| http://purl.uniprot.org/unirules/MF_00812#construct | http://www.w3.org/ns/shacl#construct | "CONSTRUCT {
_:290133 up:source unirule:MF_00812 .
_:290134 up:source unirule:MF_00812 .
_:290135 up:source unirule:MF_00812 .
_:290136 up:source unirule:MF_00812 .
_:290137 up:source unirule:MF_00812 .
_:290138 up:source unirule:MF_00812 .
_:290139 up:source unirule:MF_00812 .
_:290140 up:source unirule:MF_00812 .
_:290141 up:source unirule:MF_00812 .
_:290142 up:source unirule:MF_00812 .
_:290143 up:source unirule:MF_00812 .
_:290144 up:source unirule:MF_00812 .
_:290145 up:source unirule:MF_00812 .
_:290146 up:source unirule:MF_00812 .
_:290147 up:source unirule:MF_00812 .
_:290148 up:source unirule:MF_00812 .
?this up:alternativeName ?name1 ;
up:annotation ?annotation3 ,
?annotation5 ,
?annotation7 ;
up:classifiedWith GO:0005737 ,
GO:0008119 ,
keyword:489 ,
keyword:808 ,
keyword:949 ,
keyword:963 ;
up:recommendedName ?name0 .
?name0 up:ecName '2.1.1.67' ;
up:fullName 'Thiopurine S-methyltransferase' ;
rdf:type up:Structured_Name .
?name1 up:fullName 'Thiopurine methyltransferase' ;
rdf:type up:Structured_Name .
?gene2 skos:prefLabel 'tpm' .
?annotation3 up:activity ?activity4 ;
rdf:type up:Catalytic_Activity_Annotation .
?activity4 up:enzymeClass .
?annotation5 a up:Subcellular_Location_Annotation .
?annotation5li6 up:cellularComponent .
?annotation7 a up:Similarity_Annotation ;
rdfs:comment 'Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.' .
?pfs8 up:annotation ?annotation9 .
?annotation9 faldo:begin ?pfsb10 ;
faldo:end ?pfse11 ;
up:ligand ?ligand12 ;
rdf:type up:Binding_Site_Annotation .
?pfsb10 faldo:position ?thisPositionOn13 ;
rdf:type faldo:ExactPosition .
?pfse11 faldo:position ?thisPositionOn14 ;
rdf:type faldo:ExactPosition .
?ligand12 rdfs:subClassOf chebi:59789 .
?pfs15 up:annotation ?annotation16 .
?annotation16 faldo:begin ?pfsb17 ;
faldo:end ?pfse18 ;
up:ligand ?ligand19 ;
rdf:type up:Binding_Site_Annotation .
?pfsb17 faldo:position ?thisPositionOn20 ;
rdf:type faldo:ExactPosition .
?pfse18 faldo:position ?thisPositionOn21 ;
rdf:type faldo:ExactPosition .
?ligand19 rdfs:subClassOf chebi:59789 .
?pfs22 up:annotation ?annotation23 .
?annotation23 faldo:begin ?pfsb24 ;
faldo:end ?pfse25 ;
up:ligand ?ligand26 ;
rdf:type up:Binding_Site_Annotation .
?pfsb24 faldo:position ?thisPositionOn27 ;
rdf:type faldo:ExactPosition .
?pfse25 faldo:position ?thisPositionOn28 ;
rdf:type faldo:ExactPosition .
?ligand26 rdfs:subClassOf chebi:59789 .
?pfs29 up:annotation ?annotation30 .
?annotation30 faldo:begin ?pfsb31 ;
faldo:end ?pfse32 ;
up:ligand ?ligand33 ;
rdf:type up:Binding_Site_Annotation .
?pfsb31 faldo:position ?thisPositionOn34 ;
rdf:type faldo:ExactPosition .
?pfse32 faldo:position ?thisPositionOn35 ;
rdf:type faldo:ExactPosition .
