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Species code:	BURCA
Taxonomy:	Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; Burkholderia cepacia complex (TaxID: 331271) [NEWT/ NCBI]
Description:	The Burkholderia cepacia complex (Bcc) comprises at least nine closely related species which can be correctly identified only by polyphasic taxonomic approaches. Members of the complex are among the most metabolically versatile microorganisms known as they grow on more than 200 organic compounds, fix N2 and carry multiple antibiotic resistances. They are involved in important processes such as biodegradation of pollutants, biocontrol of root diseases but some also cause disease in plants, animals and humans. Bcc strains are isolated from very different habitats, including soil, rhizospheres, streams and infected plants, animals and human tissues, especially lungs of cystic fibrosis (CF) patients. Bcc strains have large and plastic genomes comprised of multiple (2 to 4) replicons, which is thought to give them their ecological versatility. Burkholderia cenocepacia is a Gram-negative bacterium which is ubiquitous in the environment and may cause a number of diseases in plants. Human infection can be caused by B.cenocepacia, especially in patients with CF and chronic granulomatous disease, and is often fatal. B.cenocepacia (strain AU1054) was recovered from the blood of a patient with CF. It is characterized as a representative of the B.cenocepacia PHDC clonal lineage. This clone appears to be widely distributed, having been found in CF patients in 24 US states and Europe, as well as in agricultural soil. Its genome consists of 3 chromosomes of 3.2 Mb, 2.6 Mb and 1.1 Mb (adapted from http://genome.jgi-psf.org/burca/burca.home.html).
Properties:	Presence of flagella: Yes Human pathogen: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of BURCA entries in the UniProt Knowledgebase: 6450 (419 in UniProtKB/Swiss-Prot + 6031 in UniProtKB/TrEMBL)

Genome structure:	• Chromosome 1 EMBL accession number CP000378 (circular; 3,294,563 bp) (download entry) • Chromosome 2 EMBL accession number CP000379 (circular; 2,788,459 bp) (download entry) • Chromosome 3 EMBL accession number CP000380 (circular; 1,196,094 bp) (download entry)
Reference(s):	[1] Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P. ; "Complete sequence of chromosome 1 of Burkholderia cenocepacia AU 1054."; Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases. [2] Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P. ; "Complete sequence of chromosome 2 of Burkholderia cenocepacia AU 1054."; Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases. [3] Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P. ; "Complete sequence of chromosome 3 of Burkholderia cenocepacia AU 1054."; Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
Web links:	Official genome site(s): http://genome.jgi-psf.org/burca/burca.home.html Other web sites: CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Burkholderia&GLspecies=cenocepacia&GLsupStrain=AU1054 Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid331271%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Bcen_AU1054 Pathema: http://pathema.tigr.org/tigr-scripts/Burkholderia/GenomePage.cgi?org=ntbc04 PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p13919_Bur_cenoc  EBI Proteome Analysis page

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