AC   MF_01962;
DC   Protein; auto
c?   <OC:Bacteria>
TR   HAMAP; MF_01962; -; 1; level=0
XX
Names: Adenine_deaminase
XX
ID   ADE
DE   RecName: Full=Adenine deaminase;
DE            Short=ADE;
DE            EC=3.5.4.2;
DE   AltName: Full=Adenine aminohydrolase;
DE            Short=AAH;
XX
CC   -!- FUNCTION: Catalyzes the hydrolytic deamination of adenine to
CC       hypoxanthine. Plays an important role in the purine salvage pathway and
CC       in nitrogen catabolism.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. Adenine deaminase type 2
CC       subfamily.
XX
DR   Pfam; PF00962; A_deaminase; 1; trigger=no
DR   NCBIfam; TIGR01430; Aden_deam; 1; trigger=no
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KW   Hydrolase
KW   Nucleotide metabolism
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0000034; F:adenine deaminase activity
GO   GO:0006146; P:adenine catabolic process
GO   GO:0043103; P:hypoxanthine salvage
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: ADE_PSEAE (Q9I6Y4)
FT   ACT_SITE        197
FT                   /note="Proton donor"
FT   Condition: E
FT   BINDING         14
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         16
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         194
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         275
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: D
FT   BINDING         276
FT                   /ligand="substrate"
FT   Condition: D
FT   SITE            218
FT                   /note="Important for catalytic activity"
FT   Condition: H
XX
Size: 315-367;
Related: None;
Template: Q9I6Y4; P53909;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.12 2023/06/01
//