?ligand33 rdfs:subClassOf chebi:59789 .
_:290149 a rdf:Statement ;
up:attribution _:290133 ;
rdf:subject ?this ;
rdf:predicate up:recommendedName ;
rdf:object ?name0 .
_:290150 a rdf:Statement ;
up:attribution _:290134 ;
rdf:subject ?this ;
rdf:predicate up:alternativeName ;
rdf:object ?name1 .
_:290151 a rdf:Statement ;
up:attribution _:290135 ;
rdf:subject ?gene2 ;
rdf:predicate up:encodedBy ;
rdf:object ?gene2 .
_:290152 a rdf:Statement ;
up:attribution _:290136 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation3 .
_:290153 a rdf:Statement ;
up:attribution _:290137 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation5 .
_:290154 a rdf:Statement ;
up:attribution _:290138 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation7 .
_:290155 a rdf:Statement ;
up:attribution _:290139 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:963 .
_:290156 a rdf:Statement ;
up:attribution _:290140 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:489 .
_:290157 a rdf:Statement ;
up:attribution _:290141 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:949 .
_:290158 a rdf:Statement ;
up:attribution _:290142 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:808 .
_:290159 a rdf:Statement ;
up:attribution _:290143 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0008119 .
_:290160 a rdf:Statement ;
up:attribution _:290144 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0005737 .
_:290161 a rdf:Statement ;
up:source unirule:MF_00812 ;
rdf:subject ?pfs8 ;
rdf:predicate up:annotation ;
rdf:object ?annotation9 .
_:290162 a rdf:Statement ;
up:attribution _:290145 ;
rdf:subject ?pfs8 ;
rdf:predicate up:annotation ;
rdf:object ?annotation9 .
_:290163 a rdf:Statement ;
up:source unirule:MF_00812 ;
rdf:subject ?pfs15 ;
rdf:predicate up:annotation ;
rdf:object ?annotation16 .
_:290164 a rdf:Statement ;
up:attribution _:290146 ;
rdf:subject ?pfs15 ;
rdf:predicate up:annotation ;
rdf:object ?annotation16 .
_:290165 a rdf:Statement ;
up:source unirule:MF_00812 ;
rdf:subject ?pfs22 ;
rdf:predicate up:annotation ;
rdf:object ?annotation23 .
_:290166 a rdf:Statement ;
up:attribution _:290147 ;
rdf:subject ?pfs22 ;
rdf:predicate up:annotation ;
rdf:object ?annotation23 .
_:290167 a rdf:Statement ;
up:source unirule:MF_00812 ;
rdf:subject ?pfs29 ;
rdf:predicate up:annotation ;
rdf:object ?annotation30 .
_:290168 a rdf:Statement ;
up:attribution _:290148 ;
rdf:subject ?pfs29 ;
rdf:predicate up:annotation ;
rdf:object ?annotation30 .
}
WHERE {
#baseURI: http://purl.uniprot.org/unirule/MF_00812
#Rule MF_00812 Created by:? on:2005-08-22 Modified by:Edouard de Castro on:2023-06-01
?this up:organism ?thisOrganism ;
rdfs:seeAlso signature:MF_00812 .
?thisOrganism rdfs:subClassOf+ taxon:1224 .
BIND(URI(CONCAT(STR(?this), '#MF_00812a0')) AS ?name0) .
BIND(URI(CONCAT(STR(?this), '#MF_00812a1')) AS ?name1) .
BIND(URI(CONCAT(STR(?this), '#MF_00812a3')) AS ?annotation3) .
BIND(URI(CONCAT(STR(?this), '#MF_00812a5')) AS ?annotation5) .
BIND(URI(CONCAT(STR(?this), '#MF_00812a7')) AS ?annotation7) .
OPTIONAL {
?this up:sequence ?thisSequence .
?thisSequence rdf:value ?thisSequenceValue .
