HAMAP rule MF_03061
General rule information
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Accession | MF_03061 |
Dates | 4-SEP-2009 (Created)
1-JUN-2023 (Last updated, Version 10) |
Name | mEF-G_1 |
Scope(s) |
Eukaryota |
Template(s) | Q96RP9 (EFGM_HUMAN); P25039 (EFGM_YEAST); [ Recover all ] |
Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_00054_B (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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Identifier | EFGM |
Protein name | RecName: Full=Elongation factor G, mitochondrial; Short=EF-Gmt; AltName: Full=Elongation factor G 1, mitochondrial; Short=mEF-G 1; AltName: Full=Elongation factor G1; |
case <OC:Vertebrata> | |
Gene name | Name=GFM1; Synonyms=EFG1; |
else case <OC:Fungi> | |
Gene name | Name=MEF1; |
end case |
Comments
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case <OC:Vertebrata> | |
FUNCTION | Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. |
else | |
FUNCTION | Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. |
end case | |
PATHWAY | Protein biosynthesis; polypeptide chain elongation. |
SUBCELLULAR LOCATION | Mitochondrion. |
case <OC:Saccharomyces> | |
PTM | The precursor is processed in two steps involving mitochondrial intermediate peptidase (MIP) and mitochondrial processing peptidase (MPP). |
end case | |
case not <AnyFeature:TransitM> | |
MISCELLANEOUS | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case | |
SIMILARITY | Belongs to the GTP-binding elongation factor family. EF- G/EF-2 subfamily. |
Keywords
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Gene Ontology
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GO:0003746; Molecular function:translation elongation factor activity |
GO:0003924; Molecular function:GTPase activity |
GO:0005525; Molecular function:GTP binding |
GO:0070125; Biological process:mitochondrial translational elongation |
GO:0005739; Cellular component:mitochondrion |
Cross-references
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PROSITE | PS00301; G_TR_1; 1; |
Pfam | PF00679; EFG_C; 1; |
Pfam | PF03764; EFG_IV; 1; |
Pfam | PF00009; GTP_EFTU; 1; |
Pfam | PF03144; GTP_EFTU_D2; 1; |
PRINTS | PR00315; ELONGATNFCT; 1; |
NCBIfam | TIGR00484; EF-G; 1; |
NCBIfam | TIGR00231; small_GTP; 1; |
General | TransitM; -; 0-1; |
Features
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From: EFGM_HUMAN (Q96RP9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 53 | 60 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
[AS]-H-[IV]-D-[AS]-G-K-T | ||||||||
BINDING | 120 | 124 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
D-T-P-G-H | ||||||||
BINDING | 174 | 177 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
N-K-x-D |
Additional information
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Size range | 669-872 amino acids |
Related rules |
MF_03063 |
Fusion | Nter: None Cter: None |