Home Proteomes Families Hamap-Scan Documents Downloads Links
HAMAP: Brucella abortus (strain S19) complete proteome
General information

Species:  Brucella abortus (strain S19)
Species code: BRUA1
Taxonomy: Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella (TaxID: 430066) [NEWT/ NCBI]
Description: The genus Brucella is comprised mostly of mammalian pathogens, which due to their low infectious does, aerosol transmission and treatment difficulty are classified as potential bioterrorism agents. Brucella abortus (strain S19) is a spontaneously attenuated strain discovered by Dr. John Buck in 1923. However, the underlying molecular or physiological mechanisms causing the loss of virulence is not well understood. B. abortus is the primary cause of bovine brucellosis, which results in enormous (billions of dollars) economic losses due primarily to reproductive failure and food losses. It is highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. In man, it causes undulant fever, a long debilitating disease that is treated by protracted administration of antibiotics. Since early 1930s, this strain has been used worldwide as an effective vaccine to prevent brucellosis in cattle until it was replaced by strain RB51 during the 1990s. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of BRUA1 entries in the UniProt Knowledgebase: 2993 (320 in UniProtKB/Swiss-Prot + 2673 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    S19
Genome structure:
• Chromosome 1 EMBL accession number CP000887 (circular; 2,122,487 bp) (download entry)
• Chromosome 2 EMBL accession number CP000888 (circular; 1,161,449 bp) (download entry)
Reference(s):
[1] PubMed=18478107; [ NCBI , EBI , Israel , Japan ]
Crasta O.R., Folkerts O., Fei Z., Mane S.P., Evans C., Martino-Catt S., Bricker B., Yu G., Du L., Sobral B.W. ;
"Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes.";
PLoS ONE 3:E2193-E2193(2008).
Web links:
Official genome site(s):
http://patric.vbi.vt.edu/genome/overview.php?genomeId=7202
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=18999
Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/project.php?pid=18999
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Babo_S19
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p18999_Bru_abort
 EBI Proteome Analysis page



Tools