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HAMAP: Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis) complete proteome
General information

Species:  Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis)
Species code: CHLTB
Taxonomy: Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydia/Chlamydophila group; Chlamydia (TaxID: 471473) [NEWT/ NCBI]
Description: Chlamydia trachomatis infection is an important cause of preventable blindness and sexually transmitted disease (STD) in humans. There are 15 serovariants that exhibit distinct organotropism for the eye or the urogenital tract and are separated according to the pathobiotypes. Trachoma biovariants consist of serovars A, B, Ba, C, D, E, F, G, H, I, J and K. LGV (Lymphogranuloma venereum) biovariants consist of serovars L1, L2 and L3. Trachoma biovariants are noninvasive and epitheliotropic strains that cause blinding trachoma (A to C) or sexually transmitted diseases. LGV biovariants cause sexually transmitted diseases with disseminating infection of draining regional lymph nodes. The trpBA operon encoding tryptophan synthase is functional in STD serovars, whereas trpBA harbors mutations that inactivate the enzyme in ocular serovars. Chlamydia trachomatis is an obligate intracellular parasite depending on the host machinery for ATP synthesis. Chlamydial life cycle comprehends an intracellular metabolically- active "reticular body" and an inert extracellular spore-like "elementary body" equipped with a unique disulfide-cross-linked protein envelope.

The strain L2b/UCH-1/proctitis is a variant of the L2 serovar. LGV strains are more invasive than those of serovars A-K. They cause systemic infections, infect monocytes and disseminate to the local lymph nodes where they can cause large swellings characteristic of bubonic diseases. LGV serovars are endemic in parts of Africa, South East Asia, South America and the Caribbean. The incidence of LGV is low in the West, however a recent outbreak has been reported in the Netherlands. Chlamydia trachomatis L2b/UCH-1/proctitis was isolated from this recent outbreak of proctitis in Europe.
Properties: Presence of flagella: Yes
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia (intracellular obligate)
Number of membranes: 2
Number of inteins:0
Statistics: Number of CHLTB entries in the UniProt Knowledgebase: 883 (211 in UniProtKB/Swiss-Prot + 672 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    UCH-1/proctitis
Genome structure:
• Chromosome EMBL accession number AM884177 (circular; 1,038,863 bp) (download entry)
• Plasmid pUCH-1 EMBL accession number AM886279 (circular; 7,500 bp) (download entry)
Reference(s):
[1] PubMed=18032721; [ NCBI , EBI , Israel , Japan ]
Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. ;
"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates.";
Genome Res. 18:161-171(2008).
Web links:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=28585
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Ctra_UCH1
 EBI Proteome Analysis page



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