?templateMotifMatch40 faldo:location ?templateMotifSequenceMatchRegionQ9KSN041 ;
edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ9KSN043 ;
rdf:type edam:data_0869 ;
rdf:value ?templateMotifCigarQ9KSN0MF_0081236 .
?templateMotifSequenceMatchRegionQ9KSN041 faldo:begin ?templateMotifSequenceMatchBeginQ9KSN042 .
?templateMotifSequenceMatchBeginQ9KSN042 faldo:position ?templateMotifSequenceMatchBeginPositionQ9KSN037 ;
faldo:reference isoform:Q9KSN0-1 .
?templateMotifSequenceProfileAlignmentOperationQ9KSN043 edam:has_input signature:MF_00812 ;
rdf:type edam:operation_0300 .
?targetMotifMatch44 faldo:location ?targetMotifMatchRegionMatch45 ;
edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0081247 ;
rdf:type edam:data_0869 ;
rdf:value ?targetMotifMatchCigarQ9KSN0MF_0081238 .
?targetMotifMatchRegionMatch45 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0081246 .
?targetMotifMatchRegionMatchBeginMF_0081246 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0081239 ;
faldo:reference ?thisSequence .
?targetMotifSequenceAlignmentOperationMF_0081247 edam:has_input signature:MF_00812 ;
rdf:type edam:operation_0300 .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ9KSN0MF_0081236, 1, (STRLEN(?templateMotifCigarQ9KSN0MF_0081236) - STRLEN(REPLACE(?templateMotifCigarQ9KSN0MF_0081236, CONCAT('^(?:-*[^-]){', STR(((11 - ?templateMotifSequenceMatchBeginPositionQ9KSN037) + 1)), '}'), '')))), '[a-z]', '')) AS ?step148) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ9KSN0MF_0081238, 1, (STRLEN(?targetMotifMatchCigarQ9KSN0MF_0081238) - STRLEN(REPLACE(?targetMotifMatchCigarQ9KSN0MF_0081238, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step148), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ9KSN0MF_0081238, 1, (STRLEN(?targetMotifMatchCigarQ9KSN0MF_0081238) - STRLEN(REPLACE(?targetMotifMatchCigarQ9KSN0MF_0081238, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step148), '}'), '')))), '[^-]', ''))) AS ?step249) .
BIND(((?step249 + ?targetMotifMatchRegionMatchBeginPositionMF_0081239) - 1) AS ?thisPositionOn13) .
BIND(?thisPositionOn13 AS ?thisPositionOn14) .
BIND(?this AS ?pfs1t50) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn13))) AS ?pfsb10) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn14))) AS ?pfse11) .
FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn13, 1) = 'W')) .
BIND(URI(CONCAT(STR(?this), '#MF_00812a9')) AS ?annotation9) .
BIND(?this AS ?pfs8) .
}
OPTIONAL {
?this up:sequence ?thisSequence .
?thisSequence rdf:value ?thisSequenceValue .
?templateMotifMatch55 faldo:location ?templateMotifSequenceMatchRegionQ9KSN056 ;
edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ9KSN058 ;
rdf:type edam:data_0869 ;
rdf:value ?templateMotifCigarQ9KSN0MF_0081251 .
?templateMotifSequenceMatchRegionQ9KSN056 faldo:begin ?templateMotifSequenceMatchBeginQ9KSN057 .
?templateMotifSequenceMatchBeginQ9KSN057 faldo:position ?templateMotifSequenceMatchBeginPositionQ9KSN052 ;
faldo:reference isoform:Q9KSN0-1 .
?templateMotifSequenceProfileAlignmentOperationQ9KSN058 edam:has_input signature:MF_00812 ;
rdf:type edam:operation_0300 .
?targetMotifMatch59 faldo:location ?targetMotifMatchRegionMatch60 ;
edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0081262 ;
rdf:type edam:data_0869 ;
rdf:value ?targetMotifMatchCigarQ9KSN0MF_0081253 .
?targetMotifMatchRegionMatch60 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0081261 .
