| http://purl.uniprot.org/unirules/MF_00108#construct | http://www.w3.org/ns/shacl#construct | "CONSTRUCT {
_:42486 up:source unirule:MF_00108 .
_:42487 up:source unirule:MF_00108 .
_:42488 up:source unirule:MF_00108 .
_:42489 up:source unirule:MF_00108 .
_:42490 up:source unirule:MF_00108 .
_:42491 up:source unirule:MF_00108 .
_:42492 up:source unirule:MF_00108 .
_:42493 up:source unirule:MF_00108 .
_:42494 up:source unirule:MF_00108 .
_:42495 up:source unirule:MF_00108 .
_:42496 up:source unirule:MF_00108 .
_:42497 up:source unirule:MF_00108 .
_:42498 up:source unirule:MF_00108 .
_:42499 up:source unirule:MF_00108 .
_:42500 up:source unirule:MF_00108 .
_:42501 up:source unirule:MF_00108 .
_:42502 up:source unirule:MF_00108 .
?this up:alternativeName ?name1 ,
?name2 ;
up:annotation ?annotation4 ,
?annotation5 ,
?annotation7 ,
?annotation8 ;
up:classifiedWith GO:0019288 ,
GO:0050518 ,
keyword:414 ,
keyword:548 ,
keyword:808 ;
up:recommendedName ?name0 .
?name0 up:ecName '2.7.7.60' ;
up:fullName '2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase' ;
rdf:type up:Structured_Name .
?name1 up:fullName '4-diphosphocytidyl-2C-methyl-D-erythritol synthase' ;
rdf:type up:Structured_Name .
?name2 up:fullName 'MEP cytidylyltransferase' ;
up:shortName 'MCT' ;
rdf:type up:Structured_Name .
?gene3 skos:prefLabel 'ispD' .
?annotation4 a up:Function_Annotation ;
rdfs:comment 'Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).' .
?annotation5 up:activity ?activity6 ;
rdf:type up:Catalytic_Activity_Annotation .
?activity6 up:catalyticActivity ;
up:enzymeClass .
?annotation7 a up:Pathway_Annotation ;
rdfs:comment 'Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.' .
?annotation8 a up:Similarity_Annotation ;
rdfs:comment 'Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.' .
?pfs10 up:annotation ?annotation11 .
?annotation11 faldo:begin ?pfsb12 ;
faldo:end ?pfse13 ;
rdf:type up:Site_Annotation ;
rdfs:comment 'Transition state stabilizer' .
?pfsb12 faldo:position ?thisPositionOn14 ;
rdf:type faldo:ExactPosition .
?pfse13 faldo:position ?thisPositionOn15 ;
rdf:type faldo:ExactPosition .
?pfs16 up:annotation ?annotation17 .
?annotation17 faldo:begin ?pfsb18 ;
faldo:end ?pfse19 ;
rdf:type up:Site_Annotation ;
rdfs:comment 'Transition state stabilizer' .
?pfsb18 faldo:position ?thisPositionOn20 ;
rdf:type faldo:ExactPosition .
?pfse19 faldo:position ?thisPositionOn21 ;
rdf:type faldo:ExactPosition .
?pfs22 up:annotation ?annotation23 .
?annotation23 faldo:begin ?pfsb24 ;
faldo:end ?pfse25 ;
rdf:type up:Site_Annotation ;
rdfs:comment 'Positions MEP for the nucleophilic attack' .
?pfsb24 faldo:position ?thisPositionOn26 ;
rdf:type faldo:ExactPosition .
?pfse25 faldo:position ?thisPositionOn27 ;
rdf:type faldo:ExactPosition .
?pfs28 up:annotation ?annotation29 .
?annotation29 faldo:begin ?pfsb30 ;
faldo:end ?pfse31 ;
rdf:type up:Site_Annotation ;
rdfs:comment 'Positions MEP for the nucleophilic attack' .
?pfsb30 faldo:position ?thisPositionOn32 ;
rdf:type faldo:ExactPosition .
