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Species code:	BORRA
Taxonomy:	Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia (TaxID: 412418) [NEWT/ NCBI]
Description:	Relapsing fever (RF) is a disease caused by several spirochetes of the genus Borrelia. Relapsing fever borrelioses are characterized by recurrent febrile episodes and spirochetemia. There are 2 forms; louse-borne relapsing fever (also known as urban or epidemic RF) is caused by Borrelia recurrentis, and is transmitted by the body louse Pediculus humanus humanus. It currently known in Ethiopia. Endemic tick-borne relapsing fever (TBRF) is a zoonotic disease transmitted worldwide by softbody ticks of the genus Ornithodoros. It is caused by at least 15 distinct Borrelia species throughout the world. Borrelia recurrentis strain A1 was isolated from an adult with RF in Ethiopia. RF causes fewer relapses that TBRF but has a higher spontaneous mortality rate despite antibiotics. Previous work suggested that B.recurrentis was very closely related to B.duttonii; the current sequencing project suggests that in fact B.recurrentis should be considered a strain of B.duttonii that is undergoing considerable gene decay. Decay is probably due at least in part to mutated recA and mutS genes in A1. All 6 plasmids in strain A1 have a counterpart in B.duttonii strain Ly (BORDL).
Properties:	Presence of flagella: Yes Human pathogen: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of BORRA entries in the UniProt Knowledgebase: 977 (116 in UniProtKB/Swiss-Prot + 861 in UniProtKB/TrEMBL)

Genome structure:	• Chromosome EMBL accession number CP000993 (linear; 930,981 bp) (download entry) • Plasmid pl124 EMBL accession number CP000994 (linear; 123,937 bp) (download entry) • Plasmid pl23 EMBL accession number CP000995 (linear; 22,945 bp) (download entry) • Plasmid pl33 EMBL accession number CP000996 (linear; 33,213 bp) (download entry) • Plasmid pl35 EMBL accession number CP000997 (linear; 35,315 bp) (download entry) • Plasmid pl37 EMBL accession number CP000998 (linear; 36,869 bp) (download entry) • Plasmid pl53 EMBL accession number CP000999 (linear; 52,772 bp) (download entry) • Plasmid pl6 EMBL accession number CP001000 (linear; 6,131 bp) (download entry)
Reference(s):	[1] PubMed=18787695; [ NCBI , EBI , Israel , Japan ] Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M. ; "The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii."; PLoS Genet. 4:E1000185-E1000185(2008).
Web links:	Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=18233 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Brec_A1 PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p18233_Bor_recur  EBI Proteome Analysis page

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