?targetMotifMatchRegionMatchBeginMF_0081261 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0081254 ;
faldo:reference ?thisSequence .
?targetMotifSequenceAlignmentOperationMF_0081262 edam:has_input signature:MF_00812 ;
rdf:type edam:operation_0300 .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ9KSN0MF_0081251, 1, (STRLEN(?templateMotifCigarQ9KSN0MF_0081251) - STRLEN(REPLACE(?templateMotifCigarQ9KSN0MF_0081251, CONCAT('^(?:-*[^-]){', STR(((46 - ?templateMotifSequenceMatchBeginPositionQ9KSN052) + 1)), '}'), '')))), '[a-z]', '')) AS ?step163) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ9KSN0MF_0081253, 1, (STRLEN(?targetMotifMatchCigarQ9KSN0MF_0081253) - STRLEN(REPLACE(?targetMotifMatchCigarQ9KSN0MF_0081253, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step163), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ9KSN0MF_0081253, 1, (STRLEN(?targetMotifMatchCigarQ9KSN0MF_0081253) - STRLEN(REPLACE(?targetMotifMatchCigarQ9KSN0MF_0081253, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step163), '}'), '')))), '[^-]', ''))) AS ?step264) .
BIND(((?step264 + ?targetMotifMatchRegionMatchBeginPositionMF_0081254) - 1) AS ?thisPositionOn20) .
BIND(?thisPositionOn20 AS ?thisPositionOn21) .
BIND(?this AS ?pfs1t65) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn20))) AS ?pfsb17) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn21))) AS ?pfse18) .
FILTER (REGEX('[LM]', SUBSTR(?thisSequenceValue, ?thisPositionOn20, 1))) .
BIND(URI(CONCAT(STR(?this), '#MF_00812a16')) AS ?annotation16) .
BIND(?this AS ?pfs15) .
}
OPTIONAL {
?this up:sequence ?thisSequence .
?thisSequence rdf:value ?thisSequenceValue .
?templateMotifMatch70 faldo:location ?templateMotifSequenceMatchRegionQ9KSN071 ;
edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ9KSN073 ;
rdf:type edam:data_0869 ;
rdf:value ?templateMotifCigarQ9KSN0MF_0081266 .
?templateMotifSequenceMatchRegionQ9KSN071 faldo:begin ?templateMotifSequenceMatchBeginQ9KSN072 .
?templateMotifSequenceMatchBeginQ9KSN072 faldo:position ?templateMotifSequenceMatchBeginPositionQ9KSN067 ;
faldo:reference isoform:Q9KSN0-1 .
?templateMotifSequenceProfileAlignmentOperationQ9KSN073 edam:has_input signature:MF_00812 ;
rdf:type edam:operation_0300 .
?targetMotifMatch74 faldo:location ?targetMotifMatchRegionMatch75 ;
edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0081277 ;
rdf:type edam:data_0869 ;
rdf:value ?targetMotifMatchCigarQ9KSN0MF_0081268 .
?targetMotifMatchRegionMatch75 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0081276 .
?targetMotifMatchRegionMatchBeginMF_0081276 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0081269 ;
faldo:reference ?thisSequence .
?targetMotifSequenceAlignmentOperationMF_0081277 edam:has_input signature:MF_00812 ;
rdf:type edam:operation_0300 .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ9KSN0MF_0081266, 1, (STRLEN(?templateMotifCigarQ9KSN0MF_0081266) - STRLEN(REPLACE(?templateMotifCigarQ9KSN0MF_0081266, CONCAT('^(?:-*[^-]){', STR(((67 - ?templateMotifSequenceMatchBeginPositionQ9KSN067) + 1)), '}'), '')))), '[a-z]', '')) AS ?step178) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ9KSN0MF_0081268, 1, (STRLEN(?targetMotifMatchCigarQ9KSN0MF_0081268) - STRLEN(REPLACE(?targetMotifMatchCigarQ9KSN0MF_0081268, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step178), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ9KSN0MF_0081268, 1, (STRLEN(?targetMotifMatchCigarQ9KSN0MF_0081268) - STRLEN(REPLACE(?targetMotifMatchCigarQ9KSN0MF_0081268, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step178), '}'), '')))), '[^-]', ''))) AS ?step279) .
