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Species code:	BRUSU
Taxonomy:	Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella (TaxID: 204722) [NEWT/ NCBI]
Description:	The genus Brucella is comprised mostly of mammalian pathogens, which due to their low infectious does, aerosol transmission and treatment difficulty are classified as potential bioterrorism agents. Brucellosis is a major infectious disease for both human and animals. Several Brucella species (B.abortus, B.melitensis and B.suis) have been isolated from many different animals. All three Brucella species cause a severe human disease characterized in its acute phase by undulant fever and in its chronic phase by damage of different organs. When the infection is localized to the brain or the heart, it can result in a fatal meningitidis or fatal endocarditis, respectively. Brucellosis is a major problem in the Mediterranean region and parts of Asia, Africa and Latin America. Brucella suis was the first pathogenic organism weaponized by the U.S. military during the 1950s. Although Brucellae contain a large set of flagellar genes, they display a species-specific gene inactivation and consequently are nonmotile. Strain 1330, which causes porcine brucellosis, was first sequenced in 2002. It has subsequently been resequenced in 2011. The new sequence has identified with a very high confidence a total of 12 sequence differences, including 10 indels and two substitutions between the original and revised reference sequences. Comparisons with other sequenced Brucella lead to the hypothesis that the differences are due to original sequence assembly errors rather than mutation of 1330 in the intervening years (adapted from 22038969).
Properties:	Presence of flagella: No Human pathogen: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of BRUSU entries in the UniProt Knowledgebase: 3256 (576 in UniProtKB/Swiss-Prot + 2680 in UniProtKB/TrEMBL)

Genome structure:	• Chromosome I EMBL accession number CP002997 (circular; 2,107,783 bp) (download entry) • Chromosome II EMBL accession number CP002998 (circular; 1,207,380 bp) (download entry)
Reference(s):	[1] PubMed=22038969; [ NCBI , EBI , Israel , Japan ] Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. ; "Revised genome sequence of Brucella suis 1330."; J. Bacteriol. 193:6410-6410(2011).
Web links:	BioProject: http://www.ncbi.nlm.nih.gov/bioproject/70695

Genome structure:	• Chromosome I EMBL accession number AE014291 (circular; 2,107,794 bp) (download entry) • Chromosome II EMBL accession number AE014292 (circular; 1,207,381 bp) (download entry)
Reference(s):	[1] MEDLINE=22247741; PubMed=12271122; [ NCBI , EBI , Israel , Japan ] Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. ; "The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."; Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
Web links:	BioProject: http://www.ncbi.nlm.nih.gov/bioproject/320 CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Brucella&GLspecies=Suis&GLstrain=1330 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Bsui_1330 GOLD: http://genomesonline.org/cgi-bin/GOLD/bin/GOLDCards.cgi?goldstamp=Gc00101 img/geba: http://img.jgi.doe.gov/cgi-bin/geba/main.cgi?section=TaxonDetail&page=taxonDetail&taxon_oid=637000042 JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=gbr Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Brucella_suis.html PATRIC: http://img.jgi.doe.gov/cgi-bin/geba/main.cgi?section=TaxonDetail&page=taxonDetail&taxon_oid=637000042 PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p320_Bru_suis RhizoDB: http://xbase.bham.ac.uk/rhizodb/genome.pl?id=970  EBI Proteome Analysis page  UniProtKB/Swiss-Prot document

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