| http://purl.uniprot.org/unirules/MF_00217#construct | http://www.w3.org/ns/shacl#construct | "CONSTRUCT {
_:90932 up:source unirule:MF_00217 .
_:90933 up:source unirule:MF_00217 .
_:90934 up:source unirule:MF_00217 .
_:90935 up:source unirule:MF_00217 .
_:90936 up:source unirule:MF_00217 .
_:90937 up:source unirule:MF_00217 .
_:90938 up:source unirule:MF_00217 .
_:90939 up:source unirule:MF_00217 .
_:90940 up:source unirule:MF_00217 .
_:90941 up:source unirule:MF_00217 .
_:90942 up:source unirule:MF_00217 .
_:90943 up:source unirule:MF_00217 .
_:90944 up:source unirule:MF_00217 .
_:90945 up:source unirule:MF_00217 .
_:90946 up:source unirule:MF_00217 .
_:90947 up:source unirule:MF_00217 .
_:90948 up:source unirule:MF_00217 .
_:90949 up:source unirule:MF_00217 .
_:90950 up:source unirule:MF_00217 .
_:90951 up:source unirule:MF_00217 .
_:90952 up:source unirule:MF_00217 .
_:90953 up:source unirule:MF_00217 .
_:90954 up:source unirule:MF_00217 .
_:90955 up:source unirule:MF_00217 .
_:90956 up:source unirule:MF_00217 .
?this up:annotation ?annotation2 ,
?annotation3 ,
?annotation5 ,
?annotation6 ,
?annotation7 ,
?annotation8 ,
?annotation10 ;
up:classifiedWith GO:0000287 ,
GO:0004496 ,
GO:0005524 ,
GO:0005737 ,
GO:0019287 ,
keyword:414 ,
keyword:418 ,
keyword:443 ,
keyword:444 ,
keyword:460 ,
keyword:547 ,
keyword:67 ,
keyword:808 ,
keyword:963 ;
up:recommendedName ?name0 .
?name0 up:ecName '2.7.1.36' ;
up:fullName 'Mevalonate kinase' ;
up:shortName 'MK' ,
'MVK' ;
rdf:type up:Structured_Name .
?gene1 skos:prefLabel 'mvk' .
?annotation2 a up:Function_Annotation ;
rdfs:comment 'Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.' .
?annotation3 up:activity ?activity4 ;
rdf:type up:Catalytic_Activity_Annotation .
?activity4 up:catalyticActivity ;
up:enzymeClass .
?annotation5 up:cofactor chebi:18420 ;
rdf:type up:Cofactor_Annotation .
?annotation6 a up:Pathway_Annotation ;
rdfs:comment 'Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.' .
?annotation7 a up:Subunit_Annotation ;
rdfs:comment 'Homodimer.' .
?annotation8 a up:Subcellular_Location_Annotation .
?annotation8li9 up:cellularComponent .
?annotation10 a up:Similarity_Annotation ;
rdfs:comment 'Belongs to the GHMP kinase family. Mevalonate kinase subfamily.' .
?pfs11 up:annotation ?annotation12 .
?annotation12 faldo:begin ?pfsb13 ;
faldo:end ?pfse14 ;
up:ligand ?ligand15 ;
rdf:type up:Binding_Site_Annotation .
?pfsb13 faldo:position ?thisPositionOn16 ;
rdf:type faldo:ExactPosition .
?pfse14 faldo:position ?thisPositionOn17 ;
rdf:type faldo:ExactPosition .
?ligand15 rdfs:subClassOf chebi:30616 .
?pfs18 up:annotation ?annotation19 .
?annotation19 faldo:begin ?pfsb20 ;
faldo:end ?pfse21 ;
rdf:type up:Active_Site_Annotation ;
rdfs:comment 'Proton acceptor' .
?pfsb20 faldo:position ?thisPositionOn22 ;
rdf:type faldo:ExactPosition .
?pfse21 faldo:position ?thisPositionOn23 ;
rdf:type faldo:ExactPosition .
_:90957 a rdf:Statement ;
up:attribution _:90932 ;
rdf:subject ?this ;
rdf:predicate up:recommendedName ;
rdf:object ?name0 .
_:90958 a rdf:Statement ;
up:attribution _:90933 ;
rdf:subject ?gene1 ;
rdf:predicate up:encodedBy ;
rdf:object ?gene1 .
_:90959 a rdf:Statement ;
up:attribution _:90934 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation2 .
_:90960 a rdf:Statement ;
up:attribution _:90935 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation3 .
_:90961 a rdf:Statement ;
up:attribution _:90936 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation5 .
_:90962 a rdf:Statement ;
up:attribution _:90937 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation6 .
_:90963 a rdf:Statement ;
up:attribution _:90938 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation7 .
_:90964 a rdf:Statement ;
up:attribution _:90939 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation8 .
_:90965 a rdf:Statement ;
up:attribution _:90940 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation10 .
