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HAMAP rule MF_03061

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General rule information [?]

Accession MF_03061
Dates 4-SEP-2009 (Created)
1-JUN-2023 (Last updated, Version 10)
Name mEF-G_1
Scope(s) Eukaryota
Template(s) Q96RP9 (EFGM_HUMAN); P25039 (EFGM_YEAST); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_00054_B (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier EFGM
Protein name RecName: Full=Elongation factor G, mitochondrial;
                 Short=EF-Gmt;
AltName: Full=Elongation factor G 1, mitochondrial;
                 Short=mEF-G 1;
AltName: Full=Elongation factor G1;
case <OC:Vertebrata>
Gene name Name=GFM1; Synonyms=EFG1;
else case <OC:Fungi>
Gene name Name=MEF1;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTIONMitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
else
FUNCTIONMitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
end case
PATHWAYProtein biosynthesis; polypeptide chain elongation.
SUBCELLULAR LOCATIONMitochondrion.
case <OC:Saccharomyces>
PTMThe precursor is processed in two steps involving mitochondrial intermediate peptidase (MIP) and mitochondrial processing peptidase (MPP).
end case
case not <AnyFeature:TransitM>
MISCELLANEOUSThis protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
SIMILARITYBelongs to the GTP-binding elongation factor family. EF- G/EF-2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0003746; Molecular function:translation elongation factor activity
GO:0003924; Molecular function:GTPase activity
GO:0005525; Molecular function:GTP binding
GO:0070125; Biological process:mitochondrial translational elongation
GO:0005739; Cellular component:mitochondrion

Cross-references [?]

PROSITE PS00301; G_TR_1; 1;
Pfam PF00679; EFG_C; 1;
Pfam PF03764; EFG_IV; 1;
Pfam PF00009; GTP_EFTU; 1;
Pfam PF03144; GTP_EFTU_D2; 1;
PRINTS PR00315; ELONGATNFCT; 1;
NCBIfam TIGR00484; EF-G; 1;
NCBIfam TIGR00231; small_GTP; 1;
General TransitM; -; 0-1;

Features [?]

From: EFGM_HUMAN (Q96RP9)
Key From To Description Tag Condition FTGroup
BINDING 53 60 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
[AS]-H-[IV]-D-[AS]-G-K-T
BINDING 120 124 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
D-T-P-G-H
BINDING 174 177 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
N-K-x-D

Additional information [?]

Size range 669-872 amino acids
Related rules MF_03063
Fusion Nter: None Cter: None



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