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Species code:	BURCH
Taxonomy:	Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; Burkholderia cepacia complex (TaxID: 331272) [NEWT/ NCBI]
Description:	The Burkholderia cepacia complex (Bcc) comprises at least nine closely related species which can be correctly identified only by polyphasic taxonomic approaches. Members of the complex are among the most metabolically versatile microorganisms known as they grow on more than 200 organic compounds, fix N2 and carry multiple antibiotic resistances. They are involved in important processes such as biodegradation of pollutants, biocontrol of root diseases but some also cause disease in plants, animals and humans. Bcc strains are isolated from very different habitats, including soil, rhizospheres, streams and infected plants, animals and human tissues, especially lungs of cystic fibrosis (CF) patients. Bcc strains have large and plastic genomes comprised of multiple (2 to 4) replicons, which is thought to give them their ecological versatility. Burkholderia cenocepacia (strain HI2424) was recovered from agricultural soil in upstate NY. By using various genotyping methods, including macrorestriction digestion with pulsed field gel electrophoresis and multilocus sequence typing, it has been characterized as a representative of the B. cenocepacia PHDC clonal lineage. This clone appears to be widely distributed as a human pathogen, having been recovered from CF patients in 24 US states and in Europe (adapted from http://genome.jgi-psf.org/burce/burce.home.html).
Properties:	Presence of flagella: Yes Human pathogen: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of BURCH entries in the UniProt Knowledgebase: 6898 (402 in UniProtKB/Swiss-Prot + 6496 in UniProtKB/TrEMBL)

Genome structure:	• Chromosome 1 EMBL accession number CP000458 (circular; 3,483,902 bp) (download entry) • Chromosome 2 EMBL accession number CP000459 (circular; 2,998,664 bp) (download entry) • Chromosome 3 EMBL accession number CP000460 (circular; 1,055,417 bp) (download entry) • Plasmid pHI2424-1 EMBL accession number CP000461 (circular; 164,857 bp) (download entry)
Reference(s):	[1] Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. ; "Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424."; Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. [2] Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. ; "Complete sequence of chromosome 2 of Burkholderia cenocepacia HI2424."; Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. [3] Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. ; "Complete sequence of chromosome 3 of Burkholderia cenocepacia HI2424."; Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. [4] Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. ; "Complete sequence of plasmid 1 of Burkholderia cenocepacia HI2424."; Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
Web links:	Official genome site(s): http://genome.jgi-psf.org/burce/burce.home.html Other web sites: Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid331272%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Bcen_HI2424 PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p13918_Bur_cenoc  EBI Proteome Analysis page

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