?pfse31 faldo:position ?thisPositionOn33 ;
rdf:type faldo:ExactPosition .
_:42503 a rdf:Statement ;
up:attribution _:42486 ;
rdf:subject ?this ;
rdf:predicate up:recommendedName ;
rdf:object ?name0 .
_:42504 a rdf:Statement ;
up:attribution _:42487 ;
rdf:subject ?this ;
rdf:predicate up:alternativeName ;
rdf:object ?name1 .
_:42505 a rdf:Statement ;
up:attribution _:42488 ;
rdf:subject ?this ;
rdf:predicate up:alternativeName ;
rdf:object ?name2 .
_:42506 a rdf:Statement ;
up:attribution _:42489 ;
rdf:subject ?gene3 ;
rdf:predicate up:encodedBy ;
rdf:object ?gene3 .
_:42507 a rdf:Statement ;
up:attribution _:42490 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation4 .
_:42508 a rdf:Statement ;
up:attribution _:42491 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation5 .
_:42509 a rdf:Statement ;
up:attribution _:42492 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation7 .
_:42510 a rdf:Statement ;
up:attribution _:42493 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation8 .
_:42511 a rdf:Statement ;
up:attribution _:42494 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:414 .
_:42512 a rdf:Statement ;
up:attribution _:42495 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:548 .
_:42513 a rdf:Statement ;
up:attribution _:42496 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:808 .
_:42514 a rdf:Statement ;
up:attribution _:42497 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0050518 .
_:42515 a rdf:Statement ;
up:attribution _:42498 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0019288 .
_:42516 a rdf:Statement ;
up:source unirule:MF_00108 ;
rdf:subject ?pfs10 ;
rdf:predicate up:annotation ;
rdf:object ?annotation11 .
_:42517 a rdf:Statement ;
up:attribution _:42499 ;
rdf:subject ?pfs10 ;
rdf:predicate up:annotation ;
rdf:object ?annotation11 .
_:42518 a rdf:Statement ;
up:source unirule:MF_00108 ;
rdf:subject ?pfs16 ;
rdf:predicate up:annotation ;
rdf:object ?annotation17 .
_:42519 a rdf:Statement ;
up:attribution _:42500 ;
rdf:subject ?pfs16 ;
rdf:predicate up:annotation ;
rdf:object ?annotation17 .
_:42520 a rdf:Statement ;
up:source unirule:MF_00108 ;
rdf:subject ?pfs22 ;
rdf:predicate up:annotation ;
rdf:object ?annotation23 .
_:42521 a rdf:Statement ;
up:attribution _:42501 ;
rdf:subject ?pfs22 ;
rdf:predicate up:annotation ;
rdf:object ?annotation23 .
_:42522 a rdf:Statement ;
up:source unirule:MF_00108 ;
rdf:subject ?pfs28 ;
rdf:predicate up:annotation ;
rdf:object ?annotation29 .
_:42523 a rdf:Statement ;
up:attribution _:42502 ;
rdf:subject ?pfs28 ;
rdf:predicate up:annotation ;
rdf:object ?annotation29 .
}
WHERE {
#baseURI: http://purl.uniprot.org/unirule/MF_00108
#Rule MF_00108 Created by:? on:2005-02-28 Modified by:Catherine Rivoire on:2024-03-12
?this up:organism ?thisOrganism ;
rdfs:seeAlso signature:MF_00108 .
?thisOrganism rdfs:subClassOf+ taxon:2 .
FILTER (! (EXISTS {
?this rdfs:seeAlso signature:MF_01520 .
})) .
BIND(URI(CONCAT(STR(?this), '#MF_00108a0')) AS ?name0) .
BIND(URI(CONCAT(STR(?this), '#MF_00108a1')) AS ?name1) .
BIND(URI(CONCAT(STR(?this), '#MF_00108a2')) AS ?name2) .
