| http://purl.uniprot.org/unirules/MF_04074#construct | http://www.w3.org/ns/shacl#construct | "CONSTRUCT {
_:929582 up:source unirule:MF_04074 .
_:929583 up:source unirule:MF_04074 .
_:929584 up:source unirule:MF_04074 .
_:929585 up:source unirule:MF_04074 .
_:929586 up:source unirule:MF_04074 .
_:929587 up:source unirule:MF_04074 .
_:929588 up:source unirule:MF_04074 .
_:929589 up:source unirule:MF_04074 .
_:929590 up:source unirule:MF_04074 .
_:929591 up:source unirule:MF_04074 .
_:929592 up:source unirule:MF_04074 .
_:929593 up:source unirule:MF_04074 .
_:929594 up:source unirule:MF_04074 .
_:929595 up:source unirule:MF_04074 .
_:929596 up:source unirule:MF_04074 .
_:929597 up:source unirule:MF_04074 .
_:929598 up:source unirule:MF_04074 .
_:929599 up:source unirule:MF_04074 .
_:929600 up:source unirule:MF_04074 .
_:929601 up:source unirule:MF_04074 .
_:929602 up:source unirule:MF_04074 .
_:929603 up:source unirule:MF_04074 .
_:929604 up:source unirule:MF_04074 .
_:929605 up:source unirule:MF_04074 .
_:929606 up:source unirule:MF_04074 .
_:929607 up:source unirule:MF_04074 .
_:929608 up:source unirule:MF_04074 .
_:929609 up:source unirule:MF_04074 .
?this up:alternativeName ?name1 ,
?name2 ,
?name3 ;
up:annotation ?annotation5 ,
?annotation6 ,
?annotation7 ,
?annotation11 ,
?annotation12 ;
up:classifiedWith GO:0006351 ,
GO:0019079 ,
GO:0033650 ,
GO:0039592 ,
GO:0042025 ,
GO:0085033 ,
keyword:1035 ,
keyword:1045 ,
keyword:1048 ,
keyword:1074 ,
keyword:1079 ,
keyword:10 ,
keyword:1121 ,
keyword:53 ,
keyword:804 ,
keyword:805 ,
keyword:945 ;
up:recommendedName ?name0 .
?name0 up:fullName 'Protein X' ;
rdf:type up:Structured_Name .
?name1 up:fullName 'HBx' ;
rdf:type up:Structured_Name .
?name2 up:fullName 'Peptide X' ;
rdf:type up:Structured_Name .
?name3 up:fullName 'pX' ;
rdf:type up:Structured_Name .
?gene4 skos:prefLabel 'X' .
?annotation5 a up:Function_Annotation ;
rdfs:comment 'Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.' .
?annotation6 a up:Subunit_Annotation ;
rdfs:comment 'May form homodimer. May interact with host CEBPA, CFLAR, CREB1, DDB1, E4F1, HBXIP, HSPD1/HSP60, NFKBIA, POLR2E and SMAD4. Interacts with host SMC5-SMC6 complex and induces its degradation.' .
?annotation7 a up:Subcellular_Location_Annotation ;
rdfs:comment 'Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes' .
?annotation7li8 up:cellularComponent .
?annotation7li9 up:cellularComponent .
?annotation7li10 up:cellularComponent .
?annotation11 a up:PTM_Annotation ;
rdfs:comment 'A fraction may be phosphorylated in insect cells and HepG2 cells, a human hepatoblastoma cell line. Phosphorylated in vitro by host protein kinase C or mitogen-activated protein kinase. N-acetylated in insect cells.' .
?annotation12 a up:Similarity_Annotation ;
rdfs:comment 'Belongs to the orthohepadnavirus protein X family.' .
?pfs13 up:annotation ?annotation14 .
?annotation14 faldo:begin ?pfsb15 ;
faldo:end ?pfse16 ;
rdf:type up:Region_Annotation ;
rdfs:comment 'Mitochondrial targeting sequence' .
?pfsb15 faldo:position ?thisPositionOn17 ;
rdf:type faldo:ExactPosition .
?pfse16 faldo:position ?thisPositionOn18 ;
rdf:type faldo:ExactPosition .
_:929610 a rdf:Statement ;
up:attribution _:929582 ;
rdf:subject ?this ;
rdf:predicate up:recommendedName ;
rdf:object ?name0 .
_:929611 a rdf:Statement ;
up:attribution _:929583 ;
rdf:subject ?this ;
rdf:predicate up:alternativeName ;
rdf:object ?name1 .
