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Species code:	BORDL
Taxonomy:	Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia (TaxID: 412419) [NEWT/ NCBI]
Description:	Relapsing fever (RF) is a disease caused by several spirochetes of the genus Borrelia. Relapsing fever borrelioses are characterized by recurrent febrile episodes and spirochetemia. There are 2 forms; louse-borne relapsing fever (also known as urban or epidemic RF) is caused by Borrelia recurrentis, and is transmitted by the body louse Pediculus humanus humanus. It currently known in Ethiopia. Endemic tick-borne relapsing fever (TBRF) is a zoonotic disease transmitted worldwide by softbody ticks of the genus Ornithodoros. It is caused by at least 15 distinct Borrelia species throughout the world. Borrelia duttonii is endemic in Western Africa, where it causes TBRF, causing up to 6 relapses, no mortality but often adverse perinatal outcomes. Strain Ly was isolated from a 2-year-old girl with TBRF in Tanzania, and has 16 plasmids. Interestingly B.recurrentis strain A1 (BORRA), a causative agent of louse-borne relapsing fever RF, and sequenced by the same group at the same time, has been deduced to be a reduced form of B.duttonii undergoing genome decay.
Properties:	Presence of flagella: Yes Human pathogen: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of BORDL entries in the UniProt Knowledgebase: 1287 (120 in UniProtKB/Swiss-Prot + 1167 in UniProtKB/TrEMBL)

Genome structure:	• Chromosome EMBL accession number CP000976 (linear; 931,674 bp) (download entry) • Plasmid pl165 EMBL accession number CP000979 (linear; 163,884 bp) (download entry) • Plasmid pl70 EMBL accession number CP000990 (linear; 66,407 bp) (download entry) • Plasmid pl42 EMBL accession number CP000989 (linear; 42,153 bp) (download entry) • Plasmid pl41 EMBL accession number CP000988 (linear; 41,259 bp) (download entry) • Plasmid pl40 EMBL accession number CP000987 (linear; 40,353 bp) (download entry) • Plasmid pl36 EMBL accession number CP000986 (linear; 35,831 bp) (download entry) • Plasmid pl35 EMBL accession number CP000985 (linear; 35,286 bp) (download entry) • Plasmid pl32 EMBL accession number CP000992 (linear; 31,663 bp) (download entry) • Plasmid pl31 EMBL accession number CP000991 (linear; 31,021 bp) (download entry) • Plasmid pl28 EMBL accession number CP000984 (linear; 28,343 bp) (download entry) • Plasmid pl27 EMBL accession number CP000983 (circular; 27,476 bp) (download entry) • Plasmid pl26 EMBL accession number CP000982 (linear; 26,917 bp) (download entry) • Plasmid pl23 EMBL accession number CP000980 (linear; 23,303 bp) (download entry) • Plasmid pl23b EMBL accession number CP000981 (linear; 23,036 bp) (download entry) • Plasmid pl15 EMBL accession number CP000978 (linear; 15,049 bp) (download entry) • Plasmid pl11 EMBL accession number CP000977 (linear; 11,226 bp) (download entry)
Reference(s):	[1] PubMed=18787695; [ NCBI , EBI , Israel , Japan ] Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M. ; "The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii."; PLoS Genet. 4:E1000185-E1000185(2008).
Web links:	Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=18231 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Bdut_Ly PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p18231_Bor_dutto  EBI Proteome Analysis page

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