BIND(URI(CONCAT(STR(?this), '#MF_00108a4')) AS ?annotation4) .
BIND(URI(CONCAT(STR(?this), '#MF_00108a5')) AS ?annotation5) .
BIND(URI(CONCAT(STR(?this), '#MF_00108a7')) AS ?annotation7) .
BIND(URI(CONCAT(STR(?this), '#MF_00108a8')) AS ?annotation8) .
OPTIONAL {
?this up:sequence ?thisSequence .
?thisSequence rdf:value ?thisSequenceValue .
?templateMotifMatch38 faldo:location ?templateMotifSequenceMatchRegionQ4689339 ;
edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ4689341 ;
rdf:type edam:data_0869 ;
rdf:value ?templateMotifCigarQ46893MF_0010834 .
?templateMotifSequenceMatchRegionQ4689339 faldo:begin ?templateMotifSequenceMatchBeginQ4689340 .
?templateMotifSequenceMatchBeginQ4689340 faldo:position ?templateMotifSequenceMatchBeginPositionQ4689335 ;
faldo:reference isoform:Q46893-1 .
?templateMotifSequenceProfileAlignmentOperationQ4689341 edam:has_input signature:MF_00108 ;
rdf:type edam:operation_0300 .
?targetMotifMatch42 faldo:location ?targetMotifMatchRegionMatch43 ;
edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0010845 ;
rdf:type edam:data_0869 ;
rdf:value ?targetMotifMatchCigarQ46893MF_0010836 .
?targetMotifMatchRegionMatch43 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0010844 .
?targetMotifMatchRegionMatchBeginMF_0010844 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0010837 ;
faldo:reference ?thisSequence .
?targetMotifSequenceAlignmentOperationMF_0010845 edam:has_input signature:MF_00108 ;
rdf:type edam:operation_0300 .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ46893MF_0010834, 1, (STRLEN(?templateMotifCigarQ46893MF_0010834) - STRLEN(REPLACE(?templateMotifCigarQ46893MF_0010834, CONCAT('^(?:-*[^-]){', STR(((20 - ?templateMotifSequenceMatchBeginPositionQ4689335) + 1)), '}'), '')))), '[a-z]', '')) AS ?step146) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ46893MF_0010836, 1, (STRLEN(?targetMotifMatchCigarQ46893MF_0010836) - STRLEN(REPLACE(?targetMotifMatchCigarQ46893MF_0010836, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step146), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ46893MF_0010836, 1, (STRLEN(?targetMotifMatchCigarQ46893MF_0010836) - STRLEN(REPLACE(?targetMotifMatchCigarQ46893MF_0010836, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step146), '}'), '')))), '[^-]', ''))) AS ?step247) .
BIND(((?step247 + ?targetMotifMatchRegionMatchBeginPositionMF_0010837) - 1) AS ?thisPositionOn14) .
BIND(?thisPositionOn14 AS ?thisPositionOn15) .
BIND(?this AS ?pfs1t48) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn14))) AS ?pfsb12) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn15))) AS ?pfse13) .
FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn14, 1) = 'R')) .
BIND(URI(CONCAT(STR(?this), '#MF_00108a11')) AS ?annotation11) .
BIND(?this AS ?pfs10) .
}
OPTIONAL {
?this up:sequence ?thisSequence .
?thisSequence rdf:value ?thisSequenceValue .
?templateMotifMatch53 faldo:location ?templateMotifSequenceMatchRegionQ4689354 ;
edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ4689356 ;
rdf:type edam:data_0869 ;
rdf:value ?templateMotifCigarQ46893MF_0010849 .
?templateMotifSequenceMatchRegionQ4689354 faldo:begin ?templateMotifSequenceMatchBeginQ4689355 .
?templateMotifSequenceMatchBeginQ4689355 faldo:position ?templateMotifSequenceMatchBeginPositionQ4689350 ;
faldo:reference isoform:Q46893-1 .
?templateMotifSequenceProfileAlignmentOperationQ4689356 edam:has_input signature:MF_00108 ;
rdf:type edam:operation_0300 .
