Home | Contact

Species code:	BRUME
Taxonomy:	Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella (TaxID: 224914) [NEWT/ NCBI]
Description:	The genus Brucella is comprised mostly of mammalian pathogens, which due to their low infectious does, aerosol transmission and treatment difficulty are classified as potential bioterrorism agents. Brucellosis is a major infectious disease for both human and animals. Several Brucella species (B.abortus, B. melitensis and B.suis) have been isolated from many different animals. All three Brucella species cause a severe human disease characterized in its acute phase by undulant fever and in its chronic phase by damage of different organs. When the infection is localized to the brain or the heart, it can result in a fatal meningitidis or fatal endocarditis, respectively. Brucellosis is a major problem in the Mediterranean region and parts of Asia, Africa and Latin America. Brucella melitensis is a facultative intracellular bacterial pathogen that causes abortion in goats and sheep and undulant fever in humans. The disease is transmitted to human by consumption of nonpasteurized milk and milk products or by direct contact with infected animals and carcasses. Although Brucellae contain a large set of flagellar genes, they display a species-specific gene inactivation and consequently are nonmotile.
Properties:	Presence of flagella: No Human pathogen: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of BRUME entries in the UniProt Knowledgebase: 4966 (572 in UniProtKB/Swiss-Prot + 4394 in UniProtKB/TrEMBL)

Genome structure:	• Chromosome I EMBL accession number AE008917 (circular; 2,117,144 bp) (download entry) • Chromosome II EMBL accession number AE008918 (circular; 1,177,787 bp) (download entry)
Reference(s):	[1] MEDLINE=20020109; PubMed=11756688; [ NCBI , EBI , Israel , Japan ] DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. ; "The genome sequence of the facultative intracellular pathogen Brucella melitensis."; Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
Web links:	CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Brucella&GLspecies=melitensis&GLstrain=16M Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid224914%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Bmel_16M JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=ntbm01 Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Brucella_melitensis.html PATRIC: http://patric.vbi.vt.edu/genome/overview.php?genomeId=10 PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p180_Bru_melit RhizoDB: http://xbase.bham.ac.uk/rhizodb/genome.pl?id=967  EBI Proteome Analysis page  UniProtKB/Swiss-Prot document

Genome structure:	Unassembled WGS sequence EMBL accession number ACJL01000000 (unknown;  bp) (download entry)
Reference(s):
Web links:

• Perform a BLAST search against all proteins from this proteome
  
  
• Download all UniProt Knowledgebase entries of this proteome
  • in UniProt Knowledgebase format
  • in FASTA format
  
  
• Retrieve set of characterized or identified proteins for this proteome
  
  
• Retrieve set of proteins with 3D structure for this proteome

Swiss Institute of Bioinformatics | Disclaimer