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Subject | Predicate | Object |
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http://purl.uniprot.org/unirules/MF_01487#construct-template-59 | http://spinrdf.org/sp#subject | http://purl.uniprot.org/unirules/MF_01487#construct-var-5 |
http://purl.uniprot.org/unirules/MF_01487#construct-template-59 | http://spinrdf.org/sp#predicate | http://www.w3.org/2000/01/rdf-schema#comment |
http://purl.uniprot.org/unirules/MF_01487#construct-template-59 | http://spinrdf.org/sp#object | "A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD."xsd:string |
http://purl.uniprot.org/unirules/MF_01487#construct | https://hamap.expasy.org/rdf/vocab#addsTriple | http://purl.uniprot.org/unirules/MF_01487#construct-template-59 |
http://purl.uniprot.org/unirules/MF_01487#construct-template-list-59 | http://www.w3.org/1999/02/22-rdf-syntax-ns#first | http://purl.uniprot.org/unirules/MF_01487#construct-template-59 |