?targetMotifMatch57 faldo:location ?targetMotifMatchRegionMatch58 ;
edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0010860 ;
rdf:type edam:data_0869 ;
rdf:value ?targetMotifMatchCigarQ46893MF_0010851 .
?targetMotifMatchRegionMatch58 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0010859 .
?targetMotifMatchRegionMatchBeginMF_0010859 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0010852 ;
faldo:reference ?thisSequence .
?targetMotifSequenceAlignmentOperationMF_0010860 edam:has_input signature:MF_00108 ;
rdf:type edam:operation_0300 .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ46893MF_0010849, 1, (STRLEN(?templateMotifCigarQ46893MF_0010849) - STRLEN(REPLACE(?templateMotifCigarQ46893MF_0010849, CONCAT('^(?:-*[^-]){', STR(((27 - ?templateMotifSequenceMatchBeginPositionQ4689350) + 1)), '}'), '')))), '[a-z]', '')) AS ?step161) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ46893MF_0010851, 1, (STRLEN(?targetMotifMatchCigarQ46893MF_0010851) - STRLEN(REPLACE(?targetMotifMatchCigarQ46893MF_0010851, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step161), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ46893MF_0010851, 1, (STRLEN(?targetMotifMatchCigarQ46893MF_0010851) - STRLEN(REPLACE(?targetMotifMatchCigarQ46893MF_0010851, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step161), '}'), '')))), '[^-]', ''))) AS ?step262) .
BIND(((?step262 + ?targetMotifMatchRegionMatchBeginPositionMF_0010852) - 1) AS ?thisPositionOn20) .
BIND(?thisPositionOn20 AS ?thisPositionOn21) .
BIND(?this AS ?pfs1t63) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn20))) AS ?pfsb18) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn21))) AS ?pfse19) .
FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn20, 1) = 'K')) .
BIND(URI(CONCAT(STR(?this), '#MF_00108a17')) AS ?annotation17) .
BIND(?this AS ?pfs16) .
}
OPTIONAL {
?this up:sequence ?thisSequence .
?thisSequence rdf:value ?thisSequenceValue .
?templateMotifMatch68 faldo:location ?templateMotifSequenceMatchRegionQ4689369 ;
edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ4689371 ;
rdf:type edam:data_0869 ;
rdf:value ?templateMotifCigarQ46893MF_0010864 .
?templateMotifSequenceMatchRegionQ4689369 faldo:begin ?templateMotifSequenceMatchBeginQ4689370 .
?templateMotifSequenceMatchBeginQ4689370 faldo:position ?templateMotifSequenceMatchBeginPositionQ4689365 ;
faldo:reference isoform:Q46893-1 .
?templateMotifSequenceProfileAlignmentOperationQ4689371 edam:has_input signature:MF_00108 ;
rdf:type edam:operation_0300 .
?targetMotifMatch72 faldo:location ?targetMotifMatchRegionMatch73 ;
edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0010875 ;
rdf:type edam:data_0869 ;
rdf:value ?targetMotifMatchCigarQ46893MF_0010866 .
?targetMotifMatchRegionMatch73 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0010874 .
?targetMotifMatchRegionMatchBeginMF_0010874 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0010867 ;
faldo:reference ?thisSequence .
?targetMotifSequenceAlignmentOperationMF_0010875 edam:has_input signature:MF_00108 ;
rdf:type edam:operation_0300 .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ46893MF_0010864, 1, (STRLEN(?templateMotifCigarQ46893MF_0010864) - STRLEN(REPLACE(?templateMotifCigarQ46893MF_0010864, CONCAT('^(?:-*[^-]){', STR(((157 - ?templateMotifSequenceMatchBeginPositionQ4689365) + 1)), '}'), '')))), '[a-z]', '')) AS ?step176) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ46893MF_0010866, 1, (STRLEN(?targetMotifMatchCigarQ46893MF_0010866) - STRLEN(REPLACE(?targetMotifMatchCigarQ46893MF_0010866, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step176), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ46893MF_0010866, 1, (STRLEN(?targetMotifMatchCigarQ46893MF_0010866) - STRLEN(REPLACE(?targetMotifMatchCigarQ46893MF_0010866, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step176), '}'), '')))), '[^-]', ''))) AS ?step277) .