BIND(((?step279 + ?targetMotifMatchRegionMatchBeginPositionMF_0081269) - 1) AS ?thisPositionOn27) .
BIND(?thisPositionOn27 AS ?thisPositionOn28) .
BIND(?this AS ?pfs1t80) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn27))) AS ?pfsb24) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn28))) AS ?pfse25) .
FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn27, 1) = 'E')) .
BIND(URI(CONCAT(STR(?this), '#MF_00812a23')) AS ?annotation23) .
BIND(?this AS ?pfs22) .
}
OPTIONAL {
?this up:sequence ?thisSequence .
?thisSequence rdf:value ?thisSequenceValue .
?templateMotifMatch85 faldo:location ?templateMotifSequenceMatchRegionQ9KSN086 ;
edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ9KSN088 ;
rdf:type edam:data_0869 ;
rdf:value ?templateMotifCigarQ9KSN0MF_0081281 .
?templateMotifSequenceMatchRegionQ9KSN086 faldo:begin ?templateMotifSequenceMatchBeginQ9KSN087 .
?templateMotifSequenceMatchBeginQ9KSN087 faldo:position ?templateMotifSequenceMatchBeginPositionQ9KSN082 ;
faldo:reference isoform:Q9KSN0-1 .
?templateMotifSequenceProfileAlignmentOperationQ9KSN088 edam:has_input signature:MF_00812 ;
rdf:type edam:operation_0300 .
?targetMotifMatch89 faldo:location ?targetMotifMatchRegionMatch90 ;
edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0081292 ;
rdf:type edam:data_0869 ;
rdf:value ?targetMotifMatchCigarQ9KSN0MF_0081283 .
?targetMotifMatchRegionMatch90 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0081291 .
?targetMotifMatchRegionMatchBeginMF_0081291 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0081284 ;
faldo:reference ?thisSequence .
?targetMotifSequenceAlignmentOperationMF_0081292 edam:has_input signature:MF_00812 ;
rdf:type edam:operation_0300 .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ9KSN0MF_0081281, 1, (STRLEN(?templateMotifCigarQ9KSN0MF_0081281) - STRLEN(REPLACE(?templateMotifCigarQ9KSN0MF_0081281, CONCAT('^(?:-*[^-]){', STR(((122 - ?templateMotifSequenceMatchBeginPositionQ9KSN082) + 1)), '}'), '')))), '[a-z]', '')) AS ?step193) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ9KSN0MF_0081283, 1, (STRLEN(?targetMotifMatchCigarQ9KSN0MF_0081283) - STRLEN(REPLACE(?targetMotifMatchCigarQ9KSN0MF_0081283, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step193), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ9KSN0MF_0081283, 1, (STRLEN(?targetMotifMatchCigarQ9KSN0MF_0081283) - STRLEN(REPLACE(?targetMotifMatchCigarQ9KSN0MF_0081283, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step193), '}'), '')))), '[^-]', ''))) AS ?step294) .
BIND(((?step294 + ?targetMotifMatchRegionMatchBeginPositionMF_0081284) - 1) AS ?thisPositionOn34) .
BIND(?thisPositionOn34 AS ?thisPositionOn35) .
BIND(?this AS ?pfs1t95) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn34))) AS ?pfsb31) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn35))) AS ?pfse32) .
FILTER ((SUBSTR(?thisSequenceValue, ?thisPositionOn34, 1) = 'R')) .
BIND(URI(CONCAT(STR(?this), '#MF_00812a30')) AS ?annotation30) .
BIND(?this AS ?pfs29) .
}
}
"xsd:string |
