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HAMAP: Clostridium botulinum (strain Alaska E43 / Type E3) complete proteome
General information

Species:  Clostridium botulinum (strain Alaska E43 / Type E3)
Species code: CLOBA
Taxonomy: Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium (TaxID: 508767) [NEWT/ NCBI]
Description: Clostridium botulinum produces botulinum neurotoxin, one of deadliest toxins known. It inhibits acetylcholine release in neuromuscular junctions, causing paralysis by inhibiting muscle contraction. In most cases the affected person dies of asphyxiation or heart failure. Strains of C. botulinum are physiologically heterogeneous, and four distinct phenotypic groups (I to IV) are recognized. These four metabolically distinct groups do not, however, necessarily correlate with the serological specificities of the botulinum neurotoxin produced, which are classified into 7 serotypes, A-F. The type A toxin is used in minute doses to treat both painful muscle spasms and as a cosmetic treatment to temporarily remove frown lines between eyebrows.

C.botulinum strain Alaska E43 produces toxin type E3. It may have been isolated from from salmon eggs associated with a foodborne case of botulism in Alaska.
Properties: Presence of flagella: Yes
Human pathogen: Yes
Interaction: Saprophyte; Animal pathogen in Mammalia
Number of membranes: 1
Number of inteins:0
Statistics: Number of CLOBA entries in the UniProt Knowledgebase: 3254 (290 in UniProtKB/Swiss-Prot + 2964 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    Alaska E43 / Type E3
Genome structure:
Chromosome EMBL accession number CP001078 (circular; 3,659,644 bp) (download entry)
Reference(s):
[1] Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S. ;
"Complete genome sequence of Clostridium botulinum E3 str. Alaska E43.";
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
Web links:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=28855
 EBI Proteome Analysis page



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