Home Proteomes Families Hamap-Scan Documents Downloads Links
HAMAP: Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) complete proteome
General information

Species:  Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Species code: CHLT2
Taxonomy: Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydia/Chlamydophila group; Chlamydia (TaxID: 471472) [NEWT/ NCBI]
Description: Chlamydia trachomatis infection is an important cause of preventable blindness and sexually transmitted disease (STD) in humans. There are 15 serovariants that exhibit distinct organotropism for the eye or the urogenital tract and are separated according to the pathobiotypes. Trachoma biovariants consist of serovars A, B, Ba, C, D, E, F, G, H, I, J and K. LGV (Lymphogranuloma venereum) biovariants consist of serovars L1, L2 and L3. Trachoma biovariants are noninvasive and epitheliotropic strains that cause blinding trachoma (A to C) or sexually transmitted diseases. LGV biovariants cause sexually transmitted diseases with disseminating infection of draining regional lymph nodes. The trpBA operon encoding tryptophan synthase is functional in STD serovars, whereas trpBA harbors mutations that inactivate the enzyme in ocular serovars. Chlamydia trachomatis is an obligate intracellular parasite depending on the host machinery for ATP synthesis. Chlamydial life cycle comprehends an intracellular metabolically- active "reticular body" and an inert extracellular spore-like "elementary body" equipped with a unique disulfide-cross-linked protein envelope.

Chlamydia trachomatis (strain L2/434/Bu / ATCC VR902B) belongs to the LGV serovar. It was originally isolated from an inguinal bubo of a LGV case 40 years ago in California. LGV strains are more invasive than those of serovars A-K. They cause systemic infections, infect monocytes and disseminate to the local lymph nodes where they can cause large swellings characteristic of bubonic diseases. LGV serovars are endemic in parts of Africa, South East Asia, South America and the Caribbean. The incidence of LGV is low in the West, however a recent outbreak has been reported in the Netherlands. The typical characteristics of LGV in the tropics, genital ulcerations and inguinal buboes, were absent and the patients rather presented proctitis. This may explain the initial difficulties encountered in describing the outbreak.
Properties: Presence of flagella: Yes
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia (intracellular obligate)
Number of membranes: 2
Number of inteins:0
Statistics: Number of CHLT2 entries in the UniProt Knowledgebase: 884 (229 in UniProtKB/Swiss-Prot + 655 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    434/Bu / ATCC VR-902B
Genome structure:
• Chromosome EMBL accession number AM884176 (circular; 1,038,842 bp) (download entry)
• Plasmid pL2 EMBL accession number AM886278 (circular; 7,499 bp) (download entry)
Reference(s):
[1] PubMed=18032721; [ NCBI , EBI , Israel , Japan ]
Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. ;
"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates.";
Genome Res. 18:161-171(2008).
Web links:
Official genome site(s):
http://www.sanger.ac.uk/Projects/C_trachomatis_L2/
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=28583
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Ctra_434Bu
 EBI Proteome Analysis page



Tools