_:90966 a rdf:Statement ;
up:attribution _:90941 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:963 .
_:90967 a rdf:Statement ;
up:attribution _:90942 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:808 .
_:90968 a rdf:Statement ;
up:attribution _:90943 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:418 .
_:90969 a rdf:Statement ;
up:attribution _:90944 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:67 .
_:90970 a rdf:Statement ;
up:attribution _:90945 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:547 .
_:90971 a rdf:Statement ;
up:attribution _:90946 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:460 .
_:90972 a rdf:Statement ;
up:attribution _:90947 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:414 .
_:90973 a rdf:Statement ;
up:attribution _:90948 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:444 .
_:90974 a rdf:Statement ;
up:attribution _:90949 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:443 .
_:90975 a rdf:Statement ;
up:attribution _:90950 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0005524 .
_:90976 a rdf:Statement ;
up:attribution _:90951 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0000287 .
_:90977 a rdf:Statement ;
up:attribution _:90952 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0004496 .
_:90978 a rdf:Statement ;
up:attribution _:90953 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0019287 .
_:90979 a rdf:Statement ;
up:attribution _:90954 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0005737 .
_:90980 a rdf:Statement ;
up:source unirule:MF_00217 ;
rdf:subject ?pfs11 ;
rdf:predicate up:annotation ;
rdf:object ?annotation12 .
_:90981 a rdf:Statement ;
up:attribution _:90955 ;
rdf:subject ?pfs11 ;
rdf:predicate up:annotation ;
rdf:object ?annotation12 .
_:90982 a rdf:Statement ;
up:source unirule:MF_00217 ;
rdf:subject ?pfs18 ;
rdf:predicate up:annotation ;
rdf:object ?annotation19 .
_:90983 a rdf:Statement ;
up:attribution _:90956 ;
rdf:subject ?pfs18 ;
rdf:predicate up:annotation ;
rdf:object ?annotation19 .
}
WHERE {
#baseURI: http://purl.uniprot.org/unirule/MF_00217
#Rule MF_00217 Created by:? on:2005-02-28 Modified by:Catherine Rivoire on:2024-03-12
?this up:organism ?thisOrganism ;
rdfs:seeAlso signature:MF_00217 .
?thisOrganism rdfs:subClassOf+ taxon:2157 .
BIND(URI(CONCAT(STR(?this), '#MF_00217a0')) AS ?name0) .
BIND(URI(CONCAT(STR(?this), '#MF_00217a2')) AS ?annotation2) .
BIND(URI(CONCAT(STR(?this), '#MF_00217a3')) AS ?annotation3) .
BIND(URI(CONCAT(STR(?this), '#MF_00217a5')) AS ?annotation5) .
BIND(URI(CONCAT(STR(?this), '#MF_00217a6')) AS ?annotation6) .
BIND(URI(CONCAT(STR(?this), '#MF_00217a7')) AS ?annotation7) .
BIND(URI(CONCAT(STR(?this), '#MF_00217a8')) AS ?annotation8) .
BIND(URI(CONCAT(STR(?this), '#MF_00217a10')) AS ?annotation10) .
OPTIONAL {
?this up:sequence ?thisSequence .
?thisSequence rdf:value ?thisSequenceValue .
?templateMotifMatch28 faldo:location ?templateMotifSequenceMatchRegionQ5848729 ;
edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ5848731 ;
rdf:type edam:data_0869 ;
rdf:value ?templateMotifCigarQ58487MF_0021724 .
?templateMotifSequenceMatchRegionQ5848729 faldo:begin ?templateMotifSequenceMatchBeginQ5848730 .
?templateMotifSequenceMatchBeginQ5848730 faldo:position ?templateMotifSequenceMatchBeginPositionQ5848725 ;
faldo:reference isoform:Q58487-1 .
?templateMotifSequenceProfileAlignmentOperationQ5848731 edam:has_input signature:MF_00217 ;
rdf:type edam:operation_0300 .
?targetMotifMatch32 faldo:location ?targetMotifMatchRegionMatch33 ;
edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0021735 ;
rdf:type edam:data_0869 ;
rdf:value ?targetMotifMatchCigarQ58487MF_0021726 .
?targetMotifMatchRegionMatch33 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0021734 .
?targetMotifMatchRegionMatchBeginMF_0021734 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0021727 ;
faldo:reference ?thisSequence .
?targetMotifSequenceAlignmentOperationMF_0021735 edam:has_input signature:MF_00217 ;
rdf:type edam:operation_0300 .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ58487MF_0021724, 1, (STRLEN(?templateMotifCigarQ58487MF_0021724) - STRLEN(REPLACE(?templateMotifCigarQ58487MF_0021724, CONCAT('^(?:-*[^-]){', STR(((104 - ?templateMotifSequenceMatchBeginPositionQ5848725) + 1)), '}'), '')))), '[a-z]', '')) AS ?step136) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ58487MF_0021726, 1, (STRLEN(?targetMotifMatchCigarQ58487MF_0021726) - STRLEN(REPLACE(?targetMotifMatchCigarQ58487MF_0021726, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step136), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ58487MF_0021726, 1, (STRLEN(?targetMotifMatchCigarQ58487MF_0021726) - STRLEN(REPLACE(?targetMotifMatchCigarQ58487MF_0021726, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step136), '}'), '')))), '[^-]', ''))) AS ?step237) .
