
FT                   /note="Helical; Signal-anchor for type II membrane protein"
case not defined <Property:Membrane> or <Property:Membrane=1>
FT   TOPO_DOM        30..Cter
FT                   /note="Extracellular"
end case
case defined <Property:Membrane> and <Property:Membrane=2>
FT   TOPO_DOM        30..Cter
FT                   /note="Periplasmic"
end case
FT   BINDING         134
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: Y
FT   BINDING         130
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /note="covalent"
FT   Condition: H
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Size: 128-181;
Related: None;
Template: P69490; Q8EK44;
Scope:
 Bacteria; Deinococci
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: in PSEPF, RHIEC, SALCH, SALPA, SALTI, SALTY, RUEPO, XANAC, XANC5,
 XANC8, XANCP, XANOM, XANOR
Plasmid: in CUPNH, RHIEC, RHIET, RUEPO
Comments: In SALCH, the duplicated copy ccmE2 is fused to ccmA2, however,
 important parts of the proteins are missing and it is therefore probably
 not functional. May be a pseudogene.
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# Revision 1.28 2023/01/26
//