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Species code:	BORBZ
Taxonomy:	Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia; Borrelia burgdorferi group (TaxID: 445985) [NEWT/ NCBI]
Description:	Borreliae, the causative agent of Lyme disease, are obligatorily bound to their host organisms for survival. It is a Spirochetes, a spiral-shaped bacterium. Highly specialized, motile, with two membranes, it lives primarily as an extracellular pathogen. During their life cycle they switch from the invertebrate host tick (Ixodes spec.) to various vertebrate hosts via a tick bite. It seems that Borellia have three indispensable components; a chromosome, a circular plasmid of approximately 26 kb (maybe ZS7_cp26 in B.burgdorferi) and a linear plasmid of approximately 54 kb (probably ZS7_lp54 in B.burgdorferi ZS7), each species can also contain many other plasmids. The range of vertebrates and invertebrates used as hosts is thought to be mediated by factors encoded mainly on a large number of different plasmids found in Borreliae genomes. These plasmids are characterized by their wealth of paralogous genes. It is thought that Borreliae plasmids are not stable and are frequently rearranged leading to differing plasmid content within a species. The chromosome is also involved in fission/fusion events, and the right end of the chromosome of B. burgdorferi strains is variable due to its ability to catch plasmids. During passage plasmids can be lost due to the lack of selection pressure, which can be accompanied by the inability of Borreliae to prosper in the host. Strain ZS7 was isolated from Ixodes rizinus ticks collected by flagging in the Freiburg, Germany area in the 1980s.
Properties:	Presence of flagella: Yes Human pathogen: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of BORBZ entries in the UniProt Knowledgebase: 1223 (160 in UniProtKB/Swiss-Prot + 1063 in UniProtKB/TrEMBL)

Genome structure:	• Chromosome EMBL accession number CP001205 (linear; 906,707 bp) (download entry) • Plasmid ZS7_lp25 EMBL accession number CP001198 (linear; 24,326 bp) (download entry) • Plasmid ZS7_lp54 EMBL accession number CP001199 (linear; 53,615 bp) (download entry) • Plasmid ZS7_cp32-12 EMBL accession number CP001200 (circular; 29,806 bp) (download entry) • Plasmid ZS7_lp36 EMBL accession number CP001201 (linear; 36,852 bp) (download entry) • Plasmid ZS7_cp32-3+10 EMBL accession number CP001202 (circular; 48,168 bp) (download entry) • Plasmid ZS7_lp28-3 EMBL accession number CP001203 (linear; 28,414 bp) (download entry) • Plasmid ZS7_lp17 EMBL accession number CP001204 (linear; 17,266 bp) (download entry) • Plasmid ZS7_cp32-1 EMBL accession number CP001206 (circular; 30,330 bp) (download entry) • Plasmid ZS7_lp28-4 EMBL accession number CP001207 (linear; 28,885 bp) (download entry) • Plasmid ZS7_cp32-4 EMBL accession number CP001208 (circular; 30,964 bp) (download entry) • Plasmid ZS7_lp28-2 EMBL accession number CP001209 (linear; 29,758 bp) (download entry) • Plasmid ZS7_lp28-1 EMBL accession number CP001210 (linear; 23,422 bp) (download entry) • Plasmid ZS7_cp32-9 EMBL accession number CP001211 (circular; 30,467 bp) (download entry) • Plasmid ZS7_cp26 EMBL accession number CP001212 (circular; 26,514 bp) (download entry)
Reference(s):	[1] PubMed=20935092; [ NCBI , EBI , Israel , Japan ] Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J., Mongodin E.F., Luft B.J. ; "Whole genome sequences of thirteen isolates of Borrelia burgdorferi."; J. Bacteriol. 193:1018-1020(2011).
Web links:	Official genome site(s): http://msc.jcvi.org/borrelia/index.shtml Other web sites: Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=19839 Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/project.php?pid=19839 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Bbur_ZS7 GOLD: http://genomesonline.org/cgi-bin/GOLD/bin/GOLDCards.cgi?goldstamp=Gc01432 PATRIC: http://patricbrc.vbi.vt.edu/portal/portal/patric/Genome?cType=genome&cId=54821  EBI Proteome Analysis page

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