BIND(((?step277 + ?targetMotifMatchRegionMatchBeginPositionMF_0010867) - 1) AS ?thisPositionOn26) .
BIND(?thisPositionOn26 AS ?thisPositionOn27) .
BIND(?this AS ?pfs1t78) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn26))) AS ?pfsb24) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn27))) AS ?pfse25) .
FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn26, 1) = 'R')) .
BIND(URI(CONCAT(STR(?this), '#MF_00108a23')) AS ?annotation23) .
BIND(?this AS ?pfs22) .
}
OPTIONAL {
?this up:sequence ?thisSequence .
?thisSequence rdf:value ?thisSequenceValue .
?templateMotifMatch83 faldo:location ?templateMotifSequenceMatchRegionQ4689384 ;
edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ4689386 ;
rdf:type edam:data_0869 ;
rdf:value ?templateMotifCigarQ46893MF_0010879 .
?templateMotifSequenceMatchRegionQ4689384 faldo:begin ?templateMotifSequenceMatchBeginQ4689385 .
?templateMotifSequenceMatchBeginQ4689385 faldo:position ?templateMotifSequenceMatchBeginPositionQ4689380 ;
faldo:reference isoform:Q46893-1 .
?templateMotifSequenceProfileAlignmentOperationQ4689386 edam:has_input signature:MF_00108 ;
rdf:type edam:operation_0300 .
?targetMotifMatch87 faldo:location ?targetMotifMatchRegionMatch88 ;
edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0010890 ;
rdf:type edam:data_0869 ;
rdf:value ?targetMotifMatchCigarQ46893MF_0010881 .
?targetMotifMatchRegionMatch88 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0010889 .
?targetMotifMatchRegionMatchBeginMF_0010889 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0010882 ;
faldo:reference ?thisSequence .
?targetMotifSequenceAlignmentOperationMF_0010890 edam:has_input signature:MF_00108 ;
rdf:type edam:operation_0300 .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ46893MF_0010879, 1, (STRLEN(?templateMotifCigarQ46893MF_0010879) - STRLEN(REPLACE(?templateMotifCigarQ46893MF_0010879, CONCAT('^(?:-*[^-]){', STR(((213 - ?templateMotifSequenceMatchBeginPositionQ4689380) + 1)), '}'), '')))), '[a-z]', '')) AS ?step191) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ46893MF_0010881, 1, (STRLEN(?targetMotifMatchCigarQ46893MF_0010881) - STRLEN(REPLACE(?targetMotifMatchCigarQ46893MF_0010881, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step191), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ46893MF_0010881, 1, (STRLEN(?targetMotifMatchCigarQ46893MF_0010881) - STRLEN(REPLACE(?targetMotifMatchCigarQ46893MF_0010881, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step191), '}'), '')))), '[^-]', ''))) AS ?step292) .
BIND(((?step292 + ?targetMotifMatchRegionMatchBeginPositionMF_0010882) - 1) AS ?thisPositionOn32) .
BIND(?thisPositionOn32 AS ?thisPositionOn33) .
BIND(?this AS ?pfs1t93) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn32))) AS ?pfsb30) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn33))) AS ?pfse31) .
FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn32, 1) = 'K')) .
BIND(URI(CONCAT(STR(?this), '#MF_00108a29')) AS ?annotation29) .
BIND(?this AS ?pfs28) .
}
OPTIONAL {
?this a up:Protein .
?this up:organism ?thisOrganism .
?thisOrganism rdfs:subClassOf+ taxon:91347 .
BIND(?this AS ?case9) .
}
}
"xsd:string |