_:929612 a rdf:Statement ;
up:attribution _:929584 ;
rdf:subject ?this ;
rdf:predicate up:alternativeName ;
rdf:object ?name2 .
_:929613 a rdf:Statement ;
up:attribution _:929585 ;
rdf:subject ?this ;
rdf:predicate up:alternativeName ;
rdf:object ?name3 .
_:929614 a rdf:Statement ;
up:attribution _:929586 ;
rdf:subject ?gene4 ;
rdf:predicate up:encodedBy ;
rdf:object ?gene4 .
_:929615 a rdf:Statement ;
up:attribution _:929587 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation5 .
_:929616 a rdf:Statement ;
up:attribution _:929588 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation6 .
_:929617 a rdf:Statement ;
up:attribution _:929589 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation7 .
_:929618 a rdf:Statement ;
up:attribution _:929590 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation11 .
_:929619 a rdf:Statement ;
up:attribution _:929591 ;
rdf:subject ?this ;
rdf:predicate up:annotation ;
rdf:object ?annotation12 .
_:929620 a rdf:Statement ;
up:attribution _:929592 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:1074 .
_:929621 a rdf:Statement ;
up:attribution _:929593 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:10 .
_:929622 a rdf:Statement ;
up:attribution _:929594 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:53 .
_:929623 a rdf:Statement ;
up:attribution _:929595 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:1035 .
_:929624 a rdf:Statement ;
up:attribution _:929596 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:1079 .
_:929625 a rdf:Statement ;
up:attribution _:929597 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:1045 .
_:929626 a rdf:Statement ;
up:attribution _:929598 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:1048 .
_:929627 a rdf:Statement ;
up:attribution _:929599 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:945 .
_:929628 a rdf:Statement ;
up:attribution _:929600 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:1121 .
_:929629 a rdf:Statement ;
up:attribution _:929601 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:804 .
_:929630 a rdf:Statement ;
up:attribution _:929602 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object keyword:805 .
_:929631 a rdf:Statement ;
up:attribution _:929603 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0033650 .
_:929632 a rdf:Statement ;
up:attribution _:929604 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0042025 .
_:929633 a rdf:Statement ;
up:attribution _:929605 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0085033 .
_:929634 a rdf:Statement ;
up:attribution _:929606 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0039592 .
_:929635 a rdf:Statement ;
up:attribution _:929607 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0006351 .
_:929636 a rdf:Statement ;
up:attribution _:929608 ;
rdf:subject ?this ;
rdf:predicate up:classifiedWith ;
rdf:object GO:0019079 .
_:929637 a rdf:Statement ;
up:source unirule:MF_04074 ;
rdf:subject ?pfs13 ;
rdf:predicate up:annotation ;
rdf:object ?annotation14 .
_:929638 a rdf:Statement ;
up:attribution _:929609 ;
rdf:subject ?pfs13 ;
rdf:predicate up:annotation ;
rdf:object ?annotation14 .
}
WHERE {
#baseURI: http://purl.uniprot.org/unirule/MF_04074
#Rule MF_04074 Created by:? on:2017-05-09 Modified by:Catherine Rivoire on:2024-04-25
?this up:organism ?thisOrganism ;
rdfs:seeAlso signature:MF_04074 .
?thisOrganism rdfs:subClassOf+ taxon:10405 .
BIND(URI(CONCAT(STR(?this), '#MF_04074a0')) AS ?name0) .
BIND(URI(CONCAT(STR(?this), '#MF_04074a1')) AS ?name1) .
BIND(URI(CONCAT(STR(?this), '#MF_04074a2')) AS ?name2) .
BIND(URI(CONCAT(STR(?this), '#MF_04074a3')) AS ?name3) .
BIND(URI(CONCAT(STR(?this), '#MF_04074a5')) AS ?annotation5) .
BIND(URI(CONCAT(STR(?this), '#MF_04074a6')) AS ?annotation6) .
BIND(URI(CONCAT(STR(?this), '#MF_04074a7')) AS ?annotation7) .
BIND(URI(CONCAT(STR(?this), '#MF_04074a11')) AS ?annotation11) .
BIND(URI(CONCAT(STR(?this), '#MF_04074a12')) AS ?annotation12) .
OPTIONAL {
?this up:sequence ?thisSequence .
?thisSequence rdf:value ?thisSequenceValue .