BIND(((?step237 + ?targetMotifMatchRegionMatchBeginPositionMF_0021727) - 1) AS ?thisPositionOn16) .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ58487MF_0021724, 1, (STRLEN(?templateMotifCigarQ58487MF_0021724) - STRLEN(REPLACE(?templateMotifCigarQ58487MF_0021724, CONCAT('^(?:-*[^-]){', STR(((114 - ?templateMotifSequenceMatchBeginPositionQ5848725) + 1)), '}'), '')))), '[a-z]', '')) AS ?step138) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ58487MF_0021726, 1, (STRLEN(?targetMotifMatchCigarQ58487MF_0021726) - STRLEN(REPLACE(?targetMotifMatchCigarQ58487MF_0021726, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step138), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ58487MF_0021726, 1, (STRLEN(?targetMotifMatchCigarQ58487MF_0021726) - STRLEN(REPLACE(?targetMotifMatchCigarQ58487MF_0021726, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step138), '}'), '')))), '[^-]', ''))) AS ?step239) .
BIND(((?step239 + ?targetMotifMatchRegionMatchBeginPositionMF_0021727) - 1) AS ?thisPositionOn17) .
BIND(?this AS ?pfs1t40) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn16))) AS ?pfsb13) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn17))) AS ?pfse14) .
FILTER (REGEX('P[ARNDCQEGHILKMFPSTWYVBZJUOX]{3)GLGSSA[SA]', SUBSTR(?thisSequenceValue, ?thisPositionOn16, (?thisPositionOn17 - ?thisPositionOn16)))) .
BIND(URI(CONCAT(STR(?this), '#MF_00217a12')) AS ?annotation12) .
BIND(?this AS ?pfs11) .
}
OPTIONAL {
?this up:sequence ?thisSequence .
?thisSequence rdf:value ?thisSequenceValue .
?templateMotifMatch45 faldo:location ?templateMotifSequenceMatchRegionQ5848746 ;
edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ5848748 ;
rdf:type edam:data_0869 ;
rdf:value ?templateMotifCigarQ58487MF_0021741 .
?templateMotifSequenceMatchRegionQ5848746 faldo:begin ?templateMotifSequenceMatchBeginQ5848747 .
?templateMotifSequenceMatchBeginQ5848747 faldo:position ?templateMotifSequenceMatchBeginPositionQ5848742 ;
faldo:reference isoform:Q58487-1 .
?templateMotifSequenceProfileAlignmentOperationQ5848748 edam:has_input signature:MF_00217 ;
rdf:type edam:operation_0300 .
?targetMotifMatch49 faldo:location ?targetMotifMatchRegionMatch50 ;
edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0021752 ;
rdf:type edam:data_0869 ;
rdf:value ?targetMotifMatchCigarQ58487MF_0021743 .
?targetMotifMatchRegionMatch50 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0021751 .
?targetMotifMatchRegionMatchBeginMF_0021751 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0021744 ;
faldo:reference ?thisSequence .
?targetMotifSequenceAlignmentOperationMF_0021752 edam:has_input signature:MF_00217 ;
rdf:type edam:operation_0300 .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ58487MF_0021741, 1, (STRLEN(?templateMotifCigarQ58487MF_0021741) - STRLEN(REPLACE(?templateMotifCigarQ58487MF_0021741, CONCAT('^(?:-*[^-]){', STR(((155 - ?templateMotifSequenceMatchBeginPositionQ5848742) + 1)), '}'), '')))), '[a-z]', '')) AS ?step153) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ58487MF_0021743, 1, (STRLEN(?targetMotifMatchCigarQ58487MF_0021743) - STRLEN(REPLACE(?targetMotifMatchCigarQ58487MF_0021743, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step153), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ58487MF_0021743, 1, (STRLEN(?targetMotifMatchCigarQ58487MF_0021743) - STRLEN(REPLACE(?targetMotifMatchCigarQ58487MF_0021743, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step153), '}'), '')))), '[^-]', ''))) AS ?step254) .
BIND(((?step254 + ?targetMotifMatchRegionMatchBeginPositionMF_0021744) - 1) AS ?thisPositionOn22) .
BIND(?thisPositionOn22 AS ?thisPositionOn23) .
BIND(?this AS ?pfs1t55) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn22))) AS ?pfsb20) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn23))) AS ?pfse21) .
FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn22, 1) = 'D')) .
BIND(URI(CONCAT(STR(?this), '#MF_00217a19')) AS ?annotation19) .
BIND(?this AS ?pfs18) .
}
}
"xsd:string |