?templateMotifMatch23 faldo:location ?templateMotifSequenceMatchRegionQ6902724 ;
edam:is_output_of ?templateMotifSequenceProfileAlignmentOperationQ6902726 ;
rdf:type edam:data_0869 ;
rdf:value ?templateMotifCigarQ69027MF_0407419 .
?templateMotifSequenceMatchRegionQ6902724 faldo:begin ?templateMotifSequenceMatchBeginQ6902725 .
?templateMotifSequenceMatchBeginQ6902725 faldo:position ?templateMotifSequenceMatchBeginPositionQ6902720 ;
faldo:reference isoform:Q69027-1 .
?templateMotifSequenceProfileAlignmentOperationQ6902726 edam:has_input signature:MF_04074 ;
rdf:type edam:operation_0300 .
?targetMotifMatch27 faldo:location ?targetMotifMatchRegionMatch28 ;
edam:is_output_of ?targetMotifSequenceAlignmentOperationMF_0407430 ;
rdf:type edam:data_0869 ;
rdf:value ?targetMotifMatchCigarQ69027MF_0407421 .
?targetMotifMatchRegionMatch28 faldo:begin ?targetMotifMatchRegionMatchBeginMF_0407429 .
?targetMotifMatchRegionMatchBeginMF_0407429 faldo:position ?targetMotifMatchRegionMatchBeginPositionMF_0407422 ;
faldo:reference ?thisSequence .
?targetMotifSequenceAlignmentOperationMF_0407430 edam:has_input signature:MF_04074 ;
rdf:type edam:operation_0300 .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ69027MF_0407419, 1, (STRLEN(?templateMotifCigarQ69027MF_0407419) - STRLEN(REPLACE(?templateMotifCigarQ69027MF_0407419, CONCAT('^(?:-*[^-]){', STR(((68 - ?templateMotifSequenceMatchBeginPositionQ6902720) + 1)), '}'), '')))), '[a-z]', '')) AS ?step131) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ69027MF_0407421, 1, (STRLEN(?targetMotifMatchCigarQ69027MF_0407421) - STRLEN(REPLACE(?targetMotifMatchCigarQ69027MF_0407421, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step131), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ69027MF_0407421, 1, (STRLEN(?targetMotifMatchCigarQ69027MF_0407421) - STRLEN(REPLACE(?targetMotifMatchCigarQ69027MF_0407421, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step131), '}'), '')))), '[^-]', ''))) AS ?step232) .
BIND(((?step232 + ?targetMotifMatchRegionMatchBeginPositionMF_0407422) - 1) AS ?thisPositionOn17) .
BIND(STRLEN(REPLACE(SUBSTR(?templateMotifCigarQ69027MF_0407419, 1, (STRLEN(?templateMotifCigarQ69027MF_0407419) - STRLEN(REPLACE(?templateMotifCigarQ69027MF_0407419, CONCAT('^(?:-*[^-]){', STR(((117 - ?templateMotifSequenceMatchBeginPositionQ6902720) + 1)), '}'), '')))), '[a-z]', '')) AS ?step133) .
BIND((STRLEN(SUBSTR(?targetMotifMatchCigarQ69027MF_0407421, 1, (STRLEN(?targetMotifMatchCigarQ69027MF_0407421) - STRLEN(REPLACE(?targetMotifMatchCigarQ69027MF_0407421, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step133), '}'), ''))))) - STRLEN(REPLACE(SUBSTR(?targetMotifMatchCigarQ69027MF_0407421, 1, (STRLEN(?targetMotifMatchCigarQ69027MF_0407421) - STRLEN(REPLACE(?targetMotifMatchCigarQ69027MF_0407421, CONCAT('^(?:[a-z]*(?:[A-Z]|-)){', STR(?step133), '}'), '')))), '[^-]', ''))) AS ?step234) .
BIND(((?step234 + ?targetMotifMatchRegionMatchBeginPositionMF_0407422) - 1) AS ?thisPositionOn18) .
BIND(?this AS ?pfs1t35) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn17))) AS ?pfsb15) .
BIND(URI(CONCAT(STR(?thisSequence), '#position', STR(?thisPositionOn18))) AS ?pfse16) .
FILTER ((BOUND(?thisPositionOn17) && BOUND(?thisPositionOn18))) .
BIND(URI(CONCAT(STR(?this), '#MF_04074a14')) AS ?annotation14) .
BIND(?this AS ?pfs13) .
}
}
"xsd:string |
